Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,...Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,a new-type distribution network digital twin topology modeling method based on Common Information Model(CIM)specifications and spectral clustering is proposed.Firstly,according to the specifications of the CIM standard,the digital twin topology models of distributed resources are extended and established.Secondly,based on the digital twin topology models of distributed resources,a digital twin aggregation modelling method for new-type distribution network is proposed based on spectral clustering.Furthermore,an online linked update strategy for the digital twin model of new-type distribution network that integrates real-time topology states is proposed.Finally,a case study is conducted on a distribution network in a certain demonstration area in China,and the results verify the practicability and effectiveness of the method proposed in this paper.This lays the foundation for the application of electrical network twin analysis,such as power flow calculation,optimal power flow,economic dispatch,and safety check,in a new-type distribution network that includes diversified distributed resources.展开更多
The strength of traditional commercially pure titanium(CP-Ti) alloys often fails to meet the demand of structural materials. In order to enhance their mechanical properties, the cold-rolled CP-Ti alloys were annealed ...The strength of traditional commercially pure titanium(CP-Ti) alloys often fails to meet the demand of structural materials. In order to enhance their mechanical properties, the cold-rolled CP-Ti alloys were annealed at different temperatures, and the recrystallization behavior and texture evolution were investigated. It was found that the bimodal microstructure(equiaxed and elongated grains) was formed after partial recrystallization, and the corresponding sample exhibited an excellent combination of ultimate tensile strength(702 MPa) and total elongation(36.4%). The recrystallization nucleation of CP-Ti sheets occurred preferentially in the high strain and the high-angle grain boundaries(HAGBs) regions. Meanwhile, the internal misorientations of the deformed heterogeneous grains increased and transformed into HAGBs, which further promoted the recrystallization nucleation. The main recrystallization texture was basal TD-split texture transformed from cold-rolled basal RD-split texture, and the oriented nucleation played a dominated role during recrystallization.展开更多
Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide comp...Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide complexes(PCs)from human melanoma cell lines A375,A875,M21,M14,WM-35,and SK-HEL-1.We named the purified product as M-HSP70-PCs and determined its immunological activities.Autologous HSP70-PCs purified from primary tumor cells of melanoma patients(9 cases)were used as controls.These two tumor antigenic complexes were loaded into dendritic cells(DCs)and used to stimulate an antitumor response against tumor cells in the corresponding patients.Results Mature DCs pulsed with M-HSP70-PCs stimulated autologous T cells to secrete the same levels of type I cytokines as the autologous HSP70-PCs.Moreover,DCs pulsed with M-HSP70-PCs endued CIK cells with an equal ability as autologous HSP70-PCs to kill melanoma cells in the patients.Conclusion M-HSP70-PCs may be used as an efficient and generalized tumor antigen in the treatment of DC-based malignant melanoma.展开更多
The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial ...The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.展开更多
Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-sc...Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-scale energy storage scenarios. Nevertheless, lacking desirable electrodes for reversibly hosting the bulky K+hinders the widespread application of KIBs, and it needs to be urgently solved. Hereon, the porous S-doped Sb_(2)O_(3)-graphene-carbon(SAGC) nanofibers are manufactured through an adjustable and facile approach, which involves electrospinning, in situ etching and sulfuration. The synthesized SAGC is featured by the ultra-small amorphous Sb_(2)O_(3) homogeneously wrapped inside the carbon matrix, as well as the co-incorporation of graphene and sulfur. Tentatively,the SAGC nanofiber sheets are applied as binder-free anodes for KIBs, exhibiting a prominent cycling life(256.72 m Ah·g^(-1) over 150 cycles at 100 m A·g^(-1)) and rate·g^(-1) over 100 cycles at 1 A·g^(-1)). The positive synergy among all the active components accounts for the distinguished performances of the SAGC. By reinforcing the tolerability to the swelling stress, producing the valid electrochemical active sites, and promoting the charge transferring for reversible K+uptake, the SAGC finally renders the excellent cyclability, capacity, and rate capability. Moreover, the extrinsic electrochemical pseudocapacitance characteristics induced by the porous carbon substrate elevate the K-storage capacity of the SAGC as well. It is hoped that the conclusions drawn may offer new insights into a direction for the high-performance binderfree KIB anodes.展开更多
