Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,...Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,a new-type distribution network digital twin topology modeling method based on Common Information Model(CIM)specifications and spectral clustering is proposed.Firstly,according to the specifications of the CIM standard,the digital twin topology models of distributed resources are extended and established.Secondly,based on the digital twin topology models of distributed resources,a digital twin aggregation modelling method for new-type distribution network is proposed based on spectral clustering.Furthermore,an online linked update strategy for the digital twin model of new-type distribution network that integrates real-time topology states is proposed.Finally,a case study is conducted on a distribution network in a certain demonstration area in China,and the results verify the practicability and effectiveness of the method proposed in this paper.This lays the foundation for the application of electrical network twin analysis,such as power flow calculation,optimal power flow,economic dispatch,and safety check,in a new-type distribution network that includes diversified distributed resources.展开更多
目的:探讨带状疱疹后神经痛(postherpetic neuralgia,PHN)病人共病抑郁障碍的影响因素,并构建预测模型。方法:回顾性分析2021年3月至2024年12月期间福建医科大学附属第一医院疼痛科收治的282例PHN病人的临床资料,根据病人是否共病抑郁...目的:探讨带状疱疹后神经痛(postherpetic neuralgia,PHN)病人共病抑郁障碍的影响因素,并构建预测模型。方法:回顾性分析2021年3月至2024年12月期间福建医科大学附属第一医院疼痛科收治的282例PHN病人的临床资料,根据病人是否共病抑郁障碍分为PHN共病抑郁障碍组(n=94)和单纯PHN组(n=188),通过Logistic回归分析筛选其影响因素,构建列线图预测模型并综合评价模型性能。结果:多因素Logistic回归分析显示PHN病程、恶性肿瘤史、数字分级评分法(numerical rating scale,NRS)评分、受教育程度、社会支持评定量表(social support rating scale,SSRS)评分是PHN共病抑郁障碍的影响因素。通过Bootstrap验证法进行内部验证后,列线图预测PHN共病抑郁障碍的曲线下面积(area under the curve,AUC)值为0.970(95%CI:0.941-0.987),灵敏度0.890,特异度0.941,显示模型区分能力可靠;Hosmer-Lemeshow检验结果显示X 2=5.293,P=0.726,Brier评分为0.049,校准曲线显示模型具有较好的校准度及预测一致性;临床决策曲线分析(decision curve analysis,DCA)显示模型具有良好的临床适用性。结论:PHN病程、恶性肿瘤史、NRS评分是PHN共病抑郁障碍的独立危险因素,受教育程度、SSRS评分是其独立保护因素,据此构建的列线图模型具有可靠的临床预测价值。展开更多
特定堆型的一回路冷却剂中通过加入氨调控pH,并利用其辐解产物抑制氧化性物质的浓度,从而维持冷却剂的还原性状态。在此过程中,氨浓度与pH调控产生显著的联动影响,需要建立可模拟不同控制策略下水化学行为的模型,实现pH和溶解氢浓度控...特定堆型的一回路冷却剂中通过加入氨调控pH,并利用其辐解产物抑制氧化性物质的浓度,从而维持冷却剂的还原性状态。在此过程中,氨浓度与pH调控产生显著的联动影响,需要建立可模拟不同控制策略下水化学行为的模型,实现pH和溶解氢浓度控制。本工作基于RETA反应堆系统分析程序,开发了一个适用于压水堆型冷却剂辐解产物输运的模型,模型预测NH_(3)和H_(2)浓度与实验结果的均方误差分别为1.79×10^(−8)和5.69×10^(−8)。以KLT-40S堆型为对象,构建并对比分析了三种加氨调控策略:初始弥散加氨、源恒速加氨及基于除氢优化的源恒速加氨。在模拟过程中,设置了冷却剂初始参数与辐射场条件,逐步调整加氨速率与除氢时机。每种策略均模拟至系统达到准稳态(1.6×10^(4) s),以评估其对pH和溶解氢浓度的调控效果。结果显示,初始氨弥散策略简单直接,可维持体系的还原性但对冷却剂pH调控的时间小于5 h;源恒速加氨可长时间有效调节冷却剂pH,但会带来溶解氢浓度过高的问题,需匹配相应的除氢方案。采用基于除氢优化的源恒速加氨策略,能够同时满足稳定控制pH和溶解氢浓度的要求,加氨速率为1.64 g·s^(−1),加氨开始1200 s后开启除氢装置,除氢速率0.014 g·s^(−1),化学状态稳定后冷却剂的pH为6.9,溶解氢浓度为30~35 mL·kg−(1)(Standard Temperature and Pressure,STP)。本工作有望为新堆型研发和水化学控制策略的优化提供参考。展开更多
The strength of traditional commercially pure titanium(CP-Ti) alloys often fails to meet the demand of structural materials. In order to enhance their mechanical properties, the cold-rolled CP-Ti alloys were annealed ...The strength of traditional commercially pure titanium(CP-Ti) alloys often fails to meet the demand of structural materials. In order to enhance their mechanical properties, the cold-rolled CP-Ti alloys were annealed at different temperatures, and the recrystallization behavior and texture evolution were investigated. It was found that the bimodal microstructure(equiaxed and elongated grains) was formed after