AIM： To determine the levels of aquaporin-1（AQP-1） in the lens epithelial cells（LECs） of primary glaucoma and to clarify its correlation with lens thickness.METHODS： This study comprised 64 eyes of 64 patients w...AIM： To determine the levels of aquaporin-1（AQP-1） in the lens epithelial cells（LECs） of primary glaucoma and to clarify its correlation with lens thickness.METHODS： This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups： 25 eyes of 25 patients with acute primary angle-closure glaucoma（APACG）, 19 eyes of 19 patients with chronic primary angle-closure glaucoma（CPACG） and 20 eyes of 20 patients with primary open angle glaucoma（POAG）. This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction（RT-q PCR） and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS： The AQP-1 m RNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group（all P〈0.05）. The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 m RNA levels and the lens thickness（r=0.645, P〈0.001）. CONCLUSION： These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG.展开更多
The development of advanced and efficient anode catalysts to accelerate the kinetic rate of methanol oxidation plays an important role in the large-scale commercial application of the direct methanol fuel cells(DMFCs)...The development of advanced and efficient anode catalysts to accelerate the kinetic rate of methanol oxidation plays an important role in the large-scale commercial application of the direct methanol fuel cells(DMFCs).Herein,we report the design and construction of small-sized rhodium nanocrystals decorated on 3D hybrid aerogels built from graphene and metal-organic framework(Rh/G-ZIF)via a solvothermal co-assembly method.Benefiting from the 3D rigid crosslinked architecture,abundant porous channels,and highly dispersed ultrafine Rh nanoparticles,the optimized Rh/G-ZIF aerogel exhibits a large electrochemically active surface area,high mass and specific activities,and excellent long-term durability toward the methanol electrooxidation,all of which are significantly superior to those of Rh catalysts supported by traditional carbon materials(such as carbon black,carbon nanotube,and graphene).展开更多
基金Supported by the Science and Technology Planning Project of Guangdong Province(No.2012B050600032)the Science and Technology Planning Project of Guangzhou(No.1515000176)
文摘AIM： To determine the levels of aquaporin-1（AQP-1） in the lens epithelial cells（LECs） of primary glaucoma and to clarify its correlation with lens thickness.METHODS： This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups： 25 eyes of 25 patients with acute primary angle-closure glaucoma（APACG）, 19 eyes of 19 patients with chronic primary angle-closure glaucoma（CPACG） and 20 eyes of 20 patients with primary open angle glaucoma（POAG）. This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction（RT-q PCR） and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS： The AQP-1 m RNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group（all P〈0.05）. The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 m RNA levels and the lens thickness（r=0.645, P〈0.001）. CONCLUSION： These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG.
基金financially supported by the National Natural Science Foundation of China(No.51802077)the Fundamental Research Funds for the Central Universities(No.B220202042).
文摘The development of advanced and efficient anode catalysts to accelerate the kinetic rate of methanol oxidation plays an important role in the large-scale commercial application of the direct methanol fuel cells(DMFCs).Herein,we report the design and construction of small-sized rhodium nanocrystals decorated on 3D hybrid aerogels built from graphene and metal-organic framework(Rh/G-ZIF)via a solvothermal co-assembly method.Benefiting from the 3D rigid crosslinked architecture,abundant porous channels,and highly dispersed ultrafine Rh nanoparticles,the optimized Rh/G-ZIF aerogel exhibits a large electrochemically active surface area,high mass and specific activities,and excellent long-term durability toward the methanol electrooxidation,all of which are significantly superior to those of Rh catalysts supported by traditional carbon materials(such as carbon black,carbon nanotube,and graphene).
