To realize the application of electromagnetic wave absorption(EWA)devices in humid marine environments,bifunctional EWA materials with better EWA capacities and anticorrosion properties have great exploration signific...To realize the application of electromagnetic wave absorption(EWA)devices in humid marine environments,bifunctional EWA materials with better EWA capacities and anticorrosion properties have great exploration significance and systematic research re-quirements.By utilizing the low-cost and excellent magnetic and stable chemical characteristics of barium ferrite(BaFe_(12)O_(19))and using the high dielectric loss and excellent chemical inertia of nanocarbon clusters,a new type of nanocomposites with carbon nanoclusters en-capsulating BaFe_(12)O_(19)was designed and synthesized by combining an impregnation method and a high-temperature calcination strategy.Furthermore,Ce-Mn ions were introduced into the BaFe_(12)O_(19)lattice to improve the dielectric and magnetic properties of BaFe_(12)O_(19)cores significantly,and the energy band structure of the doped lattice and the orders of Ce replacing Fe sites were calculated.Benefiting from Ce-Mn ion doping and carbon nanocluster encapsulation,the composite material exhibited excellent dual functionality of corrosion resist-ance and EWA.When BaCe_(0.2)Mn_(0.3)Fe_(11.5)O_(19)-C(BCM-C)was calcined at 600°C,the minimum reflection loss of-20.1 dB was achieved at 14.43 GHz.The Ku band’s effective absorption bandwidth of 4.25 GHz was achieved at an absorber thickness of only 1.3 mm.The BCM-C/polydimethylsiloxane coating had excellent corrosion resistance in the simulated marine environment(3.5wt%NaCl solution).The|Z|0.01Hz value of BCM-C remained at 106Ω·cm^(2)after 12 soaking days.The successful preparation of the BaFe_(12)O_(19)composite en-capsulated with carbon nanoclusters provides new insights into the preparation of multifunctional absorbent materials and the fabrication of absorbent devices applied in humid marine environments in the future.展开更多
BACKGROUND Acute drug-induced liver injury(DILI)events caused by chronic liver disease are relatively common.Some researchers believe that nonalcoholic fatty liver(NAFL)increases the overall risk of DILI.The clinical ...BACKGROUND Acute drug-induced liver injury(DILI)events caused by chronic liver disease are relatively common.Some researchers believe that nonalcoholic fatty liver(NAFL)increases the overall risk of DILI.The clinical characteristics and prognosis of DILI in the context of NAFL disease(NAFLD)are still unclear.Therefore,hospitalized patients with NAFLD combined with DILI at the Tianjin Second People's Hospital were included in this study.The clinical manifestations,classifications,severities,laboratory indicators,and clinical outcomes of the enrolled patients were analyzed,and the clinical characteristics and prognoses of the NAFL+DILI patients were evaluated.AIM To investigate the clinical characteristics and prognosis of DILI in the context of NAFL.METHODS Eighty-nine patients diagnosed with DILI and 110 patients diagnosed with both DILI and NAFL at the Tianjin Second People's Hospital were enrolled.Clinical data,including demographic characteristics,clinical features,laboratory test results,pathology findings,autoantibody titers,suspected drugs,and outcomes,were collected from the two groups of patients.All enrolled patients were followed up to determine the liver function recovery time.RESULTS Compared with the patients in the DILI group,those in the NAFL+DILI group had higher body mass indices;Controlled Attenuation Parameter scores;and triglyceride,total cholesterol,low-density lipoprotein,and insulin levels.The levels of the cytokines interleukin-4 and complement complement c3(C3)were also greater in the NAFL+DILI group than in the DILI group.The proportions of patients with cholestatic-type DILI(16.4%vs 4.5%),cholestasis seen on pathoscopy(40.9%vs 25.8%),grade 2 or above DILI(48.18%vs 40.45%),and a recovery time for liver function ranging from 90 to 180 days(30.6%vs 15.5%)were greater in the NAFL+DILI group than in the DILI group.All of the abovementioned differences between the groups were statistically significant(P<0.05).The autoantibody positivity rates did not significantly differ between the two groups(P>0.05),and the proportions of patients who progressed to chronic drug hepatitis or autoimmune hepatitis were not significantly different between the two groups(both P>0.05).CONCLUSION In the context of NAFL,DILI is more likely to be cholestatic,with a greater degree of liver injury,a longer recovery time,and more pronounced expression of immune factors.展开更多
The single-layer Ti_(3)C_(2)T_(x)/MXene has become a special electromagnetic wave absorber near the terahertz band because of its abundant surface groups and excellent conductivity.However,the macro-preparation of sin...The single-layer Ti_(3)C_(2)T_(x)/MXene has become a special electromagnetic wave absorber near the terahertz band because of its abundant surface groups and excellent conductivity.However,the macro-preparation of single-layer Ti_(3)C_(2)T_(x)/MXene shows significantly difficult to influence its application.The two-dimensional Ti_(3)C_(2)T_(x)is easily prepared to have high production,but its weak absorption ability due to high surface conductivity also restricts its application.To realize the strong electromagnetic wave absorption of two-dimensional Ti_(3)C_(2)T_(x)/MXene,a new strategy with magnetic FeNi nanoparticles decorating Ti_(3)C_(2)T_(x)/MXene composites(FeNi-Ti_(3)C_(2)T_(x))were proposed and the effective electromagnetic wave absorption features covering 170-220 GHz that means the absorption band width reach 50 GHz.With an absorber composite film thickness being only 0.6 mm,the absorptivity of the composite is enhanced with the increase of decorating FeNi nanoparticles and promote up to 75%when the FeNi nanoparticles loading content reaches 30 wt%.The improvement of absorption is attributed to the introduction of soft magnetic FeNi to adjust the high surface conductivity of MXene and improve the electromagnetic balance of the absorber.展开更多
Objective： To evaluate the short-term clinical outcomes of intracranial germinoma patients treated with craniospinal irradiation （CSI） using helical tomotherapy （HT） system in our center. Methods： Twenty-three p...Objective： To evaluate the short-term clinical outcomes of intracranial germinoma patients treated with craniospinal irradiation （CSI） using helical tomotherapy （HT） system in our center. Methods： Twenty-three patients who were treated with CSI in our center from January 2008 to July 2012 were collected, with an average age of 20. M1 of the patients＇ CSI used the HT system. The total doses were 27-36 Gy/15-20 F （1.5-2 Gy per fraction）, and total local doses were 46-60 Gy/30-50 F （5 fractions per week）. M1 female patients for CSI were treated with left-right parallel-opposed field irradiation to protect their ovarian functions. Median follow-up time was 30.9 months （range, 5-67 months）. The SPSS19.0 software was used, and the overall survival （OS） was calculated using the Kaplan-Meier method. Results： Among 17 patients with assessable tumors, 9 cases （52.9%） were CR, 7 cases （41.2%） were PR, and 1 case （5.9%） was SD. Hematological toxicity was the severest side-effect occurred in the procedure of CSI. The level 1-4 acute leukopenia were 8.7%, 30.4%, 34.8% and 21.7% and the level 1-4 acute thrombopenia were 8.7%, 30.4%, 21.7% and 8.7%, respectively. Conclusions： For primary intracranial germinomas, HT can be used to implement CSI for simplifying radiotherapy procedures, improving radiotherapy accuracy, enhancing protection of peripheral organs at risk （ORA） and guaranteeing therapeutic effects. With the acceptable acute and long-term toxicity, CSI using HT in intracranial germinoma patients can be a safe and alternative mode.展开更多
BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resultin...BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resulting in rectal emptation and obstructive constipation.The clinical manifestations of SPFS are mainly characterized by difficult defecation,often accompanied by a sense of anal blockage and drooping.Manual defecation is usually needed during defecation.From physical examination,it is commonly observed that the patient's anal muscle tension is high,and it is difficult or even impossible to enter with his fingers.AIM To investigate the characteristics of anorectal pressure and botulinum toxin A injection combined with biofeedback in treating pelvic floor muscle spasm syndrome.METHODS Retrospective analysis of 50 patients diagnosed with pelvic floor spasm syndrome.All patients underwent pelvic floor surface electromyography assessment,anorectal dynamics examination,botulinum toxin type A injection 100 U intramuscular injection,and two cycles of biofeedback therapy.RESULTS After the botulinum toxin A injection combined with two cycles of biofeedback therapy,the patient's postoperative resting and systolic blood pressure were significantly lower than before surgery(P<0.05).Moreover,the electromyography index of the patients in the resting stage and post-resting stages was significantly lower than before surgery(P<0.05).CONCLUSION Botulinum toxin A injection combined with biofeedback can significantly reduce pelvic floor muscle tension in treating pelvic floor muscle spasm syndrome.Anorectal manometry is an effective method to evaluate the efficacy of treatment objectively.However,randomized controlled trials are needed.展开更多
Heterogenous distribution of crops,feed and livestock across China has halted the circulation of nutrients within the agricultural system and is responsible for massive nutrient losses[1,2].Generated livestock manure ...Heterogenous distribution of crops,feed and livestock across China has halted the circulation of nutrients within the agricultural system and is responsible for massive nutrient losses[1,2].Generated livestock manure exceeded optimal crop requirements in 30%and 50%of over 2300 studied counties when there was improved recycling of nitrogen(N)and phosphorus(P)in the food chain,repectively[2].Most of these counties are located in southern and coastal areas,whereas there is a deficit of livestock manure in northern and western China.Such heterogenous distribution of crop-livestock production led to 4.0 Tg manure N and 0.9 Tg manure P[2],which are economically impossible to recycle and will end up in the surrounding environment.In addition,about 40%of feed protein consumed by domestic livestock production relied on importation,putting China’s livestock production supply at high risk in the post pandemic world[3].Hence,China is facing the twin issues of too many manure nutrients but too little feed nutrients simultaneously.展开更多
In this work,a series of specimens was prepared by the casting method.Sharp cube-textured substrates were processed by heavy cold rolling and recrystallization annealing(i.e.,the rolling-assisted biaxially textured su...In this work,a series of specimens was prepared by the casting method.Sharp cube-textured substrates were processed by heavy cold rolling and recrystallization annealing(i.e.,the rolling-assisted biaxially textured substrates(RABi TS) method).Both the rolling and the recrystallization texture in the alloy tapes were investigated by X-ray diffraction and electron back-scatter diffraction,respectively.The results showed that a strong copper-type deformation texture was obtained in the heavy cold-rolled substrate.In addition,the recrystallization annealing process was found to be very important for the texture transition in the Cu–Ni alloy substrates.The cube texture content in the Cu60 Ni40 alloy substrates reached 99.7%(≤10°) after optimization of the cold-rolling procedure and the recrystallizing heat-treatment process,whereas the content of low-angle grain boundaries(from 2° to 10° misorientation) in the substrate reached 95.1%.展开更多
Erect milkvetch(Astragalus adsurgens)is a perennial legume forage crop with economic and ecological value in livestock grazing and soil-erosion control in arid and semiarid areas worldwide.Genomic information and mole...Erect milkvetch(Astragalus adsurgens)is a perennial legume forage crop with economic and ecological value in livestock grazing and soil-erosion control in arid and semiarid areas worldwide.Genomic information and molecular tools to support breeding and research in the species are limited.The objectives of this investigation were to map its genome using DNA markers and to identify quantitative trait loci(QTL)in the species.An F1 mapping population of 250 plants was developed from a cross between two parents with differing flowering-related traits.A high-density genetic linkage map containing 4821 markers on eight linkage groups(LGs)with a total genetic length of 1395 cM and a mean interval of 0.29 cM between adjacent markers was constructed with SLAF-seq technology.Comparative genomic analyses revealed the highest genome sequence similarity(8.71%)between erect milkvetch and Medicago truncatula,followed by Glycine max(7.65%),Cicer arietinum(7.53%),and Lupinus angustifolius(5.21%).A total of 64 significant QTL for flowering-related traits on six LGs were detected,accounting for 9.38 to 19.1%of the associated phenotype variation.Five and 48 key candidate genes for floret number and inflorescence length were identified based on the Glycyrrhiza uralensis genome.These candidate genes were involved in ubiquitination/degradation,pollen development,cell division,cytokinin biosynthetic process,and plant flowering.These findings shed light on the regulation of flowering traits in erect milkvetch and provide genomic resources for future molecular breeding of the crop.展开更多
Real-time acquisition of human pulse signals in daily life is clinically important for cardiovascular disease monitoring and diagnosis.Here,we propose a smart photonic wristband for pulse signal monitoring based on sp...Real-time acquisition of human pulse signals in daily life is clinically important for cardiovascular disease monitoring and diagnosis.Here,we propose a smart photonic wristband for pulse signal monitoring based on speckle pattern analysis with a polymer optical fiber(POF)integrated into a sports wristband.Several different speckle pattern processing algorithms and POFs with different core diameters were evaluated.The results indicated that the smart photonic wristband had a high signal-to-noise ratio and low latency,with the measurement error controlled at approximately 3.7%.This optimized pulse signal could be used for further medical diagnosis and was capable of objectively monitoring subtle pulse signal changes,such as the pulse waveform at different positions of Cunkou and pulse waveforms before and after exercise.With the assistance of artificial intelligence(AI),functions such as gesture recognition have been realized through the established prediction model by processing pulse signals,in which the recognition accuracy reaches 95%.Our AI-assisted smart photonic wristband has potential applications for clinical treatment of cardiovascular diseases and home monitoring,paving the way for medical Internet of Things-enabled smart systems.展开更多
Nanocrystalline TiO2 powders with high photocatalytic activity were prepared by one-step microemulsion-mediated hydrothermal method using tetrabutylorthotitanate (TiO(C4H9)4, TBOT) as precursor. The as-prepared TiO2 p...Nanocrystalline TiO2 powders with high photocatalytic activity were prepared by one-step microemulsion-mediated hydrothermal method using tetrabutylorthotitanate (TiO(C4H9)4, TBOT) as precursor. The as-prepared TiO2 powders were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and the Brunauer-Emmett-Teller (BET) specific surface area measurements. The effects of the oil/water ratio and hydrothermal temperature on the microstructures and photocatalytic activity of the TiO2 powders were investigated. The results suggest that increasing the oil/water emulsion ratio significantly decreased the particle size of the as-prepared TiO2 powders and improved the photocatalytic activity. With hydrothermal temperature increasing, the average crystallite size increased and the photocatalytic activities of TiO2 powders decreased.展开更多
