The Jianghan Basin,at the junction of the Jiangnan and Qinling-Dabie orogenic belts,has a complete Cretaceous to Paleogene stratigraphic record.However,the exhumation history of its source terrains is not well underst...The Jianghan Basin,at the junction of the Jiangnan and Qinling-Dabie orogenic belts,has a complete Cretaceous to Paleogene stratigraphic record.However,the exhumation history of its source terrains is not well understood.We conducted fission track age analysis on zircon grains(n=441)from the Cretaceous and Paleogene strata in the western Jianghan Basin.The Radial Plotter software is utilized to identify peak ages that indicate thermal events and the history of exhumation.The oldest peak at 810 Ma records the Neoproterozoic collisional orogeny between the Yangtze Craton and Cathaysian Block.Ages of 645-558 Ma reflect the convergence between the South China Block and Gondwana.Early Paleozoic ages document the collision leading to the exhumation of the western Jiangnan Orogenic Belt.Late Paleozoic to early Mesozoic peak ages correspond to the Indosinian orogeny.During the Mesozoic,the subduction of the Paleo-Pacific Plate resulted in further exhumation.The absence of Paleogene zircon fission track peak ages in the basin strata suggests limited exhumation during this period,likely due to tectonic quiescence and arid climatic conditions.展开更多
A sealed portal could significantly alter the flame shape and smoke flow characteristics in inclined tunnel fires.In inclined tunnels,two typical sealing conditions could be defined,namely the upper portal sealed and ...A sealed portal could significantly alter the flame shape and smoke flow characteristics in inclined tunnel fires.In inclined tunnels,two typical sealing conditions could be defined,namely the upper portal sealed and the lower portal sealed.In this study,the effects of tunnel slope on flame shape,flame length,along with smoke mass flow rate and induced velocity at the tunnel portal,are numerically investigated.The results show that,in all scenarios,flames initially rise vertically but tilt toward the sealed portal during the quasi-steady stage,with the largest tilt angle observed in tunnels sealed at the lower portal.The slope significantly affects the flame tilt angle.The flame tilt angle in tunnels with the lower portal sealed varies irregularly with the slope,while it decreases as the slope increases in tunnels with the upper portal sealed.Subsequently,the smoke mass flow rate and induced velocity at the tunnel portal are analyzed in detail.Drawing on the obtained data,the flame length prediction models for impinging flames and non-impinging flames under different sealing conditions are developed,along with dimensionless models for smoke mass flow rate and induced wind velocity.These findings provide a theoretical foundation for the formulation of fire rescue strategies and emergency evacuation plans in inclined tunnels with one portal sealed.展开更多
Significant increase of specific target olefin selectivity in CO_(2)hydrogenation is not only scientifically interesting but also practically valuable because of the reduction of separation cost.Here,a new composite c...Significant increase of specific target olefin selectivity in CO_(2)hydrogenation is not only scientifically interesting but also practically valuable because of the reduction of separation cost.Here,a new composite catalyst is fabricated with surface oxygen vacancy-abundant ZnZrO_(x)(H)solid solution and ultra-small H-SAPO-34(US)molecular sieve crystals.This catalyst shows a propene selectivity in hydrocarbons of 51.2%that accounts for about 63%of light olefins,along with a CO_(2)conversion of 13.5%,at 350°C and 3.0 MPa.A combination of in situ spectroscopy,isotope-labelled experiments,DFT calculations,and AIMD simulations reveals that an increase of surface oxygen vacancies in ZnZrO_(x)(H)induces formation of a coordinatively unsaturated(Zr-O)_(n)-Zn-(Ov)_(m)configuration,which elevates Zn site electron density and enhances the electronic interaction of Zn-3d and H-1s orbitals.This promotes the H_(2)dissociation and facilitates methanol intermediate formation.The ultra-small H-SAPO-34(US)crystals with a size of 100–200 nm effectively suppresses alkenes hydrogenation and subsequent aromatization in the methanol conversion process.As a result,more propene was produced.展开更多
