Objective To explore the features of various mediastinal lymphadenopathies using computed tomography perfusion(CTP).Methods CTP parameters(CTPs) of the selected mediastinal nodes from 59 patients with pathology-proven...Objective To explore the features of various mediastinal lymphadenopathies using computed tomography perfusion(CTP).Methods CTP parameters(CTPs) of the selected mediastinal nodes from 59 patients with pathology-proven malignant lymph nodes and of those from 29 patients with clinically diagnosed or pathology-proven inflammatory lymphadenopathies were collected.Patients were divided into subgroups by etiology and phase of primary disease,including different pathological malignant nodes and diverse inflammatory nodes.CTPs were defined as blood flow(BF),blood volume(BV),mean transit time(MTT),permeability(PMB),and time to peak(TTP).Differences of CTPs were compared between malignant and benign nodes,and among subgroups,respectively.Results In the mediastinum,no significant differences of CTPs were found between malignant and benign groups(all P>0.05),the same for subgroups of malignant nodes(all P>0.05).Acute lymphadenitis had higher BF and BV than chronic inflammatory,lymphoid tuberculosis,sarcoidosis and malignant nodes.The BF of malignant nodes was markedly slower than that of acute lymphadenitis(P=0.01),but faster than chronic inflammatory nodes(P=0.04) and sarcoidosis(P=0.03),with no significant difference compared with lymphoid tuberculosis.Pneumonia-complicated lymphoid tuberculosis showed the longest MTT while sarcoidosis displayed the shortest MTT,and inflammatory nodes,lymphoid tuberculosis without complicated pneumonia and malignant nodes had moderate MTT.Conclusion CTPs show promising potential in distinguishing various lymphadenopathies in the mediastinum,but more studies are needed to improve their specificity.展开更多
Objective: Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD...Objective: Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD), and the intervertebral discal degeneration (IDD). Further, to discuss a possible causation relationship between them. Methods: One hundred and eighty-six people were randomly enrolled by stratified sampling and grouped by age:?15, 16e25, 26e35, 36e45, 46e55, 56e65, 66e75, and ?76 years old. The average CTP and BMD of the third and fourth lumbar vertebrae marrow were measured and the IDD incidence of the third-fourth vertebrae was assessed. The temporalespatial distribution patterns of the age-related changes of the CTP, BMD, and IDD were described, and the correlations between them were calculated. Results: The microcirculatory perfusion function of the vertebral marrow develops to maturity by 25 years and is maintained until age 35, then declines with aging. The BMD grew to a peak from 26 to 45 years old, then decreased yearly. The IDD showed a sudden increase after 45 years of age. The CTP [BF (r ? 0.806, P ? 0.000), BV (r ? 0.685, P ? 0.005) and PMB (r ? 0.619, P ? 0.001)] showed strong positive correlations and CTP [TTP (r ? ?0.211, P ? 0.322) and MTT (r ? ?0.598, P ? 0.002)] showed negative correlations with BMD. The CTP [BF (r ? ?0.815, P ? 0.000), BV (r ? ?0.753, P ? 0.000) and PMB (r ? ?0.690, P ? 0.000)] had strong negative correlations, and CTP [TTP (r ? 0.323, P ? 0.126) and MTT (r ? 0.628, P ? 0.001)] had positive correlations with the incidence of IDD. Conclusion: The decrease with aging of the microcirculatory perfusion in the lumbar vertebral marrow preceded, and is a potential causative factor for the loss of BMD and the onset of IDD. Copyright ? 2015, Chinese Medical Association Production. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).展开更多
文摘Objective To explore the features of various mediastinal lymphadenopathies using computed tomography perfusion(CTP).Methods CTP parameters(CTPs) of the selected mediastinal nodes from 59 patients with pathology-proven malignant lymph nodes and of those from 29 patients with clinically diagnosed or pathology-proven inflammatory lymphadenopathies were collected.Patients were divided into subgroups by etiology and phase of primary disease,including different pathological malignant nodes and diverse inflammatory nodes.CTPs were defined as blood flow(BF),blood volume(BV),mean transit time(MTT),permeability(PMB),and time to peak(TTP).Differences of CTPs were compared between malignant and benign nodes,and among subgroups,respectively.Results In the mediastinum,no significant differences of CTPs were found between malignant and benign groups(all P>0.05),the same for subgroups of malignant nodes(all P>0.05).Acute lymphadenitis had higher BF and BV than chronic inflammatory,lymphoid tuberculosis,sarcoidosis and malignant nodes.The BF of malignant nodes was markedly slower than that of acute lymphadenitis(P=0.01),but faster than chronic inflammatory nodes(P=0.04) and sarcoidosis(P=0.03),with no significant difference compared with lymphoid tuberculosis.Pneumonia-complicated lymphoid tuberculosis showed the longest MTT while sarcoidosis displayed the shortest MTT,and inflammatory nodes,lymphoid tuberculosis without complicated pneumonia and malignant nodes had moderate MTT.Conclusion CTPs show promising potential in distinguishing various lymphadenopathies in the mediastinum,but more studies are needed to improve their specificity.
文摘Objective: Using a dynamic computed tomographic perfusion (CTP) imaging method to explore the age-related distribution of the microcirculation perfusion function in the vertebral marrow, the bone material density (BMD), and the intervertebral discal degeneration (IDD). Further, to discuss a possible causation relationship between them. Methods: One hundred and eighty-six people were randomly enrolled by stratified sampling and grouped by age:?15, 16e25, 26e35, 36e45, 46e55, 56e65, 66e75, and ?76 years old. The average CTP and BMD of the third and fourth lumbar vertebrae marrow were measured and the IDD incidence of the third-fourth vertebrae was assessed. The temporalespatial distribution patterns of the age-related changes of the CTP, BMD, and IDD were described, and the correlations between them were calculated. Results: The microcirculatory perfusion function of the vertebral marrow develops to maturity by 25 years and is maintained until age 35, then declines with aging. The BMD grew to a peak from 26 to 45 years old, then decreased yearly. The IDD showed a sudden increase after 45 years of age. The CTP [BF (r ? 0.806, P ? 0.000), BV (r ? 0.685, P ? 0.005) and PMB (r ? 0.619, P ? 0.001)] showed strong positive correlations and CTP [TTP (r ? ?0.211, P ? 0.322) and MTT (r ? ?0.598, P ? 0.002)] showed negative correlations with BMD. The CTP [BF (r ? ?0.815, P ? 0.000), BV (r ? ?0.753, P ? 0.000) and PMB (r ? ?0.690, P ? 0.000)] had strong negative correlations, and CTP [TTP (r ? 0.323, P ? 0.126) and MTT (r ? 0.628, P ? 0.001)] had positive correlations with the incidence of IDD. Conclusion: The decrease with aging of the microcirculatory perfusion in the lumbar vertebral marrow preceded, and is a potential causative factor for the loss of BMD and the onset of IDD. Copyright ? 2015, Chinese Medical Association Production. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
