Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats.Methods:Eighty SD rats were randomly divided into 4 groups,blank control group...Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats.Methods:Eighty SD rats were randomly divided into 4 groups,blank control group(group A)with 5 rats,treatment normal group(group B)with 25 rats,inflammation control group(group(group C)with 25 rats,inflammation treatment group(group D)with 25 rats.Immunohistochemistry and histomorphometric analysis was performed to measure the expression of IL-6,IL-8 and the firet molar to the recent movement in the distance.Results:The expression of IL-8 reached a maximum on day 5 and declined thereafter in group B;the expression of IL-6 reached a maximum on day 5 in group B.The expression of IL-6 and IL-8 was gradually weakened with time in group C.The expression of IL-6 and IL-8 were high,and reached a maximum on day 5 and declined thereafter in group D.AD of positive cells in group D were higher than group B at each time point(P<0.05).The time which 0.49 N orthodontic force was loaded was longer,orthodontic tooth movement distance was greater.Movement distance in group D were longer than group B(P<0.05).Conclusions:Orthodontic force as well as inflammatory stimulus can evoke the expression of IL-6 and IL-8.Under the combined effects of inflammation and orthodontic force,the expression of IL-6,IL-8will increase.展开更多
Nerve regeneration conditioned fluid is secreted by nerve stumps inside a nerve regeneration chamber.A better understanding of the proteinogram of nerve regeneration conditioned fluid can provide evidence for studying...Nerve regeneration conditioned fluid is secreted by nerve stumps inside a nerve regeneration chamber.A better understanding of the proteinogram of nerve regeneration conditioned fluid can provide evidence for studying the role of the microenvironment in peripheral nerve regeneration.In this study,we used cylindrical silicone tubes as the nerve regeneration chamber model for the repair of injured rat sciatic nerve.Isobaric tags for relative and absolute quantitation proteomics technology and western blot analysis confirmed that there were more than 10 complement components（complement factor I,C1q-A,C1q-B,C2,C3,C4,C5,C7,C8β and complement factor D） in the nerve regeneration conditioned fluid and each varied at different time points.These findings suggest that all these complement components have a functional role in nerve regeneration.展开更多
Although the incidence and mortality of gastric cancer(GC)have been decreasing steadily worldwide,especially in East Asia,the disease burden of this malignancy is still very heavy.Except for tremendous progress in the...Although the incidence and mortality of gastric cancer(GC)have been decreasing steadily worldwide,especially in East Asia,the disease burden of this malignancy is still very heavy.Except for tremendous progress in the management of GC by multidisciplinary treatment,surgical excision of the primary tumor is still the cornerstone intervention in the curative-intent treatment of GC.During the relatively short perioperative period,patients undergoing radical gastrectomy will suffer from at least part of the following perioperative events:Surgery,anesthesia,pain,intraoperative blood loss,allogeneic blood transfusion,postoperative complications,and their related anxiety,depression and stress response,which have been shown to affect long-term outcomes.Therefore,in recent years,studies have been carried out to find and test interventions during the perioperative period to improve the long-term survival of patients following radical gastrectomy,which will be the aim of this review.展开更多
Developing electrochemical energy storage and conversion devices(e.g.,water splitting,regenerative fuel cells and rechargeable metal-air batteries)driven by intermittent renewable energy sources holds a great potentia...Developing electrochemical energy storage and conversion devices(e.g.,water splitting,regenerative fuel cells and rechargeable metal-air batteries)driven by intermittent renewable energy sources holds a great potential to facilitate global energy transition and alleviate the associated environmental issues.However,the involved kinetically sluggish oxygen evolution reaction(OER)severely limits the entire reaction efficiency,thus designing high-performance materials toward efficient OER is of prime significance to remove this obstacle.Among various materials,cost-effective perovskite oxides have drawn particular attention due to their desirable catalytic activity,excellent stability and large reserves.To date,substantial efforts have been dedicated with varying degrees of success to promoting OER on perovskite oxides,which have generated multiple reviews from various perspectives,e.g.,electronic structure modulation and heteroatom doping and various applications.Nonetheless,the reviews that comprehensively and systematically focus on the latest intellectual design strategies of perovskite oxides toward efficient OER are quite limited.To bridge the gap,this review thus emphatically concentrates on this very topic with broader coverages,more comparative discussions and deeper insights into the synthetic modulation,doping,surface engineering,structure mutation and hybrids.More specifically,this review elucidates,in details,the underlying causality between the being-tuned physiochemical properties[e.g.,electronic structure,metal-oxygen(M-O)bonding configuration,adsorption capacity of oxygenated species and electrical conductivity]of the intellectually designed perovskite oxides and the resulting OER performances,coupled with perspectives and potential challenges on future research.It is our sincere hope for this review to provide the scientific community with more insights for developing advanced perovskite oxides with high OER catalytic efficiency and further stimulate more exciting applications.展开更多
基金supported by Department of Science and Technology in Henan Province(No 122300410407)
文摘Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats.Methods:Eighty SD rats were randomly divided into 4 groups,blank control group(group A)with 5 rats,treatment normal group(group B)with 25 rats,inflammation control group(group(group C)with 25 rats,inflammation treatment group(group D)with 25 rats.Immunohistochemistry and histomorphometric analysis was performed to measure the expression of IL-6,IL-8 and the firet molar to the recent movement in the distance.Results:The expression of IL-8 reached a maximum on day 5 and declined thereafter in group B;the expression of IL-6 reached a maximum on day 5 in group B.The expression of IL-6 and IL-8 was gradually weakened with time in group C.The expression of IL-6 and IL-8 were high,and reached a maximum on day 5 and declined thereafter in group D.AD of positive cells in group D were higher than group B at each time point(P<0.05).The time which 0.49 N orthodontic force was loaded was longer,orthodontic tooth movement distance was greater.Movement distance in group D were longer than group B(P<0.05).Conclusions:Orthodontic force as well as inflammatory stimulus can evoke the expression of IL-6 and IL-8.Under the combined effects of inflammation and orthodontic force,the expression of IL-6,IL-8will increase.