Integrated sensing and communication(ISAC)is an appealing approach to address spectrum congestion and beamforming is an effective method to realize ISAC.In this paper,we investigate the beamforming design problem for ...Integrated sensing and communication(ISAC)is an appealing approach to address spectrum congestion and beamforming is an effective method to realize ISAC.In this paper,we investigate the beamforming design problem for multiple-input multipleoutput(MIMO)ISAC systems and propose to maximize the radar beampattern gain of the target direction while ensuring the signal-to-interference-plus-noise ratio(SINR)constraints of communication users.Particularly,we discuss two cases of ISAC transmit beamforming,i.e.,Case-Ⅰand Case-Ⅱ,which do not have and do have the dedicated probing signal,respectively.For these two cases of transmit beamforming design problems,we start from the single-user scenario and provide the closed-form solutions for MIMO ISAC beamforming vectors.Then,we consider the multiuser scenario and utilize the semidefinite relaxation technique to convert the beamforming design problems into convex semidefinite programming problems.Furthermore,we investigate the impact of the channel correlation between radar and communication on the performance gain of MIMO ISAC systems and characterize the performance tradeoff.Numerical results validate that the dedicated probing signal is unnecessary in the single-user scenario,whereas it has a slight improvement in target detection performance at low SINR thresholds in the multi-user scenario.It is also shown that the stronger the correlation between radar and communication channels,the greater the performance gain of the system.展开更多
The Jianghan Basin is situated within the northern part of the South China Block,adjacent to the suture zone between the South China Block and North China Craton,a strategic position to investigate syn-and post-tecton...The Jianghan Basin is situated within the northern part of the South China Block,adjacent to the suture zone between the South China Block and North China Craton,a strategic position to investigate syn-and post-tectonic processes during continental accretion.However,the precise timing of coeval evolution between the Jianghan Basin and the surrounding orogenic belts remains contentious.Similarly,the exact timing of the Yangtze River's incursion into the Jianghan Basin,which represents a major tipping point in the regional geomorphology,is poorly constrained.We selected nine clastic samples from the Cretaceous and Paleogene strata of the Zhijiang Depression(western Jianghan Basin)to perform detrital apatite fission track thermochronology to investigate sediment provenance and thermal history of the basin.A comparison of the decomposed apatite fission track ages with the depositional ages of the corresponding sedimentary strata and published regional research suggests Jurassic(178-160 Ma)to early Cretaceous(143-96 Ma)exhumation events in the Jiangnan orogenic belt,associated with compressional deformation of the South China Block,induced by the subduction of the Paleo-Pacific Plate.Additionally,several late Cretaceous to Cenozoic apatite fission track peak ages(71-56,37-33,23-14,and 5-3 Ma)are younger than the depositional sedimentary ages of the corresponding strata,indicating subsequent tectono-thermal events in the Zhijiang Depression.The 71-56 Ma event is explained as an intra-plate response triggered by the late Cretaceous retreat of the Paleo-Pacific Plate.The Cenozoic events are thought to result from exhumation accompanying the eastward extrusion of the Tibetan crust.The Yangtze River,flowing from west to east,cuts through the Huangling Anticline and enters the Jianghan Basin,leading to a transition from a Paleogene drainage endorheic water system to exoreism during the Neogene.展开更多
目的探究妊娠期糖尿病(gestational diabetes mellitus,GDM)患者产后安全感现状及影响因素。方法采用方便抽样法选取2025年1—5月在福安市医院妇产科分娩的GDM患者及其配偶86例作为研究对象。应用一般资料调查表、产后父母安全感量表(Pa...目的探究妊娠期糖尿病(gestational diabetes mellitus,GDM)患者产后安全感现状及影响因素。方法采用方便抽样法选取2025年1—5月在福安市医院妇产科分娩的GDM患者及其配偶86例作为研究对象。应用一般资料调查表、产后父母安全感量表(Parents'Postnatal Sense of Security,PPSS)、领悟社会支持量表(Perceived Social Support Scale,PSSS)对其进行调查,采用Pearson相关进行GDM患者产后安全感与父亲产后安全感、PSSS的相关性分析,采用多元线性回归进行GDM患者产后安全感的多因素分析。结果回收80份有效问卷,GDM患者PPSS总分为(41.58±3.06)分,条目均分为(2.31±0.17)分。单因素分析结果显示,不同年龄、受教育程度、产后血糖控制情况及新生儿早产情况、新生儿畸形、新生儿血糖的GDM患者PPSS得分比较,差异均有统计学意义(P均<0.05)。Pearson相关性分析显示,GDM患者产后安全感与父亲产后安全感、PSSS总分均呈正相关(P均<0.05)。多元线性回归分析结果显示,产后血糖控制情况、父亲产后安全感、PSSS总分是GDM患者产后安全感的影响因素(P均<0.05)。结论GDM患者产后安全感水平有待提高,产后血糖控制情况、父亲产后安全感、领悟社会支持是其影响因素。展开更多
