Sodium metal batteries(SMBs)are promising candidates for next-generation energy storage devices owing to their excellent safety performance and natural abunda nce of sodium.However,the insurmountable obstacles of dend...Sodium metal batteries(SMBs)are promising candidates for next-generation energy storage devices owing to their excellent safety performance and natural abunda nce of sodium.However,the insurmountable obstacles of dendrite formation and quick capacity decay are caused by an unstable and inhomogeneous solid electrolyte interphase that resulted from the immediate interactions between the Na metal anode and organic liquid electrolyte.Herein,a customised glass fibre separator coupled with chitosan(CS@GF)was developed to modulate the sodium ion(Na^(+))flux.The CS@GF separator facilitates the Na+homogeneous deposition on the anode side through redistribution at the chitosan polyactive sites and by inhibiting the decomposition of the electrolyte to robust solid electrolyte interphase(SEI)formation.Multiphysics simulations show that chitosan incorporated into SMBs through the separator can make the local electric field around the anode uniform,thus facilitating the transfer of cations.Na|Na symmetric cells utilising a CS@GF separator exhibited an outstanding cycle stability of over 600 h(0.5 mA cm^(-2)).Meanwhile,the Na|Na_(3)V_(5)(PO_(4))_(3)full cell exhibited excellent fast-charging performance(93.47%capacity retention after 1500 cycles at 5C).This study presents a promising strategy for inhibiting dendrite growth and realizes stable Na metal batteries,which significantly boosts the development of high-performance SMBs.展开更多
Uncertainty is an important characteristic of scheduling model for scale farm machinery operation organizing. Practice shows that scheduling model without considering uncertainties is nearly useless. Uncertain influen...Uncertainty is an important characteristic of scheduling model for scale farm machinery operation organizing. Practice shows that scheduling model without considering uncertainties is nearly useless. Uncertain influence factors arisen from natural environment, society and economy, market and supply, and customer and behavior, exist widely, emerge frequently, and affect production deeply. Uncertainties interfere with the allocation of productive factors on temporal and spatial dimensions for farm machinery operation scheduling and management. Questionnaire for farm machinery organizations was designed and finished in 2014. Both occurrence frequency and influence degree for each factor were quantified. Four influence factors including operation location change, weather mutation, parts supply delay, and operation skill defects appear in both list of high occurrence and deep influence. Then results of questionnaire and results of specific investigation were used to study temporal and spatial scheduling model and system for farm machinery management. Three case studies are introduced. The first case is about the uncertainty and countermeasure of forage harvesters scheduling and monitoring for a professional forage plantation company. The second case is about the uncertainty and counter measure of cotton-picker scheduling and monitoring for a professional cotton picking company. And the third case is about the uncertainty and countermeasure of social service management for a professional cooperative. The cases show that the research has strong pertinence to deal with uncertainties and can improve management efficiency of farm machinery operation.展开更多
Due to the advantages of large workspace,low cost and the integrated vision/force sensing,robotic milling has become an important way for machining of complex parts.In recent years,many scholars have studied the probl...Due to the advantages of large workspace,low cost and the integrated vision/force sensing,robotic milling has become an important way for machining of complex parts.In recent years,many scholars have studied the problems existing in the applications of robotic milling,and lots of results have been made in the dynamics,pose planning,deformation control etc.,which provides theoretical guidance for high precision and high efficiency of robotic milling.From the perspective of complex parts robotic milling,this paper focuses on machining process planning and control techniques including the analysis of the robot-workspace,robot trajectory planning,vibration monitoring and control,deformation monitoring and compensation.As well as the principles of these technologies such as robot stiffness characteristics,dynamic characteristics,chatter mechanisms,and deformation mechanisms.The methods and characteristics related to the theory and technology of robotic milling of complex parts are summarized systematically.The latest research progress and achievements in the relevant fields are reviewed.It is hoped that the challenges,strategies and development related to robotic milling could be clarified through the carding work in this paper,so as to promote the application of related theories and technologies in high efficiency and precision intelligent milling with robot for complex parts.展开更多
In VTI media,the conventional inversion methods based on the existing approximation formulas are difficult to accurately estimate the anisotropic parameters of reservoirs,even more so for unconventional reservoirs wit...In VTI media,the conventional inversion methods based on the existing approximation formulas are difficult to accurately estimate the anisotropic parameters of reservoirs,even more so for unconventional reservoirs with strong seismic anisotropy.Theoretically,the above problems can be solved by utilizing the exact reflection coefficients equations.However,their complicated expression increases the difficulty in calculating the Jacobian matrix when applying them to the Bayesian deterministic inversion.Therefore,the new reduced approximation equations starting from the exact equations are derived here by linearizing the slowness expressions.The relatively simple form and satisfactory calculation accuracy make the reduced equations easy to apply for inversion while ensuring the accuracy of the inversion results.In addition,the blockiness constraint,which follows the differentiable Laplace distribution,is added to the prior model to improve contrasts between layers.Then,the concept of GLI and an iterative reweighted least-squares algorithm is combined to solve the objective function.Lastly,we obtain the iterative solution expression of the elastic parameters and anisotropy parameters and achieve nonlinear AVA inversion based on the reduced equations.The test results of synthetic data and field data show that the proposed method can accurately obtain the VTI parameters from prestack AVA seismic data.展开更多
