BACKGROUND Helicobacter pylori(H.pylori),a globally widespread pathogen affecting half of the global population,has been increasingly implicated in metabolic disorders,including obesity,dyslipidemia,and metabolic dysf...BACKGROUND Helicobacter pylori(H.pylori),a globally widespread pathogen affecting half of the global population,has been increasingly implicated in metabolic disorders,including obesity,dyslipidemia,and metabolic dysfunction-associated steatotic liver disease(MASLD).MASLD is a common condition,impacting nearly one in four adults globally.It also shares significant pathophysiological links with metabolic syndrome.Despite the fact that mechanistic hypotheses(such as oxidative stress and inflammation)have been proposed to explain these relationships,large-scale studies comprehensively assessing multifactorial metabolic associations are lacking.We proposed that H.pylori infection may independently correlate with unfavorable metabolic profiles and the presence of MASLD among adults in a large cohort.AIM To investigate the associations of H.pylori infection with obesity,glucose,lipids,blood pressure,and MASLD in Chinese adults.METHODS This study included 28624 adults recruited from the Physical Examination Center at Nanchang University's Second Affiliated Hospital.The 13C-urea breath test was used to identify H.pylori infection,while abdominal ultrasound was employed for MASLD diagnosis.The relationships between H.pylori infection and metabolic factors were analyzed via multivariate logistic regression.RESULTS The overall H.pylori infection incidence was 26.8%,with higher rates observed in older adults(≥70 years:26.1%vs 18-29 years:24.6%,P<0.001)and obese individuals[body mass index(BMI)≥28 kg/m^(2):30.0%vs normal BMI:25.3%,P<0.001].H.pylori-positive individuals exhibited elevated blood glucose(5.43±1.55 mmol/L vs 5.27±1.23 mmol/L,P<0.001),low-density lipoprotein cholesterol(2.97±0.76 mmol/L vs 2.94±0.75 mmol/L,P<0.001),and blood pressure(systolic:123.49±19.06 mmHg vs 122.85±18.33 mmHg,P=0.009;diastolic:75.48±12.37 vs 74.9 mmHg±11.9 mmHg,P<0.001)levels.Among MASLD patients,infection was associated with increased glucose(5.82±1.95 mmol/L vs 5.60±1.60 mmol/L,P<0.001),total cholesterol(5.05±1.03 mmol/L vs 5.00±1.00 mmol/L,P=0.039),BMI(26.23±3.00 kg/m^(2)vs 26.04±2.96 kg/m^(2),P=0.004),and blood pressure(systolic:129.5±20.00 mmHg vs 128.49±17.62 mmHg,P=0.009;diastolic:79.87±12.07 mmHg vs 79.04±11.76 mmHg,P=0.002)levels.Multivariate analysis demonstrated elevated glucose[odds ratio(OR)=1.079,P<0.001],BMI(OR=1.016,P=0.002),and diastolic pressure(OR=1.003,P=0.048)levels as independent risk factors,with high-density lipoprotein(HDL)being observed as a protective factor(OR=0.837,P<0.001).CONCLUSION H.pylori infection correlates with older age,obesity,elevated glucose levels,and elevated diastolic blood pressure,whereas HDL protects against H.pylori infection,thus underscoring its role in metabolic disturbances and MASLD.展开更多
Amorphous materials are one of the important candidates for improving heterogeneous photocata-lysts because of their unique electronic structures and abundant catalytic sites originating from dis-order atomic arrangem...Amorphous materials are one of the important candidates for improving heterogeneous photocata-lysts because of their unique electronic structures and abundant catalytic sites originating from dis-order atomic arrangements.However,there is still much room for the development of new crys-talline/amorphous heterogeneous composites for photocatalytic application.Hence efficient synthetic strategies for preparing new crystalline/amorphous heterojunctions are highly desired.Herein,we have realized the deep optimization of photocatalytic activity by fabricating crystalline/amorphous Cu_(2)O/Ti-Fe layer double hydroxide(LDH)heterojunctions.Thanks to the typical Z-scheme mechanism originating from the crystalline/amorphous interfaces,the photocharge separation and catalytic active sites obviously enhance compared to single Cu_(2)O and LDH counterparts.As expected,the photocatalytic removal of tetra-cycline(TC)of the as-prepared Cu_(2)O/Ti-Fe LDH was over 5.2 and 2.2 times those of the pristine Cu_(2)O nanospheres and Ti-Fe LDH nanosheets.This work illustrates the origin of crystalline Cu_(2)O nanospheres encapsulated in amorphous Ti-Fe layer double hydroxide nanosheets for enhanced photocatalytic activity driven by visible light,and provide a general Cu_(2)O-templated solution-phase synthetic method for the synthesis of novel double-metal layer double hydroxide amorphous nanostructures.展开更多
基金Supported by Science and Technology Research Program of Jiangxi Provincial Department of Education,No.GJJ2102252022 Provincial Health and Wellness Committee Science and Technology Program Projects,No.20221096Jiangxi Provincial Natural Science Foundation's Young Scientists Fund,No.20242BAB20358.