The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential tremor.In 2018,the first magnetic resonance-guided foc...The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential tremor.In 2018,the first magnetic resonance-guided focused ultrasound system in Chinese mainland was installed at the First Medical Center of the PLA General Hospital.This prospective,single center,open-label,single-arm study was part of a worldwide prospective multicenter clinical trial(ClinicalTrials.gov Identifier:NCT03253991)conducted to confirm the safety and efficacy of magnetic resonance-guided focused ultrasound for treating essential tremor in the local population.From 2019 to 2020,10 patients with medication refractory essential tremor were recruited into this open-label,single arm study.The treatment efficacy was determined using the Clinical Rating Scale for Tremor.Safety was evaluated according to the incidence and severity of adverse events.All of the subjects underwent a unilateral thalamotomy targeting the ventral intermediate nucleus.At the baseline assessment,the estimated marginal mean of the Clinical Rating Scale for Tremor total score was 58.3±3.6,and this improved after treatment to 23.1±6.4 at a 12-month follow-up assessment.A total of 50 adverse events were recorded,and 2 were defined as serious.The most common intraoperative adverse events were nausea and headache.The most frequent postoperative adverse events were paresthesia and equilibrium disorder.Most of the adverse events were mild and usually disappeared within a few days.Our findings suggest that magnetic resonance-guided focused ultrasound for the treatment of essential tremor is effective,with a good safety profile,for patients in Chinese mainland.展开更多
The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic ...The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic diagram are proposed in this study.Through detailed petrographic,mineralogical,and elemental analyses,four distinct shale types are identified:argillaceous shale,siliceous shale,calcareous shale,and carbonate,clay,and silt-bearing shale.The main diagenetic process in argillaceous shale is the transformation of illite to smectite,negatively impacting shale porosity.Siliceous shale undergoes carbonate cementation and quartz dissolution,contributing to increased porosity,particularly in mesopores.Calcareous shale experiences diagenesis characterised by carbonate formation and dissolution,with a prevalence of siderite.In carbonate,clay,and silt-bearing shale,the dissolution of K-feldspar contributes to illitization of kaolinite.Argillaceous shale,characterised by more clay minerals and lower mesopore volume,is identified as a potential hydrocarbon seal.Siliceous shale,with the highest pore volume and abundant inter-mineral pores,emerges as a promising shale oil reservoir.These findings contribute to a comprehensive understanding of shale properties,aiding in the prediction of shale oil exploration potential in the studied area.展开更多
The early stage evolution of local atomic structures in a multicomponent metallic glass during its crystallization process has been investigated via molecular dynamics simulation.It is found that the initial thermal s...The early stage evolution of local atomic structures in a multicomponent metallic glass during its crystallization process has been investigated via molecular dynamics simulation.It is found that the initial thermal stability and earliest stage evolution of the local atomic clusters show no strong correlation with their initial short-range orders,and this leads to an observation of a novel symmetry convergence phenomenon,which can be understood as an atomic structure manifestation of the ergodicity.Furthermore,in our system we have quantitatively proved that the crucial factor for the thermal stability against crystallization exhibited by the metallic glass is not the total amount of icosahedral clusters,but the degree of global connectivity among them.展开更多
BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2D).Insulin resistance in the brain is a common feature in patients with T2D and AD.KAT7 is ...BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2D).Insulin resistance in the brain is a common feature in patients with T2D and AD.KAT7 is a histone acetyltransferase that participates in the modulation of various genes.AIM To determine the effects of KAT7 on insulin patients with AD.METHODS APPswe/PS1-dE9 double-transgenic and db/db mice were used to mimic AD and diabetes,respectively.An in vitro model of AD was established by Aβstimulation.Insulin resistance was induced by chronic stimulation with high insulin levels.The expression of microtubule-associated protein 2(MAP2)was assessed using immunofluorescence.The protein levels of MAP2,Aβ,dual-specificity tyrosine phosphorylation-regulated kinase-1A(DYRK1A),IRS-1,p-AKT,total AKT,p-GSK3β,total GSK3β,DYRK1A,and KAT7 were measured via western blotting.Accumulation of reactive oxygen species(ROS),malondialdehyde(MDA),and SOD activity was measured to determine cellular oxidative stress.Flow cytometry and CCK-8 assay were performed to evaluate neuronal cell death and proliferation,respectively.Relative RNA levels of KAT7 and DYRK1A were examined using quantitative PCR.A chromatin immunoprecipitation assay was conducted to detect H3K14ac in DYRK1A.RESULTS KAT7 expression was suppressed in the AD mice.Overexpression of KAT7 decreased Aβaccumulation and MAP2 expression in AD brains.KAT7 overexpression decreased ROS and MDA levels,elevated SOD activity in brain tissues and neurons,and simultaneously suppressed neuronal apoptosis.KAT7 upregulated levels of p-AKT and p-GSK3βto alleviate insulin resistance,along with elevated expression of DYRK1A.KAT7 depletion suppressed DYRK1A expression and impaired H3K14ac of DYRK1A.HMGN1 overexpression recovered DYRK1A levels and reversed insulin resistance caused by KAT7 depletion.CONCLUSION We determined that KAT7 overexpression recovered insulin sensitivity in AD by recruiting HMGN1 to enhance DYRK1A acetylation.Our findings suggest that KAT7 is a novel and promising therapeutic target for the resistance in AD.展开更多
The Raman spectra in the C-H stretching region are of great importance for the study of the structure and dynamics of organic compounds.However,the Fermi resonance between the first overtone mode of C-H bending vibrat...The Raman spectra in the C-H stretching region are of great importance for the study of the structure and dynamics of organic compounds.However,the Fermi resonance between the first overtone mode of C-H bending vibration and C-H stretching vibration typically results in the disturbance of Raman bands in the C-H stretching region.In this context,a specific deuterated molecule with only one C-H bond was proposed,and it was found that the frequency of the first overtone mode of the C-H bending vibration was significantly different from the frequency of the C-H stretching vibration.Due to the significant discrepancy,Fermi resonance in the C-H stretching region was eliminated from the experimental and theoretical Raman spectra of deuterated leucine,deuterated benzoin,deuterated methanol,and deuterated ethanol.Hence then,the Raman spectra of these specific deuterated compounds in the C-H stretching region can be used to study the structure or the dynamics of the organic compounds.展开更多
