【目的】了解天宝岩国家级自然保护区森林演替发展趋势,可以更好地为保护区制定管理政策保护珍稀植物和生物多样性提供科学依据。【方法】借助空间直观景观模型LANDIS Pro 7.0对福建天宝岩国家级自然保护区未来300年(2016—2316年)的森...【目的】了解天宝岩国家级自然保护区森林演替发展趋势,可以更好地为保护区制定管理政策保护珍稀植物和生物多样性提供科学依据。【方法】借助空间直观景观模型LANDIS Pro 7.0对福建天宝岩国家级自然保护区未来300年(2016—2316年)的森林景观演变进行模拟,采用Fragstats 3.3景观格局分析软件对树种面积变化、景观聚集度、分维度、多样性指数进行分析,并对各个树种在模拟时间内的龄级组成进行分析。【结果】在演替时段内,除毛竹林外所有树种斑块分维度均在1.00~1.06之间,表明其景观斑块形状较规则且变化不大。多样性指数呈现先上升后下降趋势,均匀度指数呈现先下降后上升的趋势,且变化速度在逐渐变缓,表明树种逐渐趋于稳定。阔叶林聚集度先增加后保持稳定,其面积则始终保持增长,至演替结束,以成熟林和幼龄林为主;猴头杜鹃林、长苞铁杉林聚集度在整个演替时段内呈增加趋势,其面积在演替中后期有所增加,且以幼龄林的增加为主;杉木林面积在前150年增长,此期间幼龄林比重也在逐渐上升;后150年面积保持稳定,至演替结束,以中龄林和近熟林为主;聚集度虽保持稳定但略有增加;柳杉林聚集度在演替前100年保持稳定而后200年有所降低,至演替后期,整个柳杉林以过熟林为主,中龄林次之;马尾松林在整个演替过程中均以过熟林为主,幼龄林和中龄林比例很低;毛竹林在演替后期以过熟林占据主要地位,其次是成熟林;且马尾松林和毛竹林在演替期间聚集度均呈现降低的趋势。【结论】天宝岩森林景观的演替会依据一定的规律向顶级群落常绿阔叶林演替;马尾松林、柳杉林、毛竹林在群落中随时间的推移会逐渐被取代;杉木林、长苞铁杉林和猴头杜鹃林,在演替时段内表现出良好的发展趋势。展开更多
OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomize...OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomized, single-blind, placebo controlled trial was conducted. Children with intermittent asthma were enrolled and their baseline conditions were measured using a questionnaire. A total of 60 participants, aged 2 to 5, were randomized into either the treatment group(n = 40) or the placebo group(n = 20). The treatment group was treated with granules of TCM herbs for tonifying Qi and kidney, and replenishing spleen, and the placebo group was given placebo granules for 3 months.The number of asthma attacks was counted and TCM syndrome scores were measured at 1, 2, 3, 6, 9,and 12 months. The airway resistance and levels of eosinophil cationic protein for the two groups were observed before and after 3 months. The results were statistically analyzed.RESULTS: Compared with the placebo group, the number of asthma attacks significantly decreased in the treatment group(P < 0.05). For the treatment group, the TCM syndrome scores decreased after 1 and 2 months; there was also a significant difference in scores between the two groups(P < 0.05).The difference remained after the medicine was stopped for 9 months(P < 0.05). After the 3-month treatment, compared with the placebo group, the airway resistance decreased in the treatment group(P < 0.05). No adverse events were reported in the treatment group.CONCLUSION: The TCM herbs for tonifying Qi and kidney, and replenishing spleen reduced the number of intermittent asthma attacks, decreased the TCM syndrome scores, and reduced the airway resistance in the children aged 2 to 5.展开更多
OBJECTIVE: To assess the efficacy of Bushenjianpi prescription(BSJPP), a formula from Traditional Chinese Medicine, on a mouse model of autoimmune premature ovarian failure(POF) induced by mouse zona pellucida(ZP3) an...OBJECTIVE: To assess the efficacy of Bushenjianpi prescription(BSJPP), a formula from Traditional Chinese Medicine, on a mouse model of autoimmune premature ovarian failure(POF) induced by mouse zona pellucida(ZP3) and to investigate the mechanisms underlying the action.METHODS: After randomization, POF was induced in the model mice by immunization with ZP3. One week later, mice received low(8.1 mg/kg), moderate(16.2 mg/kg) and high(32.4 mg/kg) doses of BSJPP by gastrogavage once daily for 90 days. Premarin(0.03 mg/kg) served as the positive group. Serum samples were collected 1 week after the last dose and stored at-20 ℃ for analysis. After cervical dislocation, the uterus and ovaries were collected aseptically for evaluation by histological assessment, scanning electron microscopy, immunohistochemical staining, and Western blot and reverse transcription-polymerase chain reaction analyses.RESULTS: Serum E2 levels in POF model mice were decreased, whereas follicle-stimulating hormone(FSH) and