目的:对结直肠癌病人化疗期间营养相关症状的研究现状、评估工具、影响因素进行范围综述,以期为结直肠癌化疗病人的精准化管理提供参考。方法:计算机检索PubMed、Web of Science、Cochrane Library、EMbase、中国知网、万方数据库、中...目的:对结直肠癌病人化疗期间营养相关症状的研究现状、评估工具、影响因素进行范围综述,以期为结直肠癌化疗病人的精准化管理提供参考。方法:计算机检索PubMed、Web of Science、Cochrane Library、EMbase、中国知网、万方数据库、中国生物医学文献数据库中关于结直肠癌化疗期病人营养相关症状的研究,检索时限为建库至2024年12月31日。对纳入文献进行数据提取及汇总分析。结果:最终纳入18篇文献,结果显示,常见的症状是疲乏、食欲缺乏、嗜睡、恶心、失眠,随着化疗进程呈动态演变过程,在化疗中后期达峰值,然后逐渐缓解至稳定水平;营养相关症状的评估工具多种多样,但多数是非特异性的症状评估工具;营养相关症状的影响因素主要包括人口学因素、疾病及营养相关因素、生活方式因素以及社会心理因素。结论:未来可聚焦于开发针对结直肠癌病人化疗期的特异性症状评估工具,并结合纵向轨迹、网络分析等统计方法,注重症状的多维影响因素,进一步明确干预重点,简化症状管理方案。展开更多
The consolidation process of SiC<sub>f</sub>/Ti-6Al-4V composites by matrix-coated fiber (MCF) method via hot pressing was investigated using finite element modeling (FEM). By analyzing the elastic–plasti...The consolidation process of SiC<sub>f</sub>/Ti-6Al-4V composites by matrix-coated fiber (MCF) method via hot pressing was investigated using finite element modeling (FEM). By analyzing the elastic–plastic contact deformation of the representative aligned coated fibers, the consolidation maps delineating the time–temperature–pressure relationship for full densification were constructed. Both the flow coefficient and the contact area coefficient used to describe the contact deformation were calculated according to the model. In addition, the effect of fiber content on matrix stress distribution was analyzed. The results show that fiber content is a significant factor that influences the densification process. Higher fiber content will lower the consolidation rate.展开更多
[Objectives]This study was conducted to investigate the renal protective effects of Wuling Powder on mice with nephrotic syndrome(NS)based on Notch pathway.[Methods]Sixty KM mice were randomly divided into normal grou...[Objectives]This study was conducted to investigate the renal protective effects of Wuling Powder on mice with nephrotic syndrome(NS)based on Notch pathway.[Methods]Sixty KM mice were randomly divided into normal group,model group,prednisone acetate positive group,high-dose Wuling Powder group,medium-dose Wuling Power group and low-dose Wuling Power group,with 10 mice in each group.Three days after prophylactic administration,a comprehensive nephropathy model was prepared by injecting 1 mg/ml doxorubicin hydrochloride solution(7.5 mg/kg)into the tail vein.After successful modeling,prednisone acetate and Wuling SAN were given high,medium and low doses for intervention for 28 d,respectively.After that,urinary protein and creatinine contents of mice in each group were detected,and pathological damage of renal tissue was observed by HE and Masson staining.The mRNA levels of Notch1,Jagged1 and Hes1 in mouse kidney tissues were detected by RT-PCR,and the expression levels of Notch1,Jagged1 and Hes1 proteins were detected by Western blot.[Results]Wuling Powder could effectively reduce the contents of urine protein(P<0.01)and Scr(P<0.01)in NS mice,and alleviate the pathological injury of kidney.Compared with the model group,the prednisone acetate group and various Wuling Powder groups could down-regulate the expressions of Notch1,Jagged1 and Hes1 mRNA in the kidney tissue of mice(P<0.01),and the expression of Notch1 protein in the renal tissue of mice decreased(P<0.01).The contents of Hes1 in the prednisone acetate group and the high-and medium-dose Wuling Powder groups significantly decreased(P<0.05).[Conclusions]Wuling Powder could protect the kidneys in mice with NS through Notch pathway.展开更多
