Peracetic acid(CH_(3)C(O)OOH,PAA)-based heterogeneous advanced oxidation process(AOP)has attacked intensive interests due to production of various reactive species.Herein,Co(OH)_(2)nanoparticles decorated biochar(Co(O...Peracetic acid(CH_(3)C(O)OOH,PAA)-based heterogeneous advanced oxidation process(AOP)has attacked intensive interests due to production of various reactive species.Herein,Co(OH)_(2)nanoparticles decorated biochar(Co(OH)_(2)/BC)was fabricated by a simple and controllable method,which was used to degrade tetracycline hydrochloride(TTCH)in water through PAA activation.The results indicated that 100%TTCH(C_(0)=10μmol/L)degradation efficiency was realized within 7 min at pH 7,with a high kinetic rate constant(k_(1))of 0.64 min^(-1)by the optimized Co(OH)_(2)/BC.Material characterizations suggested that Co(OH)_(2)nanoparticle was successfully decorated on biochar,leading to more active sites and electronic structure alteration of biochar,thus greatly promoting the catalytic cleavage of PAA for radicals production.Then,the reactive oxygen species(ROS)quenching experiments and electron paramagnetic resonance(EPR)analysis demonstrated the key species were alkoxyl radicals(R–O^(·),mainly CH_(3)CO_(2)^(·)and CH_(3)CO_(3)^(·)),HO^(·)and^(1)O_(2)in this system.Besides,density functional theory(DFT)calculation on Fukui index further revealed that the vulnerable sites of TTCH and three possible degradation pathways were proposed.This study can provide a new strategy for synthesis functional materials in PAA activation AOPs for removal of antibiotics in water.展开更多
目的本研究联合应用质子磁共振波谱成像(proton magnetic resonance spectroscopy,^(1)H-MRS)与基于人工智能的自动脑分割技术,定量评估药物难治性颞叶癫痫(temporal lobe epilepsy,TLE)患者的代谢产物比值,分析海马体积占比(海马体积...目的本研究联合应用质子磁共振波谱成像(proton magnetic resonance spectroscopy,^(1)H-MRS)与基于人工智能的自动脑分割技术,定量评估药物难治性颞叶癫痫(temporal lobe epilepsy,TLE)患者的代谢产物比值,分析海马体积占比(海马体积与全脑容积之比),探讨二者在致痫灶侧别判定中的诊断效能。材料与方法采用3.0 T MRI扫描仪对27例TLE患者及27例健康对照者进行三维T1加权成像(3-dimensional T1-weighted imaging,3D-T1WI)及多体素^(1)H-MRS扫描。利用智能脑分割技术测量TLE组与正常对照组双侧海马体积占比。测定TLE组及正常对照组双侧海马头、体、尾的谷氨酸(glutamic acid,Glu)与肌酸(creatine,Cr)比值(Glu/Cr)及N-乙酰天门冬氨酸(N-acetyl-aspartate,NAA)与Cr比值(NAA/Cr)。结果^(1)H-MRS检测显示:TLE组患侧海马头Glu/Cr比值高于健侧(P=0.012)及正常对照组(P<0.001),而NAA/Cr比值在患侧与健侧海马各亚区间均显示差异无统计学意义(P>0.05),智能脑分割技术定量分析发现患侧海马体积占比(定义为患侧海马体积占全脑体积的百分比)低于健侧(P=0.033)及对照组(P<0.001)。受试者工作特征(receiver operating characteristic,ROC)曲线分析表明:海马头Glu/Cr比值定侧敏感度为88.9%,特异度为70.4%,曲线下面积(area under the curve,AUC)为0.859。海马体积占比定侧特异度为88.9%,敏感度为70.4%(AUC=0.808);二者联合诊断敏感度为81.5%,特异度为96.3%(AUC=0.941)。结论本研究证实药物难治性TLE患者患侧海马头存在特异性谷氨酸兴奋毒性和结构萎缩。海马头Glu/Cr比值(高敏感度)与海马体积占比(高特异度)的联合应用可显著提升致痫灶定侧效能,且优于单一指标,为药物难治性TLE的术前无创定位提供了高价值的影像学标志物组合。展开更多
