BACKGROUND Transcatheter arterial chemoembolization(TACE)combined with lenvatinib is an important modality for the treatment of unresectable hepatocellular carcinoma(HCC).To date,no prognostic analysis exists for clin...BACKGROUND Transcatheter arterial chemoembolization(TACE)combined with lenvatinib is an important modality for the treatment of unresectable hepatocellular carcinoma(HCC).To date,no prognostic analysis exists for clinical predictive models of TACE combined with lenvatinib in treating advanced unresectable HCC.A model was constructed through meta-analysis,and its validation was further enhanced by the collection of external clinical data,thereby providing guidance for clinical practice.AIM To identify risk factors for unresectable HCC following TACE plus lenvatinib therapy and to construct a clinical prediction model.METHODS We searched PubMed,Web of Science,EMBASE,and Cochrane Library databases for studies on TACE plus lenvatinib for unresectable HCC.Risk factors from the meta-analysis and sensitivity analyses were used to construct a prediction model.The validation set included clinical data from 106 eligible patients at the Affiliated Hospital of North Sichuan Medical College collected by June 1,2023.RESULTS This study included 43 group studies involving 5070 patients.Tumor number,microvascular invasion,Eastern Cooperative Oncology Group performance status,Child-Pugh stage,Barcelona Clinic Liver Cancer stage,extra-hepatic metastases,alpha-fetoprotein level,and hepatitis B virus status were risk factors for overall survival and progression-free survival,while triple therapy was a protective factor for both.In the validation set,the overall survival prediction model had area under the curve values of 0.616,0.643,and 0.706 at 1 year,2 years,and 3 years,respectively,and the progression-free survival model had area under the curve values of 0.702,0.696,and 0.670 at the corresponding time points,demonstrating good model performance.Calibration curves,Kaplan-Meier survival analysis,and decision curves further validated the efficacy of the model.CONCLUSION Models based on nine variables from 43 group studies predicted the efficacy of TACE plus lenvatinib in unresectable HCC,supporting evidence-based clinical decisions and treatment strategies.展开更多
Carboxymethyl cellulose(CMC)was introduced as a depressant in reverse flotation separation of quartz from magnesite.The flotation behavior and surface properties of magnesite and quartz exposed to CMC were studied by ...Carboxymethyl cellulose(CMC)was introduced as a depressant in reverse flotation separation of quartz from magnesite.The flotation behavior and surface properties of magnesite and quartz exposed to CMC were studied by zeta potential tests,atomic force microscopy imaging and contact angle measurements.The addition of CMC as the depressant in reverse flotation using dodecylamine(DDA)as the collector exhibited a selectively depressive performance towards magnesite and achieved an improved recovery of magnesite.The study of surface properties demonstrated that CMC and DDA exhibited different adsorption strengths on the surface of magnesite and quartz.It was found that the adsorption of CMC on magnesite surface was stronger than that of DDA,which hindered the subsequent adsorption of DDA on magnesite surface.On the contrary,the quartz surface was strongly adsorbed by DDA instead of CMC,which proved that the addition of CMC did not influence the flotation of quartz.展开更多
Abstract Reactivity measurement is an essential part of a zero-power physics test,which is critical to reactor design and development.The rod drop experimental technique is used to measure the control rod worth in a z...Abstract Reactivity measurement is an essential part of a zero-power physics test,which is critical to reactor design and development.The rod drop experimental technique is used to measure the control rod worth in a zero-power physics test.The conventional rod drop experimental technique is limited by the spatial effect and the difference between the calculated static reactivity and measured dynamic reactivity;thus,the method must be improved.In this study,a modified rod drop experimental technique that constrains the detector neutron flux shape function based on three-dimensional space–time dynamics to reduce the reactivity perturbation and a new method for calculating the detector neutron flux shape function are proposed.Correction factors were determined using Monte Carlo N-particle transport code and transient analysis code for a pressurized water reactor at the Ulsan National Institute of Science and Technology and Xi’an Jiaotong University,and a large reactivity of over 2000 pcm was measured using the modified technique.This research evaluated the modified technique accuracy,studied the influence of the correction factors on the modification,and investigated the effect of constraining the shape function on the reactivity perturbation reduction caused by the difference between the calculated neutron flux and true value,using the new method to calculate the shape function of the detector neutron flux and avoiding the neutron detector response function(weighting factor)calculation.展开更多