partial recrystallization, and the corresponding sample exhibited an excellent combination of ultimate tensile strength(702 MPa) and total elongation(36.4%). The recrystallization nucleation of CP-Ti sheets occurred preferentially in the high strain and the high-angle grain boundaries(HAGBs) regions. Meanwhile, the internal misorientations of the deformed heterogeneous grains increased and transformed into HAGBs, which further promoted the recrystallization nucleation. The main recrystallization texture was basal TD-split texture transformed from cold-rolled basal RD-split texture, and the oriented nucleation played a dominated role during recrystallization.展开更多
Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide comp...Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide complexes(PCs)from human melanoma cell lines A375,A875,M21,M14,WM-35,and SK-HEL-1.We named the purified product as M-HSP70-PCs and determined its immunological activities.Autologous HSP70-PCs purified from primary tumor cells of melanoma patients(9 cases)were used as controls.These two tumor antigenic complexes were loaded into dendritic cells(DCs)and used to stimulate an antitumor response against tumor cells in the corresponding patients.Results Mature DCs pulsed with M-HSP70-PCs stimulated autologous T cells to secrete the same levels of type I cytokines as the autologous HSP70-PCs.Moreover,DCs pulsed with M-HSP70-PCs endued CIK cells with an equal ability as autologous HSP70-PCs to kill melanoma cells in the patients.Conclusion M-HSP70-PCs may be used as an efficient and generalized tumor antigen in the treatment of DC-based malignant melanoma.展开更多
Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-sc...Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-scale energy storage scenarios. Nevertheless, lacking desirable electrodes for reversibly hosting the bulky K+hinders the widespread application of KIBs, and it needs to be urgently solved. Hereon, the porous S-doped Sb_(2)O_(3)-graphene-carbon(SAGC) nanofibers are manufactured through an adjustable and facile approach, which involves electrospinning, in situ etching and sulfuration. The synthesized SAGC is featured by the ultra-small amorphous Sb_(2)O_(3) homogeneously wrapped inside the carbon matrix, as well as the co-incorporation of graphene and sulfur. Tentatively,the SAGC nanofiber sheets are applied as binder-free anodes for KIBs, exhibiting a prominent cycling life(256.72 m Ah·g^(-1) over 150 cycles at 100 m A·g^(-1)) and rate·g^(-1) over 100 cycles at 1 A·g^(-1)). The positive synergy among all the active components accounts for the distinguished performances of the SAGC. By reinforcing the tolerability to the swelling stress, producing the valid electrochemical active sites, and promoting the charge transferring for reversible K+uptake, the SAGC finally renders the excellent cyclability, capacity, and rate capability. Moreover, the extrinsic electrochemical pseudocapacitance characteristics induced by the porous carbon substrate elevate the K-storage capacity of the SAGC as well. It is hoped that the conclusions drawn may offer new insights into a direction for the high-performance binderfree KIB anodes.展开更多
The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial ...The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.展开更多
基金Supported by Science and Technology Project of State Grid Corporation of China(5108-202218280A-2-396-XG).
