AIM: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer. METHODS: One hundred and seventy-seven gastric cancer patients with lymph node and/or distal m...AIM: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer. METHODS: One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed. Differences in histology of the primary and metastatic gastric cancer were assessed. MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer. RESULTS: Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177) and primary gastric cancer in 75.7% (134/177) of the patients. The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%). MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer, while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer. CONCLUSION: Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer. This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Adva...BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Advances in the identification of MEITL over the last two decades have led to its recognition as a separate entity.MEITL patients,predominantly male,typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at laparotomy.Currently,there are no standardized treatment protocols,and the optimal therapy remains unclear.CASE SUMMARY We report a case of MEITL that was initially considered to be gastrointestinal stromal tumor(GIST)and Imatinib was administered for one cycle.The 62-yearold man presented with abdominal pain,abdominal distension,and weight loss of 20 pounds.Within 2 wk,the size of the mass considerably increased on computed tomography scans.The patient underwent surgery followed by chemotherapy with CHOP(cyclophosphamide,doxorubicin,vincristine,and prednisone)and stem-cell transplant.A correct diagnosis of MEITL was established based on postoperative pathology.Immunophenotypically,the neoplastic cells fulfilled the diagnostic criteria for MEITL as they were CD3+,CD4+,CD8+,CD56+,and TIA-1+.CONCLUSION Given that MEITL has no predisposing factor and presents with vague symptoms with rapid progression,the concomitant presence of abdominal symptoms and B symptoms(weight loss,fever,and night sweats)with hypoalbuminemia,anemia,low lymphocytic count and endoscopic findings of diffuse infiltrating type lesions should alert physicians to this rare disease,especially when it comes to Asian patients.Immediate laparotomy should then be carried out followed by chemotherapy and stem-cell transplant.展开更多
Dear Editor, We present here a case report of＂Krukenberg tumor＂ in male. In 1896, Friedrich Krukenberg （1871 - 1946）, a German gynecologist and pathologist, described what he presumed as a new type of primary ova...Dear Editor, We present here a case report of＂Krukenberg tumor＂ in male. In 1896, Friedrich Krukenberg （1871 - 1946）, a German gynecologist and pathologist, described what he presumed as a new type of primary ovarian neoplasm. The true metastatic nature of this lesion was established 6 years later and termed as＂Krukenberg tumor＂？ Now, the term ＂Krukenberg tumor＂ has been used either as a broad definition to indicate all metastatic tumors to the ovaries or to describe just metastatic tumors from the gastrointestinal tract containing the typical signet ring cell with intracellular mucin.2-6 Our case, as an analog in male, has criteria to be called ＂Krukenberg tumor＂ in male.展开更多
Proteomic alterations preceding the onset of depression offer valuable insights into its development and potential interventions.Leveraging data from 46,165 UK Biobank participants and 2920 plasma proteins profiled at...Proteomic alterations preceding the onset of depression offer valuable insights into its development and potential interventions.Leveraging data from 46,165 UK Biobank participants and 2920 plasma proteins profiled at baseline,we conducted a longitudinal analysis with a median follow-up of 14.5 years to explore the relationship between plasma proteins and incident depression.Linear regression was then used to assess associations between depression-related proteins and brain structures,genetic factors,and stress-related events.Our analysis identified 157 proteins associated with incident depression(P<1.71×10^(-5)),including novel associations with proteins such as GAST,PLAUR,LRRN1,BCAN,and ITGA11.Notably,higher expression levels of GDF15(P=6.18×10-26)and PLAUR(P=2.88×10^(-14))were linked to an increased risk of depression,whereas higher levels of LRRN1(P=4.28×10^(-11))and ITGA11(P=3.68×10^(-9))were associated with a decreased risk.Dysregulation of the 157 proteins is correlated with brain regions implicated in depression,including the hippocampus and middle temporal gyrus.Additionally,these protein alterations were strongly correlated with stress-related events,including self-harm events,adult,and childhood trauma.Biological pathway enrichment analysis highlighted the critical roles of the immune response.EGFR and TNF emerged as key proteins in the protein-protein interaction network.BTN3A2,newly linked to incident depression(P=4.35×10^(-10)),was confirmed as a causal factor through Mendelian randomization analysis.In summary,our research identified the proteomic signatures associated with the onset of depression,highlighting its potential for early intervention and tailored therapeutic avenues.展开更多
文摘AIM: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer. METHODS: One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed. Differences in histology of the primary and metastatic gastric cancer were assessed. MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer. RESULTS: Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177) and primary gastric cancer in 75.7% (134/177) of the patients. The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%). MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer, while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer. CONCLUSION: Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer. This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.
