On-line chemical characterization of atmospheric particulate matter(PM)with soft ionization technique and ultrahigh-resolution Mass Spectrometry(UHRMS)provides molecular information of organic constituents in real tim...On-line chemical characterization of atmospheric particulate matter(PM)with soft ionization technique and ultrahigh-resolution Mass Spectrometry(UHRMS)provides molecular information of organic constituents in real time.Here we describe the development and application of an automatic measurement system that incorporates PM_(2.5)sampling,thermal desorption,atmospheric pressure photoionization,and UHRMS analysis.Molecular formulas of detected organic compounds were deducted from the accurate(±10 ppm)molecular weights obtained at a mass resolution of 100,000,allowing the identification of small organic compounds in PM_(2.5).Detection efficiencies of 28 standard compounds were determined and we found a high sensitivity and selectivity towards organic amines with limits of detection below 10 pg.As a proof of principle,PM_(2.5)samples collected off-line in winter in the urban area of Beijing were analyzed using the Ionization Module and HRMS of the system.The automatic system was then applied to conduct on-line measurements during the summer time at a time resolution of 2 hr.The detected organic compounds comprised mainly CHON and CHN compounds below 350 m/z.Pronounced seasonal variations in elemental composition were observed with shorter carbon backbones and higher O/C ratios in summer than that in winter.This result is consistent with stronger photochemical reactions and thus a higher oxidation state of organics in summer.Diurnal variation in signal intensity of each formula provides crucial information to reveal its source and formation pathway.In summary,the automatic measurement system serves as an important tool for the on-line characterization and identification of organic species in PM_(2.5).展开更多
Global Cancer Statistics 2022 reported the prevalence and high mortality rate of lung cancer.Notably,non-small cell lung cancer(NSCLC)accounts for the majority of the histologic types1.Precision therapy for lung cance...Global Cancer Statistics 2022 reported the prevalence and high mortality rate of lung cancer.Notably,non-small cell lung cancer(NSCLC)accounts for the majority of the histologic types1.Precision therapy for lung cancer has progressed rapidly and immune checkpoint inhibitors(ICIs)have become a leading research topic.Indeed,ICI therapy has been shown to improve the prognosis of lung cancer patients.展开更多
Objective: To research the effectiveness of ulinastatin in combination with continuous renal replacement therapy in treating sepsis acute kidney injury and its effect on systemic inflammation, immune function and miRA...Objective: To research the effectiveness of ulinastatin in combination with continuous renal replacement therapy in treating sepsis acute kidney injury and its effect on systemic inflammation, immune function and miRAN expression. Methods: The 84 patients who were diagnosed with sepsis complicated by acute kidney injury in our hospital between May 2020 and June 2022 were chosen and randomly assigned to the study group (n = 42) and the control group (n = 42). Ulinastatin in combination with continuous renal replacement therapy was administered to the study group, whereas the control group was administered with continuous renal replacement therapy alone. Both groups’ clinical effects were observed. The levels of blood urea nitrogen (BUN), serum creatinine (SCr), tumor necrosis factor-α (TNF-α), high sensitivity Creactive protein (hs-CRP), vascular cell adhesion molecule-1 (VCAM-1), IgG, IgA, IgM, expression levels of miR-233 and miR-10a were compared among both the groups, pre-, and post-treatment. Results: The study group’s overall effectiveness rate was higher that is 95.24%, in comparison to the control group’s 78.57%, and this difference was statistically significant (P α, hs-CRP, VCAM-1, and miR-233 and miR-10a expression levels in both the study and control groups were decreased, however, the study group had reduced levels in comparison to the control group, with statistically significant differences (P P Conclusion: Ulinastatin in combination with continuous renal replacement therapy for treating sepsis acute kidney injury exhibits a positive effect and can significantly improve the systemic inflammation and immune function in patients.展开更多