文摘Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,a new-type distribution network digital twin topology modeling method based on Common Information Model(CIM)specifications and spectral clustering is proposed.Firstly,according to the specifications of the CIM standard,the digital twin topology models of distributed resources are extended and established.Secondly,based on the digital twin topology models of distributed resources,a digital twin aggregation modelling method for new-type distribution network is proposed based on spectral clustering.Furthermore,an online linked update strategy for the digital twin model of new-type distribution network that integrates real-time topology states is proposed.Finally,a case study is conducted on a distribution network in a certain demonstration area in China,and the results verify the practicability and effectiveness of the method proposed in this paper.This lays the foundation for the application of electrical network twin analysis,such as power flow calculation,optimal power flow,economic dispatch,and safety check,in a new-type distribution network that includes diversified distributed resources.
文摘目的:探讨带状疱疹后神经痛(postherpetic neuralgia,PHN)病人共病抑郁障碍的影响因素,并构建预测模型。方法:回顾性分析2021年3月至2024年12月期间福建医科大学附属第一医院疼痛科收治的282例PHN病人的临床资料,根据病人是否共病抑郁障碍分为PHN共病抑郁障碍组(n=94)和单纯PHN组(n=188),通过Logistic回归分析筛选其影响因素,构建列线图预测模型并综合评价模型性能。结果:多因素Logistic回归分析显示PHN病程、恶性肿瘤史、数字分级评分法(numerical rating scale,NRS)评分、受教育程度、社会支持评定量表(social support rating scale,SSRS)评分是PHN共病抑郁障碍的影响因素。通过Bootstrap验证法进行内部验证后,列线图预测PHN共病抑郁障碍的曲线下面积(area under the curve,AUC)值为0.970(95%CI:0.941-0.987),灵敏度0.890,特异度0.941,显示模型区分能力可靠;Hosmer-Lemeshow检验结果显示X 2=5.293,P=0.726,Brier评分为0.049,校准曲线显示模型具有较好的校准度及预测一致性;临床决策曲线分析(decision curve analysis,DCA)显示模型具有良好的临床适用性。结论:PHN病程、恶性肿瘤史、NRS评分是PHN共病抑郁障碍的独立危险因素,受教育程度、SSRS评分是其独立保护因素,据此构建的列线图模型具有可靠的临床预测价值。
文摘特定堆型的一回路冷却剂中通过加入氨调控pH,并利用其辐解产物抑制氧化性物质的浓度,从而维持冷却剂的还原性状态。在此过程中,氨浓度与pH调控产生显著的联动影响,需要建立可模拟不同控制策略下水化学行为的模型,实现pH和溶解氢浓度控制。本工作基于RETA反应堆系统分析程序,开发了一个适用于压水堆型冷却剂辐解产物输运的模型,模型预测NH_(3)和H_(2)浓度与实验结果的均方误差分别为1.79×10^(−8)和5.69×10^(−8)。以KLT-40S堆型为对象,构建并对比分析了三种加氨调控策略:初始弥散加氨、源恒速加氨及基于除氢优化的源恒速加氨。在模拟过程中,设置了冷却剂初始参数与辐射场条件,逐步调整加氨速率与除氢时机。每种策略均模拟至系统达到准稳态(1.6×10^(4) s),以评估其对pH和溶解氢浓度的调控效果。结果显示,初始氨弥散策略简单直接,可维持体系的还原性但对冷却剂pH调控的时间小于5 h;源恒速加氨可长时间有效调节冷却剂pH,但会带来溶解氢浓度过高的问题,需匹配相应的除氢方案。采用基于除氢优化的源恒速加氨策略,能够同时满足稳定控制pH和溶解氢浓度的要求,加氨速率为1.64 g·s^(−1),加氨开始1200 s后开启除氢装置,除氢速率0.014 g·s^(−1),化学状态稳定后冷却剂的pH为6.9,溶解氢浓度为30~35 mL·kg−(1)(Standard Temperature and Pressure,STP)。本工作有望为新堆型研发和水化学控制策略的优化提供参考。
基金financially supported by the National Natural Science Foundation of China (No.52104372)the Fundamental Research Funds for the Central Universities,China (No.N2107001)the China Postdoctoral Science Foundation (No.2019M651129)。
文摘The strength of traditional commercially pure titanium(CP-Ti) alloys often fails to meet the demand of structural materials. In order to enhance their mechanical properties, the cold-rolled CP-Ti alloys were annealed at different temperatures, and the recrystallization behavior and texture evolution were investigated. It was found that the bimodal microstructure(equiaxed and elongated grains) was formed after partial recrystallization, and the corresponding sample exhibited an excellent combination of ultimate tensile strength(702 MPa) and total elongation(36.4%). The recrystallization nucleation of CP-Ti sheets occurred preferentially in the high strain and the high-angle grain boundaries(HAGBs) regions. Meanwhile, the internal misorientations of the deformed heterogeneous grains increased and transformed into HAGBs, which further promoted the recrystallization nucleation. The main recrystallization texture was basal TD-split texture transformed from cold-rolled basal RD-split texture, and the oriented nucleation played a dominated role during recrystallization.
