This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each...This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each associated with unique plasma parameter fluctuations.Magnetic fluctuations,particularly the disruption of magnetic surface structures caused by sawtooth crashes,may play a significant role in modulating plasma dynamics.Moreover,the crossphase term and coherence between density and velocity fluctuations were found to be key factors in these flux events,with high coherence correlating with peak inward flux.These findings enhance the understanding of fluctuation-induced transport after sawtooth crashes and have implications for plasma confinement in fusion devices.展开更多
A 100-channel double-foil soft X-ray array imaging(DSXAI)diagnostic system has been developed for the HL-2A tokamak to obtain tomographic bremsstrahlung emissivity and electron temperature(T_(e)).This system employs a...A 100-channel double-foil soft X-ray array imaging(DSXAI)diagnostic system has been developed for the HL-2A tokamak to obtain tomographic bremsstrahlung emissivity and electron temperature(T_(e)).This system employs a double-foil technique to determine T_(e) by comparing the soft X-ray(SXR)emissivities from the same plasma location through two beryllium(Be)foils of differing thickness.The DSXAI system comprises five photocameras mounted at two different poloidal cross-sections,separated toroidally by 15°,allowing for three distinct poloidal viewing angles.Each photocamera features 20 channels,offering a temporal resolution of approximately 4μs and a spatial resolution of about 8 cm,with no channel overlap.Each photocamera contains two identical optical systems,each defined by an aperture slit and a photodiode array.The double-foil configuration is realized by placing these two optical systems,each with a different Be foil,in close proximity.Initial experimental results demonstrate that the DSXAI diagnostic system performs well,successfully reconstructing 2-dimensional(2D)tomographic SXR emissivity and T_(e) on the HL-2A tokamak.This study provides valuable insights for the future implementation of similar diagnostic systems on fusion reactors like ITER.展开更多
Researches on plasma-facing materials/components(PFMs/PFCs)have become a focus in magnetic confinement fusion studies,particularly for advanced tokamak operation scenarios.Similarly,spacecraft surface materials must m...Researches on plasma-facing materials/components(PFMs/PFCs)have become a focus in magnetic confinement fusion studies,particularly for advanced tokamak operation scenarios.Similarly,spacecraft surface materials must maintain stable performance under relatively high temperatures and other harsh plasma conditions,making studies of their thermal and ablation resistance critical.Recently,a low-cost,low-energy-storage for superconducting magnets,and compact linear device,HIT-PSI,has been designed and constructed at Harbin Institute of Technology(HIT)to investigate the interaction between stable high heat flux plasma and PFMs/PFCs in scrape-off-layer(SOL)and divertor regions,as well as spacecraft surface materials.The parameters of the argon plasma beam of HIT-PSI are diagnosed using a water-cooled planar Langmuir probe and emission spectroscopy.As magnetic field rises to 2 T,the argon plasma beam generated by a cascaded arc source achieves high density exceeding 1.2×10^(21)m^(-3)at a distance of 25 cm from the source with electron temperature surpassing 4 eV,where the particle flux reaches 10^(24)m^(-2)s^(-1),and the heat flux loaded on the graphite target measured by infrared camera reaches 4 MW/m^(2).Combined with probe and emission spectroscopy data,the transport characteristics of the argon plasma beam are analyzed.展开更多
Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory reactions. Atsttrin is an engineered protein composed of three progranulin fragments and has been show...Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory reactions. Atsttrin is an engineered protein composed of three progranulin fragments and has been shown to have an effect similar to that of progranulin. Atsttrin has anti-inflammatory actions in multiple arthritis mouse models, and it protects against further arthritis development. However, whether Atsttrin has a role in neuroinflammation remains to be elucidated. In this study, we produced a neuroinflammatory mouse model by intracerebroventricular injection of 1 μL lipopolysaccharide(10 μg/μL). Atsttrin(2.5 mg/kg) was administered via intraperitoneal injection every 3 days over a period of 7 days before intracerebroventricular injection of 1 μL lipopolysaccharide(10 μg/μL). In addition, astrocyte cultures were treated with 0, 100 or 300 ng/mL lipopolysaccharide, with 200 ng/mL Atsttrin simultaneously. Immunohistochemistry, enzyme-linked immunosorbent assay and real-time reverse transcription-polymerase chain reaction were performed to examine the protein and mRNA levels of inflammatory mediators and to assess activation of the nuclear factor kappa B signaling pathway. Progranulin expression in the brain of wild-type mice and in astrocyte cultures was increased after lipopolysaccharide administration. The protein and mRNA expression levels of tumor necrosis factor-α, interleukin-1β and inducible nitric oxide synthase were increased in the brain of progranulin knockout mice after lipopolysaccharide administration. Atsttrin treatment reduced the lipopolysaccharide-induced increase in the protein and mRNA levels of tumor necrosis factor-α, interleukin-1β, matrix metalloproteinase-3 and inducible nitric oxide synthase in the brain of progranulin knockout mice. Atsttrin also reduced the expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase 3 mRNA in lipopolysaccharide-treated astrocytes in vitro, and decreased the concentration of tumor necrosis factor α and interleukin-1β in the supernatant. Furthermore, Atsttrin significantly reduced the levels of phospho-nuclear factor kappa B inhibitor α in the brain of lipopolysaccharide-treated progranulin knockout mice and astrocytes, and it decreased the expression of nuclear factor kappa B2 in astrocytes. Collectively, our findings show that the anti-neuroinflammatory effect of Atsttrin involves inhibiton of the nuclear factor kappa B signaling pathway, and they suggest that Atsttrin may have clinical potential in neuroinflammatory therapy.展开更多