In order to meet the increasingly strict environmental requirements and achieve the comprehensive utilization of waste in drilling operation,three techniques were used to harden the drilling waste.The three techniques...In order to meet the increasingly strict environmental requirements and achieve the comprehensive utilization of waste in drilling operation,three techniques were used to harden the drilling waste.The three techniques are cement hardening technology,fly ash hardening technology and quicklime-sodium silicate hardening technology.Orthogonal analysis was used to evaluate and optimize the experimental results from the three techniques.The results show that the hardening system of quicklime-sodium silicate is not satisfying,and the compressive strength of hardened body is only 1.32 MPa.The optimal mass ratio in cement hardening system is drilling waste∶water∶YHJ1∶YHJ2∶YHJ3∶cement = 10∶4∶3.2∶2.2∶0.5∶4.The optimal mass ratio in fly ash hardening system is drilling waste∶water∶YHJ1∶YHJ2∶YHJ3∶fly ash = 10∶4∶3.2∶1.8∶1.5∶2.The compressive strength reaches 3.19 and 2.95 MPa respectively.Based on this strength,the hardened body can be used as low-strength building bricks,subgrade or nutrition bowls in arid regions to achieve the reuse of drilling waste.展开更多
Objective:To explore the effects of chondroitinase ABC (Ch ABC) combined with spinal cord on neurological recovery and TGF-β1, HIF-1 and Nog-oNgR signaling pathways after spinal cord injury in rats.Methods: Sixty rat...Objective:To explore the effects of chondroitinase ABC (Ch ABC) combined with spinal cord on neurological recovery and TGF-β1, HIF-1 and Nog-oNgR signaling pathways after spinal cord injury in rats.Methods: Sixty rats were randomly divided into 4 groups: control group, model group, Ch ABC group and Ch ABC+ spinal cord. A rat spinal cord injury model was established using the Allen's method. Spinal nerve function was assessed by Basso Beattie Bresnahan (score) and somatosensory evoked potential (sEP) assays. mRNA levels were detected using RT-qPCR. Western blot was used to detect protein levels.Results: After modeling, the BBB scores of the rats were significantly decreased. After the intervention, the BBB scores of the three groups were improved. The BBB scores of the Ch ABC+ spinal cord group were significantly higher than those of the Ch ABC group. After modeling, the SEP of the rats was significantly increased. After the intervention, the BBB scores of the three groups were decreased. The BBB scores of the Ch ABC+ spinal cord group were significantly lower than those of the Ch ABC group. The TGF-β1 in the Ch ABC group and the Ch ABC+ spinal group was significantly higher than that in the model group, and the HIF-1 was significantly lower than the model group. The level of TGF-β1 in Ch ABC+ spinal cord group was significantly higher than that in Ch ABC group and HIF-1 was significantly lower than that in Ch ABC group. After treatment, the expression levels of Nog-oNgR pathway in Ch ABC group and Ch ABC + spinal cord group were significantly lower than those in model group, and the expression levels of Nogo-A, NgR and LINGO-1 in Ch ABC+ spinal cord group were significant after intervention. Lower than Ch ABC group.Conclusion: ChABC combined with spinal cord has a stronger role in promoting the recovery of neurological function. The combination of spinal cord can further inhibit the level of HIF-1 and increase the level of TGF-β1, and improve the prognosis to promote spinal healing. And the mechanism of action of the combination may be related to its role in inhibiting the growth of neurons by the Nogo-NgR signaling pathway.展开更多
基金Supported by Science and Technology Project of State Grid Corporation of China(5108-202218280A-2-396-XG).
文摘Regard to the real-time dynamic digital twin modelling problem of a new-type distribution network that includes distributed resources such as distributed photovoltaic,energy storage,charging pile,and electric vehicle,a new-type distribution network digital twin topology modeling method based on Common Information Model(CIM)specifications and spectral clustering is proposed.Firstly,according to the specifications of the CIM standard,the digital twin topology models of distributed resources are extended and established.Secondly,based on the digital twin topology models of distributed resources,a digital twin aggregation modelling method for new-type distribution network is proposed based on spectral clustering.Furthermore,an online linked update strategy for the digital twin model of new-type distribution network that integrates real-time topology states is proposed.Finally,a case study is conducted on a distribution network in a certain demonstration area in China,and the results verify the practicability and effectiveness of the method proposed in this paper.This lays the foundation for the application of electrical network twin analysis,such as power flow calculation,optimal power flow,economic dispatch,and safety check,in a new-type distribution network that includes diversified distributed resources.