文摘目的:对结直肠癌病人化疗期间营养相关症状的研究现状、评估工具、影响因素进行范围综述,以期为结直肠癌化疗病人的精准化管理提供参考。方法:计算机检索PubMed、Web of Science、Cochrane Library、EMbase、中国知网、万方数据库、中国生物医学文献数据库中关于结直肠癌化疗期病人营养相关症状的研究,检索时限为建库至2024年12月31日。对纳入文献进行数据提取及汇总分析。结果:最终纳入18篇文献,结果显示,常见的症状是疲乏、食欲缺乏、嗜睡、恶心、失眠,随着化疗进程呈动态演变过程,在化疗中后期达峰值,然后逐渐缓解至稳定水平;营养相关症状的评估工具多种多样,但多数是非特异性的症状评估工具;营养相关症状的影响因素主要包括人口学因素、疾病及营养相关因素、生活方式因素以及社会心理因素。结论:未来可聚焦于开发针对结直肠癌病人化疗期的特异性症状评估工具,并结合纵向轨迹、网络分析等统计方法,注重症状的多维影响因素,进一步明确干预重点,简化症状管理方案。
基金financially supported by the National Natural Science Foundation of China(Nos.51071122 and51271147)
文摘The consolidation process of SiC<sub>f</sub>/Ti-6Al-4V composites by matrix-coated fiber (MCF) method via hot pressing was investigated using finite element modeling (FEM). By analyzing the elastic–plastic contact deformation of the representative aligned coated fibers, the consolidation maps delineating the time–temperature–pressure relationship for full densification were constructed. Both the flow coefficient and the contact area coefficient used to describe the contact deformation were calculated according to the model. In addition, the effect of fiber content on matrix stress distribution was analyzed. The results show that fiber content is a significant factor that influences the densification process. Higher fiber content will lower the consolidation rate.
基金Supported by Natural Science Research of the Open Project of First-class Discipline Construction in Guangxi(2019XK120)Natural Science Research Project of Guangxi University of Chinese Medicine(2018MS008)College Students’Innovation and Entrepreneurship Training Program of Guangxi Autonomous Region in 2023(S202310600102).
文摘[Objectives]This study was conducted to investigate the renal protective effects of Wuling Powder on mice with nephrotic syndrome(NS)based on Notch pathway.[Methods]Sixty KM mice were randomly divided into normal group,model group,prednisone acetate positive group,high-dose Wuling Powder group,medium-dose Wuling Power group and low-dose Wuling Power group,with 10 mice in each group.Three days after prophylactic administration,a comprehensive nephropathy model was prepared by injecting 1 mg/ml doxorubicin hydrochloride solution(7.5 mg/kg)into the tail vein.After successful modeling,prednisone acetate and Wuling SAN were given high,medium and low doses for intervention for 28 d,respectively.After that,urinary protein and creatinine contents of mice in each group were detected,and pathological damage of renal tissue was observed by HE and Masson staining.The mRNA levels of Notch1,Jagged1 and Hes1 in mouse kidney tissues were detected by RT-PCR,and the expression levels of Notch1,Jagged1 and Hes1 proteins were detected by Western blot.[Results]Wuling Powder could effectively reduce the contents of urine protein(P<0.01)and Scr(P<0.01)in NS mice,and alleviate the pathological injury of kidney.Compared with the model group,the prednisone acetate group and various Wuling Powder groups could down-regulate the expressions of Notch1,Jagged1 and Hes1 mRNA in the kidney tissue of mice(P<0.01),and the expression of Notch1 protein in the renal tissue of mice decreased(P<0.01).The contents of Hes1 in the prednisone acetate group and the high-and medium-dose Wuling Powder groups significantly decreased(P<0.05).[Conclusions]Wuling Powder could protect the kidneys in mice with NS through Notch pathway.