Natural cemented calcareous sand and limestone are highly complex and not well understood in terms of the me-chanical behavior due to the difficulty of obtaining undisturbed samples from far sea.This paper proposes an...Natural cemented calcareous sand and limestone are highly complex and not well understood in terms of the me-chanical behavior due to the difficulty of obtaining undisturbed samples from far sea.This paper proposes an artificial method in a laboratory setting using microbial-induced carbonate precipitation(MICP)to simulate the natural process of cementation of limestone.The artificially cemented sand has a high degree of similarity with the natural weakly limestone in three aspects:(1)the mineral composition of the cemented material is also granular calcite and acicular aragonite;(2)the microstructure in interconnected open pore network can be gradually closed and contracted with cementation.The porosity reaches to approximately 9.2%;(3)both the stress-strain relationship and the unconfined strength closely resemble that of natural weakly limestone.Furthermore,both static and dynamic behaviors of artificial limestone were studied by quasi-static compression tests and Split Hopkinson Pressure Bar(SHPB)tests,finding that the unconfined strength of weakly artifical limestone exponentially increases with increasing strain rate.A rate-dependent bond strength was proposed and implemented in software to reveal the mechanism of strain rate effects.It is found that the loading velocity is too high to keep in sync with the initiation and propagation of cracks under impact loading.This delay-induced viscosity may restrict the movement of the surrounding balls,thus increasing resistance.展开更多
Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significant...Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients.These alterations include MET exon 14 skipping mutations(MET exon 14 skipping),MET gene amplifications,MET point mutations(primarily kinase domain mutations),and MET protein overexpression.Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes.The East China Lung Cancer Group,Youth Committee(ECLUNG YOUNG,Yangtze River Delta Lung Cancer Cooperation Group)has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations.This consensus addresses key areas,such as optimal testing timing,testing methods,testing strategies,quality control measures,and treatment approaches.By offering standardized recommendations,this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.展开更多
To investigate the response of Roadside Monitoring Stations(RSs)to traffic-related air pollution,traffic and pollutant characteristics,influencing factors,and potential source characterization in Tianjin,China were de...To investigate the response of Roadside Monitoring Stations(RSs)to traffic-related air pollution,traffic and pollutant characteristics,influencing factors,and potential source characterization in Tianjin,China were determined based on roadside monitoring of real-world data conducted at RSs in 2022.The diurnal variation trend of pollutants at RSs was consistent with that at the National Monitoring Station(NM),with notably higher pollutant fluctuations during the morning and evening peak traffic times at RSs,where the average diurnal concentration was 41.46%higher than that at the NM.The generalized additive model(GAM)for nitrogen oxides(NO_(x))and carbon monoxide(CO),responding to themultiple influencing factors,performed well at RSs,with deviance explained by 86.6%and 61.4%,respectively.The synergistic effects of wind direction and speed contributed to most of the variations in NO_(x) and CO,which were 14.74%and 12.87%,respectively.Pollutant concentrations were highest under windless conditions,with pollutants originating primarily from local vehicle emissions.The model results indicated that medium-duty truck(MDT)traffic flow predominantly contributed to the variability in NO_(x) emissions,whereas passenger car(PC)traffic flow was the primary source of CO emissions from traffic variables.MDTs should be the focus of urban NO_(x) traffic emissions control.Potential-source analysis validated the results obtained from the GAM,and both analyses showed that RSs can better characterize traffic-related air pollutants.Furthermore,more stringent emission standards have effectively mitigated the release of pollutants from motor vehicles and contributed to the modernization of vehicle fleet composition,effectively decreasing CO concentrations.展开更多
The technology of carbon dioxide(CO_(2))enhanced hydrocarbon recovery is favored over other Carbon Capture,Utilization,and Sequestration(CCUS)methods for achieving the"double carbon"goal in China due to its ...The technology of carbon dioxide(CO_(2))enhanced hydrocarbon recovery is favored over other Carbon Capture,Utilization,and Sequestration(CCUS)methods for achieving the"double carbon"goal in China due to its ability to sequester CO_(2) geologically while enhancing the recovery rates of oil and gas resources.However,current technologies face significant challenges,such as limited recovery enhancement capacity,as well as high costs and low efficiency in carbon utilization and sequestration.To address these issues,an innovative carbon-negative technology termed Carbon Capture,Circular Utilization,and Sequestration(CCCUS)is proposed.This technology integrates CO_(2)-microbial enhanced hydrocarbon recovery,CO_(2) underground bio-methanation,and CO_(2) sequestration in depleted hydrocarbon reservoirs.Compared to conventional CCUS