AIM: To compare apelin-13, a ligand of G-proteincoupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor(VEGF) serum levels in type 2 diabetes mellitus(T2DM)...AIM: To compare apelin-13, a ligand of G-proteincoupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor(VEGF) serum levels in type 2 diabetes mellitus(T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy.METHODS: Sixty-nine patients with T2 DM were enrolled.Of the 69 patients, 16 had proliferative diabetic retinopathy(PDR group), 23 had non-PDR(NPDR group)and 30 had no retinopathy(T2DM group). Subjects’ information, including demographics, medical history,and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein(CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay.Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables.Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software.RESULTS: Sex, age, body mass index(BMI), blood pressure, CRP, hemoglobin A1c(Hb A1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2 DM group(P =0.041). Differences of VEGF serum concentration in the three groups were statistically significant(P =0.007, P =0.007 and P 【0.001,respectively). Spearman rho correlation test showed that serum apelin-13 was positively correlated with BMI,serum triglycerides, VEGF, but not with age, duration of diabetes, blood pressure, CRP, Hb A1 c and total-cholesterol. Stepwise regression analysis showed that BMI also significantly associated with serum apelin-13(P =0.002), while VEGF and serum triglycerides were irrelevant. CONCLUSION: This study elucidated a positive association of apelin-13 serum level with PDR, but not with VEGF. Apelin-13 may influence the promotion of PDR but unrelated with VEGF.展开更多
Multi-wall carbon nanotubes reinforced Mg-14Li-1Al composite(MWCNTs/Mg-14Li-1Al) was prepared by the processes of electrophoretic deposition, friction stir processing, and cold rolling. The microstructure and mechanic...Multi-wall carbon nanotubes reinforced Mg-14Li-1Al composite(MWCNTs/Mg-14Li-1Al) was prepared by the processes of electrophoretic deposition, friction stir processing, and cold rolling. The microstructure and mechanical properties of the composite were investigated. The results show that, the microhardness of the composite is up to HV 84.4, which is 91.38% higher than that of the as-cast matrix alloy(HV 44.1). The yield strength and ultimate tensile strength of the composite are 259 and 313 MPa, which are 135.45% and 115.86% higher than those of the as-cast matrix alloy, respectively, and a high specific strength of 221.98 k N·m/kg is obtained. In the composite, the MWCNTs serve as nucleation particles during the friction stir processing and cold rolling, causing dynamic recrystallization and grain refinement. Furthermore, MWCNTs hinder the movement of dislocations and transfer the load from the matrix alloy, thus improving the strength.展开更多
Plate subduction leads to complex exhumation processes on continents.The Huangling Massif lies at the northern margin of the South China Block.Whether the Huangling Massif was exhumed as a watershed of the middle reac...Plate subduction leads to complex exhumation processes on continents.The Huangling Massif lies at the northern margin of the South China Block.Whether the Huangling Massif was exhumed as a watershed of the middle reaches of the Paleo-Yangtze River during the Mesozoic remains under debate.We examined the exhumation history of the Huangling Massif based on six granite bedrock samples,using apatite fission track(AFT)and apatite and zircon(U-Th)/He(AHe and ZHe)thermochronology.These samples yielded ages of 157–132 Ma(ZHe),119–106 Ma(AFT),and 114–72 Ma(AHe),respectively.Thermal modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early Cretaceous,late Early Cretaceous,and Late Cretaceous.These exhumation processes led to the high topographic relief responsible for the emergence of the Huangling Massif.The integrated of our new data with published sedimentological records suggests that the Huangling Massif might have been the watershed of the middle reaches of the Paleo-Yangtze River since the Cretaceous.At that time,the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan Basin.The subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South China Block.展开更多
Mitochondrial dysfunction has been widely reported in schizophrenia patients. To dissect the matrilineal structure of Han Chinese with or without schizophrenia and to decipher the maternal influence and evolutionary h...Mitochondrial dysfunction has been widely reported in schizophrenia patients. To dissect the matrilineal structure of Han Chinese with or without schizophrenia and to decipher the maternal influence and evolutionary history of schizophrenia, a total of 1212 schizophrenia patients and 1005 matched healthy controls, all of Han Chinese origin, were recruited in Hunan Province, China. We classified haplogroup for each individual based on mitochondrial DNA （mtDNA） sequence variations and compared the haplogroup distribution pattern between cases and controls. Haplogroup B5a presented a higher frequency in cases than in controls （P = 0.02, OR = 1.67, 95% CI = [1.09, 2.56]）, and