Prostate cancer is a malignant tumor with a high incidence in elderly men.In recent years,with the improvement of people’s living standards and the advancement of detection technology,the incidence of prostate cancer...Prostate cancer is a malignant tumor with a high incidence in elderly men.In recent years,with the improvement of people’s living standards and the advancement of detection technology,the incidence of prostate cancer has been increasing year by year.Castration-resistant prostate cancer(CRPC)is a highly challenging type of advanced prostate cancer treatment,which clinically shows resistance to hormonal deprivation therapy.The overall treatment efficacy of CRPC is currently poor and further relevant therapeutic studies are needed to improve patient survival and quality of life.Immunosuppressants can play a role in combating the immune system of tumors,and abiraterone has also achieved remarkable results in prostate cancer treatment.This study will investigate the possible clinical effects and safety of immunosuppressants combined with abiraterone in the treatment of metastatic CRPC.The population-based study will provide clinicians with more effective treatment options,as well as enhance the understanding of novel combination therapy strategies to be implemented in the future for such patients.展开更多
The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind sol...The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind solar eruptions and coronal heating,and to directly measure the coronal magnetic field.The mission will perform in situ measurements of the current sheet between coronal mass ejections and their associated solar flares,and energetic particles produced by either reconnection or fast-mode shocks driven by coronal mass ejections.This will help to resolve the nature of reconnections in current sheets,and energetic particle acceleration regions.To investigate coronal heating,the mission will observe nano-flares on scales smaller than 70 km in the solar corona and regions smaller than 40 km in the photosphere,where magnetohydrodynamic waves originate.To study solar wind acceleration mechanisms,the mission will also track the process of ion charge-state freezing in the solar wind.A key achievement will be the observation of the coronal magnetic field at unprecedented proximity to the solar photosphere.The polar regions will also be observed at close range,and the inner edge of the solar system dust disk may be identified for the first time.This work presents the detailed background,science,and mission concept of SCOPE and discusses how we aim to address the questions mentioned above.展开更多
It is common for the rotating pin largely plunging into lower sheet to break up lap interface of Friction Stir Lap Welding(FSLW)joint,but the unavoidable up-bending morphology of hook outside Nugget Zone(NZ)largely re...It is common for the rotating pin largely plunging into lower sheet to break up lap interface of Friction Stir Lap Welding(FSLW)joint,but the unavoidable up-bending morphology of hook outside Nugget Zone(NZ)largely reduces the joint bearing ability.Based on the novel Opposite-directions Flowing FSLW(OF-FSLW)by the self-developed rotating tool with an Xshaped right-left thread pin,the 2024 aluminum alloys lap joint was successfully welded in this study.The migration law of lap interface during welding was investigated by the experimental and numerical methods,and then how the rotating pin and its rotating velocity affect the formation and strength of OF-FSLW joint was further analyzed.The results show that the Material Concentrated Zone(MCZ)which formed above the original lap interface made the hook bend downward,the NZ greatly enlarged and the beginning part of cold lap compressed and thickened,thereby heightening the joint bearing ability.For the OF-FSLW joint,its maximum tensile strength was403 MPa,and the corresponding joint efficiency of 90.8%was an incredible and superb value for the 2000 series heat-treatment strengthened aluminum alloys friction stir welded joint.The OF-FSLW technology by the rotating tool with an X-shaped right-left thread pin is proven to be a greatly effective approach for manufacturing the aluminum alloys lap joint with superb strength.展开更多
Continuing advancement in astronomy,space exploration,and scientific detection,has increased demand for infrared multi-band detection systems.Traditional three-band optical systems,designed to simultaneously image at ...Continuing advancement in astronomy,space exploration,and scientific detection,has increased demand for infrared multi-band detection systems.Traditional three-band optical systems,designed to simultaneously image at infrared short-wave,mid-wave,and long-wave bands typically rely on dispersive elements,leading to bulky sizes,complex system architectures,low efficiency,and challenges in rapid assembly.To overcome these obstacles,in combination with the latest third-generation infrared detectors,we propose a design for a compact and lightweight three-band optical system,with infrared capabilities in all three required bands.The core of this approach is an integrated design philosophy that emphasizes the high steepness of mirror surfaces.This design achieves uniform correction and optimization of chromatic aberration and off-axis aberration across the spectral range.We introduce a novel integration of optical and mechanical elements to replace traditional assembly,reducing manufacturing and assembly errors,and degrees of freedom,associated with high-power optical elements.Confirming the effectiveness through a combination of simulations and experimental comparisons,the measured mid-wave full-field transfer function exceeds 0.405 at 17 lp/mm,satisfying the imaging requirements of the system.The optical system is lightweight and compact,with a total mass under 408 g and a compact volume of justΦ112 mm×117 mm.This serves as a valuable reference for the engineering application of high-performance,compact multi-band infrared composite detection systems for astronomy and space exploration.展开更多
AIM:To investigate the mRNA expression of cyclooxygensae-2(COX-2)in benign and malignant ascites,and to explore the difference in COX-2 mRNA expression among different diseases.METHODS:A total of 36 samples were colle...AIM:To investigate the mRNA expression of cyclooxygensae-2(COX-2)in benign and malignant ascites,and to explore the difference in COX-2 mRNA expression among different diseases.METHODS:A total of 36 samples were collected from the Fifth Affiliated Hospital of Sun Yat-Sen University and divided into two experimental groups:benign ascites(n=21)and malignant ascites(n=15).Benign ascites included cirrhotic ascites(n=10)and tuberculous ascites(n=5).Malignant ascites included oophoroma(n=7),cancer of colon(n=5),cancer of the liver(n=6),gastric cancer(n=2),and bladder carcinoma(n=1).The mRNA expression of COX-2 in ascites was examined with reverse transcriptase polymerase chain reaction(RT-PCR)technology,and the positive rate of COX-2 mRNA was compared between different diseases.RESULTS:The positive rate of COX-2 mRNA in malignant ascites was 42.9%(9/21),which was significantly higher than in benign ascites,6.7%(1/15),difference being significant between these two groups(χ2=4.051,P=0.044).The proportion of the positive rate in the malignant ascites was as follows:ovarian cancers57.1%(4/7),colon cancer 40.0%(2/5),liver cancer33.3%(2/6),gastric cancer 50.0%(1/2),and bladder cancer 0.00%(0/1).However,there was no significant difference in COX-2 mRNA expression among various tumors with malignant ascites(χ2=1.614,P=0.806).Among the benign ascites,COX-2 mRNA levels were different between the tuberculous ascites(0/5)and cirrhotic ascites(1/10),but there was no significant difference(P=1.000).CONCLUSION:COX-2 mRNA,detected by RT-PCR,is useful in the differential diagnosis of benign and malignant ascites,which also has potential value in the clinical diagnosis of tumors.展开更多
基金supported by the National Key R&D Program of China(Nos.2022YFB3504804 and 2023YFF0718303)the National Natural Science Foundation of China(Nos.51871219,52071324,52031014,and 52401255)+1 种基金Science and Technology Project of Shenyang City(No.22-101-0-27)Liaoning Institute of Science and Technology Doctoral Initiation Fund Project(No.2307B19).
