The Chinese government promotes smoking cessation through smoking cessation clinics(SCCs).This study aimed to identify factors associated with relapse and provide evidence to inform interventions that reduce relapse r...The Chinese government promotes smoking cessation through smoking cessation clinics(SCCs).This study aimed to identify factors associated with relapse and provide evidence to inform interventions that reduce relapse risk.Participants were SCC patients aged≥18 years who enrolled between June 2019 and December 2021,completed follow-up assessments at one and three months,and reported abstinence at one month.Short-term relapse was defined as self-reported smoking at the three-month follow-up.Treatments included counseling,first-line cessation medications,and traditional Chinese medicine(TCM).Logistic regression was used to identify factors associated with short-term relapse.Among 10,724 eligible SCC patients,11.6%experienced short-term relapse.Factors positively associated with relapse included the number of previous quit attempts(1–5 attempts:OR=1.422,95%CI:1.254–1.613,>5 attempts:OR=1.382,95%CI:1.057–1.808),high perceived difficulty in quitting(OR=1.297,95%CI:1.061–1.586),and moderate(OR=1.383,95%CI:1.174–1.629)or weak(OR=1.517,95%CI:1.251–1.841)willingness to quit.Factors negatively associated with relapse included having a college degree or higher(OR=0.796;95%CI:0.650–0.973),high confidence in quitting(OR=0.786;95%CI:0.629–0.983),and use of TCM(OR=0.276;95%CI:0.158–0.482).Enhancing self-efficacy in quitting appears crucial for preventing short-term relapse.The use of TCM may reduce relapse risk and warrants further investigation.展开更多
Human cytomegalovirus(HCMV)poses a significant risk of neural damage during pregnancy.As the most prevalent intrauterine infectious agent in low-and middle-income countries,HCMV disrupts the development of neural stem...Human cytomegalovirus(HCMV)poses a significant risk of neural damage during pregnancy.As the most prevalent intrauterine infectious agent in low-and middle-income countries,HCMV disrupts the development of neural stem cells,leading to fetal malformations and abnormal structural and physiological functions in the fetal brain.This review summarizes the current understanding of how HCMV infection dysregulates the Wnt signaling pathway to induce fetal malformations and discusses current management strategies.展开更多
Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco...Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use^([1]).Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.展开更多
AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK...AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a"tonifying qi and detoxification"("TQD")group(72 patients);and(3)a"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the"TQD"group were given a TCM formula"tonifying qi and detoxification"and general internal medicine treatment;patients in the"TTK"group were given a TCM formula of"TTK"and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,"TQD",and"TTK"groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the"TTK"group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the"TQD"group and"TTK"group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the"TQD"group and one case of gastrointestinal side effect in the"TTK"group.CONCLUSION:Treatment with"TTK"improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored.展开更多
This paper discussed the petrographic characteristics of No.6 coal from the Xiaoyugou mine,Jungar Coalfield,Ordos Basin,China.10 samples(7 coal,1 parting mudstone and 2 floor mudstone)were analysed by microscopical an...This paper discussed the petrographic characteristics of No.6 coal from the Xiaoyugou mine,Jungar Coalfield,Ordos Basin,China.10 samples(7 coal,1 parting mudstone and 2 floor mudstone)were analysed by microscopical and geochemical methods.Four maceral compositions and several associated elements parameters were selected as indicators and corresponding diagrams were drawn to explicate the sedimentary environment.The results indicate that the maceral is dominated by vitrinite and minerals are mainly kaolinite in the No.6 coal.The sedimentary facies vary from barrier island system to tidal-flat which is a deposition process of water body shallowing and the coal-forming plants are herbs and woody plants formed in swamps.展开更多
