目的:采用孟德尔随机化法探索不同铁状态(血清铁、转铁蛋白饱和度、铁蛋白和转铁蛋白)与前列腺癌(PCa)的因果关系。方法:从铁状态的全基因组关联研究中提取出与铁状态密切相关的遗传变异位点作为工具变量,进一步在the Prostate Cancer A...目的:采用孟德尔随机化法探索不同铁状态(血清铁、转铁蛋白饱和度、铁蛋白和转铁蛋白)与前列腺癌(PCa)的因果关系。方法:从铁状态的全基因组关联研究中提取出与铁状态密切相关的遗传变异位点作为工具变量,进一步在the Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome(PRACTICAL)consortium数据库中选出对应的遗传位点,把与血清铁、铁蛋白浓度、转铁蛋白饱和度增加和转铁蛋白浓度降低整体有关的单核苷酸多态性位点(SNP)作为传统组,与四种铁的生物标志物强相关的SNP作为自由组。使用逆方差加权法(IVW),MR-Egger回归和加权中位数法(WM)来评价铁状态与PCa之间的因果关系。结果:从全基因组关联分析的数据中得到11个SNP作为工具变量。在传统组中,铁状态与PCa存在因果关系(OR=0.879,95%CI:0.813~0.950,P=0.001)。同时,在自由组中,血清铁与PCa存在因果关系(OR=0.910,95%CI:0.833~0.995,P=0.039)。MR-Egger回归的截距接近0且无统计学意义,表明分析结果不会受遗传多效性的影响。其他三种铁的生物标记物(转铁蛋白饱和度、铁蛋白和转铁蛋白)与PCa之间无显著因果关系(均P>0.05)。结论:以SNP作为工具变量预测铁与PCa风险存在因果关系,为PCa的治疗和预防提供了证据。展开更多
The surface morphologies of InP epilayers grown by solid source molecular beam epitaxy at different growth temperatures and P/In flux ratios have been systematically studied by atomic force microscopy(AFM).The results...The surface morphologies of InP epilayers grown by solid source molecular beam epitaxy at different growth temperatures and P/In flux ratios have been systematically studied by atomic force microscopy(AFM).The results show that the remarkable variety of surface morphologies of samples is related to the transition of growth mode.Under a critical growth condition,a transition of growth mode is induced between a two-dimensional(2D)growth mode and a three-dimensional(3D)growth mode.On the basis of these results,a summary phased iagram is proposed for the growth mode of InP epilayers.Under the 2D growth region,high quality InP epilayers are obtained.展开更多
文摘目的:采用孟德尔随机化法探索不同铁状态(血清铁、转铁蛋白饱和度、铁蛋白和转铁蛋白)与前列腺癌(PCa)的因果关系。方法:从铁状态的全基因组关联研究中提取出与铁状态密切相关的遗传变异位点作为工具变量,进一步在the Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome(PRACTICAL)consortium数据库中选出对应的遗传位点,把与血清铁、铁蛋白浓度、转铁蛋白饱和度增加和转铁蛋白浓度降低整体有关的单核苷酸多态性位点(SNP)作为传统组,与四种铁的生物标志物强相关的SNP作为自由组。使用逆方差加权法(IVW),MR-Egger回归和加权中位数法(WM)来评价铁状态与PCa之间的因果关系。结果:从全基因组关联分析的数据中得到11个SNP作为工具变量。在传统组中,铁状态与PCa存在因果关系(OR=0.879,95%CI:0.813~0.950,P=0.001)。同时,在自由组中,血清铁与PCa存在因果关系(OR=0.910,95%CI:0.833~0.995,P=0.039)。MR-Egger回归的截距接近0且无统计学意义,表明分析结果不会受遗传多效性的影响。其他三种铁的生物标记物(转铁蛋白饱和度、铁蛋白和转铁蛋白)与PCa之间无显著因果关系(均P>0.05)。结论:以SNP作为工具变量预测铁与PCa风险存在因果关系,为PCa的治疗和预防提供了证据。
文摘The surface morphologies of InP epilayers grown by solid source molecular beam epitaxy at different growth temperatures and P/In flux ratios have been systematically studied by atomic force microscopy(AFM).The results show that the remarkable variety of surface morphologies of samples is related to the transition of growth mode.Under a critical growth condition,a transition of growth mode is induced between a two-dimensional(2D)growth mode and a three-dimensional(3D)growth mode.On the basis of these results,a summary phased iagram is proposed for the growth mode of InP epilayers.Under the 2D growth region,high quality InP epilayers are obtained.