this result could be confirmed by permutation analysis. Age estimation of haplogroup B5a in cases revealed a much younger age than that of controls, which was coincident with the Northern Hemisphere deglaciation at the end of the Last Glacial Maximum. Analysis of complete mtDNA in five patients belonging to haplogroup B5a showed that this background effect might be caused by haplogroup- defining variants m.8584G〉A and m.10398A〉G. Our results showed that matrilineal risk factor for schizophrenia had an ancient origin and might acquire a predisposing effect on schizophrenia due to the environment change and/or orchestration with other nuclear genetic factors appeared recently in human evolutionary history.展开更多
Objective To determine the possible association of anti-β1-adrenergic receptors(anti-β1-AR), anti-β2-AR and anti-α1-AR with carvedilol treatment in patients with heart failure(HF). Methods A total of 267 HF patien...Objective To determine the possible association of anti-β1-adrenergic receptors(anti-β1-AR), anti-β2-AR and anti-α1-AR with carvedilol treatment in patients with heart failure(HF). Methods A total of 267 HF patients were prospectively enrolled. Blood samples were measured by an enzyme-linked immunosorbent assay. All of the patients received carvedilol for their HF. Each patient was followed up for six months and their cardiac function was measured. Results The final analysis encompassed 137 patients comprising 65 patients with three autoantibodies(positive group) and 72 patients without all three autoantibodies but with one or two autoantibodies(negative group). The frequency and geometric mean titer of anti-β1-AR, anti-β2-AR, and anti-α1-AR were significantly lower in the group without all three autoantibodies after six months of carvedilol treatment(all P < 0.01;from 100% to 57%, 50%, and 49%, respectively;and from 1: 118, 1: 138, and 1: 130 to 1: 72, 1: 61, and 1: 67, respectively). Furthermore, 28 patients in the positive group demonstrated complete ablation of autoantibodies. In addition, left ventricular remodelling and function was significantly improved by the use of carvedilol combined with the standard treatment regime for six months in the positive group(P < 0.01) when compared to the negative group(P < 0.05). Conclusions Carvedilol treatment significantly decreases frequency and geometric mean titer in patients with all three autoantibodies, even up to complete ablation, and significantly improved cardiac function and remodelling. The effect of carvedilol is probably correlated to the presence of all three autoantibodies.展开更多
DEAR EDITOR,Cognitive flexibility is crucial for animal survival but is frequently impaired in neuropsychiatric disorders.Although many brain structures and functional networks are involved in cognitive flexibility,th...DEAR EDITOR,Cognitive flexibility is crucial for animal survival but is frequently impaired in neuropsychiatric disorders.Although many brain structures and functional networks are involved in cognitive flexibility,the neural mechanisms underlying cooperation among specific functional networks remain unclear from a global perspective.In this study,[^(18)F]-fluorodeoxyglucose positron emission tomography(FDG-PET)was performed on 19 male tree shrews after four different visual discrimination tasks,including baseline,learning expert(LE),reversal naive(RN),and reversal expert(RE).展开更多
基金the financial support provided by the National Natural Science Foundation of China(Grant No.41972212)the Hubei Chutian Scholars Talent Program(Grant No.8210403)。
文摘The Jianghan Basin,at the junction of the Jiangnan and Qinling-Dabie orogenic belts,has a complete Cretaceous to Paleogene stratigraphic record.However,the exhumation history of its source terrains is not well understood.We conducted fission track age analysis on zircon grains(n=441)from the Cretaceous and Paleogene strata in the western Jianghan Basin.The Radial Plotter software is utilized to identify peak ages that indicate thermal events and the history of exhumation.The oldest peak at 810 Ma records the Neoproterozoic collisional orogeny between the Yangtze Craton and Cathaysian Block.Ages of 645-558 Ma reflect the convergence between the South China Block and Gondwana.Early Paleozoic ages document the collision leading to the exhumation of the western Jiangnan Orogenic Belt.Late Paleozoic to early Mesozoic peak ages correspond to the Indosinian orogeny.During the Mesozoic,the subduction of the Paleo-Pacific Plate resulted in further exhumation.The absence of Paleogene zircon fission track peak ages in the basin strata suggests limited exhumation during this period,likely due to tectonic quiescence and arid climatic conditions.