In this article,the design of a Lyman-alpha-based beam emission spectroscopy(LAB)diagnostic on the HL-2A tokamak has been proposed for the first time.The purpose of this novel diagnostic is to measure density fluctuat...In this article,the design of a Lyman-alpha-based beam emission spectroscopy(LAB)diagnostic on the HL-2A tokamak has been proposed for the first time.The purpose of this novel diagnostic is to measure density fluctuations of tokamak plasma.The light-collection system of LAB,which consists of the first mirror and two groups of coaxial double-mirror telescopes,can realize a twosegmented viewing field ofρ=0–0.2 andρ=0.75–1,which is optimized to measure plasma density fluctuation,not only in the edge transport barrier region but also in the internal transport barrier region,to investigate the underlying physics of turbulence in tokamaks.Spectrometers are developed to separate out the Doppler-shifted target line(122.03 and 122.17 nm)from the background Lyman-alpha line(121.53 nm).Here,30 Core-LAB channels and 30 Edge-LAB channels are under development on the HL-2A tokamak.It has high radial spatial resolutions of about 2.7 mm and 3.3 mm for the core and edge channels,respectively.Taking the high light intensity of this Lyman-alpha line into account,temporal resolution of 200 k Hz can be ensured by broad bandwidth amplifiers.This high spatio-temporal resolution makes LAB a potential keen tool to experimentally investigate tokamak plasma physics.展开更多
The scaling law of divertor heat flux width is one of the key topics of magnetic confinement fusion,which is almost inversely proportional to the poloidal magnetic field on some opened divertor tokamaks.This work focu...The scaling law of divertor heat flux width is one of the key topics of magnetic confinement fusion,which is almost inversely proportional to the poloidal magnetic field on some opened divertor tokamaks.This work focuses on the scaling laws of the closed divertor heat flux width in the HL-2 A tokamak under different discharge conditions,such as the Ohmic,L-and H-modes.The results indicate that there are basic similarities of the scaling laws of the heat flux width between the opened and closed divertors.However,a larger spreading width in the private flux region is found,which is relevant to a small expansion factor of the magnetic flux in the closed divertor.展开更多
We have developed a novel method for co-adding multiple under-sampled images that combines the iteratively reweighted least squares and divide-and-conquer algorithms.Our approach not only allows for the anti-aliasing ...We have developed a novel method for co-adding multiple under-sampled images that combines the iteratively reweighted least squares and divide-and-conquer algorithms.Our approach not only allows for the anti-aliasing of the images but also enables Point-Spread Function(PSF)deconvolution,resulting in enhanced restoration of extended sources,the highest peak signal-to-noise ratio,and reduced ringing artefacts.To test our method,we conducted numerical simulations that replicated observation runs of the China Space Station Telescope/the VLT Survey Telescope(VST)and compared our results to those obtained using previous algorithms.The simulation showed that our method outperforms previous approaches in several ways,such as restoring the profile of extended sources and minimizing ringing artefacts.Additionally,because our method relies on the inherent advantages of least squares fitting,it is more versatile and does not depend on the local uniformity hypothesis for the PSF.However,the new method consumes much more computation than the other approaches.展开更多
An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the HL-2A tokamak.The 20-channel edge LyBES,which is intended t...An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the HL-2A tokamak.The 20-channel edge LyBES,which is intended to measure the density fluctuation in plasma edge(from R=1960 mm to R=2026 mm)with an improved spatial resolution of 3.3 mm,is a complement to the existing conventional beam emission spectroscopy(BES)diagnostic.In this article,we introduce the progress of LyBES diagnostic,including the collection optics,the monochromator,and the detector system.The reflectance of the collection mirrors is measured to be~82%at 122 nm,and the aberration geometrical radius of the collection optics is tested to be~150μm in the aimed area.The linear dispersion of the LyBES monochromator is designed to be~0.09 nm mm^(-1).The bandwidth of the detector system with the 5×10^(7)V A^(-1)preamplifier gain is measured to be~280 kHz,and the peak-to-peak noise of the detector system is tested to be~16 mV.The finalized design,components development and testing of the LyBES diagnostic have been completed at present,and an overall performance of the LyBES diagnostic is to be confirmed in the next HL-2A campaign.展开更多
This paper reports an improved time-delay estimation(TDE)technique for the derivation of turbulence structures based on gas-puff imaging data.The improved TDE technique,integrating an inverse timing search and hierarc...This paper reports an improved time-delay estimation(TDE)technique for the derivation of turbulence structures based on gas-puff imaging data.The improved TDE technique,integrating an inverse timing search and hierarchical strategy,offers superior accuracy in calculating turbulent velocity field maps and analyzing blob dynamics,which has the power to obtain the radial profiles of equilibrium poloidal velocity,blob size and its radial velocity,even the fluctuation analysis,such as geodesic acoustic modes and quasi-coherent mode,etc.This improved technique could provide important 2D information for the study of edge turbulence and blob dynamics,advancing the understanding of edge turbulence physics in fusion plasmas.展开更多