文摘BACKGROUND Helicobacter pylori(H.pylori),a globally widespread pathogen affecting half of the global population,has been increasingly implicated in metabolic disorders,including obesity,dyslipidemia,and metabolic dysfunction-associated steatotic liver disease(MASLD).MASLD is a common condition,impacting nearly one in four adults globally.It also shares significant pathophysiological links with metabolic syndrome.Despite the fact that mechanistic hypotheses(such as oxidative stress and inflammation)have been proposed to explain these relationships,large-scale studies comprehensively assessing multifactorial metabolic associations are lacking.We proposed that H.pylori infection may independently correlate with unfavorable metabolic profiles and the presence of MASLD among adults in a large cohort.AIM To investigate the associations of H.pylori infection with obesity,glucose,lipids,blood pressure,and MASLD in Chinese adults.METHODS This study included 28624 adults recruited from the Physical Examination Center at Nanchang University's Second Affiliated Hospital.The 13C-urea breath test was used to identify H.pylori infection,while abdominal ultrasound was employed for MASLD diagnosis.The relationships between H.pylori infection and metabolic factors were analyzed via multivariate logistic regression.RESULTS The overall H.pylori infection incidence was 26.8%,with higher rates observed in older adults(≥70 years:26.1%vs 18-29 years:24.6%,P<0.001)and obese individuals[body mass index(BMI)≥28 kg/m^(2):30.0%vs normal BMI:25.3%,P<0.001].H.pylori-positive individuals exhibited elevated blood glucose(5.43±1.55 mmol/L vs 5.27±1.23 mmol/L,P<0.001),low-density lipoprotein cholesterol(2.97±0.76 mmol/L vs 2.94±0.75 mmol/L,P<0.001),and blood pressure(systolic:123.49±19.06 mmHg vs 122.85±18.33 mmHg,P=0.009;diastolic:75.48±12.37 vs 74.9 mmHg±11.9 mmHg,P<0.001)levels.Among MASLD patients,infection was associated with increased glucose(5.82±1.95 mmol/L vs 5.60±1.60 mmol/L,P<0.001),total cholesterol(5.05±1.03 mmol/L vs 5.00±1.00 mmol/L,P=0.039),BMI(26.23±3.00 kg/m^(2)vs 26.04±2.96 kg/m^(2),P=0.004),and blood pressure(systolic:129.5±20.00 mmHg vs 128.49±17.62 mmHg,P=0.009;diastolic:79.87±12.07 mmHg vs 79.04±11.76 mmHg,P=0.002)levels.Multivariate analysis demonstrated elevated glucose[odds ratio(OR)=1.079,P<0.001],BMI(OR=1.016,P=0.002),and diastolic pressure(OR=1.003,P=0.048)levels as independent risk factors,with high-density lipoprotein(HDL)being observed as a protective factor(OR=0.837,P<0.001).CONCLUSION H.pylori infection correlates with older age,obesity,elevated glucose levels,and elevated diastolic blood pressure,whereas HDL protects against H.pylori infection,thus underscoring its role in metabolic disturbances and MASLD.
文摘Amorphous materials are one of the important candidates for improving heterogeneous photocata-lysts because of their unique electronic structures and abundant catalytic sites originating from dis-order atomic arrangements.However,there is still much room for the development of new crys-talline/amorphous heterogeneous composites for photocatalytic application.Hence efficient synthetic strategies for preparing new crystalline/amorphous heterojunctions are highly desired.Herein,we have realized the deep optimization of photocatalytic activity by fabricating crystalline/amorphous Cu_(2)O/Ti-Fe layer double hydroxide(LDH)heterojunctions.Thanks to the typical Z-scheme mechanism originating from the crystalline/amorphous interfaces,the photocharge separation and catalytic active sites obviously enhance compared to single Cu_(2)O and LDH counterparts.As expected,the photocatalytic removal of tetra-cycline(TC)of the as-prepared Cu_(2)O/Ti-Fe LDH was over 5.2 and 2.2 times those of the pristine Cu_(2)O nanospheres and Ti-Fe LDH nanosheets.This work illustrates the origin of crystalline Cu_(2)O nanospheres encapsulated in amorphous Ti-Fe layer double hydroxide nanosheets for enhanced photocatalytic activity driven by visible light,and provide a general Cu_(2)O-templated solution-phase synthetic method for the synthesis of novel double-metal layer double hydroxide amorphous nanostructures.