基金financially supported by National Natural Science Foundation of China(NSFC)under Grant No.52208115Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of Chain(No.2023KJ122)+2 种基金Leading Researcher Studio Fund of Jinan(No.202333050)Natural Science Foundation of Shandong Province(ZR2024ME027)Young Talent of Lifting engineering for Science and Technology in Shandong,China(SDAST2024QTA077).
文摘A sealed portal could significantly alter the flame shape and smoke flow characteristics in inclined tunnel fires.In inclined tunnels,two typical sealing conditions could be defined,namely the upper portal sealed and the lower portal sealed.In this study,the effects of tunnel slope on flame shape,flame length,along with smoke mass flow rate and induced velocity at the tunnel portal,are numerically investigated.The results show that,in all scenarios,flames initially rise vertically but tilt toward the sealed portal during the quasi-steady stage,with the largest tilt angle observed in tunnels sealed at the lower portal.The slope significantly affects the flame tilt angle.The flame tilt angle in tunnels with the lower portal sealed varies irregularly with the slope,while it decreases as the slope increases in tunnels with the upper portal sealed.Subsequently,the smoke mass flow rate and induced velocity at the tunnel portal are analyzed in detail.Drawing on the obtained data,the flame length prediction models for impinging flames and non-impinging flames under different sealing conditions are developed,along with dimensionless models for smoke mass flow rate and induced wind velocity.These findings provide a theoretical foundation for the formulation of fire rescue strategies and emergency evacuation plans in inclined tunnels with one portal sealed.
基金supported by the National Key R&D Program of China(2023YFB4103102)National Natural Science Foundation of China(21991090,21991092,22322208,22272195,U22A20431)+2 种基金the Basic Research Program of Shanxi Province of China(202203021224009)Innovation foundation of Institute of Coal Chemistry,Chinese Academy of Sciences(SCJC-DT-2023-06)Youth Innovation Promotion Association of Chinese Academy of Sciences(CAS)(2021172).
文摘Significant increase of specific target olefin selectivity in CO_(2)hydrogenation is not only scientifically interesting but also practically valuable because of the reduction of separation cost.Here,a new composite catalyst is fabricated with surface oxygen vacancy-abundant ZnZrO_(x)(H)solid solution and ultra-small H-SAPO-34(US)molecular sieve crystals.This catalyst shows a propene selectivity in hydrocarbons of 51.2%that accounts for about 63%of light olefins,along with a CO_(2)conversion of 13.5%,at 350°C and 3.0 MPa.A combination of in situ spectroscopy,isotope-labelled experiments,DFT calculations,and AIMD simulations reveals that an increase of surface oxygen vacancies in ZnZrO_(x)(H)induces formation of a coordinatively unsaturated(Zr-O)_(n)-Zn-(Ov)_(m)configuration,which elevates Zn site electron density and enhances the electronic interaction of Zn-3d and H-1s orbitals.This promotes the H_(2)dissociation and facilitates methanol intermediate formation.The ultra-small H-SAPO-34(US)crystals with a size of 100–200 nm effectively suppresses alkenes hydrogenation and subsequent aromatization in the methanol conversion process.As a result,more propene was produced.