The optical design of near-infrared phase contrast imaging(NI-PCI)diagnosis on HL-2A is introduced in this paper.This scheme benefits from the great progress of near-infrared laser technology and is a broadening of tr...The optical design of near-infrared phase contrast imaging(NI-PCI)diagnosis on HL-2A is introduced in this paper.This scheme benefits from the great progress of near-infrared laser technology and is a broadening of traditional phase contrast technology.This diagnostic can work as a keen tool to measure plasma wavenumber spectra by inferring string-integrated plasma density fluctuations.Design of both the front optical path which is the path before the laser transmitting into the tokamak plasma and the rear optics which is the path after the laser passing through the plasma is detailed.The 1550 nm laser is chosen as the probe beam and highprecision optical components are designed to fit the laser beam,in which a phase plate with a 194-nm-deep silver groove is the key.Compared with the conventional 10.6μm laser-based PCI system on HL-2A,NI-PCI significantly overcomes the unwanted phase scintillation effect and promotes the measurement capability of high-wavenumber turbulence with an increased maximal measurable wavenumber from 15 cm^(-1)to 32.6 cm^(-1).展开更多
A dual-route optical emission spectroscopy(D-OES)diagnostic is newly developed to monitor the optical emission from the X-point plasma region on the HL-2 A tokamak.This diagnostic is composed of an imaging system,a be...A dual-route optical emission spectroscopy(D-OES)diagnostic is newly developed to monitor the optical emission from the X-point plasma region on the HL-2 A tokamak.This diagnostic is composed of an imaging system,a beam-splitting system for dual-route measurements,fiber bundles,a spectrometer system,and a control and acquisition system.One route is used to obtain wide-spectral-range spectra,and the other route is used to acquire high-wavelengthresolution line shapes.The spectral resolution of the wide-range spectrometers is 0.8 nm with a coverage of 800 nm(@200-1000 nm).The spectral resolution of the high-resolution spectrometer is 0.01 nm with a coverage of 6 nm(@200-660 nm).The spatial resolution of each route of D-OES is about 4 cm with 11 channels.The temporal resolution is 16 ms at maximum in the single-channel mode.Wide-range spectra(containing Balmer series and a Fulcher band)and highly resolved Ha line shapes are obtained by D-OES in the hydrogen glow discharge in the lab.D-OES measurements are carried out in the high-density deuterium experiments of HL-2A.The electron density n_(e)and deuterium temperature T_(D) in the X-point multifaceted asymmetric radiation from the edge(MARFE)region are derived simultaneously by fitting the measured D_(a) shape.The density n_(e)is observed to increase from~8.7×10^(18)m^(-3)to~7.8×10^(19)m^(-3),and the temperature T_(D)drops from~14.4 eV to~2.3 eV after the onset of MARFE in the discharge#38260.展开更多
Background:Alpha-glucosidase inhibitors or dipeptidyl peptidase-4 inhibitors are both hypoglycemia agents that specifically impact on postprandial hyperglycemia.We compared the effects of acarbose and sitagliptin add ...Background:Alpha-glucosidase inhibitors or dipeptidyl peptidase-4 inhibitors are both hypoglycemia agents that specifically impact on postprandial hyperglycemia.We compared the effects of acarbose and sitagliptin add on to metformin on time in range(TIR)and glycemic variability(GV)in Chinese patients with type 2 diabetes mellitus through continuous glucose monitoring(CGM).Methods:This study was a randomized,open-label,active-controlled,parallel-group trial conducted at 15 centers in China from January 2020 to August 2022.We recruited patients with type 2 diabetes aged 18–65 years with body mass index(BMI)within 19–40 kg/m 2 and hemoglobin A1c(HbA1c)between 6.5%and 9.0%.Eligible patients were randomized to receive either metformin combined with acarbose 100 mg three times daily or metformin combined with sitagliptin 100 mg once daily for 28 days.After the first 14-day treatment period,patients wore CGM and entered another 14-day treatment period.The primary outcome was the level of TIR after treatment between groups.We also performed time series decomposition,dimensionality reduction,and clustering using the CGM data.Results:A total of 701 participants received either acarbose or sitagliptin treatment in combination with metformin.There was no statistically significant difference in TIR between the two groups.Time below range(TBR)and coefficient of variation(CV)levels in acarbose users were significantly lower than those in sitagliptin users.Median(25th percentile,75th percentile)of TBR below target level<3.9 mmol/L(TBR 3.9):Acarbose:0.45%(0,2.13%)vs.Sitagliptin:0.78%(0,3.12%),P=0.042;Median(25th percentile,75th percentile)of TBR below target level<3.0 mmol/L(TBR 3.0):Acarbose:0(0,0.22%)vs.Sitagliptin:0(0,0.63%),P=0.033;CV:Acarbose:22.44±5.08%vs.Sitagliptin:23.96±5.19%,P<0.001.By using time series analysis and clustering,we distinguished three groups of patients with representative metabolism characteristics,especially in GV(group with small wave,moderate wave and big wave).No significant difference was found in the complexity of glucose time series index(CGI)between acarbose users and sitagliptin users.By using time series analysis and clustering,we distinguished three groups of patients with representative metabolism characteristics,especially in GV.Conclusions:Acarbose had slight advantages over sitagliptin in improving GV and reducing the risk of hypoglycemia.Time series analysis of CGM data may predict GV and the risk of hypoglycemia.Trial Registration:Chinese Clinical Trial Registry:ChiCTR2000039424.展开更多
A gas puff imaging(GPI) diagnostic has been developed and applied to measure edge plasma turbulence on the HL-2A tokamak.The principle and experimental setup of GPI are described.GPI is applied to investigate blobs in...A gas puff imaging(GPI) diagnostic has been developed and applied to measure edge plasma turbulence on the HL-2A tokamak.The principle and experimental setup of GPI are described.GPI is applied to investigate blobs in the edge and scrape-off layer.Statistical characterizations of GPI line emission intensity are calculated, including the probability density functions(PDFs),skewness, and kurtosis of the intensity, which are found to be consistent with measurements by Langmuir probes.Besides, the track of blob motions is recorded by time sequence of individual frames.The characteristics of the original images and the relatively high-frequency(>10 kHz)/low-frequency(1–10 kHz) component images are illustrated.The observation of the blob’s structures and high-speed motions proves the success and high performance of the GPI diagnostic.展开更多