technologies,CCCUS stands out through both its modes of carbon utilization and the forms in which carbon exists,by cyclically biochemically converting endogenous and exogenous CO_(2) into renewable natural gas(RNG).A preliminary assessment indicates that CCCUS holds significant developmental potential in China,with 661 million tonnes of CO_(2) utilized per cycle and 3.47 billion tonnes ultimately sequestered.However,there is a significant lack of research on the core technology of CCCUS,specifically CO_(2) underground bio-methanation,in China.To bridge this gap and mitigate potential challenges during the development of CCCUS,targeted proposals have been formulated.This paper provides new insights into advancing the development of a circular carbon economy and accelerating the achievement of carbon neutrality in China.展开更多
Severe haze pollution that occurred in January 2014 in Wuhan was investigated. The factors leading to Wuhan’s PM2.5 pollution and the characteristics and formation mechanism were found to be significantly different f...Severe haze pollution that occurred in January 2014 in Wuhan was investigated. The factors leading to Wuhan’s PM2.5 pollution and the characteristics and formation mechanism were found to be significantly different from other megacities, like Beijing. Both the growth rates and decline rates of PM2.5 concentrations in Wuhan were lower than those in Beijing, but the monthly PM2.5 value was approximately twice that in Beijing. Furthermore, the sharp increases of PM2.5 concentrations were often accompanied by strong winds. A high-precision modeling system with an online source-tagged method was established to explore the formation mechanism of five haze episodes. The long-range transport of the polluted air masses from the North China Plain (NCP) was the main factor leading to the sharp increases of PM2.5 concentrations in Wuhan, which contributed 53.4% of the monthly PM2.5 concentrations and 38.5% of polluted days. Furthermore, the change in meteorological conditions such as weakened winds and stable weather conditions led to the accumulation of air pollutants in Wuhan after the long-range transport. The contribution from Wuhan and surrounding cities to the PM2.5 concentrations was determined to be 67.4% during this period. Under the complex regional transport of pollutants from surrounding cities, the NCP, East China, and South China, the five episodes resulted in 30 haze days in Wuhan. The findings reveal important roles played by transregional and intercity transport in haze formation in Wuhan.展开更多
基金supported by the National Natural Science Foundation of China(No.41805105)。
文摘On-line chemical characterization of atmospheric particulate matter(PM)with soft ionization technique and ultrahigh-resolution Mass Spectrometry(UHRMS)provides molecular information of organic constituents in real time.Here we describe the development and application of an automatic measurement system that incorporates PM_(2.5)sampling,thermal desorption,atmospheric pressure photoionization,and UHRMS analysis.Molecular formulas of detected organic compounds were deducted from the accurate(±10 ppm)molecular weights obtained at a mass resolution of 100,000,allowing the identification of small organic compounds in PM_(2.5).Detection efficiencies of 28 standard compounds were determined and we found a high sensitivity and selectivity towards organic amines with limits of detection below 10 pg.As a proof of principle,PM_(2.5)samples collected off-line in winter in the urban area of Beijing were analyzed using the Ionization Module and HRMS of the system.The automatic system was then applied to conduct on-line measurements during the summer time at a time resolution of 2 hr.The detected organic compounds comprised mainly CHON and CHN compounds below 350 m/z.Pronounced seasonal variations in elemental composition were observed with shorter carbon backbones and higher O/C ratios in summer than that in winter.This result is consistent with stronger photochemical reactions and thus a higher oxidation state of organics in summer.Diurnal variation in signal intensity of each formula provides crucial information to reveal its source and formation pathway.In summary,the automatic measurement system serves as an important tool for the on-line characterization and identification of organic species in PM_(2.5).
基金the Hunan Lung Cancer Clinical Medical Research Center(Grant No.2023SK4024 to LW)the Hunan Science and Technology Innovation Program(Grant No.2021SK51121 to LW)the Hunan Cancer Hospital Climb plan(Grant No.ZX2020005-5 to LW)。
文摘Global Cancer Statistics 2022 reported the prevalence and high mortality rate of lung cancer.Notably,non-small cell lung cancer(NSCLC)accounts for the majority of the histologic types1.Precision therapy for lung cancer has progressed rapidly and immune checkpoint inhibitors(ICIs)have become a leading research topic.Indeed,ICI therapy has been shown to improve the prognosis of lung cancer patients.