文摘To realize the application of electromagnetic wave absorption(EWA)devices in humid marine environments,bifunctional EWA materials with better EWA capacities and anticorrosion properties have great exploration significance and systematic research re-quirements.By utilizing the low-cost and excellent magnetic and stable chemical characteristics of barium ferrite(BaFe_(12)O_(19))and using the high dielectric loss and excellent chemical inertia of nanocarbon clusters,a new type of nanocomposites with carbon nanoclusters en-capsulating BaFe_(12)O_(19)was designed and synthesized by combining an impregnation method and a high-temperature calcination strategy.Furthermore,Ce-Mn ions were introduced into the BaFe_(12)O_(19)lattice to improve the dielectric and magnetic properties of BaFe_(12)O_(19)cores significantly,and the energy band structure of the doped lattice and the orders of Ce replacing Fe sites were calculated.Benefiting from Ce-Mn ion doping and carbon nanocluster encapsulation,the composite material exhibited excellent dual functionality of corrosion resist-ance and EWA.When BaCe_(0.2)Mn_(0.3)Fe_(11.5)O_(19)-C(BCM-C)was calcined at 600°C,the minimum reflection loss of-20.1 dB was achieved at 14.43 GHz.The Ku band’s effective absorption bandwidth of 4.25 GHz was achieved at an absorber thickness of only 1.3 mm.The BCM-C/polydimethylsiloxane coating had excellent corrosion resistance in the simulated marine environment(3.5wt%NaCl solution).The|Z|0.01Hz value of BCM-C remained at 106Ω·cm^(2)after 12 soaking days.The successful preparation of the BaFe_(12)O_(19)composite en-capsulated with carbon nanoclusters provides new insights into the preparation of multifunctional absorbent materials and the fabrication of absorbent devices applied in humid marine environments in the future.
文摘BACKGROUND Acute drug-induced liver injury(DILI)events caused by chronic liver disease are relatively common.Some researchers believe that nonalcoholic fatty liver(NAFL)increases the overall risk of DILI.The clinical characteristics and prognosis of DILI in the context of NAFL disease(NAFLD)are still unclear.Therefore,hospitalized patients with NAFLD combined with DILI at the Tianjin Second People's Hospital were included in this study.The clinical manifestations,classifications,severities,laboratory indicators,and clinical outcomes of the enrolled patients were analyzed,and the clinical characteristics and prognoses of the NAFL+DILI patients were evaluated.AIM To investigate the clinical characteristics and prognosis of DILI in the context of NAFL.METHODS Eighty-nine patients diagnosed with DILI and 110 patients diagnosed with both DILI and NAFL at the Tianjin Second People's Hospital were enrolled.Clinical data,including demographic characteristics,clinical features,laboratory test results,pathology findings,autoantibody titers,suspected drugs,and outcomes,were collected from the two groups of patients.All enrolled patients were followed up to determine the liver function recovery time.RESULTS Compared with the patients in the DILI group,those in the NAFL+DILI group had higher body mass indices;Controlled Attenuation Parameter scores;and triglyceride,total cholesterol,low-density lipoprotein,and insulin levels.The levels of the cytokines interleukin-4 and complement complement c3(C3)were also greater in the NAFL+DILI group than in the DILI group.The proportions of patients with cholestatic-type DILI(16.4%vs 4.5%),cholestasis seen on pathoscopy(40.9%vs 25.8%),grade 2 or above DILI(48.18%vs 40.45%),and a recovery time for liver function ranging from 90 to 180 days(30.6%vs 15.5%)were greater in the NAFL+DILI group than in the DILI group.All of the abovementioned differences between the groups were statistically significant(P<0.05).The autoantibody positivity rates did not significantly differ between the two groups(P>0.05),and the proportions of patients who progressed to chronic drug hepatitis or autoimmune hepatitis were not significantly different between the two groups(both P>0.05).CONCLUSION In the context of NAFL,DILI is more likely to be cholestatic,with a greater degree of liver injury,a longer recovery time,and more pronounced expression of immune factors.
基金supported by the National Key R&D Program of China(Nos.2023YFF0718303 and 2022YFB3504804)the National Natural Science Foundation of China(Nos.51871219,52031014 and 52401255)the Science and Technology Project of Shenyang City(No.22-101-0-27).
文摘The single-layer Ti_(3)C_(2)T_(x)/MXene has become a special electromagnetic wave absorber near the terahertz band because of its abundant surface groups and excellent conductivity.However,the macro-preparation of single-layer Ti_(3)C_(2)T_(x)/MXene shows significantly difficult to influence its application.The two-dimensional Ti_(3)C_(2)T_(x)is easily prepared to have high production,but its weak absorption ability due to high surface conductivity also restricts its application.To realize the strong electromagnetic wave absorption of two-dimensional Ti_(3)C_(2)T_(x)/MXene,a new strategy with magnetic FeNi nanoparticles decorating Ti_(3)C_(2)T_(x)/MXene composites(FeNi-Ti_(3)C_(2)T_(x))were proposed and the effective electromagnetic wave absorption features covering 170-220 GHz that means the absorption band width reach 50 GHz.With an absorber composite film thickness being only 0.6 mm,the absorptivity of the composite is enhanced with the increase of decorating FeNi nanoparticles and promote up to 75%when the FeNi nanoparticles loading content reaches 30 wt%.The improvement of absorption is attributed to the introduction of soft magnetic FeNi to adjust the high surface conductivity of MXene and improve the electromagnetic balance of the absorber.
文摘Objective： To evaluate the short-term clinical outcomes of intracranial germinoma patients treated with craniospinal irradiation （CSI） using helical tomotherapy （HT） system in our center. Methods： Twenty-three patients who were treated with CSI in our center from January 2008 to July 2012 were collected, with an average age of 20. M1 of the patients＇ CSI used the HT system. The total doses were 27-36 Gy/15-20 F （1.5-2 Gy per fraction）, and total local doses were 46-60 Gy/30-50 F （5 fractions per week）. M1 female patients for CSI were treated with left-right parallel-opposed field irradiation to protect their ovarian functions. Median follow-up time was 30.9 months （range, 5-67 months）. The SPSS19.0 software was used, and the overall survival （OS） was calculated using the Kaplan-Meier method. Results： Among 17 patients with assessable tumors, 9 cases （52.9%） were CR, 7 cases （41.2%） were PR, and 1 case （5.9%） was SD. Hematological toxicity was the severest side-effect occurred in the procedure of CSI. The level 1-4 acute leukopenia were 8.7%, 30.4%, 34.8% and 21.7% and the level 1-4 acute thrombopenia were 8.7%, 30.4%, 21.7% and 8.7%, respectively. Conclusions： For primary intracranial germinomas, HT can be used to implement CSI for simplifying radiotherapy procedures, improving radiotherapy accuracy, enhancing protection of peripheral organs at risk （ORA） and guaranteeing therapeutic effects. With the acceptable acute and long-term toxicity, CSI using HT in intracranial germinoma patients can be a safe and alternative mode.
文摘BACKGROUND Spastic pelvic floor syndrome(SPFS)is a refractory pelvic floor disease characterized by abnormal(uncoordinated)contractions of the external anal sphincter and puborectalis muscle during defecation,resulting in rectal emptation and obstructive constipation.The clinical manifestations of SPFS are mainly characterized by difficult defecation,often accompanied by a sense of anal blockage and drooping.Manual defecation is usually needed during defecation.From physical examination,it is commonly observed that the patient's anal muscle tension is high,and it is difficult or even impossible to enter with his fingers.AIM To investigate the characteristics of anorectal pressure and botulinum toxin A injection combined with biofeedback in treating pelvic floor muscle spasm syndrome.METHODS Retrospective analysis of 50 patients diagnosed with pelvic floor spasm syndrome.All patients underwent pelvic floor surface electromyography assessment,anorectal dynamics examination,botulinum toxin type A injection 100 U intramuscular injection,and two cycles of biofeedback therapy.RESULTS After the botulinum toxin A injection combined with two cycles of biofeedback therapy,the patient's postoperative resting and systolic blood pressure were significantly lower than before surgery(P<0.05).Moreover,the electromyography index of the patients in the resting stage and post-resting stages was significantly lower than before surgery(P<0.05).CONCLUSION Botulinum toxin A injection combined with biofeedback can significantly reduce pelvic floor muscle tension in treating pelvic floor muscle spasm syndrome.Anorectal manometry is an effective method to evaluate the efficacy of treatment objectively.However,randomized controlled trials are needed.