基金supported by the National Key Research and Development Program of China(Nos.2022YFF1303102 and 2021YFA1202500)Beijing Natural Science Foundation(No.8232035)+2 种基金the National Natural Science Foundation of China(Nos.52270053,52200083 and 52200084)the Beijing Nova Program(No.20220484215)the Key Special Projects for Science and Technology of Inner Mongolia(No.2021EEDSCXSFQZD001)。
文摘Peracetic acid(CH_(3)C(O)OOH,PAA)-based heterogeneous advanced oxidation process(AOP)has attacked intensive interests due to production of various reactive species.Herein,Co(OH)_(2)nanoparticles decorated biochar(Co(OH)_(2)/BC)was fabricated by a simple and controllable method,which was used to degrade tetracycline hydrochloride(TTCH)in water through PAA activation.The results indicated that 100%TTCH(C_(0)=10μmol/L)degradation efficiency was realized within 7 min at pH 7,with a high kinetic rate constant(k_(1))of 0.64 min^(-1)by the optimized Co(OH)_(2)/BC.Material characterizations suggested that Co(OH)_(2)nanoparticle was successfully decorated on biochar,leading to more active sites and electronic structure alteration of biochar,thus greatly promoting the catalytic cleavage of PAA for radicals production.Then,the reactive oxygen species(ROS)quenching experiments and electron paramagnetic resonance(EPR)analysis demonstrated the key species were alkoxyl radicals(R–O^(·),mainly CH_(3)CO_(2)^(·)and CH_(3)CO_(3)^(·)),HO^(·)and^(1)O_(2)in this system.Besides,density functional theory(DFT)calculation on Fukui index further revealed that the vulnerable sites of TTCH and three possible degradation pathways were proposed.This study can provide a new strategy for synthesis functional materials in PAA activation AOPs for removal of antibiotics in water.
文摘目的本研究联合应用质子磁共振波谱成像(proton magnetic resonance spectroscopy,^(1)H-MRS)与基于人工智能的自动脑分割技术,定量评估药物难治性颞叶癫痫(temporal lobe epilepsy,TLE)患者的代谢产物比值,分析海马体积占比(海马体积与全脑容积之比),探讨二者在致痫灶侧别判定中的诊断效能。材料与方法采用3.0 T MRI扫描仪对27例TLE患者及27例健康对照者进行三维T1加权成像(3-dimensional T1-weighted imaging,3D-T1WI)及多体素^(1)H-MRS扫描。利用智能脑分割技术测量TLE组与正常对照组双侧海马体积占比。测定TLE组及正常对照组双侧海马头、体、尾的谷氨酸(glutamic acid,Glu)与肌酸(creatine,Cr)比值(Glu/Cr)及N-乙酰天门冬氨酸(N-acetyl-aspartate,NAA)与Cr比值(NAA/Cr)。结果^(1)H-MRS检测显示:TLE组患侧海马头Glu/Cr比值高于健侧(P=0.012)及正常对照组(P<0.001),而NAA/Cr比值在患侧与健侧海马各亚区间均显示差异无统计学意义(P>0.05),智能脑分割技术定量分析发现患侧海马体积占比(定义为患侧海马体积占全脑体积的百分比)低于健侧(P=0.033)及对照组(P<0.001)。受试者工作特征(receiver operating characteristic,ROC)曲线分析表明:海马头Glu/Cr比值定侧敏感度为88.9%,特异度为70.4%,曲线下面积(area under the curve,AUC)为0.859。海马体积占比定侧特异度为88.9%,敏感度为70.4%(AUC=0.808);二者联合诊断敏感度为81.5%,特异度为96.3%(AUC=0.941)。结论本研究证实药物难治性TLE患者患侧海马头存在特异性谷氨酸兴奋毒性和结构萎缩。海马头Glu/Cr比值(高敏感度)与海马体积占比(高特异度)的联合应用可显著提升致痫灶定侧效能,且优于单一指标,为药物难治性TLE的术前无创定位提供了高价值的影像学标志物组合。