基金supported by grants from the National Natural Science Foundation of China,No.30925034,81101437
文摘Nerve regeneration conditioned fluid is secreted by nerve stumps inside a nerve regeneration chamber.A better understanding of the proteinogram of nerve regeneration conditioned fluid can provide evidence for studying the role of the microenvironment in peripheral nerve regeneration.In this study,we used cylindrical silicone tubes as the nerve regeneration chamber model for the repair of injured rat sciatic nerve.Isobaric tags for relative and absolute quantitation proteomics technology and western blot analysis confirmed that there were more than 10 complement components（complement factor I,C1q-A,C1q-B,C2,C3,C4,C5,C7,C8β and complement factor D） in the nerve regeneration conditioned fluid and each varied at different time points.These findings suggest that all these complement components have a functional role in nerve regeneration.
基金the Health Commission of Mianyang City and the Science and Education Department of the Third Hospital of Mianyang for their support
文摘Although the incidence and mortality of gastric cancer(GC)have been decreasing steadily worldwide,especially in East Asia,the disease burden of this malignancy is still very heavy.Except for tremendous progress in the management of GC by multidisciplinary treatment,surgical excision of the primary tumor is still the cornerstone intervention in the curative-intent treatment of GC.During the relatively short perioperative period,patients undergoing radical gastrectomy will suffer from at least part of the following perioperative events:Surgery,anesthesia,pain,intraoperative blood loss,allogeneic blood transfusion,postoperative complications,and their related anxiety,depression and stress response,which have been shown to affect long-term outcomes.Therefore,in recent years,studies have been carried out to find and test interventions during the perioperative period to improve the long-term survival of patients following radical gastrectomy,which will be the aim of this review.
基金supported by the National Natural Science Foundation of China(NSFC,Grant No.22109182)the Natural Science Foundation of Hunan Province,China(2022JJ30684)+1 种基金the Start-up Funding of Central South University(No.206030104)the Natural Sciences and Engineering Research Council(NSERC)of Canada Discovery Grant(GRPIN−2016−05494).
文摘Developing electrochemical energy storage and conversion devices(e.g.,water splitting,regenerative fuel cells and rechargeable metal-air batteries)driven by intermittent renewable energy sources holds a great potential to facilitate global energy transition and alleviate the associated environmental issues.However,the involved kinetically sluggish oxygen evolution reaction(OER)severely limits the entire reaction efficiency,thus designing high-performance materials toward efficient OER is of prime significance to remove this obstacle.Among various materials,cost-effective perovskite oxides have drawn particular attention due to their desirable catalytic activity,excellent stability and large reserves.To date,substantial efforts have been dedicated with varying degrees of success to promoting OER on perovskite oxides,which have generated multiple reviews from various perspectives,e.g.,electronic structure modulation and heteroatom doping and various applications.Nonetheless,the reviews that comprehensively and systematically focus on the latest intellectual design strategies of perovskite oxides toward efficient OER are quite limited.To bridge the gap,this review thus emphatically concentrates on this very topic with broader coverages,more comparative discussions and deeper insights into the synthetic modulation,doping,surface engineering,structure mutation and hybrids.More specifically,this review elucidates,in details,the underlying causality between the being-tuned physiochemical properties[e.g.,electronic structure,metal-oxygen(M-O)bonding configuration,adsorption capacity of oxygenated species and electrical conductivity]of the intellectually designed perovskite oxides and the resulting OER performances,coupled with perspectives and potential challenges on future research.It is our sincere hope for this review to provide the scientific community with more insights for developing advanced perovskite oxides with high OER catalytic efficiency and further stimulate more exciting applications.