基金National Natural Science Foundation of China under Grant 62571248 and Grant 62201266Key Laboratory of Intelligent Space TTC&O(Space Engineering University),Ministry of Education under Grant CYK2025-01-12。
文摘Integrated sensing and communication(ISAC)is an appealing approach to address spectrum congestion and beamforming is an effective method to realize ISAC.In this paper,we investigate the beamforming design problem for multiple-input multipleoutput(MIMO)ISAC systems and propose to maximize the radar beampattern gain of the target direction while ensuring the signal-to-interference-plus-noise ratio(SINR)constraints of communication users.Particularly,we discuss two cases of ISAC transmit beamforming,i.e.,Case-Ⅰand Case-Ⅱ,which do not have and do have the dedicated probing signal,respectively.For these two cases of transmit beamforming design problems,we start from the single-user scenario and provide the closed-form solutions for MIMO ISAC beamforming vectors.Then,we consider the multiuser scenario and utilize the semidefinite relaxation technique to convert the beamforming design problems into convex semidefinite programming problems.Furthermore,we investigate the impact of the channel correlation between radar and communication on the performance gain of MIMO ISAC systems and characterize the performance tradeoff.Numerical results validate that the dedicated probing signal is unnecessary in the single-user scenario,whereas it has a slight improvement in target detection performance at low SINR thresholds in the multi-user scenario.It is also shown that the stronger the correlation between radar and communication channels,the greater the performance gain of the system.
基金financially supported by the National Natural Science Foundation of China(Grant 41972212,42030305,W2411033)Research Foundation of Chutian Scholars Program of Hubei Province(No.8210403).
文摘The Jianghan Basin is situated within the northern part of the South China Block,adjacent to the suture zone between the South China Block and North China Craton,a strategic position to investigate syn-and post-tectonic processes during continental accretion.However,the precise timing of coeval evolution between the Jianghan Basin and the surrounding orogenic belts remains contentious.Similarly,the exact timing of the Yangtze River's incursion into the Jianghan Basin,which represents a major tipping point in the regional geomorphology,is poorly constrained.We selected nine clastic samples from the Cretaceous and Paleogene strata of the Zhijiang Depression(western Jianghan Basin)to perform detrital apatite fission track thermochronology to investigate sediment provenance and thermal history of the basin.A comparison of the decomposed apatite fission track ages with the depositional ages of the corresponding sedimentary strata and published regional research suggests Jurassic(178-160 Ma)to early Cretaceous(143-96 Ma)exhumation events in the Jiangnan orogenic belt,associated with compressional deformation of the South China Block,induced by the subduction of the Paleo-Pacific Plate.Additionally,several late Cretaceous to Cenozoic apatite fission track peak ages(71-56,37-33,23-14,and 5-3 Ma)are younger than the depositional sedimentary ages of the corresponding strata,indicating subsequent tectono-thermal events in the Zhijiang Depression.The 71-56 Ma event is explained as an intra-plate response triggered by the late Cretaceous retreat of the Paleo-Pacific Plate.The Cenozoic events are thought to result from exhumation accompanying the eastward extrusion of the Tibetan crust.The Yangtze River,flowing from west to east,cuts through the Huangling Anticline and enters the Jianghan Basin,leading to a transition from a Paleogene drainage endorheic water system to exoreism during the Neogene.