基金Supported by a grant from the National Natural Sciences Foundation of Inner Mongolia(No.2017MS(LH)0847)。
文摘Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide complexes(PCs)from human melanoma cell lines A375,A875,M21,M14,WM-35,and SK-HEL-1.We named the purified product as M-HSP70-PCs and determined its immunological activities.Autologous HSP70-PCs purified from primary tumor cells of melanoma patients(9 cases)were used as controls.These two tumor antigenic complexes were loaded into dendritic cells(DCs)and used to stimulate an antitumor response against tumor cells in the corresponding patients.Results Mature DCs pulsed with M-HSP70-PCs stimulated autologous T cells to secrete the same levels of type I cytokines as the autologous HSP70-PCs.Moreover,DCs pulsed with M-HSP70-PCs endued CIK cells with an equal ability as autologous HSP70-PCs to kill melanoma cells in the patients.Conclusion M-HSP70-PCs may be used as an efficient and generalized tumor antigen in the treatment of DC-based malignant melanoma.
基金financially supported by the National Natural Science Foundation of China (Nos.51404103,51574117 and 61376073)Hunan Provincial Education Department(No.20C0613)the College Student Innovation and Entrepreneurship Training Program of Hunan Province (No.S2022115350874)。
文摘Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-scale energy storage scenarios. Nevertheless, lacking desirable electrodes for reversibly hosting the bulky K+hinders the widespread application of KIBs, and it needs to be urgently solved. Hereon, the porous S-doped Sb_(2)O_(3)-graphene-carbon(SAGC) nanofibers are manufactured through an adjustable and facile approach, which involves electrospinning, in situ etching and sulfuration. The synthesized SAGC is featured by the ultra-small amorphous Sb_(2)O_(3) homogeneously wrapped inside the carbon matrix, as well as the co-incorporation of graphene and sulfur. Tentatively,the SAGC nanofiber sheets are applied as binder-free anodes for KIBs, exhibiting a prominent cycling life(256.72 m Ah·g^(-1) over 150 cycles at 100 m A·g^(-1)) and rate·g^(-1) over 100 cycles at 1 A·g^(-1)). The positive synergy among all the active components accounts for the distinguished performances of the SAGC. By reinforcing the tolerability to the swelling stress, producing the valid electrochemical active sites, and promoting the charge transferring for reversible K+uptake, the SAGC finally renders the excellent cyclability, capacity, and rate capability. Moreover, the extrinsic electrochemical pseudocapacitance characteristics induced by the porous carbon substrate elevate the K-storage capacity of the SAGC as well. It is hoped that the conclusions drawn may offer new insights into a direction for the high-performance binderfree KIB anodes.
基金Supported by the National Natural Science Foundation of China(91338101,91338108,61132002,6132106)Research Fund of Tsinghua University(2011Z05117)Co-innovation Laboratory of Aerospace Broadband Network Technology
文摘The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.