AIM To investigate the protective mechanism of mitofusin-2 (Mfn2) in rat remote ischemic perconditioning (RIC) models and revalidate it in alpha mouse liver-12 (AML-12) hypoxia cell lines. METHODS Sprague-Dawley rats ...AIM To investigate the protective mechanism of mitofusin-2 (Mfn2) in rat remote ischemic perconditioning (RIC) models and revalidate it in alpha mouse liver-12 (AML-12) hypoxia cell lines. METHODS Sprague-Dawley rats were divided into three groups (n = 6 each): sham, orthotopic liver transplantation and RIC. After operation, blood samples were collected to test alanine aminotransferase and aspartate aminotransferase. The liver lobes were harvested for histopathological examination, western blotting (WB) and quantitative real-time (qRT)-PCR. AML-12 cell lines were then subjected to normal culture, anoxic incubator tank culture (hypoxia) and anoxic incubator tank culture with Mfn2 knockdown (hypoxia + Si), and data of qRT-PCR, WB, mitochondrial membrane potential (Delta psi m), apoptosis, endoplasmic reticulum Ca2+ concentrations and mitochondrial Ca2+ concentrations were collected. RESULTS Both sham and normal culture groups showed no injury during the experiment. The RIC group showed amelioration of liver function compared with the orthotopic liver transplantation group (P < 0.05). qRTPCR and WB confirmed that Mfn2-mitochondrial Ca2+ uptake 1/2 (MICUs) axis was changed (P < 0.005). In AML-12 cell lines, compared with the hypoxia group, the hypoxia + Si group attenuated the collapse of..m and apoptosis (P < 0.005). The endoplasmic reticulum Ca2+ decrease and mitochondrial Ca2+ overloading observed in the hypoxia group were also attenuated in the hypoxia + Si group (P < 0.005). Finally, qRT-PCR and WB confirmed the Mfn2-MICUs axis change in all the groups (P < 0.005). CONCLUSION Mfn2 participates in liver injury in rat RIC models and AML-12 hypoxia cell lines by regulating the MICUs pathway.展开更多
Background: With the increased use of extended-criteria donors, static cold storage has failed to provide optimal preservation of liver grafts, resulting in early allograft dysfunction and long-term complications Mach...Background: With the increased use of extended-criteria donors, static cold storage has failed to provide optimal preservation of liver grafts, resulting in early allograft dysfunction and long-term complications Machine perfusion(MP) is a beneficial alternative preservation strategy for donor livers, particularly fo those considered to be of suboptimal quality, and could expand the limited donor pool. Data sources: A comprehensive search in Pub Med, EMBASE, Ovid databases and Clinical Trials.gov website was conducted using the medical subject heading terms "machine perfusion", "machine preservation""liver transplantation", combined with free text terms such as "hypothermic", "normothermic" and "sub normothermic". The deadline for the search was September 30, 2017. Results: MP can be classified as hypothermic, subnormothermic, and normothermic with the tempera ture maintained at 0–12 °C, 25–34 °C and 35–38 °C, respectively. Twelve clinical trials of MP have been reported in recent years. MP effectively decreased AST/ALT level and the incidence of early allograft dys function. However, the graft and patient survival rate after MP were similar to static cold storage. The detailed clinical characteristics such as liver function, graft survival, patient survival and early allograf dysfunction were reviewed.Conclusions: Clinical trial results showed that MP improves delayed graft function, primary non-function and biliary strictures. However, MP still requires validation in large clinical trials and the key parameters during MP still require optimization.展开更多
AIM：To investigate the relationship between high myopia [with or without complete congenital stationary night blindness（CSNB1）] and TRPM1 and NYX.METHODS： Two unrelated families with early-onset high myopia（eo HM...AIM：To investigate the relationship between high myopia [with or without complete congenital stationary night blindness（CSNB1）] and TRPM1 and NYX.METHODS： Two unrelated families with early-onset high myopia（eo HM） and 96 normal controls were recruited.Sanger sequencing or clone sequencing were used for mutation screening.Further analyses of the available family members and the 96 normal controls were subsequently conducted to obtain additional evidence of the pathogenicity of these variants.The initial diagnosis of the probands was eo HM.We performed a further comprehensive examination of the available family members after mutations were detected in TRPM1 or NYX. RESULTS： Two novel compound heterozygous mutations in TRPM1 were detected in the recruited families.The proband in family A with eo HM carried a c.2594 C 〉T missense mutation in exon 19 and a c.669 ＋3_669 ＋6del AAGT splicing mutation,which was co-segregated with CSNB1 in this family.A patient in family B with a compound heterozygous missense mutation（c.3262 G〉A and c.3250 T〉C） was detected.No mutations were found in NYX.These two identified compound heterozygous mutations were not found in the 96 normal controls.After further examination of the family members,the patients in family A could be diagnosed as eo HM with CSNB1.However due to the limited clinic data,the patient in family B cloud not clearly diagnosed as CSNB1.CONCLUSION： This study has expanded the mutation spectrum of TRPM1 for CSNB1 and additional studiesare needed to elucidate the association between isolated high myopia and TRPM1 and NYX.展开更多
