OBJECTIVE:To confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.METHODS:This multicenter,positive controlled,randomized clinical trial has trial and contro...OBJECTIVE:To confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.METHODS:This multicenter,positive controlled,randomized clinical trial has trial and control groups.There were 240 patients randomly assigned to the trial group and the control group,and both groups received their respective intervention treatment methods for a period of 12 weeks.The time windows for clinical data collection were before treatment,immediately after treatment,3-d 1,2,4,8,and 12-week after treatment,and follow-up was conducted at 26 and 52-week after treatment.The observed indicators used include primary outcome index and secondary outcome index,with the primary outcome index being the assessment of neck pain severity,which is evaluated by patients using Numerical Rating Scale(NRS).Secondary secondary outcome index include,(a)cervical dysfunction index,measured by patients using the Neck Disability Index(NDI)for self-assessment;(b)Cervical activity measurement,measured through the cervical range of motion measurement program on Android mobile system;(c)Satisfaction treatment assessment,determined by the patient's self-evaluation;(d)Safety index,recorded the incidence of adverse reactions and adverse event.Results:The results showed that these efficacy indices were improved in different degrees in both groups.At immediate after intervention,there was significant difference in NRS,NDI,Cervical Range of Motion(ROM)between the two groups(P<0.01),the trial group was superior to the control group.At 3-d after intervention,there was significant difference in NRS,NDI,ROM between the two groups(P<0.01).At 1-week and 2-week after intervention,there was significant difference in NDI and ROM between the two groups(P<0.01).At 4-week and 6-week after intervention,there was significant difference in NDI,ROM between the two groups(P<0.05).At 8-week after intervention,there was significant difference in NDI,lateral-bending and axial-rotation ROM between the two groups(P<0.05).At 12-week after intervention,there was significant difference in NDI between the two groups(P<0.01).At 26-week and 52-week after intervention,there was significant difference in NDI,NRS between the two groups(P<0.01).In addition,the adverse reaction of trial group is significantly lower than that of control group(P<0.05).The satisfaction of patients in the trial group was better than that in the control group(P<0.01).CONCLUSION:Our findings suggest that Shi's manipulation can be a good complementary treatment option in patients with acute and subacute neck pain.展开更多
目的了解福建省MSM人群HIV新近感染状况,探讨其分子流行特征和相关影响因素,为制定艾滋病防治策略提供科学依据。方法对福建省2019年MSM哨点监测人群HIV抗体阳性样本采用HIV-1限制性抗原亲和力酶联免疫法(简称LAg-Avidity EIA)进行新近...目的了解福建省MSM人群HIV新近感染状况,探讨其分子流行特征和相关影响因素,为制定艾滋病防治策略提供科学依据。方法对福建省2019年MSM哨点监测人群HIV抗体阳性样本采用HIV-1限制性抗原亲和力酶联免疫法(简称LAg-Avidity EIA)进行新近感染检测,用多因素Logistic回归分析其影响因素,通过RT-PCR扩增pol和gag区,利用系统进化树和HIV db Program软件对序列进行基因亚型和耐药突变分析。结果福建省2019年哨点监测MSM人群863人,其中总的HIV抗体阳性率为12.17%(105/863),HIV新近感染率为11.97%;Logistic回归分析显示,样本来源和最近6个月内同性肛交安全套使用频率是新近感染的影响因素;基因亚型以CRF07_BC(47.61%)和CRF01_AE(38.10%)为主,其次为CRF55-01B(9.52%)、B亚型(4.76%);HIV-1耐药率为6.67%(1/15),其中15例对蛋白酶类抑制剂、核苷类逆转录抑制剂均敏感;1例对非核苷类逆转录酶抑制剂efavirenz(EFV)和nevirapine(NVP)产生高度耐药,1例为潜在耐药。结论福建省2019年哨点监测MSM人群HIV新近感染率处于较高水平,多种亚型并存,发现原发耐药株传播,应加强对HIV新近感染者的分子流行特征变化趋势以及原发耐药传播的动态监测,及时调整防控策略,有效控制福建省艾滋病感染与传播。展开更多
系统评价针刺治疗腰背肌筋膜炎的临床疗效。计算机检索PubMed、Cochrane Library、Web of Science、EMbase、Scopus、中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献服务...系统评价针刺治疗腰背肌筋膜炎的临床疗效。计算机检索PubMed、Cochrane Library、Web of Science、EMbase、Scopus、中国期刊全文数据库(CNKI)、万方数据知识服务平台(Wanfang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献服务系统(SinoMed)中针刺治疗腰背肌筋膜炎的随机对照试验中英文文献,检索时间为建库至2022年8月1日。采用Cochrane风险偏倚评估工具对所有纳入的文献进行偏倚风险评价,采用Review Manager 5.3软件对提取的数据进行统计分析。最终纳入12篇随机对照试验文献,共1087例腰背肌筋膜炎患者。Meta分析结果显示:观察组患者疼痛视觉模拟量表(VAS)评分低于口服非甾体抗炎药对照[SMD=-1.67,95%CI(-2.44,-0.90),Z=4.26,P<0.0001]和其他治疗方法对照[低频电刺激、推拿、电磁波照射联合吡罗昔康凝胶,SMD=-1.98,95%CI(-2.48,-1.48),Z=7.74,P<0.00001]。观察组患者疼痛分级指数(PRI)评分低于利多卡因注射对照[MD=-2.17,95%CI(-3.41,-0.93),Z=3.44,P=0.0006]和其他治疗方法对照[低频电刺激、推拿,MD=-5.75,95%CI(-9.97,-1.53),Z=2.67,P=0.008]。观察组患者现有疼痛强度(PPI)评分低于其他治疗方法[低频电刺激、推拿,MD=-1.04,95%CI(-1.55,-0.53),Z=4.01,P<0.0001]。针刺治疗腰背肌筋膜炎较口服非甾体抗炎药、低频电刺激、推拿、电磁波联合吡罗昔康凝胶在降低患者疼痛方面有更好的效果;针刺较利多卡因注射在改善PRI评分方面具有优势;针刺较推拿和低频电刺激在改善PRI、PPI评分方面效果更好。展开更多