A CO2 laser-based phase contrast imaging(PCI) diagnostic has been developed on HL-2A tokamak.It can detect line integrated plasma density fluctuations by measuring the phase shift of laser beam after being scattered b...A CO2 laser-based phase contrast imaging(PCI) diagnostic has been developed on HL-2A tokamak.It can detect line integrated plasma density fluctuations by measuring the phase shift of laser beam after being scattered by the bulk plasma.The diagnosed radial region ranges from ρ≡r/a =0.625 to 0.7.32-channel HgCdTe detectors with alternative-current biased amplifiers are arranged in line at the imaging plane of the optical path.This PCI is able to diagnose density fluctuations with wavenumbers ranging from 2 to 15 cm-1 and the time resolution is better than 2 μs.The first experimental data were achieved in 2018 spring campaign of HL-2A tokamak.High performance is confirmed in different discharging configurations and makes it a keen tool in broadband turbulence investigations.展开更多
A newly developed Doppler coherence imaging spectroscopy(CIS)technique has been implemented in the HL-2 A tokamak for carbon impurity emissivity and flow measurement.In CIS diagnostics,the emissivity and flow profiles...A newly developed Doppler coherence imaging spectroscopy(CIS)technique has been implemented in the HL-2 A tokamak for carbon impurity emissivity and flow measurement.In CIS diagnostics,the emissivity and flow profiles inside the plasma are measured by a camera from the line-integrated emissivity and line-averaged flow,respectively.A standard inference method,called tomographic inversion,is necessary.Such an inversion is relatively challenging due to the ill-conditioned nature.In this article,we report the recent application and comparison of two different tomography algorithms,Gaussian process tomography and Tikhonov tomography,on light intensity measured by CIS,including feasibility and benchmark studies.Finally,the tomographic results for real measurement data in HL-2A are presented.展开更多
Several results based on the Langmuir probes’data on the HL-2A tokamak are presented.The blob structures’radial and poloidal drift velocities,estimated by the gradient of floating potential and by time delay evaluat...Several results based on the Langmuir probes’data on the HL-2A tokamak are presented.The blob structures’radial and poloidal drift velocities,estimated by the gradient of floating potential and by time delay evaluation,are compared in different line-averaged density and electron cyclotron resonance heating conditions.A positive correlation is observed in the comparison between blobs’radial velocity estimated by the two methods mentioned above,regardless of the situation differences mentioned above.Correlation is also observed in the comparison between the blobs’poloidal velocity estimated by the two methods in different situations,while a shift due to the different line-averaged density is observed.These results imply that the radial gradient of floating potential may have some value as a reference during data analysis in low-parameter discharge.展开更多
Oncolytic alphavirus M1 has been shown to selectively target and kill cancer cells,but cytopathic morphologies induced by M1 virus and the life cycle of the M1 strain in cancer cells remain unclear.Here,we study the k...Oncolytic alphavirus M1 has been shown to selectively target and kill cancer cells,but cytopathic morphologies induced by M1 virus and the life cycle of the M1 strain in cancer cells remain unclear.Here,we study the key stages of M1 virus infection and replication in the M1 virus-sensitive HepG2 liver cancer cell line by transmission electron microscopy,specifically examining viral entry,assembly,maturation and release.We found that M1 virus induces vacuolization of cancer cells during infection and ultimately nuclear marginalization,a typical indicator of apoptosis.Specifically,our results suggest that the endoplasmic reticulum participates in the assembly of nucleocapsids.In the early and late stage of infection,three kinds of special cytopathic vacuoles are formed and appear to be involved in the replication,maturation and release of the virus.Taken together,our data displayed the process of M1 virus infection of tumor cells and provide the structural basis for the study of M1 virus-host interactions.展开更多
This paper presents the characteristics of L-mode detachment,together with the behavior of edge turbulent transport and plasma confinement on the HL-2A tokamak.Partially detached and pronounced detached states have be...This paper presents the characteristics of L-mode detachment,together with the behavior of edge turbulent transport and plasma confinement on the HL-2A tokamak.Partially detached and pronounced detached states have been achieved in L-mode plasma.Stored energy was maintained before and after detachment.Edge turbulence and its transport have increased obviously in the partially detached state.In the pronounced detached state,redistribution of the density and temperature profiles due to detachment leads to low amplitude of electron temperature and pressure,as well as very weak edge turbulence and transport.Despite strong plasma radiation in the pronounced detached state,reduced edge turbulent transport contributes to maintaining stored energy in detached L-mode plasma in HL-2A.Different detachment states play an important role in the redistribution of density and temperature profiles,which requires further study.展开更多
基金support of these experiments.This work was supported by the National Natural Science Foundation of China(12405268,12175227,11875255,12375226,and 11975231)the National Magnetic Confinement Fusion Science Program of China(2022YFE03060003,2022YFE03100004)+1 种基金the Fundamental Research Funds for the Central Universities(WK2140000016)the China Postdoctoral Science Foundation(2022M723066).
文摘This study investigates the inward flux events following sawtooth crashes in the edge of HL-2A neutral beam heated plasmas.We identified three distinct types of inward fluxes with varying magnitudes and durations,each associated with unique plasma parameter fluctuations.Magnetic fluctuations,particularly the disruption of magnetic surface structures caused by sawtooth crashes,may play a significant role in modulating plasma dynamics.Moreover,the crossphase term and coherence between density and velocity fluctuations were found to be key factors in these flux events,with high coherence correlating with peak inward flux.These findings enhance the understanding of fluctuation-induced transport after sawtooth crashes and have implications for plasma confinement in fusion devices.