Four new 9,19-cycloartane triterpenoids,cimilactone E(1),cimilactone F(2),20-O-(E)-butenoyl-23-epi-26-deoxyactein(3),and 20,12b-O-diacetylcimiracemonol-3-O-b-D-xylopyranoside(4),together with four known constituents(5...Four new 9,19-cycloartane triterpenoids,cimilactone E(1),cimilactone F(2),20-O-(E)-butenoyl-23-epi-26-deoxyactein(3),and 20,12b-O-diacetylcimiracemonol-3-O-b-D-xylopyranoside(4),together with four known constituents(5–8)were isolated from the roots of Cimicifuga foetida.The new structures were elucidated by extensive spectroscopic analysis.In addition,compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity,with IC50 values of 3.33 and 13.34 lM,respectively,using the luciferase reporter gene assay.展开更多
To the Editor:Hepatic ischemia-reperfusion(I/R)injury is the component of liver injury related to liver transplantation and liver surgery[1-3].The hepatic sinus microcirculation injury is a central part of hep-atic I/...To the Editor:Hepatic ischemia-reperfusion(I/R)injury is the component of liver injury related to liver transplantation and liver surgery[1-3].The hepatic sinus microcirculation injury is a central part of hep-atic I/R injury,which eventually leads to hepatocyte injury.This process is closely associated with the participation of liver non-parenchymal cells such as Kuffer cells,hepatic stellate cells,liver sinusoidal endothelial cells(LSECs),and cytokines.展开更多
Three new physalin steroids,physalin Ⅲ(1),physalin IV(2),3-O-methylphysalin X(3),together with five known physalins(4-8)were isolated from the 80%EtOH extract of calyces of Physalis alkekengi var.franchetii.The struc...Three new physalin steroids,physalin Ⅲ(1),physalin IV(2),3-O-methylphysalin X(3),together with five known physalins(4-8)were isolated from the 80%EtOH extract of calyces of Physalis alkekengi var.franchetii.The structures of the new compounds were revealed through 1D and 2D NMR and mass spectroscopic studies.展开更多
Background:Wernicke encephalopathy(WE)is an acute neurological disease resulting from vitamin B1 deficiency,and there are only very few case reports of WE after liver transplantation.The present study aimed to investi...Background:Wernicke encephalopathy(WE)is an acute neurological disease resulting from vitamin B1 deficiency,and there are only very few case reports of WE after liver transplantation.The present study aimed to investigate the clinical characteristics,etiology,magnetic resonance imaging(MRI)features,treatment and prognosis of patients with WE after liver transplantation.Methods:Twenty-three patients with WE after liver transplantation from the First Affiliated Hospital,Zhejiang University School of Medicine and Jiangxi Provincial People’s Hospital between January 2011 and December 2021 were retrospectively analyzed.Results:Among the 23 patients diagnosed with WE after liver transplantation,6(26%)had a classic triad of impaired consciousness,oculomotor palsy and ataxia,and 17(74%)had two features.The misdiagno-sis rate was 65%.After treatment with high-dose vitamin B1,19(83%)patients showed improvement,whereas 4(17%)showed no improvement,including 3 with residual short-term memory impairments and 1 with residual spatial and temporal disorientation and ataxia.Conclusions:The misdiagnosis rate is high in the early stage of WE,and the prognosis is closely asso-ciated with whether WE is diagnosed early and treated timely.High-dose glucose or glucocorticoids can trigger WE and cannot be administered before vitamin B1 treatment.Vitamin B1 is suggested to be used as a prophylactic treatment for patients with WE after liver transplantation.展开更多
目的探讨运用图像存档与通信系统(picture archiving and communication systems,PACS)并结合翻转课堂CBL教学方法在住院医师规范化培训儿科超声心动图教学中的应用。方法将24名住院医师分为观察组和对照组,各12人,观察组接受体验式教学...目的探讨运用图像存档与通信系统(picture archiving and communication systems,PACS)并结合翻转课堂CBL教学方法在住院医师规范化培训儿科超声心动图教学中的应用。方法将24名住院医师分为观察组和对照组,各12人,观察组接受体验式教学法,即基于PACS系统的翻转课堂CBL教学法,对照组接受传统教学方法,均完成培训及先心病病例描述与诊断考核。对比分析两组住院医师的考核成绩、教学反馈及满意度调查情况。结果两组一般资料比较,差异无统计学意义(P>0.05)。观察组考核成绩高于对照组,差异有统计学意义(P<0.05)。观察组在学习自主性、学习质量与对照组比较,差异有统计学意义(P<0.05)。结论基于PACS的CBL教学法是一种更优化而且受欢迎的先心病超声心动图教学模式。展开更多
Genetic diversity and relationship of 183 tea germplasms were assessed by inter-simple sequence repeat(ISSR) marker.The study optimized the ISSR-PCR system for tea plants.Results show that genetic similarity among 183...Genetic diversity and relationship of 183 tea germplasms were assessed by inter-simple sequence repeat(ISSR) marker.The study optimized the ISSR-PCR system for tea plants.Results show that genetic similarity among 183 tea ascensions was between 0.52-0.93,indicating a wide gene pool and a broad genetic variation of Wuling tea resources.The highest similarity of all materials between No1 and No2 was 0.93.Dendrogram of the183 tea germplasms were protracted by UPGMA clustering analysis also revealed the genetic diversity and relationship of the tea germplasms of Wuling mountainous area.Besides,fingerprint of the 183 tea germplasms were constructed.展开更多
2,4-dinitroanisole(DNAN)is a good replacement for 2,4,6-trinitrotoluene(TNT)in melt-cast explosives due to its superior insensitivity.With the increasing use of DNAN-based melt-cast explosives,the prediction of reacti...2,4-dinitroanisole(DNAN)is a good replacement for 2,4,6-trinitrotoluene(TNT)in melt-cast explosives due to its superior insensitivity.With the increasing use of DNAN-based melt-cast explosives,the prediction of reaction violence and hazard assessment of the explosives subjected to shock is of great significance.This study investigated the shock initiation characteristics for a DNAN-based melt-cast explosive,DHFA,using the one-dimensional Lagrangian apparatus.The embedded manganin gauges in the apparatus record the pressure histories at four Lagrangian positions and show that shock-todetonation transition in DHFA needs a high input shock pressure.The experimental data are analyzed to calibrate the Ignition and Growth model.The calibration is performed using an objective function based on both pressure history and the arrival time of shock.Good agreement between experimental and calculated pressure histories indicates the high accuracy of the calibrated parameters with the optimization method.展开更多