基金the National Key R&D Program of China(2016YFD0800106)the National Natural Science Foundation of China(31572210,31872403,71961137011)+5 种基金Key Research Program of Frontier Sciences-CAS(QYZDY-SSWSMC014)Key Laboratory of Agricultural Water Resources-CAS(ZD201802)the Key Research Program-CAS(KFJ-STS-ZDTP-053)Hebei Dairy Cattle Innovation Team of Modern Agroindustry Technology Research System,China(HBCT2018120206)the Youth Innovation Promotion Association,CAS(2019101)Outstanding Young Scientists Project of Natural Science Foundation of Hebei(C2019503054).
文摘Heterogenous distribution of crops,feed and livestock across China has halted the circulation of nutrients within the agricultural system and is responsible for massive nutrient losses[1,2].Generated livestock manure exceeded optimal crop requirements in 30%and 50%of over 2300 studied counties when there was improved recycling of nitrogen(N)and phosphorus(P)in the food chain,repectively[2].Most of these counties are located in southern and coastal areas,whereas there is a deficit of livestock manure in northern and western China.Such heterogenous distribution of crop-livestock production led to 4.0 Tg manure N and 0.9 Tg manure P[2],which are economically impossible to recycle and will end up in the surrounding environment.In addition,about 40%of feed protein consumed by domestic livestock production relied on importation,putting China’s livestock production supply at high risk in the post pandemic world[3].Hence,China is facing the twin issues of too many manure nutrients but too little feed nutrients simultaneously.
基金financially supported by the National Natural Science Foundation of China (No.51571002)the Beijing Natural Science Foundation (No.2172008)+4 种基金the Doctoral Program of Higher Education of Special Research Fund of China (No.20121103110012)the Beijing Municipal Natural Science Foundation B Type (No.KZ201310005003)the China Scholarship Councilthe Technology Program of Beijing CityBeijing University of Technology
文摘In this work,a series of specimens was prepared by the casting method.Sharp cube-textured substrates were processed by heavy cold rolling and recrystallization annealing(i.e.,the rolling-assisted biaxially textured substrates(RABi TS) method).Both the rolling and the recrystallization texture in the alloy tapes were investigated by X-ray diffraction and electron back-scatter diffraction,respectively.The results showed that a strong copper-type deformation texture was obtained in the heavy cold-rolled substrate.In addition,the recrystallization annealing process was found to be very important for the texture transition in the Cu–Ni alloy substrates.The cube texture content in the Cu60 Ni40 alloy substrates reached 99.7%(≤10°) after optimization of the cold-rolling procedure and the recrystallizing heat-treatment process,whereas the content of low-angle grain boundaries(from 2° to 10° misorientation) in the substrate reached 95.1%.
基金supported by the Chinese Universities Scientific Fund(2021RC001)the China Agriculture Research System(CARS34)the National Program for Forage Germplasm Conservation(2130135).
文摘Erect milkvetch(Astragalus adsurgens)is a perennial legume forage crop with economic and ecological value in livestock grazing and soil-erosion control in arid and semiarid areas worldwide.Genomic information and molecular tools to support breeding and research in the species are limited.The objectives of this investigation were to map its genome using DNA markers and to identify quantitative trait loci(QTL)in the species.An F1 mapping population of 250 plants was developed from a cross between two parents with differing flowering-related traits.A high-density genetic linkage map containing 4821 markers on eight linkage groups(LGs)with a total genetic length of 1395 cM and a mean interval of 0.29 cM between adjacent markers was constructed with SLAF-seq technology.Comparative genomic analyses revealed the highest genome sequence similarity(8.71%)between erect milkvetch and Medicago truncatula,followed by Glycine max(7.65%),Cicer arietinum(7.53%),and Lupinus angustifolius(5.21%).A total of 64 significant QTL for flowering-related traits on six LGs were detected,accounting for 9.38 to 19.1%of the associated phenotype variation.Five and 48 key candidate genes for floret number and inflorescence length were identified based on the Glycyrrhiza uralensis genome.These candidate genes were involved in ubiquitination/degradation,pollen development,cell division,cytokinin biosynthetic process,and plant flowering.These findings shed light on the regulation of flowering traits in erect milkvetch and provide genomic resources for future molecular breeding of the crop.
基金financial supports from National Key R&D Program of China (2022YFE0140400)National Natural Science Foundation of China(62003046, 62111530238)+7 种基金Guangdong Basic and Applied Basic Research Foundation (2021A1515011997)The Supplemental Funds for Major Scientific Research Projects of Beijing Normal University,Zhuhai(ZHPT2023007)Special project in key field of Guangdong Provincial Department of Education (2021ZDZX1050)The Innovation Team Project of Guangdong Provincial Department of Education (2021KCXTD014)Fundação para a Ciência e a Tecnologia (FCT) through the 2021.00667CEECIND (iAqua project)PTDC/EEI-EEE/0415/2021 (DigiAqua project)The project i3N,UIDB/50025/2020 n&UIDP/50025/2020, financed by national funds through the FCT/MEC
文摘Real-time acquisition of human pulse signals in daily life is clinically important for cardiovascular disease monitoring and diagnosis.Here,we propose a smart photonic wristband for pulse signal monitoring based on speckle pattern analysis with a polymer optical fiber(POF)integrated into a sports wristband.Several different speckle pattern processing algorithms and POFs with different core diameters were evaluated.The results indicated that the smart photonic wristband had a high signal-to-noise ratio and low latency,with the measurement error controlled at approximately 3.7%.This optimized pulse signal could be used for further medical diagnosis and was capable of objectively monitoring subtle pulse signal changes,such as the pulse waveform at different positions of Cunkou and pulse waveforms before and after exercise.With the assistance of artificial intelligence(AI),functions such as gesture recognition have been realized through the established prediction model by processing pulse signals,in which the recognition accuracy reaches 95%.Our AI-assisted smart photonic wristband has potential applications for clinical treatment of cardiovascular diseases and home monitoring,paving the way for medical Internet of Things-enabled smart systems.
文摘Nanocrystalline TiO2 powders with high photocatalytic activity were prepared by one-step microemulsion-mediated hydrothermal method using tetrabutylorthotitanate (TiO(C4H9)4, TBOT) as precursor. The as-prepared TiO2 powders were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and the Brunauer-Emmett-Teller (BET) specific surface area measurements. The effects of the oil/water ratio and hydrothermal temperature on the microstructures and photocatalytic activity of the TiO2 powders were investigated. The results suggest that increasing the oil/water emulsion ratio significantly decreased the particle size of the as-prepared TiO2 powders and improved the photocatalytic activity. With hydrothermal temperature increasing, the average crystallite size increased and the photocatalytic activities of TiO2 powders decreased.