文摘Objective: To research the effectiveness of ulinastatin in combination with continuous renal replacement therapy in treating sepsis acute kidney injury and its effect on systemic inflammation, immune function and miRAN expression. Methods: The 84 patients who were diagnosed with sepsis complicated by acute kidney injury in our hospital between May 2020 and June 2022 were chosen and randomly assigned to the study group (n = 42) and the control group (n = 42). Ulinastatin in combination with continuous renal replacement therapy was administered to the study group, whereas the control group was administered with continuous renal replacement therapy alone. Both groups’ clinical effects were observed. The levels of blood urea nitrogen (BUN), serum creatinine (SCr), tumor necrosis factor-α (TNF-α), high sensitivity Creactive protein (hs-CRP), vascular cell adhesion molecule-1 (VCAM-1), IgG, IgA, IgM, expression levels of miR-233 and miR-10a were compared among both the groups, pre-, and post-treatment. Results: The study group’s overall effectiveness rate was higher that is 95.24%, in comparison to the control group’s 78.57%, and this difference was statistically significant (P α, hs-CRP, VCAM-1, and miR-233 and miR-10a expression levels in both the study and control groups were decreased, however, the study group had reduced levels in comparison to the control group, with statistically significant differences (P P Conclusion: Ulinastatin in combination with continuous renal replacement therapy for treating sepsis acute kidney injury exhibits a positive effect and can significantly improve the systemic inflammation and immune function in patients.
基金The authors would like to acknowledge the support of the National Natural Science Foundation of China(No.52279097,No.51779264)Blue and Green Project of Jiangsu Province.
文摘Natural cemented calcareous sand and limestone are highly complex and not well understood in terms of the me-chanical behavior due to the difficulty of obtaining undisturbed samples from far sea.This paper proposes an artificial method in a laboratory setting using microbial-induced carbonate precipitation(MICP)to simulate the natural process of cementation of limestone.The artificially cemented sand has a high degree of similarity with the natural weakly limestone in three aspects:(1)the mineral composition of the cemented material is also granular calcite and acicular aragonite;(2)the microstructure in interconnected open pore network can be gradually closed and contracted with cementation.The porosity reaches to approximately 9.2%;(3)both the stress-strain relationship and the unconfined strength closely resemble that of natural weakly limestone.Furthermore,both static and dynamic behaviors of artificial limestone were studied by quasi-static compression tests and Split Hopkinson Pressure Bar(SHPB)tests,finding that the unconfined strength of weakly artifical limestone exponentially increases with increasing strain rate.A rate-dependent bond strength was proposed and implemented in software to reveal the mechanism of strain rate effects.It is found that the loading velocity is too high to keep in sync with the initiation and propagation of cracks under impact loading.This delay-induced viscosity may restrict the movement of the surrounding balls,thus increasing resistance.
文摘Alterations in the mesenchymal-epithelial transition factor(MET)gene are critical drivers of non-small cell lung cancer(NSCLC).In recent years advances in precision therapies targeting MET alterations have significantly expanded treatment options for NSCLC patients.These alterations include MET exon 14 skipping mutations(MET exon 14 skipping),MET gene amplifications,MET point mutations(primarily kinase domain mutations),and MET protein overexpression.Accurate identification of these alterations and appropriate selection of patient populations and targeted therapies are essential for improving clinical outcomes.The East China Lung Cancer Group,Youth Committee(ECLUNG YOUNG,Yangtze River Delta Lung Cancer Cooperation Group)has synthesized insights from China’s innovative drug development landscape and clinical practice to formulate an expert consensus on the diagnosis and treatment of NSCLC patients with MET alterations.This consensus addresses key areas,such as optimal testing timing,testing methods,testing strategies,quality control measures,and treatment approaches.By offering standardized recommendations,this guidance aims to streamline diagnostic and therapeutic processes and enhance clinical decision-making for NSCLC with MET alterations.