luteinizing hormone(LH) levels were dramatically increased. Serum levels of E2,LH and FSH were reduced in POF model mice treated with BSJPP(moderate and high doses) and premarin. Anti-bone morphogenetic protein 15(BMP-15) and connexin 43(Cx43) were repressed in autoimmune POF model mice, whereas high expression was observed in control mice and those treated with BSJPP(moderate and high doses)and premarin.CONCLUSION: BSJPP is effective in treating ZP3-induced POF in mice and the increase in the expression of BMP-15 and Cx43 may be implicated in the mechanism underpinning the action.展开更多
To promote the development of Traditional Chinese Medicine (TCM), it is necessary to innovate the traditional prescription. It is feasible to use one or several components to substitute TCM, which can be regarded as a...To promote the development of Traditional Chinese Medicine (TCM), it is necessary to innovate the traditional prescription. It is feasible to use one or several components to substitute TCM, which can be regarded as a process of discarding the dregs and preserving the essential components. In this way, traditional prescription can be converted into various combinations of pharmacological ingredients deriving from several TCMs. Furthermore, some of pharmacological ingredients should be modified to increase their efficacy. It is practical to select the main structural unit with specific substituents having strong pharmacological activity. After the innovation mentioned above, the prescription will evolve into a variety of modified components having distinct pharmacological activity, and this is the novel integration of active ingredients.展开更多
文摘【目的】了解天宝岩国家级自然保护区森林演替发展趋势,可以更好地为保护区制定管理政策保护珍稀植物和生物多样性提供科学依据。【方法】借助空间直观景观模型LANDIS Pro 7.0对福建天宝岩国家级自然保护区未来300年(2016—2316年)的森林景观演变进行模拟,采用Fragstats 3.3景观格局分析软件对树种面积变化、景观聚集度、分维度、多样性指数进行分析,并对各个树种在模拟时间内的龄级组成进行分析。【结果】在演替时段内,除毛竹林外所有树种斑块分维度均在1.00~1.06之间,表明其景观斑块形状较规则且变化不大。多样性指数呈现先上升后下降趋势,均匀度指数呈现先下降后上升的趋势,且变化速度在逐渐变缓,表明树种逐渐趋于稳定。阔叶林聚集度先增加后保持稳定,其面积则始终保持增长,至演替结束,以成熟林和幼龄林为主;猴头杜鹃林、长苞铁杉林聚集度在整个演替时段内呈增加趋势,其面积在演替中后期有所增加,且以幼龄林的增加为主;杉木林面积在前150年增长,此期间幼龄林比重也在逐渐上升;后150年面积保持稳定,至演替结束,以中龄林和近熟林为主;聚集度虽保持稳定但略有增加;柳杉林聚集度在演替前100年保持稳定而后200年有所降低,至演替后期,整个柳杉林以过熟林为主,中龄林次之;马尾松林在整个演替过程中均以过熟林为主,幼龄林和中龄林比例很低;毛竹林在演替后期以过熟林占据主要地位,其次是成熟林;且马尾松林和毛竹林在演替期间聚集度均呈现降低的趋势。【结论】天宝岩森林景观的演替会依据一定的规律向顶级群落常绿阔叶林演替;马尾松林、柳杉林、毛竹林在群落中随时间的推移会逐渐被取代;杉木林、长苞铁杉林和猴头杜鹃林,在演替时段内表现出良好的发展趋势。
基金Supported by the Research Fund of Capital Medical Development(Traditional Chinese Medicine):Function Evaluation on Influence of TCM Herbs for Tonifying Qi and Kidney,and Replenishing Spleen To Children with Intermittent Asthma(No.SF-2007-Ⅲ-16)
文摘OBJECTIVE: To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM) herbs for tonifying Qi and kidney, and replenishing spleen on intermittent asthma in children aged 2 and 5 years.METHODS: A randomized, single-blind, placebo controlled trial was conducted. Children with intermittent asthma were enrolled and their baseline conditions were measured using a questionnaire. A total of 60 participants, aged 2 to 5, were randomized into either the treatment group(n = 40) or the placebo group(n = 20). The treatment group was treated with granules of TCM herbs for tonifying Qi and kidney, and replenishing spleen, and the placebo group was given placebo granules for 3 months.The number of asthma attacks was counted and TCM syndrome scores were measured at 1, 2, 3, 6, 9,and 12 months. The airway resistance and levels of eosinophil cationic protein for the two groups were observed before and after 3 months. The results were statistically analyzed.RESULTS: Compared with the placebo group, the number of asthma attacks significantly decreased in the treatment group(P < 0.05). For the treatment group, the