文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 mo.Advances in the identification of MEITL over the last two decades have led to its recognition as a separate entity.MEITL patients,predominantly male,typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at laparotomy.Currently,there are no standardized treatment protocols,and the optimal therapy remains unclear.CASE SUMMARY We report a case of MEITL that was initially considered to be gastrointestinal stromal tumor(GIST)and Imatinib was administered for one cycle.The 62-yearold man presented with abdominal pain,abdominal distension,and weight loss of 20 pounds.Within 2 wk,the size of the mass considerably increased on computed tomography scans.The patient underwent surgery followed by chemotherapy with CHOP(cyclophosphamide,doxorubicin,vincristine,and prednisone)and stem-cell transplant.A correct diagnosis of MEITL was established based on postoperative pathology.Immunophenotypically,the neoplastic cells fulfilled the diagnostic criteria for MEITL as they were CD3+,CD4+,CD8+,CD56+,and TIA-1+.CONCLUSION Given that MEITL has no predisposing factor and presents with vague symptoms with rapid progression,the concomitant presence of abdominal symptoms and B symptoms(weight loss,fever,and night sweats)with hypoalbuminemia,anemia,low lymphocytic count and endoscopic findings of diffuse infiltrating type lesions should alert physicians to this rare disease,especially when it comes to Asian patients.Immediate laparotomy should then be carried out followed by chemotherapy and stem-cell transplant.
文摘Dear Editor, We present here a case report of＂Krukenberg tumor＂ in male. In 1896, Friedrich Krukenberg （1871 - 1946）, a German gynecologist and pathologist, described what he presumed as a new type of primary ovarian neoplasm. The true metastatic nature of this lesion was established 6 years later and termed as＂Krukenberg tumor＂？ Now, the term ＂Krukenberg tumor＂ has been used either as a broad definition to indicate all metastatic tumors to the ovaries or to describe just metastatic tumors from the gastrointestinal tract containing the typical signet ring cell with intracellular mucin.2-6 Our case, as an analog in male, has criteria to be called ＂Krukenberg tumor＂ in male.
基金supported by the National Key R&D Program of China(2018YFC1312904 and 2019YFA0709502)the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)+8 种基金the 111 Project(B18015)Shanghai Center for Brain Science and Brain-Inspired Technology,Zhangjiang Lab,the National Natural Science Foundation of China(82472055 and 82071997)and the Shanghai Rising-Star Program(21QA1408700)the Science and Technology Innovation 2030 Major Projects(2022ZD0211600)National Natural Science Foundation of China(82071201,81971032,and 92249305)Shanghai Municipal Science and Technology Major Project(2018SHZDZX01),Research Start-up Fund of Huashan Hospital(2022QD002)Excellence 2025 Talent Cultivation Program at Fudan University(3030277001)Shanghai Talent Development Funding for The Project(2019074)ZHANGJIANG LAB,Tianqiao and Chrissy Chen Institute,and the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education,Fudan University,National Key R&D Program of China(2019YFA0709501)the National Natural Science Foundation of China(T2122005,81801773).
文摘Proteomic alterations preceding the onset of depression offer valuable insights into its development and potential interventions.Leveraging data from 46,165 UK Biobank participants and 2920 plasma proteins profiled at baseline,we conducted a longitudinal analysis with a median follow-up of 14.5 years to explore the relationship between plasma proteins and incident depression.Linear regression was then used to assess associations between depression-related proteins and brain structures,genetic factors,and stress-related events.Our analysis identified 157 proteins associated with incident depression(P<1.71×10^(-5)),including novel associations with proteins such as GAST,PLAUR,LRRN1,BCAN,and ITGA11.Notably,higher expression levels of GDF15(P=6.18×10-26)and PLAUR(P=2.88×10^(-14))were linked to an increased risk of depression,whereas higher levels of LRRN1(P=4.28×10^(-11))and ITGA11(P=3.68×10^(-9))were associated with a decreased risk.Dysregulation of the 157 proteins is correlated with brain regions implicated in depression,including the hippocampus and middle temporal gyrus.Additionally,these protein alterations were strongly correlated with stress-related events,including self-harm events,adult,and childhood trauma.Biological pathway enrichment analysis highlighted the critical roles of the immune response.EGFR and TNF emerged as key proteins in the protein-protein interaction network.BTN3A2,newly linked to incident depression(P=4.35×10^(-10)),was confirmed as a causal factor through Mendelian randomization analysis.In summary,our research identified the proteomic signatures associated with the onset of depression,highlighting its potential for early intervention and tailored therapeutic avenues.