基金supported by the National Magnetic Confinement Fusion Science Program of China (Nos.2022YFE03100004,2017YFE0301700,2017YFE0301701 and 2022YFE03060003)National Natural Science Foundation of China (Nos.12375226,12175227,11875255 and 11975231)+2 种基金the China Postdoctoral Science Foundation (No.2022M723066)the Fundamental Research Funds for the Central Universitiesthe Collaborative Innovation Program of Hefei Science Center,CAS (No.2022HSCCIP022)。
文摘A 100-channel double-foil soft X-ray array imaging(DSXAI)diagnostic system has been developed for the HL-2A tokamak to obtain tomographic bremsstrahlung emissivity and electron temperature(T_(e)).This system employs a double-foil technique to determine T_(e) by comparing the soft X-ray(SXR)emissivities from the same plasma location through two beryllium(Be)foils of differing thickness.The DSXAI system comprises five photocameras mounted at two different poloidal cross-sections,separated toroidally by 15°,allowing for three distinct poloidal viewing angles.Each photocamera features 20 channels,offering a temporal resolution of approximately 4μs and a spatial resolution of about 8 cm,with no channel overlap.Each photocamera contains two identical optical systems,each defined by an aperture slit and a photodiode array.The double-foil configuration is realized by placing these two optical systems,each with a different Be foil,in close proximity.Initial experimental results demonstrate that the DSXAI diagnostic system performs well,successfully reconstructing 2-dimensional(2D)tomographic SXR emissivity and T_(e) on the HL-2A tokamak.This study provides valuable insights for the future implementation of similar diagnostic systems on fusion reactors like ITER.
基金supported by National Natural Science Foundation of China(No.12105067)the ITER Organization and China Domestic Agency for the support of this work(No.ITER5.5.P01.CN.05)。
文摘Researches on plasma-facing materials/components(PFMs/PFCs)have become a focus in magnetic confinement fusion studies,particularly for advanced tokamak operation scenarios.Similarly,spacecraft surface materials must maintain stable performance under relatively high temperatures and other harsh plasma conditions,making studies of their thermal and ablation resistance critical.Recently,a low-cost,low-energy-storage for superconducting magnets,and compact linear device,HIT-PSI,has been designed and constructed at Harbin Institute of Technology(HIT)to investigate the interaction between stable high heat flux plasma and PFMs/PFCs in scrape-off-layer(SOL)and divertor regions,as well as spacecraft surface materials.The parameters of the argon plasma beam of HIT-PSI are diagnosed using a water-cooled planar Langmuir probe and emission spectroscopy.As magnetic field rises to 2 T,the argon plasma beam generated by a cascaded arc source achieves high density exceeding 1.2×10^(21)m^(-3)at a distance of 25 cm from the source with electron temperature surpassing 4 eV,where the particle flux reaches 10^(24)m^(-2)s^(-1),and the heat flux loaded on the graphite target measured by infrared camera reaches 4 MW/m^(2).Combined with probe and emission spectroscopy data,the transport characteristics of the argon plasma beam are analyzed.
基金supported by the National Natural Science Foundation of China,No.81572191(to LC)and 81601067(to HZ)
文摘Progranulin is closely related to neuronal survival in a neuroinflammatory mouse model and attenuates inflammatory reactions. Atsttrin is an engineered protein composed of three progranulin fragments and has been shown to have an effect similar to that of progranulin. Atsttrin has anti-inflammatory actions in multiple arthritis mouse models, and it protects against further arthritis development. However, whether Atsttrin has a role in neuroinflammation remains to be elucidated. In this study, we produced a neuroinflammatory mouse model by intracerebroventricular injection of 1 μL lipopolysaccharide(10 μg/μL). Atsttrin(2.5 mg/kg) was administered via intraperitoneal injection every 3 days over a period of 7 days before intracerebroventricular injection of 1 μL lipopolysaccharide(10 μg/μL). In addition, astrocyte cultures were treated with 0, 100 or 300 ng/mL lipopolysaccharide, with 200 ng/mL Atsttrin simultaneously. Immunohistochemistry, enzyme-linked immunosorbent assay and real-time reverse transcription-polymerase chain reaction were performed to examine the protein and mRNA levels of inflammatory mediators and to assess activation of the nuclear factor kappa B signaling pathway. Progranulin expression in the brain of wild-type mice and in astrocyte cultures was increased after lipopolysaccharide administration. The protein and mRNA expression levels of tumor necrosis factor-α, interleukin-1β and inducible nitric oxide synthase were increased in the brain of progranulin knockout mice after lipopolysaccharide administration. Atsttrin treatment reduced the lipopolysaccharide-induced increase in the protein and mRNA levels of tumor necrosis factor-α, interleukin-1β, matrix metalloproteinase-3 and inducible nitric oxide synthase in the brain of progranulin knockout mice. Atsttrin also reduced the expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase 3 mRNA in lipopolysaccharide-treated astrocytes in vitro, and decreased the concentration of tumor necrosis factor α and interleukin-1β in the supernatant. Furthermore, Atsttrin significantly reduced the levels of phospho-nuclear factor kappa B inhibitor α in the brain of lipopolysaccharide-treated progranulin knockout mice and astrocytes, and it decreased the expression of nuclear factor kappa B2 in astrocytes. Collectively, our findings show that the anti-neuroinflammatory effect of Atsttrin involves inhibiton of the nuclear factor kappa B signaling pathway, and they suggest that Atsttrin may have clinical potential in neuroinflammatory therapy.