Collinear Holography was proposed by OPTWARE Corporation, in which the information and reference beams were aligned co-axially and modulated by the same SLM. With this unique configuration the optical pickup can be de...Collinear Holography was proposed by OPTWARE Corporation, in which the information and reference beams were aligned co-axially and modulated by the same SLM. With this unique configuration the optical pickup can be designed as small as the DVD ′ s, and can be placed on one side of the recording disc. A 2-dimensional digital page data format was used and the shift-multiplexing method was employed to increased recording density of HVD. As the servo technology is being introduced to control the objective lens to be maintained precisely to the disc in the recording and the reconstructing process, a vibration isolator is no longer necessary. In HVD, the pre-formatted meta-data reflective layer was used for the focus/tracking servo and reading address information, and the dichroic mirror layer was used for detecting holographic recording information without interfering with the preformatted information.Experimental and theoretical studies suggest that the holographic material is very effective to increased recording density of the system. HVD will be compatible with existing disc storage systems, like CD and DVD, and enable us to expand its applications into other optical information storage systems.展开更多
目的阐明2016—2022年深圳市≥55岁常住人口的肿瘤疾病负担。方法测算2016—2022年33个肿瘤类型造成的早死损失寿命年(years of life lost,YLLs)、伤残损失寿命年(years lost due to disability,YLDs)、伤残调整寿命年(disability-adjus...目的阐明2016—2022年深圳市≥55岁常住人口的肿瘤疾病负担。方法测算2016—2022年33个肿瘤类型造成的早死损失寿命年(years of life lost,YLLs)、伤残损失寿命年(years lost due to disability,YLDs)、伤残调整寿命年(disability-adjusted life years,DALYs)。采用Joinpoint回归模型计算DALYs粗率的平均年度变化百分比,以量化其时间变化趋势;构建年龄-时期-队列模型,分解重点肿瘤的YLLs粗率和YLDs粗率,以估计其年龄、时期和出生队列效应。结果≥55岁常住人口DALYs粗率和YLLs粗率的前3位肿瘤类型相同,从高到低依次为:(1)气管、支气管和肺癌;(2)肝癌;(3)结肠癌和直肠癌。YLDs粗率的前3位肿瘤类型从高到低依次为:(1)结肠癌和直肠癌;(2)气管、支气管和肺癌;(3)乳腺癌。重点肿瘤的年龄效应从55岁起上升(最高率比=5461.86,95%CI:5121.36~5824.99);1956年后的出生队列,结肠癌和直肠癌(最高率比=1.81,95%CI:1.68~1.95)、胰腺癌(最高率比=1.94,95%CI:1.74~2.15)的风险升高,肝癌(最高率比=0.77,95%CI:0.73~0.82)风险降低;与2020年相比,重点肿瘤的时期效应于2021年升高(最高率比=1.08,95%CI:1.04~1.13),2022年降低(最低率比=0.91,95%CI:0.89~0.94)。结论深圳市≥55岁常住人口的肿瘤负担以气管、支气管和肺癌、肝癌、结肠癌和直肠癌为主。展开更多
文摘The Chinese government promotes smoking cessation through smoking cessation clinics(SCCs).This study aimed to identify factors associated with relapse and provide evidence to inform interventions that reduce relapse risk.Participants were SCC patients aged≥18 years who enrolled between June 2019 and December 2021,completed follow-up assessments at one and three months,and reported abstinence at one month.Short-term relapse was defined as self-reported smoking at the three-month follow-up.Treatments included counseling,first-line cessation medications,and traditional Chinese medicine(TCM).Logistic regression was used to identify factors associated with short-term relapse.Among 10,724 eligible SCC patients,11.6%experienced short-term relapse.Factors positively associated with relapse included the number of previous quit attempts(1–5 attempts:OR=1.422,95%CI:1.254–1.613,>5 attempts:OR=1.382,95%CI:1.057–1.808),high perceived difficulty in quitting(OR=1.297,95%CI:1.061–1.586),and moderate(OR=1.383,95%CI:1.174–1.629)or weak(OR=1.517,95%CI:1.251–1.841)willingness to quit.Factors negatively associated with relapse included having a college degree or higher(OR=0.796;95%CI:0.650–0.973),high confidence in quitting(OR=0.786;95%CI:0.629–0.983),and use of TCM(OR=0.276;95%CI:0.158–0.482).Enhancing self-efficacy in quitting appears crucial for preventing short-term relapse.The use of TCM may reduce relapse risk and warrants further investigation.
基金supported by the Natural Science Foundation of Shandong Province(ZR2019MC059)the Traditional Chinese Medicine Science Project of Shandong Province(M-2023093)the Weifang Municipal Science and Technology Development Program(2025YX037).
文摘Human cytomegalovirus(HCMV)poses a significant risk of neural damage during pregnancy.As the most prevalent intrauterine infectious agent in low-and middle-income countries,HCMV disrupts the development of neural stem cells,leading to fetal malformations and abnormal structural and physiological functions in the fetal brain.This review summarizes the current understanding of how HCMV infection dysregulates the Wnt signaling pathway to induce fetal malformations and discusses current management strategies.
基金supported by the World Health Organization Global Youth Tobacco Survey(WPDHP1206671)the Global Health Capacity Building and Tobacco Control Project:Tobacco Epidemic Monitoring and Comprehensive Tobacco Control Intervention。
文摘Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use^([1]).Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.