To the Editor:Peliosis hepatis(PH)is an uncommon benign vascular disorder characterized by widespread blood-filled cysts in the liver.This dis-ease was first described by Wagner in 1861,and because the liver lesions w...To the Editor:Peliosis hepatis(PH)is an uncommon benign vascular disorder characterized by widespread blood-filled cysts in the liver.This dis-ease was first described by Wagner in 1861,and because the liver lesions were generally red or blue-purple,it was first named PH by Schoenlack in 1916[1].The etiology of PH is not completely clear now,which is mainly related to drug factors,immune fac-tors,and infections.The diagnosis of PH is difficult because of the lack of specific clinical manifestations and imaging features.展开更多
Introduction The immune system is the cornerstone of human health,with most diseases and health conditions closely related to immune status.Therefore,immune status management is a core health issue.In recent years,sig...Introduction The immune system is the cornerstone of human health,with most diseases and health conditions closely related to immune status.Therefore,immune status management is a core health issue.In recent years,significant research breakthroughs in immunosuppressants,immune cell therapy,and immune checkpoint inhibitors have enabled clinical experts and researchers to effectively modulate immune status and regulate immunity more efficient.Key questions in the field of immunology include:How can immune function be visually assessed?What constitutes normal immune cell function status?How can immune cell function status be quantitatively evaluated?How can a standardized system for assessing immune cell function status be established?Currently,there is no consensus on these issues worldwide.On August 28,2023,the National Natural Science Foundation of China announced the National Major Research Plan:Immune Power Digital Decoding Research.Traditional research models have failed to systematically reveal the generation and evolution of immune power.展开更多
Dear Editor,Tuberculosis(TB)is an infectious disease which has been considered as a global public health emergency problem during the past 25y.The World Health Organization has estimated that approximately one-third o...Dear Editor,Tuberculosis(TB)is an infectious disease which has been considered as a global public health emergency problem during the past 25y.The World Health Organization has estimated that approximately one-third of the world’s population are infected by TB.However,only 10%of patients with TB is symptomatic.TB can affect multiple organs throughout the body.Eighty percent of those infected are pulmonary TB.Ocular TB can occur with or without lung or other systemic TB.It is a rare extrapulmonary form of the disease and occupied about 3.5%–5%of all of the TB.It should not be disregarded as its potential influence on vision loss.The intraocular and/or extraocular structures could be impacted by ocular TB[1].Uvea was the most common affected structure[2].展开更多
Stabilities of supersonic jets are examined with different velocities, momentum thicknesses, and core temperatures. Amplification rates of instability waves at inlet are evaluated by linear stability theory （LST）. I...Stabilities of supersonic jets are examined with different velocities, momentum thicknesses, and core temperatures. Amplification rates of instability waves at inlet are evaluated by linear stability theory （LST）. It is found that increased velocity and core temperature would increase amplification rates substantially and such influence varies for different azimuthal wavenumbers. The most unstable modes in thin momentum thickness cases usually have higher frequencies and azimuthal wavenumbers. Mode switching is observed for low azimuthal wavenumbers, but it appears merely in high velocity cases. In addition, the results provided by linear parabolized stability equations show that the mean-flow divergence affects the spatial evolution of instability waves greatly. The most amplified instability waves globally are sometimes found to be different from that given by LST.展开更多
In this paper, we investigate the microfluid induced vibration of a nanotube in thermal environment. Attention is focused on a special case that the law of energy equipartition is unreliable unless the quantum effect ...In this paper, we investigate the microfluid induced vibration of a nanotube in thermal environment. Attention is focused on a special case that the law of energy equipartition is unreliable unless the quantum effect is taken into account. A nonlocal luler-Bernoulli beam model is used to model the transverse vibration of a single-walled nanotube （SWCNT）. Results reveal that the root of mean squared （RMS） amplitude of thermal vibration of the fluid-conveying SWCNT predicted from the quantum theory is lower than that predicted from the law of energy equipartition. The quantum effect on the thermal vibration of the fluid-conveying SWCNT is more significant for the cases of higher-order modes, lower flow velocity, lower temperature, and lower fluid density.展开更多
基金funded by the Key Research and Development Program of Shandong Province(2023CXPT069)Opening Funds of the State Key Laboratory of Building Safety and Built Environment(BSBE2022-EET-06)Innovation Project of Guangwei Group Academician Workstation(GWYS-2022-04)。