基金supported by the National Key R&D Program of China(Nos.2022YFE03100002,2017YFE0301201 and 2018YFE0303102)Sichuan Science and Technology Program(Nos.2022JDJQ0038 and 2020JDTD0030)National Natural Science Foundation of China(No.12205087)。
文摘In this article,the design of a Lyman-alpha-based beam emission spectroscopy(LAB)diagnostic on the HL-2A tokamak has been proposed for the first time.The purpose of this novel diagnostic is to measure density fluctuations of tokamak plasma.The light-collection system of LAB,which consists of the first mirror and two groups of coaxial double-mirror telescopes,can realize a twosegmented viewing field ofρ=0–0.2 andρ=0.75–1,which is optimized to measure plasma density fluctuation,not only in the edge transport barrier region but also in the internal transport barrier region,to investigate the underlying physics of turbulence in tokamaks.Spectrometers are developed to separate out the Doppler-shifted target line(122.03 and 122.17 nm)from the background Lyman-alpha line(121.53 nm).Here,30 Core-LAB channels and 30 Edge-LAB channels are under development on the HL-2A tokamak.It has high radial spatial resolutions of about 2.7 mm and 3.3 mm for the core and edge channels,respectively.Taking the high light intensity of this Lyman-alpha line into account,temporal resolution of 200 k Hz can be ensured by broad bandwidth amplifiers.This high spatio-temporal resolution makes LAB a potential keen tool to experimentally investigate tokamak plasma physics.
基金partially supported by the National Natural Science Foundation of China (Grant No. 11875020)the National Key R&D Program of China (Grant No. 2019YFE03030002)。
文摘The scaling law of divertor heat flux width is one of the key topics of magnetic confinement fusion,which is almost inversely proportional to the poloidal magnetic field on some opened divertor tokamaks.This work focuses on the scaling laws of the closed divertor heat flux width in the HL-2 A tokamak under different discharge conditions,such as the Ohmic,L-and H-modes.The results indicate that there are basic similarities of the scaling laws of the heat flux width between the opened and closed divertors.However,a larger spreading width in the private flux region is found,which is relevant to a small expansion factor of the magnetic flux in the closed divertor.
基金supported by the GHfund A(202302017475)supported by the Foundation for Distinguished Young Scholars of Jiangsu Province(No.BK20140050)+5 种基金the National Natural Science Foundation of China(Nos.11973070,11333008,11273061,11825303,and 11673065)the China Manned Space Project with No.CMS-CSST-2021-A01,CMSCSST-2021-A03,CMS-CSST-2021-B01the Joint Funds of the National Natural Science Foundation of China(No.U1931210)the support from Key Research Program of Frontier Sciences,CAS,grant No.ZDBS-LY-7013Program of Shanghai Academic/Technology Research Leaderthe support from the science research grants from the China Manned Space Project with CMS-CSST-2021-A04,CMS-CSST-2021-A07。
文摘We have developed a novel method for co-adding multiple under-sampled images that combines the iteratively reweighted least squares and divide-and-conquer algorithms.Our approach not only allows for the anti-aliasing of the images but also enables Point-Spread Function(PSF)deconvolution,resulting in enhanced restoration of extended sources,the highest peak signal-to-noise ratio,and reduced ringing artefacts.To test our method,we conducted numerical simulations that replicated observation runs of the China Space Station Telescope/the VLT Survey Telescope(VST)and compared our results to those obtained using previous algorithms.The simulation showed that our method outperforms previous approaches in several ways,such as restoring the profile of extended sources and minimizing ringing artefacts.Additionally,because our method relies on the inherent advantages of least squares fitting,it is more versatile and does not depend on the local uniformity hypothesis for the PSF.However,the new method consumes much more computation than the other approaches.
基金supported by Sichuan Science and Technology Program(No.2022JDJQ0038)the National Key R&D Program of China(Nos.2022YFE03100002 and 2018YFE0303102)National Natural Science Foundation of China(Nos.12205087 and 12075241)。
文摘An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the HL-2A tokamak.The 20-channel edge LyBES,which is intended to measure the density fluctuation in plasma edge(from R=1960 mm to R=2026 mm)with an improved spatial resolution of 3.3 mm,is a complement to the existing conventional beam emission spectroscopy(BES)diagnostic.In this article,we introduce the progress of LyBES diagnostic,including the collection optics,the monochromator,and the detector system.The reflectance of the collection mirrors is measured to be~82%at 122 nm,and the aberration geometrical radius of the collection optics is tested to be~150μm in the aimed area.The linear dispersion of the LyBES monochromator is designed to be~0.09 nm mm^(-1).The bandwidth of the detector system with the 5×10^(7)V A^(-1)preamplifier gain is measured to be~280 kHz,and the peak-to-peak noise of the detector system is tested to be~16 mV.The finalized design,components development and testing of the LyBES diagnostic have been completed at present,and an overall performance of the LyBES diagnostic is to be confirmed in the next HL-2A campaign.
基金partially supported by the National Key R&D Program of China(Nos.2019YFE03030002 and 2022YFE03030001)National Natural Science Foundation of China(Nos.12175186 and 12175055)the Natural Science Foundation of Sichuan Province(Nos.2022NSFSC1820 and 2023NSFSC1289)。
文摘This paper reports an improved time-delay estimation(TDE)technique for the derivation of turbulence structures based on gas-puff imaging data.The improved TDE technique,integrating an inverse timing search and hierarchical strategy,offers superior accuracy in calculating turbulent velocity field maps and analyzing blob dynamics,which has the power to obtain the radial profiles of equilibrium poloidal velocity,blob size and its radial velocity,even the fluctuation analysis,such as geodesic acoustic modes and quasi-coherent mode,etc.This improved technique could provide important 2D information for the study of edge turbulence and blob dynamics,advancing the understanding of edge turbulence physics in fusion plasmas.
