The warehouse environment parameter monitoring system is designed to avoid the networking and high cost of traditional monitoring system.A sensor error correction model which combines particle swarm optimization(PSO)w...The warehouse environment parameter monitoring system is designed to avoid the networking and high cost of traditional monitoring system.A sensor error correction model which combines particle swarm optimization(PSO)with back propagation(BP)neural network algorithm is established to reduce nonlinear characteristics and improve test accuracy of the system.Simulation and experiments indicate that the PSO-BP neural network algorithm has advantages of fast convergence rate and high diagnostic accuracy.The monitoring system can provide higher measurement precision,lower power consume,stable network data communication and fault diagnoses function.The system has been applied to monitoring environment parameter of warehouse,special vehicles and ships,etc.展开更多
Magnolin is a herbal compound from Magnolia biondii Pamp. It possesses numerous biological activities. Cystic fibrosis transmembrane conductance regulator（CFTR） is an epithelial chloride channel that plays a key rol...Magnolin is a herbal compound from Magnolia biondii Pamp. It possesses numerous biological activities. Cystic fibrosis transmembrane conductance regulator（CFTR） is an epithelial chloride channel that plays a key role in the fluid secretion of various exocrine organs. In the present study, the activation of CFTR-mediated chloride transport by magnolin is indentified and characterized. In CFTR stably transfected FRT cells, magnolin increases CFTR CI- currents in a concentration-dependent manner. The activation of magnolin on CFTR is rapid, reversible, and cAMP-dependent. Magnolin does not elevate cellular cAMP level, indicating that it activates CFTR by direct binding and interaction with CFTR protein. Magnolin selectively activates wildtype CFTR rather than mutant CFTR. Magnolin may present a novel class of therapeutic lead compound tbr the treatment of diseases associated with reduced CFTR function such as keratoconjunctivitis sicca, idiopathic chronic pancreatiti, and chronic constipation.展开更多
文摘The warehouse environment parameter monitoring system is designed to avoid the networking and high cost of traditional monitoring system.A sensor error correction model which combines particle swarm optimization(PSO)with back propagation(BP)neural network algorithm is established to reduce nonlinear characteristics and improve test accuracy of the system.Simulation and experiments indicate that the PSO-BP neural network algorithm has advantages of fast convergence rate and high diagnostic accuracy.The monitoring system can provide higher measurement precision,lower power consume,stable network data communication and fault diagnoses function.The system has been applied to monitoring environment parameter of warehouse,special vehicles and ships,etc.
基金Supported by the National Natural Science Foundation of China(Nos30470405 and 30570864)
文摘Magnolin is a herbal compound from Magnolia biondii Pamp. It possesses numerous biological activities. Cystic fibrosis transmembrane conductance regulator（CFTR） is an epithelial chloride channel that plays a key role in the fluid secretion of various exocrine organs. In the present study, the activation of CFTR-mediated chloride transport by magnolin is indentified and characterized. In CFTR stably transfected FRT cells, magnolin increases CFTR CI- currents in a concentration-dependent manner. The activation of magnolin on CFTR is rapid, reversible, and cAMP-dependent. Magnolin does not elevate cellular cAMP level, indicating that it activates CFTR by direct binding and interaction with CFTR protein. Magnolin selectively activates wildtype CFTR rather than mutant CFTR. Magnolin may present a novel class of therapeutic lead compound tbr the treatment of diseases associated with reduced CFTR function such as keratoconjunctivitis sicca, idiopathic chronic pancreatiti, and chronic constipation.
