AIM： To investigate the protective effect of mistletoe combined with carboxymethyl cellulose eye drops on dry eye in postmenopausal women.METHODS： Sixty postmenopause female patients diagnosed of dry eye were assign...AIM： To investigate the protective effect of mistletoe combined with carboxymethyl cellulose eye drops on dry eye in postmenopausal women.METHODS： Sixty postmenopause female patients diagnosed of dry eye were assigned randomly to mistletoe combined with carboxymethyl cellulose eye drops treatment group（n=30） and control group treated with normal saline eye drops（n=30）. The subjective symptoms of ocular surface, Ocular Surface Disease Index（OSDI）, tear film function tests, tear protein and corneal morphology by confocal scanning microscopy were analyzed before treatment and at 1, 2, 4 and 8 wk after treatment respectively. To ensure the safety of the trial, all patients were examined with systolic pressure, diastolic pressure, glutamic-pyruvic transaminase, glutamic oxaloacetic transaminase, urine creatinine, and blood urea nitrogen at 8 wk after treatment.RESULTS： There were no obvious differences between two groups before the treatment（P〉0.05）. In two months after the treatment, the symptoms of ocular surface, OSDI, tear protein, and tear film function were only slightly changed in normal saline eye drops group. However, all indices were improved after the treatment of mistletoe combined with carboxymethyl cellulose eye drops group（P〈0.05）. In addition, the average amount of corneal epithelium basal cells and inflammatory cells of mistletoe treated group were 3174±379 and 38±25 cells/mm2, significantly decreased as compared to the control group with 4309±612 and 158± 61 cells/mm2, respectively. In the control group, althoughnerves still maintained straight under corneal epithelium, the number of nerves were significantly decreased, as compared with normal female. In the mistletoe treated group, the number of nerves was only slightly reduced, compared with normal female.CONCLUSION： Mistletoe combined with carboxymethyl cellulose eye drops can alleviate the symptoms and signs of dry eye symptoms.展开更多
AIM：To determine typical corneal changes of congenital aniridic keratopathy（CAK）using corneal topography and confocal systems,and to identify characteristics that might assist in early diagnosis.METHODS：Patients w...AIM：To determine typical corneal changes of congenital aniridic keratopathy（CAK）using corneal topography and confocal systems,and to identify characteristics that might assist in early diagnosis.METHODS：Patients with CAK and healthy control subjects underwent detailed ophthalmic examinations including axial length,corneal thickness,tear film condition,corneal topography,and laser-scanning in vivo confocal microscopy（IVCM）. RESULTS：In early stage aniridic keratopathy,Schirmer I test（SIT）,break-up time（BUT）,mean keratometry（mean K）and simulated keratometry（sim K）were reduced relative to controls（P〈0.05）,while simulation of corneal astigmatism（sim A）and corneal thickness were increased（P〈0.05）. In addition,significantly more eyes exhibited flat cornea compared with the control group. Inflammatory dendritic cells were present in the aniridic epithelium,with significantly increased density relative to controls（P〈0.05）. Palisade ridge-like features and abnormal cell morphology were observed in six out of sixteen CAK cases. In central cornea area,the aniridic corneas had the increased subbasal nerve density. CONCLUSION：These changes in corneal morphology in borderline situations can be useful to confirm the diagnosis of CAK.展开更多
基金Supported by the National Natural Science Foundation of China (No.81460092, No.81660158 and No.81400372)Natural Science Key Project of Jiangxi Province (No.20161ACB21017)+1 种基金Youth Science Foundation of Jiangxi Province (No.20151BAB215016)Technology and Science Foundation of Jiangxi Province (No.20151BBG70223)
文摘AIM： To investigate the protective effect of mistletoe combined with carboxymethyl cellulose eye drops on dry eye in postmenopausal women.METHODS： Sixty postmenopause female patients diagnosed of dry eye were assigned randomly to mistletoe combined with carboxymethyl cellulose eye drops treatment group（n=30） and control group treated with normal saline eye drops（n=30）. The subjective symptoms of ocular surface, Ocular Surface Disease Index（OSDI）, tear film function tests, tear protein and corneal morphology by confocal scanning microscopy were analyzed before treatment and at 1, 2, 4 and 8 wk after treatment respectively. To ensure the safety of the trial, all patients were examined with systolic pressure, diastolic pressure, glutamic-pyruvic transaminase, glutamic oxaloacetic transaminase, urine creatinine, and blood urea nitrogen at 8 wk after treatment.RESULTS： There were no obvious differences between two groups before the treatment（P〉0.05）. In two months after the treatment, the symptoms of ocular surface, OSDI, tear protein, and tear film function were only slightly changed in normal saline eye drops group. However, all indices were improved after the treatment of mistletoe combined with carboxymethyl cellulose eye drops group（P〈0.05）. In addition, the average amount of corneal epithelium basal cells and inflammatory cells of mistletoe treated group were 3174±379 and 38±25 cells/mm2, significantly decreased as compared to the control group with 4309±612 and 158± 61 cells/mm2, respectively. In the control group, althoughnerves still maintained straight under corneal epithelium, the number of nerves were significantly decreased, as compared with normal female. In the mistletoe treated group, the number of nerves was only slightly reduced, compared with normal female.CONCLUSION： Mistletoe combined with carboxymethyl cellulose eye drops can alleviate the symptoms and signs of dry eye symptoms.
基金Supported by the National Natural Science Foundation of China(No.81660158No.81400372No.81160118)
文摘AIM：To determine typical corneal changes of congenital aniridic keratopathy（CAK）using corneal topography and confocal systems,and to identify characteristics that might assist in early diagnosis.METHODS：Patients with CAK and healthy control subjects underwent detailed ophthalmic examinations including axial length,corneal thickness,tear film condition,corneal topography,and laser-scanning in vivo confocal microscopy（IVCM）. RESULTS：In early stage aniridic keratopathy,Schirmer I test（SIT）,break-up time（BUT）,mean keratometry（mean K）and simulated keratometry（sim K）were reduced relative to controls（P〈0.05）,while simulation of corneal astigmatism（sim A）and corneal thickness were increased（P〈0.05）. In addition,significantly more eyes exhibited flat cornea compared with the control group. Inflammatory dendritic cells were present in the aniridic epithelium,with significantly increased density relative to controls（P〈0.05）. Palisade ridge-like features and abnormal cell morphology were observed in six out of sixteen CAK cases. In central cornea area,the aniridic corneas had the increased subbasal nerve density. CONCLUSION：These changes in corneal morphology in borderline situations can be useful to confirm the diagnosis of CAK.