TCM syndrome scores decreased after 1 and 2 months; there was also a significant difference in scores between the two groups(P < 0.05).The difference remained after the medicine was stopped for 9 months(P < 0.05). After the 3-month treatment, compared with the placebo group, the airway resistance decreased in the treatment group(P < 0.05). No adverse events were reported in the treatment group.CONCLUSION: The TCM herbs for tonifying Qi and kidney, and replenishing spleen reduced the number of intermittent asthma attacks, decreased the TCM syndrome scores, and reduced the airway resistance in the children aged 2 to 5.
基金Supported by Fundamental and Frontier Research Fund of Henan Provincial Science and Technology Department(Grant No.15106)Fundamental and Frontier Research Fund of Henan Provincial Science and Technology Department(Grant No.142300410415)
文摘OBJECTIVE: To assess the efficacy of Bushenjianpi prescription(BSJPP), a formula from Traditional Chinese Medicine, on a mouse model of autoimmune premature ovarian failure(POF) induced by mouse zona pellucida(ZP3) and to investigate the mechanisms underlying the action.METHODS: After randomization, POF was induced in the model mice by immunization with ZP3. One week later, mice received low(8.1 mg/kg), moderate(16.2 mg/kg) and high(32.4 mg/kg) doses of BSJPP by gastrogavage once daily for 90 days. Premarin(0.03 mg/kg) served as the positive group. Serum samples were collected 1 week after the last dose and stored at-20 ℃ for analysis. After cervical dislocation, the uterus and ovaries were collected aseptically for evaluation by histological assessment, scanning electron microscopy, immunohistochemical staining, and Western blot and reverse transcription-polymerase chain reaction analyses.RESULTS: Serum E2 levels in POF model mice were decreased, whereas follicle-stimulating hormone(FSH) and luteinizing hormone(LH) levels were dramatically increased. Serum levels of E2,LH and FSH were reduced in POF model mice treated with BSJPP(moderate and high doses) and premarin. Anti-bone morphogenetic protein 15(BMP-15) and connexin 43(Cx43) were repressed in autoimmune POF model mice, whereas high expression was observed in control mice and those treated with BSJPP(moderate and high doses)and premarin.CONCLUSION: BSJPP is effective in treating ZP3-induced POF in mice and the increase in the expression of BMP-15 and Cx43 may be implicated in the mechanism underpinning the action.
基金Supported by Natural Science Foundation-funded Project:study of velvet antler polypeptides differentiating mesenchymal stem cells toward neurons in vitro(No.81470171)Natural Science Foundation-funded Project:Suxiaopingchuan prescription can therapy model mice of airway remodeling in asthma and reduce the inflammatory secretion of sensitized nci-h292 cells by inhibiting the TGFβ1-SMAD3-SMURF2 signaling pathway(81803915)
文摘To promote the development of Traditional Chinese Medicine (TCM), it is necessary to innovate the traditional prescription. It is feasible to use one or several components to substitute TCM, which can be regarded as a process of discarding the dregs and preserving the essential components. In this way, traditional prescription can be converted into various combinations of pharmacological ingredients deriving from several TCMs. Furthermore, some of pharmacological ingredients should be modified to increase their efficacy. It is practical to select the main structural unit with specific substituents having strong pharmacological activity. After the innovation mentioned above, the prescription will evolve into a variety of modified components having distinct pharmacological activity, and this is the novel integration of active ingredients.