基金supported by the National Key Research and Development Program of China(Nos.2019YFE03090100 and 2022YFE03100002)National Natural Science Foundation of China(No.12075241)。
文摘The optical design of near-infrared phase contrast imaging(NI-PCI)diagnosis on HL-2A is introduced in this paper.This scheme benefits from the great progress of near-infrared laser technology and is a broadening of traditional phase contrast technology.This diagnostic can work as a keen tool to measure plasma wavenumber spectra by inferring string-integrated plasma density fluctuations.Design of both the front optical path which is the path before the laser transmitting into the tokamak plasma and the rear optics which is the path after the laser passing through the plasma is detailed.The 1550 nm laser is chosen as the probe beam and highprecision optical components are designed to fit the laser beam,in which a phase plate with a 194-nm-deep silver groove is the key.Compared with the conventional 10.6μm laser-based PCI system on HL-2A,NI-PCI significantly overcomes the unwanted phase scintillation effect and promotes the measurement capability of high-wavenumber turbulence with an increased maximal measurable wavenumber from 15 cm^(-1)to 32.6 cm^(-1).
基金supported by the National MCF Energy R&D Program of China(Nos.2018YFE0301102,2022YFE03100004 and 2018YFE 0303102)National Natural Science Foundation of China(Nos.12375210 and 12305238)the Sichuan Natural Science Foundation(Nos.2022NSFSC1791,2022JDRC0014 and 2022TFQCCXTD)。
文摘A dual-route optical emission spectroscopy(D-OES)diagnostic is newly developed to monitor the optical emission from the X-point plasma region on the HL-2 A tokamak.This diagnostic is composed of an imaging system,a beam-splitting system for dual-route measurements,fiber bundles,a spectrometer system,and a control and acquisition system.One route is used to obtain wide-spectral-range spectra,and the other route is used to acquire high-wavelengthresolution line shapes.The spectral resolution of the wide-range spectrometers is 0.8 nm with a coverage of 800 nm(@200-1000 nm).The spectral resolution of the high-resolution spectrometer is 0.01 nm with a coverage of 6 nm(@200-660 nm).The spatial resolution of each route of D-OES is about 4 cm with 11 channels.The temporal resolution is 16 ms at maximum in the single-channel mode.Wide-range spectra(containing Balmer series and a Fulcher band)and highly resolved Ha line shapes are obtained by D-OES in the hydrogen glow discharge in the lab.D-OES measurements are carried out in the high-density deuterium experiments of HL-2A.The electron density n_(e)and deuterium temperature T_(D) in the X-point multifaceted asymmetric radiation from the edge(MARFE)region are derived simultaneously by fitting the measured D_(a) shape.The density n_(e)is observed to increase from~8.7×10^(18)m^(-3)to~7.8×10^(19)m^(-3),and the temperature T_(D)drops from~14.4 eV to~2.3 eV after the onset of MARFE in the discharge#38260.
文摘Background:Alpha-glucosidase inhibitors or dipeptidyl peptidase-4 inhibitors are both hypoglycemia agents that specifically impact on postprandial hyperglycemia.We compared the effects of acarbose and sitagliptin add on to metformin on time in range(TIR)and glycemic variability(GV)in Chinese patients with type 2 diabetes mellitus through continuous glucose monitoring(CGM).Methods:This study was a randomized,open-label,active-controlled,parallel-group trial conducted at 15 centers in China from January 2020 to August 2022.We recruited patients with type 2 diabetes aged 18–65 years with body mass index(BMI)within 19–40 kg/m 2 and hemoglobin A1c(HbA1c)between 6.5%and 9.0%.Eligible patients were randomized to receive either metformin combined with acarbose 100 mg three times daily or metformin combined with sitagliptin 100 mg once daily for 28 days.After the first 14-day treatment period,patients wore CGM and entered another 14-day treatment period.The primary outcome was the level of TIR after treatment between groups.We also performed time series decomposition,dimensionality reduction,and clustering using the CGM data.Results:A total of 701 participants received either acarbose or sitagliptin treatment in combination with metformin.There was no statistically significant difference in TIR between the two groups.Time below range(TBR)and coefficient of variation(CV)levels in acarbose users were significantly lower than those in sitagliptin users.Median(25th percentile,75th percentile)of TBR below target level<3.9 mmol/L(TBR 3.9):Acarbose:0.45%(0,2.13%)vs.Sitagliptin:0.78%(0,3.12%),P=0.042;Median(25th percentile,75th percentile)of TBR below target level<3.0 mmol/L(TBR 3.0):Acarbose:0(0,0.22%)vs.Sitagliptin:0(0,0.63%),P=0.033;CV:Acarbose:22.44±5.08%vs.Sitagliptin:23.96±5.19%,P<0.001.By using time series analysis and clustering,we distinguished three groups of patients with representative metabolism characteristics,especially in GV(group with small wave,moderate wave and big wave).No significant difference was found in the complexity of glucose time series index(CGI)between acarbose users and sitagliptin users.By using time series analysis and clustering,we distinguished three groups of patients with representative metabolism characteristics,especially in GV.Conclusions:Acarbose had slight advantages over sitagliptin in improving GV and reducing the risk of hypoglycemia.Time series analysis of CGM data may predict GV and the risk of hypoglycemia.Trial Registration:Chinese Clinical Trial Registry:ChiCTR2000039424.