基金sponsored by Insightec Co.Ltd.(Israel)China National Clinical Research Center for Geriatrics,No.NCRCG-PLAGH-2019005 (to LP)
文摘The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential tremor.In 2018,the first magnetic resonance-guided focused ultrasound system in Chinese mainland was installed at the First Medical Center of the PLA General Hospital.This prospective,single center,open-label,single-arm study was part of a worldwide prospective multicenter clinical trial(ClinicalTrials.gov Identifier:NCT03253991)conducted to confirm the safety and efficacy of magnetic resonance-guided focused ultrasound for treating essential tremor in the local population.From 2019 to 2020,10 patients with medication refractory essential tremor were recruited into this open-label,single arm study.The treatment efficacy was determined using the Clinical Rating Scale for Tremor.Safety was evaluated according to the incidence and severity of adverse events.All of the subjects underwent a unilateral thalamotomy targeting the ventral intermediate nucleus.At the baseline assessment,the estimated marginal mean of the Clinical Rating Scale for Tremor total score was 58.3±3.6,and this improved after treatment to 23.1±6.4 at a 12-month follow-up assessment.A total of 50 adverse events were recorded,and 2 were defined as serious.The most common intraoperative adverse events were nausea and headache.The most frequent postoperative adverse events were paresthesia and equilibrium disorder.Most of the adverse events were mild and usually disappeared within a few days.Our findings suggest that magnetic resonance-guided focused ultrasound for the treatment of essential tremor is effective,with a good safety profile,for patients in Chinese mainland.
基金founded by National Natural Science Foundation of China(grant Nos.:42072186 and 42090025)National Science and Technology Major Project,China(grant No.:2016ZX05046001)+3 种基金Science and Technology Research Project of Petro China Company Limited,China(grant No.:2021DJ1806)the fund support from China Scholarship Council(No.201806440002)the International Postdoctoral Exchange Fellowship Program,China(Talent-Introduction Program,No.270152)Lin Ma wishes to acknowledge the fund support from Natural Environment Research Council,United Kingdom(NE/R013527/1)。
文摘The mineralogical development and diagenetic sequence of lacustrine shales in the Chang 7 Member of the Yanchang Formation in the Ordos Basin are detailed studied.A model of their depositional system and a diagenetic diagram are proposed in this study.Through detailed petrographic,mineralogical,and elemental analyses,four distinct shale types are identified:argillaceous shale,siliceous shale,calcareous shale,and carbonate,clay,and silt-bearing shale.The main diagenetic process in argillaceous shale is the transformation of illite to smectite,negatively impacting shale porosity.Siliceous shale undergoes carbonate cementation and quartz dissolution,contributing to increased porosity,particularly in mesopores.Calcareous shale experiences diagenesis characterised by carbonate formation and dissolution,with a prevalence of siderite.In carbonate,clay,and silt-bearing shale,the dissolution of K-feldspar contributes to illitization of kaolinite.Argillaceous shale,characterised by more clay minerals and lower mesopore volume,is identified as a potential hydrocarbon seal.Siliceous shale,with the highest pore volume and abundant inter-mineral pores,emerges as a promising shale oil reservoir.These findings contribute to a comprehensive understanding of shale properties,aiding in the prediction of shale oil exploration potential in the studied area.
基金supported by the National Natural Science Foundation of China (Grant Nos. 52031016 and 11804027)the China Scholarship Council for financial support during part of this work
文摘The early stage evolution of local atomic structures in a multicomponent metallic glass during its crystallization process has been investigated via molecular dynamics simulation.It is found that the initial thermal stability and earliest stage evolution of the local atomic clusters show no strong correlation with their initial short-range orders,and this leads to an observation of a novel symmetry convergence phenomenon,which can be understood as an atomic structure manifestation of the ergodicity.Furthermore,in our system we have quantitatively proved that the crucial factor for the thermal stability against crystallization exhibited by the metallic glass is not the total amount of icosahedral clusters,but the degree of global connectivity among them.
基金Supported by Natural Science Foundation of Shandong Province,No.ZR2020MH147National Natural Science Foundation of China,No.82002343.
文摘BACKGROUND Epidemiological studies have revealed a correlation between Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2D).Insulin resistance in the brain is a common feature in patients with T2D and AD.KAT7 is a histone acetyltransferase that participates in the modulation of various genes.AIM To determine the effects of KAT7 on insulin patients with AD.METHODS APPswe/PS1-dE9 double-transgenic and db/db mice were used to mimic AD and diabetes,respectively.An in vitro model of AD was established by Aβstimulation.Insulin resistance was induced by chronic stimulation with high insulin levels.The expression of microtubule-associated protein 2(MAP2)was assessed using immunofluorescence.The protein levels of MAP2,Aβ,dual-specificity tyrosine phosphorylation-regulated kinase-1A(DYRK1A),IRS-1,p-AKT,total AKT,p-GSK3β,total GSK3β,DYRK1A,and KAT7 were measured via western blotting.Accumulation of reactive oxygen species(ROS),malondialdehyde(MDA),and SOD activity was measured to determine cellular oxidative stress.Flow cytometry and CCK-8 assay were performed to evaluate neuronal cell death and proliferation,respectively.Relative RNA levels of KAT7 and DYRK1A were examined using quantitative PCR.A chromatin immunoprecipitation assay was conducted to detect H3K14ac in DYRK1A.RESULTS KAT7 expression was suppressed in the AD mice.Overexpression of KAT7 decreased Aβaccumulation and MAP2 expression in AD brains.KAT7 overexpression decreased ROS and MDA levels,elevated SOD activity in brain tissues and neurons,and simultaneously suppressed neuronal apoptosis.KAT7 upregulated levels of p-AKT and p-GSK3βto alleviate insulin resistance,along with elevated expression of DYRK1A.KAT7 depletion suppressed DYRK1A expression and impaired H3K14ac of DYRK1A.HMGN1 overexpression recovered DYRK1A levels and reversed insulin resistance caused by KAT7 depletion.CONCLUSION We determined that KAT7 overexpression recovered insulin sensitivity in AD by recruiting HMGN1 to enhance DYRK1A acetylation.Our findings suggest that KAT7 is a novel and promising therapeutic target for the resistance in AD.
基金supported by the Key Research Project of Shaanxi Provincial Science and Technology Department(2023-YBNY-158)the Xi'an Science and Technology Project(22NYYF016)+3 种基金the Natural Science Foundation of Shaanxi Province(2022JM-087)the Open Fund of the State Key Laboratory of Molecular Reaction Dynamics in DICP,CAS,(SKLMRDK202413)the Fundamental Research Funds for the Central Universities(QTZX23007)the 111 Project.
文摘The Raman spectra in the C-H stretching region are of great importance for the study of the structure and dynamics of organic compounds.However,the Fermi resonance between the first overtone mode of C-H bending vibration and C-H stretching vibration typically results in the disturbance of Raman bands in the C-H stretching region.In this context,a specific deuterated molecule with only one C-H bond was proposed,and it was found that the frequency of the first overtone mode of the C-H bending vibration was significantly different from the frequency of the C-H stretching vibration.Due to the significant discrepancy,Fermi resonance in the C-H stretching region was eliminated from the experimental and theoretical Raman spectra of deuterated leucine,deuterated benzoin,deuterated methanol,and deuterated ethanol.Hence then,the Raman spectra of these specific deuterated compounds in the C-H stretching region can be used to study the structure or the dynamics of the organic compounds.