基金the National Natural Science Foundation of China:Biomechanical Mechanism of Tendon Off-position and Joint Subluxation and Manual Treatment for Adolescent Neck Pain(No.82374467)the Research on the Mechanism of Manipulation to Regulate Internalizing Integrin and its Downstream Focal Adhesion Kinase/Ras Homolog Gene Family Member A/Rho-associated Coiled-coil Containing Protein Kinase 1 Signaling Pathway to Repair Chronic Skeletal Muscle Injury(No.82374481)the Mechanism of Huaizhen Nourishing the Liver Capsule to Maintain the Balance of Knee Joint from the Coupling and Interaction of Skeletal Muscle-subchondral Bone Dynamics Rresponse(No.81704103)。
文摘OBJECTIVE:To confirm the effectiveness and safety of Shi's manipulation in treating acute and subacute neck pain patients.METHODS:This multicenter,positive controlled,randomized clinical trial has trial and control groups.There were 240 patients randomly assigned to the trial group and the control group,and both groups received their respective intervention treatment methods for a period of 12 weeks.The time windows for clinical data collection were before treatment,immediately after treatment,3-d 1,2,4,8,and 12-week after treatment,and follow-up was conducted at 26 and 52-week after treatment.The observed indicators used include primary outcome index and secondary outcome index,with the primary outcome index being the assessment of neck pain severity,which is evaluated by patients using Numerical Rating Scale(NRS).Secondary secondary outcome index include,(a)cervical dysfunction index,measured by patients using the Neck Disability Index(NDI)for self-assessment;(b)Cervical activity measurement,measured through the cervical range of motion measurement program on Android mobile system;(c)Satisfaction treatment assessment,determined by the patient's self-evaluation;(d)Safety index,recorded the incidence of adverse reactions and adverse event.Results:The results showed that these efficacy indices were improved in different degrees in both groups.At immediate after intervention,there was significant difference in NRS,NDI,Cervical Range of Motion(ROM)between the two groups(P<0.01),the trial group was superior to the control group.At 3-d after intervention,there was significant difference in NRS,NDI,ROM between the two groups(P<0.01).At 1-week and 2-week after intervention,there was significant difference in NDI and ROM between the two groups(P<0.01).At 4-week and 6-week after intervention,there was significant difference in NDI,ROM between the two groups(P<0.05).At 8-week after intervention,there was significant difference in NDI,lateral-bending and axial-rotation ROM between the two groups(P<0.05).At 12-week after intervention,there was significant difference in NDI between the two groups(P<0.01).At 26-week and 52-week after intervention,there was significant difference in NDI,NRS between the two groups(P<0.01).In addition,the adverse reaction of trial group is significantly lower than that of control group(P<0.05).The satisfaction of patients in the trial group was better than that in the control group(P<0.01).CONCLUSION:Our findings suggest that Shi's manipulation can be a good complementary treatment option in patients with acute and subacute neck pain.
文摘目的了解福建省MSM人群HIV新近感染状况,探讨其分子流行特征和相关影响因素,为制定艾滋病防治策略提供科学依据。方法对福建省2019年MSM哨点监测人群HIV抗体阳性样本采用HIV-1限制性抗原亲和力酶联免疫法(简称LAg-Avidity EIA)进行新近感染检测,用多因素Logistic回归分析其影响因素,通过RT-PCR扩增pol和gag区,利用系统进化树和HIV db Program软件对序列进行基因亚型和耐药突变分析。结果福建省2019年哨点监测MSM人群863人,其中总的HIV抗体阳性率为12.17%(105/863),HIV新近感染率为11.97%;Logistic回归分析显示,样本来源和最近6个月内同性肛交安全套使用频率是新近感染的影响因素;基因亚型以CRF07_BC(47.61%)和CRF01_AE(38.10%)为主,其次为CRF55-01B(9.52%)、B亚型(4.76%);HIV-1耐药率为6.67%(1/15),其中15例对蛋白酶类抑制剂、核苷类逆转录抑制剂均敏感;1例对非核苷类逆转录酶抑制剂efavirenz(EFV)和nevirapine(NVP)产生高度耐药,1例为潜在耐药。结论福建省2019年哨点监测MSM人群HIV新近感染率处于较高水平,多种亚型并存,发现原发耐药株传播,应加强对HIV新近感染者的分子流行特征变化趋势以及原发耐药传播的动态监测,及时调整防控策略,有效控制福建省艾滋病感染与传播。
