Human cytomegalovirus(HCMV)poses a significant risk of neural damage during pregnancy.As the most prevalent intrauterine infectious agent in low-and middle-income countries,HCMV disrupts the development of neural stem...Human cytomegalovirus(HCMV)poses a significant risk of neural damage during pregnancy.As the most prevalent intrauterine infectious agent in low-and middle-income countries,HCMV disrupts the development of neural stem cells,leading to fetal malformations and abnormal structural and physiological functions in the fetal brain.This review summarizes the current understanding of how HCMV infection dysregulates the Wnt signaling pathway to induce fetal malformations and discusses current management strategies.展开更多
目的阐明2016—2022年深圳市≥55岁常住人口的肿瘤疾病负担。方法测算2016—2022年33个肿瘤类型造成的早死损失寿命年(years of life lost,YLLs)、伤残损失寿命年(years lost due to disability,YLDs)、伤残调整寿命年(disability-adjus...目的阐明2016—2022年深圳市≥55岁常住人口的肿瘤疾病负担。方法测算2016—2022年33个肿瘤类型造成的早死损失寿命年(years of life lost,YLLs)、伤残损失寿命年(years lost due to disability,YLDs)、伤残调整寿命年(disability-adjusted life years,DALYs)。采用Joinpoint回归模型计算DALYs粗率的平均年度变化百分比,以量化其时间变化趋势;构建年龄-时期-队列模型,分解重点肿瘤的YLLs粗率和YLDs粗率,以估计其年龄、时期和出生队列效应。结果≥55岁常住人口DALYs粗率和YLLs粗率的前3位肿瘤类型相同,从高到低依次为:(1)气管、支气管和肺癌;(2)肝癌;(3)结肠癌和直肠癌。YLDs粗率的前3位肿瘤类型从高到低依次为:(1)结肠癌和直肠癌;(2)气管、支气管和肺癌;(3)乳腺癌。重点肿瘤的年龄效应从55岁起上升(最高率比=5461.86,95%CI:5121.36~5824.99);1956年后的出生队列,结肠癌和直肠癌(最高率比=1.81,95%CI:1.68~1.95)、胰腺癌(最高率比=1.94,95%CI:1.74~2.15)的风险升高,肝癌(最高率比=0.77,95%CI:0.73~0.82)风险降低;与2020年相比,重点肿瘤的时期效应于2021年升高(最高率比=1.08,95%CI:1.04~1.13),2022年降低(最低率比=0.91,95%CI:0.89~0.94)。结论深圳市≥55岁常住人口的肿瘤负担以气管、支气管和肺癌、肝癌、结肠癌和直肠癌为主。展开更多
基金supported by the Natural Science Foundation of Shandong Province(ZR2019MC059)the Traditional Chinese Medicine Science Project of Shandong Province(M-2023093)the Weifang Municipal Science and Technology Development Program(2025YX037).
文摘Human cytomegalovirus(HCMV)poses a significant risk of neural damage during pregnancy.As the most prevalent intrauterine infectious agent in low-and middle-income countries,HCMV disrupts the development of neural stem cells,leading to fetal malformations and abnormal structural and physiological functions in the fetal brain.This review summarizes the current understanding of how HCMV infection dysregulates the Wnt signaling pathway to induce fetal malformations and discusses current management strategies.
文摘目的阐明2016—2022年深圳市≥55岁常住人口的肿瘤疾病负担。方法测算2016—2022年33个肿瘤类型造成的早死损失寿命年(years of life lost,YLLs)、伤残损失寿命年(years lost due to disability,YLDs)、伤残调整寿命年(disability-adjusted life years,DALYs)。采用Joinpoint回归模型计算DALYs粗率的平均年度变化百分比,以量化其时间变化趋势;构建年龄-时期-队列模型,分解重点肿瘤的YLLs粗率和YLDs粗率,以估计其年龄、时期和出生队列效应。结果≥55岁常住人口DALYs粗率和YLLs粗率的前3位肿瘤类型相同,从高到低依次为:(1)气管、支气管和肺癌;(2)肝癌;(3)结肠癌和直肠癌。YLDs粗率的前3位肿瘤类型从高到低依次为:(1)结肠癌和直肠癌;(2)气管、支气管和肺癌;(3)乳腺癌。重点肿瘤的年龄效应从55岁起上升(最高率比=5461.86,95%CI:5121.36~5824.99);1956年后的出生队列,结肠癌和直肠癌(最高率比=1.81,95%CI:1.68~1.95)、胰腺癌(最高率比=1.94,95%CI:1.74~2.15)的风险升高,肝癌(最高率比=0.77,95%CI:0.73~0.82)风险降低;与2020年相比,重点肿瘤的时期效应于2021年升高(最高率比=1.08,95%CI:1.04~1.13),2022年降低(最低率比=0.91,95%CI:0.89~0.94)。结论深圳市≥55岁常住人口的肿瘤负担以气管、支气管和肺癌、肝癌、结肠癌和直肠癌为主。