基金financially supported by the National Natural Science Foundation of China (No.52104372)the Fundamental Research Funds for the Central Universities,China (No.N2107001)the China Postdoctoral Science Foundation (No.2019M651129)。
文摘The strength of traditional commercially pure titanium(CP-Ti) alloys often fails to meet the demand of structural materials. In order to enhance their mechanical properties, the cold-rolled CP-Ti alloys were annealed at different temperatures, and the recrystallization behavior and texture evolution were investigated. It was found that the bimodal microstructure(equiaxed and elongated grains) was formed after partial recrystallization, and the corresponding sample exhibited an excellent combination of ultimate tensile strength(702 MPa) and total elongation(36.4%). The recrystallization nucleation of CP-Ti sheets occurred preferentially in the high strain and the high-angle grain boundaries(HAGBs) regions. Meanwhile, the internal misorientations of the deformed heterogeneous grains increased and transformed into HAGBs, which further promoted the recrystallization nucleation. The main recrystallization texture was basal TD-split texture transformed from cold-rolled basal RD-split texture, and the oriented nucleation played a dominated role during recrystallization.
基金Supported by a grant from the National Natural Sciences Foundation of Inner Mongolia(No.2017MS(LH)0847)。
文摘Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide complexes(PCs)from human melanoma cell lines A375,A875,M21,M14,WM-35,and SK-HEL-1.We named the purified product as M-HSP70-PCs and determined its immunological activities.Autologous HSP70-PCs purified from primary tumor cells of melanoma patients(9 cases)were used as controls.These two tumor antigenic complexes were loaded into dendritic cells(DCs)and used to stimulate an antitumor response against tumor cells in the corresponding patients.Results Mature DCs pulsed with M-HSP70-PCs stimulated autologous T cells to secrete the same levels of type I cytokines as the autologous HSP70-PCs.Moreover,DCs pulsed with M-HSP70-PCs endued CIK cells with an equal ability as autologous HSP70-PCs to kill melanoma cells in the patients.Conclusion M-HSP70-PCs may be used as an efficient and generalized tumor antigen in the treatment of DC-based malignant melanoma.
基金Supported by the National Natural Science Foundation of China(91338101,91338108,61132002,6132106)Research Fund of Tsinghua University(2011Z05117)Co-innovation Laboratory of Aerospace Broadband Network Technology
文摘The scheduling efficiency of the tracking and data relay satellite system（TDRSS）is strictly limited by the scheduling degrees of freedom（DoF）,including time DoF defined by jobs＇ flexible time windows and spatial DoF brought by multiple servable tracking and data relay satellites（TDRSs）.In this paper,ageneralized multiple time windows（GMTW）model is proposed to fully exploit the time and spatial DoF.Then,the improvements of service capability and job-completion probability based on the GMTW are theoretically proved.Further,an asymmetric path-relinking（APR）based heuristic job scheduling framework is presented to maximize the usage of DoF provided by the GMTW.Simulation results show that by using our proposal 11%improvement of average jobcompletion probability can be obtained.Meanwhile,the computing time of the time-to-target can be shorten to 1/9 of the GRASP.