文摘Sodium metal batteries(SMBs)are promising candidates for next-generation energy storage devices owing to their excellent safety performance and natural abunda nce of sodium.However,the insurmountable obstacles of dendrite formation and quick capacity decay are caused by an unstable and inhomogeneous solid electrolyte interphase that resulted from the immediate interactions between the Na metal anode and organic liquid electrolyte.Herein,a customised glass fibre separator coupled with chitosan(CS@GF)was developed to modulate the sodium ion(Na^(+))flux.The CS@GF separator facilitates the Na+homogeneous deposition on the anode side through redistribution at the chitosan polyactive sites and by inhibiting the decomposition of the electrolyte to robust solid electrolyte interphase(SEI)formation.Multiphysics simulations show that chitosan incorporated into SMBs through the separator can make the local electric field around the anode uniform,thus facilitating the transfer of cations.Na|Na symmetric cells utilising a CS@GF separator exhibited an outstanding cycle stability of over 600 h(0.5 mA cm^(-2)).Meanwhile,the Na|Na_(3)V_(5)(PO_(4))_(3)full cell exhibited excellent fast-charging performance(93.47%capacity retention after 1500 cycles at 5C).This study presents a promising strategy for inhibiting dendrite growth and realizes stable Na metal batteries,which significantly boosts the development of high-performance SMBs.
文摘Uncertainty is an important characteristic of scheduling model for scale farm machinery operation organizing. Practice shows that scheduling model without considering uncertainties is nearly useless. Uncertain influence factors arisen from natural environment, society and economy, market and supply, and customer and behavior, exist widely, emerge frequently, and affect production deeply. Uncertainties interfere with the allocation of productive factors on temporal and spatial dimensions for farm machinery operation scheduling and management. Questionnaire for farm machinery organizations was designed and finished in 2014. Both occurrence frequency and influence degree for each factor were quantified. Four influence factors including operation location change, weather mutation, parts supply delay, and operation skill defects appear in both list of high occurrence and deep influence. Then results of questionnaire and results of specific investigation were used to study temporal and spatial scheduling model and system for farm machinery management. Three case studies are introduced. The first case is about the uncertainty and countermeasure of forage harvesters scheduling and monitoring for a professional forage plantation company. The second case is about the uncertainty and counter measure of cotton-picker scheduling and monitoring for a professional cotton picking company. And the third case is about the uncertainty and countermeasure of social service management for a professional cooperative. The cases show that the research has strong pertinence to deal with uncertainties and can improve management efficiency of farm machinery operation.
基金supported by National Science Fund for Distinguished Young Scholars of China(No.51625502)Innovative Group Project of National Natural Science Foundation of China(No.51721092)Innovative Group Project of Hubei Province of China(No.2017CFA003)。
文摘Due to the advantages of large workspace,low cost and the integrated vision/force sensing,robotic milling has become an important way for machining of complex parts.In recent years,many scholars have studied the problems existing in the applications of robotic milling,and lots of results have been made in the dynamics,pose planning,deformation control etc.,which provides theoretical guidance for high precision and high efficiency of robotic milling.From the perspective of complex parts robotic milling,this paper focuses on machining process planning and control techniques including the analysis of the robot-workspace,robot trajectory planning,vibration monitoring and control,deformation monitoring and compensation.As well as the principles of these technologies such as robot stiffness characteristics,dynamic characteristics,chatter mechanisms,and deformation mechanisms.The methods and characteristics related to the theory and technology of robotic milling of complex parts are summarized systematically.The latest research progress and achievements in the relevant fields are reviewed.It is hoped that the challenges,strategies and development related to robotic milling could be clarified through the carding work in this paper,so as to promote the application of related theories and technologies in high efficiency and precision intelligent milling with robot for complex parts.
文摘In VTI media,the conventional inversion methods based on the existing approximation formulas are difficult to accurately estimate the anisotropic parameters of reservoirs,even more so for unconventional reservoirs with strong seismic anisotropy.Theoretically,the above problems can be solved by utilizing the exact reflection coefficients equations.However,their complicated expression increases the difficulty in calculating the Jacobian matrix when applying them to the Bayesian deterministic inversion.Therefore,the new reduced approximation equations starting from the exact equations are derived here by linearizing the slowness expressions.The relatively simple form and satisfactory calculation accuracy make the reduced equations easy to apply for inversion while ensuring the accuracy of the inversion results.In addition,the blockiness constraint,which follows the differentiable Laplace distribution,is added to the prior model to improve contrasts between layers.Then,the concept of GLI and an iterative reweighted least-squares algorithm is combined to solve the objective function.Lastly,we obtain the iterative solution expression of the elastic parameters and anisotropy parameters and achieve nonlinear AVA inversion based on the reduced equations.The test results of synthetic data and field data show that the proposed method can accurately obtain the VTI parameters from prestack AVA seismic data.