文摘BACKGROUND Transcatheter arterial chemoembolization(TACE)combined with lenvatinib is an important modality for the treatment of unresectable hepatocellular carcinoma(HCC).To date,no prognostic analysis exists for clinical predictive models of TACE combined with lenvatinib in treating advanced unresectable HCC.A model was constructed through meta-analysis,and its validation was further enhanced by the collection of external clinical data,thereby providing guidance for clinical practice.AIM To identify risk factors for unresectable HCC following TACE plus lenvatinib therapy and to construct a clinical prediction model.METHODS We searched PubMed,Web of Science,EMBASE,and Cochrane Library databases for studies on TACE plus lenvatinib for unresectable HCC.Risk factors from the meta-analysis and sensitivity analyses were used to construct a prediction model.The validation set included clinical data from 106 eligible patients at the Affiliated Hospital of North Sichuan Medical College collected by June 1,2023.RESULTS This study included 43 group studies involving 5070 patients.Tumor number,microvascular invasion,Eastern Cooperative Oncology Group performance status,Child-Pugh stage,Barcelona Clinic Liver Cancer stage,extra-hepatic metastases,alpha-fetoprotein level,and hepatitis B virus status were risk factors for overall survival and progression-free survival,while triple therapy was a protective factor for both.In the validation set,the overall survival prediction model had area under the curve values of 0.616,0.643,and 0.706 at 1 year,2 years,and 3 years,respectively,and the progression-free survival model had area under the curve values of 0.702,0.696,and 0.670 at the corresponding time points,demonstrating good model performance.Calibration curves,Kaplan-Meier survival analysis,and decision curves further validated the efficacy of the model.CONCLUSION Models based on nine variables from 43 group studies predicted the efficacy of TACE plus lenvatinib in unresectable HCC,supporting evidence-based clinical decisions and treatment strategies.
基金the financial support from the National Natural Science Foundation of China(No.51774041)。
文摘Carboxymethyl cellulose(CMC)was introduced as a depressant in reverse flotation separation of quartz from magnesite.The flotation behavior and surface properties of magnesite and quartz exposed to CMC were studied by zeta potential tests,atomic force microscopy imaging and contact angle measurements.The addition of CMC as the depressant in reverse flotation using dodecylamine(DDA)as the collector exhibited a selectively depressive performance towards magnesite and achieved an improved recovery of magnesite.The study of surface properties demonstrated that CMC and DDA exhibited different adsorption strengths on the surface of magnesite and quartz.It was found that the adsorption of CMC on magnesite surface was stronger than that of DDA,which hindered the subsequent adsorption of DDA on magnesite surface.On the contrary,the quartz surface was strongly adsorbed by DDA instead of CMC,which proved that the addition of CMC did not influence the flotation of quartz.
文摘Abstract Reactivity measurement is an essential part of a zero-power physics test,which is critical to reactor design and development.The rod drop experimental technique is used to measure the control rod worth in a zero-power physics test.The conventional rod drop experimental technique is limited by the spatial effect and the difference between the calculated static reactivity and measured dynamic reactivity;thus,the method must be improved.In this study,a modified rod drop experimental technique that constrains the detector neutron flux shape function based on three-dimensional space–time dynamics to reduce the reactivity perturbation and a new method for calculating the detector neutron flux shape function are proposed.Correction factors were determined using Monte Carlo N-particle transport code and transient analysis code for a pressurized water reactor at the Ulsan National Institute of Science and Technology and Xi’an Jiaotong University,and a large reactivity of over 2000 pcm was measured using the modified technique.This research evaluated the modified technique accuracy,studied the influence of the correction factors on the modification,and investigated the effect of constraining the shape function on the reactivity perturbation reduction caused by the difference between the calculated neutron flux and true value,using the new method to calculate the shape function of the detector neutron flux and avoiding the neutron detector response function(weighting factor)calculation.