基金financially supported by the National Natural Science Foundation of China (Nos.51404103,51574117 and 61376073)Hunan Provincial Education Department(No.20C0613)the College Student Innovation and Entrepreneurship Training Program of Hunan Province (No.S2022115350874)。
文摘Considering the intrinsic advantages of natural copiousness and cost-effectiveness of potassium resource,potassium-ion batteries(KIBs) are booming as prospective alternatives to lithium-ion batteries(LIBs) in large-scale energy storage scenarios. Nevertheless, lacking desirable electrodes for reversibly hosting the bulky K+hinders the widespread application of KIBs, and it needs to be urgently solved. Hereon, the porous S-doped Sb_(2)O_(3)-graphene-carbon(SAGC) nanofibers are manufactured through an adjustable and facile approach, which involves electrospinning, in situ etching and sulfuration. The synthesized SAGC is featured by the ultra-small amorphous Sb_(2)O_(3) homogeneously wrapped inside the carbon matrix, as well as the co-incorporation of graphene and sulfur. Tentatively,the SAGC nanofiber sheets are applied as binder-free anodes for KIBs, exhibiting a prominent cycling life(256.72 m Ah·g^(-1) over 150 cycles at 100 m A·g^(-1)) and rate·g^(-1) over 100 cycles at 1 A·g^(-1)). The positive synergy among all the active components accounts for the distinguished performances of the SAGC. By reinforcing the tolerability to the swelling stress, producing the valid electrochemical active sites, and promoting the charge transferring for reversible K+uptake, the SAGC finally renders the excellent cyclability, capacity, and rate capability. Moreover, the extrinsic electrochemical pseudocapacitance characteristics induced by the porous carbon substrate elevate the K-storage capacity of the SAGC as well. It is hoped that the conclusions drawn may offer new insights into a direction for the high-performance binderfree KIB anodes.
基金Supported by National Natural Science Foundation of China(51874343)State Key Development Program for Basic Research of China(973 Project)(2015CB251200)Yangtze River Scholars Innovation Team of Ministry of Education(IRT_14R58)。
文摘In order to meet the increasingly strict environmental requirements and achieve the comprehensive utilization of waste in drilling operation,three techniques were used to harden the drilling waste.The three techniques are cement hardening technology,fly ash hardening technology and quicklime-sodium silicate hardening technology.Orthogonal analysis was used to evaluate and optimize the experimental results from the three techniques.The results show that the hardening system of quicklime-sodium silicate is not satisfying,and the compressive strength of hardened body is only 1.32 MPa.The optimal mass ratio in cement hardening system is drilling waste∶water∶YHJ1∶YHJ2∶YHJ3∶cement = 10∶4∶3.2∶2.2∶0.5∶4.The optimal mass ratio in fly ash hardening system is drilling waste∶water∶YHJ1∶YHJ2∶YHJ3∶fly ash = 10∶4∶3.2∶1.8∶1.5∶2.The compressive strength reaches 3.19 and 2.95 MPa respectively.Based on this strength,the hardened body can be used as low-strength building bricks,subgrade or nutrition bowls in arid regions to achieve the reuse of drilling waste.
文摘Objective:To explore the effects of chondroitinase ABC (Ch ABC) combined with spinal cord on neurological recovery and TGF-β1, HIF-1 and Nog-oNgR signaling pathways after spinal cord injury in rats.Methods: Sixty rats were randomly divided into 4 groups: control group, model group, Ch ABC group and Ch ABC+ spinal cord. A rat spinal cord injury model was established using the Allen's method. Spinal nerve function was assessed by Basso Beattie Bresnahan (score) and somatosensory evoked potential (sEP) assays. mRNA levels were detected using RT-qPCR. Western blot was used to detect protein levels.Results: After modeling, the BBB scores of the rats were significantly decreased. After the intervention, the BBB scores of the three groups were improved. The BBB scores of the Ch ABC+ spinal cord group were significantly higher than those of the Ch ABC group. After modeling, the SEP of the rats was significantly increased. After the intervention, the BBB scores of the three groups were decreased. The BBB scores of the Ch ABC+ spinal cord group were significantly lower than those of the Ch ABC group. The TGF-β1 in the Ch ABC group and the Ch ABC+ spinal group was significantly higher than that in the model group, and the HIF-1 was significantly lower than the model group. The level of TGF-β1 in Ch ABC+ spinal cord group was significantly higher than that in Ch ABC group and HIF-1 was significantly lower than that in Ch ABC group. After treatment, the expression levels of Nog-oNgR pathway in Ch ABC group and Ch ABC + spinal cord group were significantly lower than those in model group, and the expression levels of Nogo-A, NgR and LINGO-1 in Ch ABC+ spinal cord group were significant after intervention. Lower than Ch ABC group.Conclusion: ChABC combined with spinal cord has a stronger role in promoting the recovery of neurological function. The combination of spinal cord can further inhibit the level of HIF-1 and increase the level of TGF-β1, and improve the prognosis to promote spinal healing. And the mechanism of action of the combination may be related to its role in inhibiting the growth of neurons by the Nogo-NgR signaling pathway.