基金Supported by Science and Technology Innovation Talents Support Plan,Department of Education,Henan Province,China,No.17HASTIT044China Postdoctoral Science Foundation,No.2017M610374
文摘AIM To investigate the protective mechanism of mitofusin-2 (Mfn2) in rat remote ischemic perconditioning (RIC) models and revalidate it in alpha mouse liver-12 (AML-12) hypoxia cell lines. METHODS Sprague-Dawley rats were divided into three groups (n = 6 each): sham, orthotopic liver transplantation and RIC. After operation, blood samples were collected to test alanine aminotransferase and aspartate aminotransferase. The liver lobes were harvested for histopathological examination, western blotting (WB) and quantitative real-time (qRT)-PCR. AML-12 cell lines were then subjected to normal culture, anoxic incubator tank culture (hypoxia) and anoxic incubator tank culture with Mfn2 knockdown (hypoxia + Si), and data of qRT-PCR, WB, mitochondrial membrane potential (Delta psi m), apoptosis, endoplasmic reticulum Ca2+ concentrations and mitochondrial Ca2+ concentrations were collected. RESULTS Both sham and normal culture groups showed no injury during the experiment. The RIC group showed amelioration of liver function compared with the orthotopic liver transplantation group (P < 0.05). qRTPCR and WB confirmed that Mfn2-mitochondrial Ca2+ uptake 1/2 (MICUs) axis was changed (P < 0.005). In AML-12 cell lines, compared with the hypoxia group, the hypoxia + Si group attenuated the collapse of..m and apoptosis (P < 0.005). The endoplasmic reticulum Ca2+ decrease and mitochondrial Ca2+ overloading observed in the hypoxia group were also attenuated in the hypoxia + Si group (P < 0.005). Finally, qRT-PCR and WB confirmed the Mfn2-MICUs axis change in all the groups (P < 0.005). CONCLUSION Mfn2 participates in liver injury in rat RIC models and AML-12 hypoxia cell lines by regulating the MICUs pathway.
基金supported by grants from the National Natural Science Foundation of China(81470891)China Postdoctoral Science Foundation(2017M610374)+1 种基金Science and Technology Bureau of Zhejiang Province,China(2016C33145)Innovative Research Groups of the National Natural Science Foundation of China(81421062)
文摘Background: With the increased use of extended-criteria donors, static cold storage has failed to provide optimal preservation of liver grafts, resulting in early allograft dysfunction and long-term complications Machine perfusion(MP) is a beneficial alternative preservation strategy for donor livers, particularly fo those considered to be of suboptimal quality, and could expand the limited donor pool. Data sources: A comprehensive search in Pub Med, EMBASE, Ovid databases and Clinical Trials.gov website was conducted using the medical subject heading terms "machine perfusion", "machine preservation""liver transplantation", combined with free text terms such as "hypothermic", "normothermic" and "sub normothermic". The deadline for the search was September 30, 2017. Results: MP can be classified as hypothermic, subnormothermic, and normothermic with the tempera ture maintained at 0–12 °C, 25–34 °C and 35–38 °C, respectively. Twelve clinical trials of MP have been reported in recent years. MP effectively decreased AST/ALT level and the incidence of early allograft dys function. However, the graft and patient survival rate after MP were similar to static cold storage. The detailed clinical characteristics such as liver function, graft survival, patient survival and early allograf dysfunction were reviewed.Conclusions: Clinical trial results showed that MP improves delayed graft function, primary non-function and biliary strictures. However, MP still requires validation in large clinical trials and the key parameters during MP still require optimization.
基金Supported by the National Nature Science Foundation of China(No.81362138)
文摘AIM：To investigate the relationship between high myopia [with or without complete congenital stationary night blindness（CSNB1）] and TRPM1 and NYX.METHODS： Two unrelated families with early-onset high myopia（eo HM） and 96 normal controls were recruited.Sanger sequencing or clone sequencing were used for mutation screening.Further analyses of the available family members and the 96 normal controls were subsequently conducted to obtain additional evidence of the pathogenicity of these variants.The initial diagnosis of the probands was eo HM.We performed a further comprehensive examination of the available family members after mutations were detected in TRPM1 or NYX. RESULTS： Two novel compound heterozygous mutations in TRPM1 were detected in the recruited families.The proband in family A with eo HM carried a c.2594 C 〉T missense mutation in exon 19 and a c.669 ＋3_669 ＋6del AAGT splicing mutation,which was co-segregated with CSNB1 in this family.A patient in family B with a compound heterozygous missense mutation（c.3262 G〉A and c.3250 T〉C） was detected.No mutations were found in NYX.These two identified compound heterozygous mutations were not found in the 96 normal controls.After further examination of the family members,the patients in family A could be diagnosed as eo HM with CSNB1.However due to the limited clinic data,the patient in family B cloud not clearly diagnosed as CSNB1.CONCLUSION： This study has expanded the mutation spectrum of TRPM1 for CSNB1 and additional studiesare needed to elucidate the association between isolated high myopia and TRPM1 and NYX.
基金Program for National Natural Science Foundation of China(Nos.U1132604 and 81302670)The Major Deployment Program of the CAS(No.KSZDEW-Z-004-01)Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2008-ZZ05).