文摘Prostate cancer is a malignant tumor with a high incidence in elderly men.In recent years,with the improvement of people’s living standards and the advancement of detection technology,the incidence of prostate cancer has been increasing year by year.Castration-resistant prostate cancer(CRPC)is a highly challenging type of advanced prostate cancer treatment,which clinically shows resistance to hormonal deprivation therapy.The overall treatment efficacy of CRPC is currently poor and further relevant therapeutic studies are needed to improve patient survival and quality of life.Immunosuppressants can play a role in combating the immune system of tumors,and abiraterone has also achieved remarkable results in prostate cancer treatment.This study will investigate the possible clinical effects and safety of immunosuppressants combined with abiraterone in the treatment of metastatic CRPC.The population-based study will provide clinicians with more effective treatment options,as well as enhance the understanding of novel combination therapy strategies to be implemented in the future for such patients.
基金supported by the National Key R&D Program of China (2022YFF0503800)National Natural Science Foundation of China grants (12073073, 11933009, 12273107 and U2031141)+6 种基金grants associated with the Yunnan Revitalization Talent Support Programthe Foundation of the Chinese Academy of Sciences (Light of West China Program)the Yunling Scholar Project of Yunnan Provincethe Yunnan Province Scientist Workshop of Solar Physicsthe Applied Basic Research of Yunnan Province grants (202101AT070018 and 2019FB005)supported by the National Natural Science Foundation of China grants (12273107 and U2031141)the Yunnan Key Laboratory of Solar Physics and Space Science (202205AG070009)
文摘The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind solar eruptions and coronal heating,and to directly measure the coronal magnetic field.The mission will perform in situ measurements of the current sheet between coronal mass ejections and their associated solar flares,and energetic particles produced by either reconnection or fast-mode shocks driven by coronal mass ejections.This will help to resolve the nature of reconnections in current sheets,and energetic particle acceleration regions.To investigate coronal heating,the mission will observe nano-flares on scales smaller than 70 km in the solar corona and regions smaller than 40 km in the photosphere,where magnetohydrodynamic waves originate.To study solar wind acceleration mechanisms,the mission will also track the process of ion charge-state freezing in the solar wind.A key achievement will be the observation of the coronal magnetic field at unprecedented proximity to the solar photosphere.The polar regions will also be observed at close range,and the inner edge of the solar system dust disk may be identified for the first time.This work presents the detailed background,science,and mission concept of SCOPE and discusses how we aim to address the questions mentioned above.
基金supported by the National Natural Science Foundation of China(Nos.51874201 and 52074184)Natural Science Foundation project of Liaoning Province(2023-MS238)+1 种基金Liaoning Revitalization talents program(XLYC2203009)the Fundamental Research Funds for the Universities of Liaoning Province。
文摘It is common for the rotating pin largely plunging into lower sheet to break up lap interface of Friction Stir Lap Welding(FSLW)joint,but the unavoidable up-bending morphology of hook outside Nugget Zone(NZ)largely reduces the joint bearing ability.Based on the novel Opposite-directions Flowing FSLW(OF-FSLW)by the self-developed rotating tool with an Xshaped right-left thread pin,the 2024 aluminum alloys lap joint was successfully welded in this study.The migration law of lap interface during welding was investigated by the experimental and numerical methods,and then how the rotating pin and its rotating velocity affect the formation and strength of OF-FSLW joint was further analyzed.The results show that the Material Concentrated Zone(MCZ)which formed above the original lap interface made the hook bend downward,the NZ greatly enlarged and the beginning part of cold lap compressed and thickened,thereby heightening the joint bearing ability.For the OF-FSLW joint,its maximum tensile strength was403 MPa,and the corresponding joint efficiency of 90.8%was an incredible and superb value for the 2000 series heat-treatment strengthened aluminum alloys friction stir welded joint.The OF-FSLW technology by the rotating tool with an X-shaped right-left thread pin is proven to be a greatly effective approach for manufacturing the aluminum alloys lap joint with superb strength.
基金National Natural Science Foundation of China(12073028,12473084).
文摘Continuing advancement in astronomy,space exploration,and scientific detection,has increased demand for infrared multi-band detection systems.Traditional three-band optical systems,designed to simultaneously image at infrared short-wave,mid-wave,and long-wave bands typically rely on dispersive elements,leading to bulky sizes,complex system architectures,low efficiency,and challenges in rapid assembly.To overcome these obstacles,in combination with the latest third-generation infrared detectors,we propose a design for a compact and lightweight three-band optical system,with infrared capabilities in all three required bands.The core of this approach is an integrated design philosophy that emphasizes the high steepness of mirror surfaces.This design achieves uniform correction and optimization of chromatic aberration and off-axis aberration across the spectral range.We introduce a novel integration of optical and mechanical elements to replace traditional assembly,reducing manufacturing and assembly errors,and degrees of freedom,associated with high-power optical elements.Confirming the effectiveness through a combination of simulations and experimental comparisons,the measured mid-wave full-field transfer function exceeds 0.405 at 17 lp/mm,satisfying the imaging requirements of the system.The optical system is lightweight and compact,with a total mass under 408 g and a compact volume of justΦ112 mm×117 mm.This serves as a valuable reference for the engineering application of high-performance,compact multi-band infrared composite detection systems for astronomy and space exploration.
基金Supported by Fund of Science and Technology Plan Project in Zhuhai,No.PC20061084
文摘AIM:To investigate the mRNA expression of cyclooxygensae-2(COX-2)in benign and malignant ascites,and to explore the difference in COX-2 mRNA expression among different diseases.METHODS:A total of 36 samples were collected from the Fifth Affiliated Hospital of Sun Yat-Sen University and divided into two experimental groups:benign ascites(n=21)and malignant ascites(n=15).Benign ascites included cirrhotic ascites(n=10)and tuberculous ascites(n=5).Malignant ascites included oophoroma(n=7),cancer of colon(n=5),cancer of the liver(n=6),gastric cancer(n=2),and bladder carcinoma(n=1).The mRNA expression of COX-2 in ascites was examined with reverse transcriptase polymerase chain reaction(RT-PCR)technology,and the positive rate of COX-2 mRNA was compared between different diseases.RESULTS:The positive rate of COX-2 mRNA in malignant ascites was 42.9%(9/21),which was significantly higher than in benign ascites,6.7%(1/15),difference being significant between these two groups(χ2=4.051,P=0.044).The proportion of the positive rate in the malignant ascites was as follows:ovarian cancers57.1%(4/7),colon cancer 40.0%(2/5),liver cancer33.3%(2/6),gastric cancer 50.0%(1/2),and bladder cancer 0.00%(0/1).However,there was no significant difference in COX-2 mRNA expression among various tumors with malignant ascites(χ2=1.614,P=0.806).Among the benign ascites,COX-2 mRNA levels were different between the tuberculous ascites(0/5)and cirrhotic ascites(1/10),but there was no significant difference(P=1.000).CONCLUSION:COX-2 mRNA,detected by RT-PCR,is useful in the differential diagnosis of benign and malignant ascites,which also has potential value in the clinical diagnosis of tumors.