基金Supported by National Science and Technology Key Projects on"Major Infectious Diseases such as HIV/AIDS,Viral Hepatitis Prevention and Treatment",No.2008ZX10005-007Research Projects of Key Disease of National Traditional Chinese Medicine(Hepatopathy)Clinical Research Center(Hubei Province),No.JDZX2012054+3 种基金National Natural Science Foundation of China,No.81373513,No.90709041,No.30672590,No.30271562,No.30371787,No.81102531 and No.81274147Key Projects of Natural Science Foundation of Hubei Province,No.2011CDB463Specialized Research Fund for the Doctoral Programs in Institution of Higher Education,No.20124230110001Key Subjects of Department of Science and Technology of Wuhan City,No.201260523199
文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a"tonifying qi and detoxification"("TQD")group(72 patients);and(3)a"tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment"("TTK")group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the"TQD"group were given a TCM formula"tonifying qi and detoxification"and general internal medicine treatment;patients in the"TTK"group were given a TCM formula of"TTK"and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,"TQD",and"TTK"groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the"TTK"group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the"TQD"group and"TTK"group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the"TQD"group and one case of gastrointestinal side effect in the"TTK"group.CONCLUSION:Treatment with"TTK"improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored.
文摘This paper discussed the petrographic characteristics of No.6 coal from the Xiaoyugou mine,Jungar Coalfield,Ordos Basin,China.10 samples(7 coal,1 parting mudstone and 2 floor mudstone)were analysed by microscopical and geochemical methods.Four maceral compositions and several associated elements parameters were selected as indicators and corresponding diagrams were drawn to explicate the sedimentary environment.The results indicate that the maceral is dominated by vitrinite and minerals are mainly kaolinite in the No.6 coal.The sedimentary facies vary from barrier island system to tidal-flat which is a deposition process of water body shallowing and the coal-forming plants are herbs and woody plants formed in swamps.
文摘Collinear Holography was proposed by OPTWARE Corporation, in which the information and reference beams were aligned co-axially and modulated by the same SLM. With this unique configuration the optical pickup can be designed as small as the DVD ′ s, and can be placed on one side of the recording disc. A 2-dimensional digital page data format was used and the shift-multiplexing method was employed to increased recording density of HVD. As the servo technology is being introduced to control the objective lens to be maintained precisely to the disc in the recording and the reconstructing process, a vibration isolator is no longer necessary. In HVD, the pre-formatted meta-data reflective layer was used for the focus/tracking servo and reading address information, and the dichroic mirror layer was used for detecting holographic recording information without interfering with the preformatted information.Experimental and theoretical studies suggest that the holographic material is very effective to increased recording density of the system. HVD will be compatible with existing disc storage systems, like CD and DVD, and enable us to expand its applications into other optical information storage systems.
文摘目的阐明2016—2022年深圳市≥55岁常住人口的肿瘤疾病负担。方法测算2016—2022年33个肿瘤类型造成的早死损失寿命年(years of life lost,YLLs)、伤残损失寿命年(years lost due to disability,YLDs)、伤残调整寿命年(disability-adjusted life years,DALYs)。采用Joinpoint回归模型计算DALYs粗率的平均年度变化百分比,以量化其时间变化趋势;构建年龄-时期-队列模型,分解重点肿瘤的YLLs粗率和YLDs粗率,以估计其年龄、时期和出生队列效应。结果≥55岁常住人口DALYs粗率和YLLs粗率的前3位肿瘤类型相同,从高到低依次为:(1)气管、支气管和肺癌;(2)肝癌;(3)结肠癌和直肠癌。YLDs粗率的前3位肿瘤类型从高到低依次为:(1)结肠癌和直肠癌;(2)气管、支气管和肺癌;(3)乳腺癌。重点肿瘤的年龄效应从55岁起上升(最高率比=5461.86,95%CI:5121.36~5824.99);1956年后的出生队列,结肠癌和直肠癌(最高率比=1.81,95%CI:1.68~1.95)、胰腺癌(最高率比=1.94,95%CI:1.74~2.15)的风险升高,肝癌(最高率比=0.77,95%CI:0.73~0.82)风险降低;与2020年相比,重点肿瘤的时期效应于2021年升高(最高率比=1.08,95%CI:1.04~1.13),2022年降低(最低率比=0.91,95%CI:0.89~0.94)。结论深圳市≥55岁常住人口的肿瘤负担以气管、支气管和肺癌、肝癌、结肠癌和直肠癌为主。