文摘Four new 9,19-cycloartane triterpenoids,cimilactone E(1),cimilactone F(2),20-O-(E)-butenoyl-23-epi-26-deoxyactein(3),and 20,12b-O-diacetylcimiracemonol-3-O-b-D-xylopyranoside(4),together with four known constituents(5–8)were isolated from the roots of Cimicifuga foetida.The new structures were elucidated by extensive spectroscopic analysis.In addition,compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity,with IC50 values of 3.33 and 13.34 lM,respectively,using the luciferase reporter gene assay.
基金supported by grants from the Scientific Research Foundation of Traditional Chinese Medicine of Zhejiang Province(2015ZA085)Scientific Research Project of Zhejiang Provincial Health Commission(2021448467)the Basic Public Welfare Re-search Project of Zhejiang Province(LGF20H030011).
文摘To the Editor:Hepatic ischemia-reperfusion(I/R)injury is the component of liver injury related to liver transplantation and liver surgery[1-3].The hepatic sinus microcirculation injury is a central part of hep-atic I/R injury,which eventually leads to hepatocyte injury.This process is closely associated with the participation of liver non-parenchymal cells such as Kuffer cells,hepatic stellate cells,liver sinusoidal endothelial cells(LSECs),and cytokines.
基金This project was financially supported by the National Major Basic Research Program(No.SB2007FY400)the National Ministry of Science and Technology of China,the National Knowledge Innovation Program of Chinese Academy of Sciences(No.KSCX2-YW-G-038)the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ14).
文摘Three new physalin steroids,physalin Ⅲ(1),physalin IV(2),3-O-methylphysalin X(3),together with five known physalins(4-8)were isolated from the 80%EtOH extract of calyces of Physalis alkekengi var.franchetii.The structures of the new compounds were revealed through 1D and 2D NMR and mass spectroscopic studies.
基金approved by Jiangxi Provincial People’s Hospital and First Affiliated Hospital,Zhejiang University School of Medicine(2022068 and 2022370).Written informed consent was obtained from all participants.
文摘Background:Wernicke encephalopathy(WE)is an acute neurological disease resulting from vitamin B1 deficiency,and there are only very few case reports of WE after liver transplantation.The present study aimed to investigate the clinical characteristics,etiology,magnetic resonance imaging(MRI)features,treatment and prognosis of patients with WE after liver transplantation.Methods:Twenty-three patients with WE after liver transplantation from the First Affiliated Hospital,Zhejiang University School of Medicine and Jiangxi Provincial People’s Hospital between January 2011 and December 2021 were retrospectively analyzed.Results:Among the 23 patients diagnosed with WE after liver transplantation,6(26%)had a classic triad of impaired consciousness,oculomotor palsy and ataxia,and 17(74%)had two features.The misdiagno-sis rate was 65%.After treatment with high-dose vitamin B1,19(83%)patients showed improvement,whereas 4(17%)showed no improvement,including 3 with residual short-term memory impairments and 1 with residual spatial and temporal disorientation and ataxia.Conclusions:The misdiagnosis rate is high in the early stage of WE,and the prognosis is closely asso-ciated with whether WE is diagnosed early and treated timely.High-dose glucose or glucocorticoids can trigger WE and cannot be administered before vitamin B1 treatment.Vitamin B1 is suggested to be used as a prophylactic treatment for patients with WE after liver transplantation.
文摘目的探讨运用图像存档与通信系统(picture archiving and communication systems,PACS)并结合翻转课堂CBL教学方法在住院医师规范化培训儿科超声心动图教学中的应用。方法将24名住院医师分为观察组和对照组,各12人,观察组接受体验式教学法,即基于PACS系统的翻转课堂CBL教学法,对照组接受传统教学方法,均完成培训及先心病病例描述与诊断考核。对比分析两组住院医师的考核成绩、教学反馈及满意度调查情况。结果两组一般资料比较,差异无统计学意义(P>0.05)。观察组考核成绩高于对照组,差异有统计学意义(P<0.05)。观察组在学习自主性、学习质量与对照组比较,差异有统计学意义(P<0.05)。结论基于PACS的CBL教学法是一种更优化而且受欢迎的先心病超声心动图教学模式。
基金supported by the earmarked fund for Modern Agro-industry Technology Research System of China (CARS-23)the Priority Academic Program Development of Jiangsu Higher Education Institutions+2 种基金the Science and Technology Program of Suzhou (SZGD201067,WZC65,WNZ1002)The PhD Gathering Program of Jiangsuthe Science and Technology Program of Jiangsu Province (BE2011319,BE2012440,BE2013426)
文摘Genetic diversity and relationship of 183 tea germplasms were assessed by inter-simple sequence repeat(ISSR) marker.The study optimized the ISSR-PCR system for tea plants.Results show that genetic similarity among 183 tea ascensions was between 0.52-0.93,indicating a wide gene pool and a broad genetic variation of Wuling tea resources.The highest similarity of all materials between No1 and No2 was 0.93.Dendrogram of the183 tea germplasms were protracted by UPGMA clustering analysis also revealed the genetic diversity and relationship of the tea germplasms of Wuling mountainous area.Besides,fingerprint of the 183 tea germplasms were constructed.