基金supported by the National Key Research and Development Program of China (No.2017YFE0300405)National Natural Science Foundation of China (Nos.11575055, 11705052, 11875124, 11475058, and 11475056)+1 种基金the National Key Research and Development Program of China (Nos.2017YFE0301201, 2018YFE0303102, 2018YFE0309103)the Chinese National Fusion Project for ITER (No.2015GB104000)
文摘A gas puff imaging(GPI) diagnostic has been developed and applied to measure edge plasma turbulence on the HL-2A tokamak.The principle and experimental setup of GPI are described.GPI is applied to investigate blobs in the edge and scrape-off layer.Statistical characterizations of GPI line emission intensity are calculated, including the probability density functions(PDFs),skewness, and kurtosis of the intensity, which are found to be consistent with measurements by Langmuir probes.Besides, the track of blob motions is recorded by time sequence of individual frames.The characteristics of the original images and the relatively high-frequency(>10 kHz)/low-frequency(1–10 kHz) component images are illustrated.The observation of the blob’s structures and high-speed motions proves the success and high performance of the GPI diagnostic.
基金supported by the National Key Research and Development Program of China (No.2017YFE0300405)National Natural Science Foundation of China (Nos.11875124, 11705052, 11575055 and 11611130164)the National Magnetic Confinement Fusion Science Program of China (No.2015GB120002)
文摘A CO2 laser-based phase contrast imaging(PCI) diagnostic has been developed on HL-2A tokamak.It can detect line integrated plasma density fluctuations by measuring the phase shift of laser beam after being scattered by the bulk plasma.The diagnosed radial region ranges from ρ≡r/a =0.625 to 0.7.32-channel HgCdTe detectors with alternative-current biased amplifiers are arranged in line at the imaging plane of the optical path.This PCI is able to diagnose density fluctuations with wavenumbers ranging from 2 to 15 cm-1 and the time resolution is better than 2 μs.The first experimental data were achieved in 2018 spring campaign of HL-2A tokamak.High performance is confirmed in different discharging configurations and makes it a keen tool in broadband turbulence investigations.
文摘A newly developed Doppler coherence imaging spectroscopy(CIS)technique has been implemented in the HL-2 A tokamak for carbon impurity emissivity and flow measurement.In CIS diagnostics,the emissivity and flow profiles inside the plasma are measured by a camera from the line-integrated emissivity and line-averaged flow,respectively.A standard inference method,called tomographic inversion,is necessary.Such an inversion is relatively challenging due to the ill-conditioned nature.In this article,we report the recent application and comparison of two different tomography algorithms,Gaussian process tomography and Tikhonov tomography,on light intensity measured by CIS,including feasibility and benchmark studies.Finally,the tomographic results for real measurement data in HL-2A are presented.
基金supported by the National Key Research and Development Program of China(Nos.2017YFE0300500,2017YFE0300501)No.2018YFE0309100National Natural Science Foundation of China(Nos.11705052,11875124,11905050,11875020 and U1867222)。
文摘Several results based on the Langmuir probes’data on the HL-2A tokamak are presented.The blob structures’radial and poloidal drift velocities,estimated by the gradient of floating potential and by time delay evaluation,are compared in different line-averaged density and electron cyclotron resonance heating conditions.A positive correlation is observed in the comparison between blobs’radial velocity estimated by the two methods mentioned above,regardless of the situation differences mentioned above.Correlation is also observed in the comparison between the blobs’poloidal velocity estimated by the two methods in different situations,while a shift due to the different line-averaged density is observed.These results imply that the radial gradient of floating potential may have some value as a reference during data analysis in low-parameter discharge.
基金This research was supported by the Science and Technology Program of Guangzhou(201707020003)the Pioneering Talents Project of Guangzhou Development Zone,Guangdong Province(CY2018-012)+2 种基金the Guangzhou People's Livelihood Science and Technology Tackling Key Project(201803010113)the Young Teacher Training Program of Sun Yat-sen University(20ykpy22)the National Natural Science Foundation of China(No.81802536).
文摘Oncolytic alphavirus M1 has been shown to selectively target and kill cancer cells,but cytopathic morphologies induced by M1 virus and the life cycle of the M1 strain in cancer cells remain unclear.Here,we study the key stages of M1 virus infection and replication in the M1 virus-sensitive HepG2 liver cancer cell line by transmission electron microscopy,specifically examining viral entry,assembly,maturation and release.We found that M1 virus induces vacuolization of cancer cells during infection and ultimately nuclear marginalization,a typical indicator of apoptosis.Specifically,our results suggest that the endoplasmic reticulum participates in the assembly of nucleocapsids.In the early and late stage of infection,three kinds of special cytopathic vacuoles are formed and appear to be involved in the replication,maturation and release of the virus.Taken together,our data displayed the process of M1 virus infection of tumor cells and provide the structural basis for the study of M1 virus-host interactions.
基金National Key Research and Development Program of China(Nos.2018YFE0303102,2018YFE0309103,2017YFE0300405 and 2017YFE0301203)National Natural Science Foundation of China(Nos.U1867222,11875124,11905051,11805055 and 11875020)Sichuan Youth Science and Technology Innovation Team Project(No.2020JDTD0030)。
文摘This paper presents the characteristics of L-mode detachment,together with the behavior of edge turbulent transport and plasma confinement on the HL-2A tokamak.Partially detached and pronounced detached states have been achieved in L-mode plasma.Stored energy was maintained before and after detachment.Edge turbulence and its transport have increased obviously in the partially detached state.In the pronounced detached state,redistribution of the density and temperature profiles due to detachment leads to low amplitude of electron temperature and pressure,as well as very weak edge turbulence and transport.Despite strong plasma radiation in the pronounced detached state,reduced edge turbulent transport contributes to maintaining stored energy in detached L-mode plasma in HL-2A.Different detachment states play an important role in the redistribution of density and temperature profiles,which requires further study.