文摘目的探究妊娠期糖尿病(gestational diabetes mellitus,GDM)患者产后安全感现状及影响因素。方法采用方便抽样法选取2025年1—5月在福安市医院妇产科分娩的GDM患者及其配偶86例作为研究对象。应用一般资料调查表、产后父母安全感量表(Parents'Postnatal Sense of Security,PPSS)、领悟社会支持量表(Perceived Social Support Scale,PSSS)对其进行调查,采用Pearson相关进行GDM患者产后安全感与父亲产后安全感、PSSS的相关性分析,采用多元线性回归进行GDM患者产后安全感的多因素分析。结果回收80份有效问卷,GDM患者PPSS总分为(41.58±3.06)分,条目均分为(2.31±0.17)分。单因素分析结果显示,不同年龄、受教育程度、产后血糖控制情况及新生儿早产情况、新生儿畸形、新生儿血糖的GDM患者PPSS得分比较,差异均有统计学意义(P均<0.05)。Pearson相关性分析显示,GDM患者产后安全感与父亲产后安全感、PSSS总分均呈正相关(P均<0.05)。多元线性回归分析结果显示,产后血糖控制情况、父亲产后安全感、PSSS总分是GDM患者产后安全感的影响因素(P均<0.05)。结论GDM患者产后安全感水平有待提高,产后血糖控制情况、父亲产后安全感、领悟社会支持是其影响因素。
基金Supported by National Natural Science Foundation of China (No.30971392 No.81170741)Science Foundation of Xi'an Bureau of Public Health (No.2013020)
文摘AIM: To compare apelin-13, a ligand of G-proteincoupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor(VEGF) serum levels in type 2 diabetes mellitus(T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy.METHODS: Sixty-nine patients with T2 DM were enrolled.Of the 69 patients, 16 had proliferative diabetic retinopathy(PDR group), 23 had non-PDR(NPDR group)and 30 had no retinopathy(T2DM group). Subjects’ information, including demographics, medical history,and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein(CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay.Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables.Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software.RESULTS: Sex, age, body mass index(BMI), blood pressure, CRP, hemoglobin A1c(Hb A1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2 DM group(P =0.041). Differences of VEGF serum concentration in the three groups were statistically significant(P =0.007, P =0.007 and P 【0.001,respectively). Spearman rho correlation test showed that serum apelin-13 was positively correlated with BMI,serum triglycerides, VEGF, but not with age, duration of diabetes, blood pressure, CRP, Hb A1 c and total-cholesterol. Stepwise regression analysis showed that BMI also significantly associated with serum apelin-13(P =0.002), while VEGF and serum triglycerides were irrelevant. CONCLUSION: This study elucidated a positive association of apelin-13 serum level with PDR, but not with VEGF. Apelin-13 may influence the promotion of PDR but unrelated with VEGF.
基金supported by the National Natural Science Foundation of China (Nos. 51871068, 51971071, 52011530025, and U21A2049)the National Key Research and Development Program of China (No. 2021YFE0103200)+1 种基金the Zhejiang Province Key Research and Development Program, China (No. 2021C01086)the Fundamental Research Funds for the Central Universities, China (No. 3072021CFT1010)。
文摘Multi-wall carbon nanotubes reinforced Mg-14Li-1Al composite(MWCNTs/Mg-14Li-1Al) was prepared by the processes of electrophoretic deposition, friction stir processing, and cold rolling. The microstructure and mechanical properties of the composite were investigated. The results show that, the microhardness of the composite is up to HV 84.4, which is 91.38% higher than that of the as-cast matrix alloy(HV 44.1). The yield strength and ultimate tensile strength of the composite are 259 and 313 MPa, which are 135.45% and 115.86% higher than those of the as-cast matrix alloy, respectively, and a high specific strength of 221.98 k N·m/kg is obtained. In the composite, the MWCNTs serve as nucleation particles during the friction stir processing and cold rolling, causing dynamic recrystallization and grain refinement. Furthermore, MWCNTs hinder the movement of dislocations and transfer the load from the matrix alloy, thus improving the strength.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.41671011,41871019,41877292,41972212)Research Foundation of Chutian Scholars Program of Hubei Province(Grant No.8210403)Shanxi Key Research and Development program:Feng Cheng(Grant No.2021SF2-03).
文摘Plate subduction leads to complex exhumation processes on continents.The Huangling Massif lies at the northern margin of the South China Block.Whether the Huangling Massif was exhumed as a watershed of the middle reaches of the Paleo-Yangtze River during the Mesozoic remains under debate.We examined the exhumation history of the Huangling Massif based on six granite bedrock samples,using apatite fission track(AFT)and apatite and zircon(U-Th)/He(AHe and ZHe)thermochronology.These samples yielded ages of 157–132 Ma(ZHe),119–106 Ma(AFT),and 114–72 Ma(AHe),respectively.Thermal modeling revealed that three phases of rapid cooling occurred during the Late Jurassic–Early Cretaceous,late Early Cretaceous,and Late Cretaceous.These exhumation processes led to the high topographic relief responsible for the emergence of the Huangling Massif.The integrated of our new data with published sedimentological records suggests that the Huangling Massif might have been the watershed of the middle reaches of the Paleo-Yangtze River since the Cretaceous.At that time,the rivers flowed westward into the Sichuan Basin and eastward into the Jianghan Basin.The subduction of the Pacific Plate beneath the Asian continent in the Mesozoic deeply influenced the geomorphic evolution of the South China Block.