基金supported by the National Key Research and Development Program of China(Nos.2023YFC3707301 and 2023YFC3705400)the Fundamental Research Funds for the Central Universities(Nos.ZB23003425 and 63211075)。
文摘To investigate the response of Roadside Monitoring Stations(RSs)to traffic-related air pollution,traffic and pollutant characteristics,influencing factors,and potential source characterization in Tianjin,China were determined based on roadside monitoring of real-world data conducted at RSs in 2022.The diurnal variation trend of pollutants at RSs was consistent with that at the National Monitoring Station(NM),with notably higher pollutant fluctuations during the morning and evening peak traffic times at RSs,where the average diurnal concentration was 41.46%higher than that at the NM.The generalized additive model(GAM)for nitrogen oxides(NO_(x))and carbon monoxide(CO),responding to themultiple influencing factors,performed well at RSs,with deviance explained by 86.6%and 61.4%,respectively.The synergistic effects of wind direction and speed contributed to most of the variations in NO_(x) and CO,which were 14.74%and 12.87%,respectively.Pollutant concentrations were highest under windless conditions,with pollutants originating primarily from local vehicle emissions.The model results indicated that medium-duty truck(MDT)traffic flow predominantly contributed to the variability in NO_(x) emissions,whereas passenger car(PC)traffic flow was the primary source of CO emissions from traffic variables.MDTs should be the focus of urban NO_(x) traffic emissions control.Potential-source analysis validated the results obtained from the GAM,and both analyses showed that RSs can better characterize traffic-related air pollutants.Furthermore,more stringent emission standards have effectively mitigated the release of pollutants from motor vehicles and contributed to the modernization of vehicle fleet composition,effectively decreasing CO concentrations.
基金funded by the European Union's“Horizon Europe programme”-LOC3G(Grant No.101129729)the Henan Center for Outstanding Overseas Scientists(Grant No.GZS2024001).
文摘The technology of carbon dioxide(CO_(2))enhanced hydrocarbon recovery is favored over other Carbon Capture,Utilization,and Sequestration(CCUS)methods for achieving the"double carbon"goal in China due to its ability to sequester CO_(2) geologically while enhancing the recovery rates of oil and gas resources.However,current technologies face significant challenges,such as limited recovery enhancement capacity,as well as high costs and low efficiency in carbon utilization and sequestration.To address these issues,an innovative carbon-negative technology termed Carbon Capture,Circular Utilization,and Sequestration(CCCUS)is proposed.This technology integrates CO_(2)-microbial enhanced hydrocarbon recovery,CO_(2) underground bio-methanation,and CO_(2) sequestration in depleted hydrocarbon reservoirs.Compared to conventional CCUS technologies,CCCUS stands out through both its modes of carbon utilization and the forms in which carbon exists,by cyclically biochemically converting endogenous and exogenous CO_(2) into renewable natural gas(RNG).A preliminary assessment indicates that CCCUS holds significant developmental potential in China,with 661 million tonnes of CO_(2) utilized per cycle and 3.47 billion tonnes ultimately sequestered.However,there is a significant lack of research on the core technology of CCCUS,specifically CO_(2) underground bio-methanation,in China.To bridge this gap and mitigate potential challenges during the development of CCCUS,targeted proposals have been formulated.This paper provides new insights into advancing the development of a circular carbon economy and accelerating the achievement of carbon neutrality in China.
基金supported by the National Key R&D Program (Grant Nos. 2017YFC0212603 and 2017YFC0212604)the Chinese Academy of Sciences Strategic Priority Research Program (Grant No. XDA19040201)the National Natural Science Foundation of China (Grant Nos. 41575128 and 41620104008)
文摘Severe haze pollution that occurred in January 2014 in Wuhan was investigated. The factors leading to Wuhan’s PM2.5 pollution and the characteristics and formation mechanism were found to be significantly different from other megacities, like Beijing. Both the growth rates and decline rates of PM2.5 concentrations in Wuhan were lower than those in Beijing, but the monthly PM2.5 value was approximately twice that in Beijing. Furthermore, the sharp increases of PM2.5 concentrations were often accompanied by strong winds. A high-precision modeling system with an online source-tagged method was established to explore the formation mechanism of five haze episodes. The long-range transport of the polluted air masses from the North China Plain (NCP) was the main factor leading to the sharp increases of PM2.5 concentrations in Wuhan, which contributed 53.4% of the monthly PM2.5 concentrations and 38.5% of polluted days. Furthermore, the change in meteorological conditions such as weakened winds and stable weather conditions led to the accumulation of air pollutants in Wuhan after the long-range transport. The contribution from Wuhan and surrounding cities to the PM2.5 concentrations was determined to be 67.4% during this period. Under the complex regional transport of pollutants from surrounding cities, the NCP, East China, and South China, the five episodes resulted in 30 haze days in Wuhan. The findings reveal important roles played by transregional and intercity transport in haze formation in Wuhan.