基金Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology(Grant No.2021yjrc38)Anhui Provincial Natural Science Foundation(Grant No.2208085QA27)+1 种基金National Natural Science Foundation of China(Grant Nos.11972046,12002266)the authors would like to thank these foundations for financial support.
文摘2,4-dinitroanisole(DNAN)is a good replacement for 2,4,6-trinitrotoluene(TNT)in melt-cast explosives due to its superior insensitivity.With the increasing use of DNAN-based melt-cast explosives,the prediction of reaction violence and hazard assessment of the explosives subjected to shock is of great significance.This study investigated the shock initiation characteristics for a DNAN-based melt-cast explosive,DHFA,using the one-dimensional Lagrangian apparatus.The embedded manganin gauges in the apparatus record the pressure histories at four Lagrangian positions and show that shock-todetonation transition in DHFA needs a high input shock pressure.The experimental data are analyzed to calibrate the Ignition and Growth model.The calibration is performed using an objective function based on both pressure history and the arrival time of shock.Good agreement between experimental and calculated pressure histories indicates the high accuracy of the calibrated parameters with the optimization method.
文摘To the Editor:Peliosis hepatis(PH)is an uncommon benign vascular disorder characterized by widespread blood-filled cysts in the liver.This dis-ease was first described by Wagner in 1861,and because the liver lesions were generally red or blue-purple,it was first named PH by Schoenlack in 1916[1].The etiology of PH is not completely clear now,which is mainly related to drug factors,immune fac-tors,and infections.The diagnosis of PH is difficult because of the lack of specific clinical manifestations and imaging features.
基金supported by grants from the National Natural Science Foundation of China(82370665,81471590 and 81571554)Beijing Natural Science Foundation(7212042,7222303 and 7232068)+1 种基金Beijing Chaoyang Hospital Golden Seeds Foundation(CYJZ202204)Science and Technology Innovation Fund of Beijing Chaoyang Hospital Affiliated to Capital Medical University in 2021(21kcjj-4).
文摘Introduction The immune system is the cornerstone of human health,with most diseases and health conditions closely related to immune status.Therefore,immune status management is a core health issue.In recent years,significant research breakthroughs in immunosuppressants,immune cell therapy,and immune checkpoint inhibitors have enabled clinical experts and researchers to effectively modulate immune status and regulate immunity more efficient.Key questions in the field of immunology include:How can immune function be visually assessed?What constitutes normal immune cell function status?How can immune cell function status be quantitatively evaluated?How can a standardized system for assessing immune cell function status be established?Currently,there is no consensus on these issues worldwide.On August 28,2023,the National Natural Science Foundation of China announced the National Major Research Plan:Immune Power Digital Decoding Research.Traditional research models have failed to systematically reveal the generation and evolution of immune power.
基金Natural Science Foundation of Sichuan Province(No.2022NSFSC1370).
文摘Dear Editor,Tuberculosis(TB)is an infectious disease which has been considered as a global public health emergency problem during the past 25y.The World Health Organization has estimated that approximately one-third of the world’s population are infected by TB.However,only 10%of patients with TB is symptomatic.TB can affect multiple organs throughout the body.Eighty percent of those infected are pulmonary TB.Ocular TB can occur with or without lung or other systemic TB.It is a rare extrapulmonary form of the disease and occupied about 3.5%–5%of all of the TB.It should not be disregarded as its potential influence on vision loss.The intraocular and/or extraocular structures could be impacted by ocular TB[1].Uvea was the most common affected structure[2].
基金supported by the National Natural Science Foundation of China(11232011 and 11402262)China Postdoctral Science Foundation Funded Project(2014M561833)111 Project(B07033)
文摘Stabilities of supersonic jets are examined with different velocities, momentum thicknesses, and core temperatures. Amplification rates of instability waves at inlet are evaluated by linear stability theory （LST）. It is found that increased velocity and core temperature would increase amplification rates substantially and such influence varies for different azimuthal wavenumbers. The most unstable modes in thin momentum thickness cases usually have higher frequencies and azimuthal wavenumbers. Mode switching is observed for low azimuthal wavenumbers, but it appears merely in high velocity cases. In addition, the results provided by linear parabolized stability equations show that the mean-flow divergence affects the spatial evolution of instability waves greatly. The most amplified instability waves globally are sometimes found to be different from that given by LST.
基金supported by the National Natural Science Foundation of China (project nos.11672187 and 11402151)Natural Science Foundation of Liaoning Province (project no.201602573)Program for Liaoning Excellent Talents in University (no.LJQ2013020)
文摘In this paper, we investigate the microfluid induced vibration of a nanotube in thermal environment. Attention is focused on a special case that the law of energy equipartition is unreliable unless the quantum effect is taken into account. A nonlocal luler-Bernoulli beam model is used to model the transverse vibration of a single-walled nanotube （SWCNT）. Results reveal that the root of mean squared （RMS） amplitude of thermal vibration of the fluid-conveying SWCNT predicted from the quantum theory is lower than that predicted from the law of energy equipartition. The quantum effect on the thermal vibration of the fluid-conveying SWCNT is more significant for the cases of higher-order modes, lower flow velocity, lower temperature, and lower fluid density.