基金supported by the National Basic Research Program of China(Nos.2011CB910902 and 2012CB517904)the National Natural Science Foundation of China(Nos.31171225,81371480,81271484 and 30925021)
文摘Mitochondrial dysfunction has been widely reported in schizophrenia patients. To dissect the matrilineal structure of Han Chinese with or without schizophrenia and to decipher the maternal influence and evolutionary history of schizophrenia, a total of 1212 schizophrenia patients and 1005 matched healthy controls, all of Han Chinese origin, were recruited in Hunan Province, China. We classified haplogroup for each individual based on mitochondrial DNA （mtDNA） sequence variations and compared the haplogroup distribution pattern between cases and controls. Haplogroup B5a presented a higher frequency in cases than in controls （P = 0.02, OR = 1.67, 95% CI = [1.09, 2.56]）, and this result could be confirmed by permutation analysis. Age estimation of haplogroup B5a in cases revealed a much younger age than that of controls, which was coincident with the Northern Hemisphere deglaciation at the end of the Last Glacial Maximum. Analysis of complete mtDNA in five patients belonging to haplogroup B5a showed that this background effect might be caused by haplogroup- defining variants m.8584G〉A and m.10398A〉G. Our results showed that matrilineal risk factor for schizophrenia had an ancient origin and might acquire a predisposing effect on schizophrenia due to the environment change and/or orchestration with other nuclear genetic factors appeared recently in human evolutionary history.
基金the Beijing Natural Science Foundation (No. 7174306)。
文摘Objective To determine the possible association of anti-β1-adrenergic receptors(anti-β1-AR), anti-β2-AR and anti-α1-AR with carvedilol treatment in patients with heart failure(HF). Methods A total of 267 HF patients were prospectively enrolled. Blood samples were measured by an enzyme-linked immunosorbent assay. All of the patients received carvedilol for their HF. Each patient was followed up for six months and their cardiac function was measured. Results The final analysis encompassed 137 patients comprising 65 patients with three autoantibodies(positive group) and 72 patients without all three autoantibodies but with one or two autoantibodies(negative group). The frequency and geometric mean titer of anti-β1-AR, anti-β2-AR, and anti-α1-AR were significantly lower in the group without all three autoantibodies after six months of carvedilol treatment(all P < 0.01;from 100% to 57%, 50%, and 49%, respectively;and from 1: 118, 1: 138, and 1: 130 to 1: 72, 1: 61, and 1: 67, respectively). Furthermore, 28 patients in the positive group demonstrated complete ablation of autoantibodies. In addition, left ventricular remodelling and function was significantly improved by the use of carvedilol combined with the standard treatment regime for six months in the positive group(P < 0.01) when compared to the negative group(P < 0.05). Conclusions Carvedilol treatment significantly decreases frequency and geometric mean titer in patients with all three autoantibodies, even up to complete ablation, and significantly improved cardiac function and remodelling. The effect of carvedilol is probably correlated to the presence of all three autoantibodies.
基金supported by the National Natural Science Foundation of China(11975249,81771923,12175268,32071029,31861143037)China Postdoctoral Science Foundation(2021T140668)Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32020000)。
文摘DEAR EDITOR,Cognitive flexibility is crucial for animal survival but is frequently impaired in neuropsychiatric disorders.Although many brain structures and functional networks are involved in cognitive flexibility,the neural mechanisms underlying cooperation among specific functional networks remain unclear from a global perspective.In this study,[^(18)F]-fluorodeoxyglucose positron emission tomography(FDG-PET)was performed on 19 male tree shrews after four different visual discrimination tasks,including baseline,learning expert(LE),reversal naive(RN),and reversal expert(RE).
