OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic stroke...OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic stroke.METHODS:Network pharmacology was used to determine the compatibility of TM,YLC,and BP,and their potential mechanism.The middle cerebral artery occlusion(MCAO)rat model was used to evaluate the curative effect of the six combinations of TM,YLC,and BP(TZB1-TZB6)on cerebral ischemia,by using the weight matching method to form.The potential component changes of TM and YLC in the blood and brains of rats were analyzed using ultra performance liquid chromatography-mass spectrometry.Finally,molecular docking linked the results of animal experiments and network pharmacology,determining the potential component contributors of TM and YLC to treating ischemic stroke.RESULTS:TZB reduced the cerebral infarct volume and protected the nerve cells in MCAO rats.The components of TM and YLC were also identified in the blood and brain homogenate,and BP can facilitate the entry of the components of TM and YLC into the blood and brain.Diosgenin,pennogenin,and gastrodin induced effective binding activities with adenosine receptor a1.CONCLUSION:We investigate an approach that improves the means of folk prescription combined with multi technology that maybe promote the transformation of Chinese medicinal prescription into component-based Chinese medicine.展开更多
The basic environmental variables and adaptability ofphytoplankton communities to low light and salinity were stud- ied using incubation experiments in Kongsfjorden, a high Arctic fjord of Spitsbergen, in late summer ...The basic environmental variables and adaptability ofphytoplankton communities to low light and salinity were stud- ied using incubation experiments in Kongsfjorden, a high Arctic fjord of Spitsbergen, in late summer 2006. Chlorophyll a concentrations were steady or decreased slightly in darkness after one day or one week incubation. Chlorophyll a concentrations showed an initial decline when exposed to natural light after one week incubation in darkness, and then increased significantly. In a salinity experiment, the maximal growth rate was observed at a dilution ratio of 10%, however, higher dilution ratios （≥0%） had an obvious negative effect on phytoplankton growth. We suggest that the phytoplankton communities in fjords in late summer are dark- ness adapted, and the inflow of glacial melt water is favorable for phytoplankton growth in the outer fiords where the influence of freshwater is limited.展开更多
Information hiding in Joint Photographic Experts Group （JPEG） compressed images are investigated in this paper. Quantization is the source of information loss in JPEG compression process. Therefore, information hidd...Information hiding in Joint Photographic Experts Group （JPEG） compressed images are investigated in this paper. Quantization is the source of information loss in JPEG compression process. Therefore, information hidden in images is probably destroyed by JPEG compression. This paper presents an algorithm to reliably embed information into the JPEG bit streams in the process of JPEG encoding. Information extraction is performed in the process of JPEG decoding. The basic idea of our algorithm is to modify the quantized direct current （DC） coefficients and non zero alternating currenl （AC） coefficients to represent one bit information （0 or 1 ）. Experimental results on gray images using baseline sequential JPEG encoding show that the cover images （images without scoret information） and the stego-images （images with secret information） are perceptually indiscernible.展开更多
基金Supported by Natural Science Foundation of China:Study on the Mechanism of Adjusting Yin and Eliminating Toxicity in Tujia Medicine to Treat Vascular Dementia based on Angiogenesisregulation by Angiogemic Switch and Nrf2/ARE pathway(No.81473793)Youth Talent Project from Beijing Education Commission:Optimization of Prescription of Tianzhu San,a Tujia medicine,based on Identification and Targeted Separation of Active Ingredients(No.YETP1293)
文摘OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic stroke.METHODS:Network pharmacology was used to determine the compatibility of TM,YLC,and BP,and their potential mechanism.The middle cerebral artery occlusion(MCAO)rat model was used to evaluate the curative effect of the six combinations of TM,YLC,and BP(TZB1-TZB6)on cerebral ischemia,by using the weight matching method to form.The potential component changes of TM and YLC in the blood and brains of rats were analyzed using ultra performance liquid chromatography-mass spectrometry.Finally,molecular docking linked the results of animal experiments and network pharmacology,determining the potential component contributors of TM and YLC to treating ischemic stroke.RESULTS:TZB reduced the cerebral infarct volume and protected the nerve cells in MCAO rats.The components of TM and YLC were also identified in the blood and brain homogenate,and BP can facilitate the entry of the components of TM and YLC into the blood and brain.Diosgenin,pennogenin,and gastrodin induced effective binding activities with adenosine receptor a1.CONCLUSION:We investigate an approach that improves the means of folk prescription combined with multi technology that maybe promote the transformation of Chinese medicinal prescription into component-based Chinese medicine.
基金supported by the National Natural Science Foundation of China (Grant nos. 41076130, 40576002)the Youth Marine Science Foundation of SOA (Grant no. 2010116)
文摘The basic environmental variables and adaptability ofphytoplankton communities to low light and salinity were stud- ied using incubation experiments in Kongsfjorden, a high Arctic fjord of Spitsbergen, in late summer 2006. Chlorophyll a concentrations were steady or decreased slightly in darkness after one day or one week incubation. Chlorophyll a concentrations showed an initial decline when exposed to natural light after one week incubation in darkness, and then increased significantly. In a salinity experiment, the maximal growth rate was observed at a dilution ratio of 10%, however, higher dilution ratios （≥0%） had an obvious negative effect on phytoplankton growth. We suggest that the phytoplankton communities in fjords in late summer are dark- ness adapted, and the inflow of glacial melt water is favorable for phytoplankton growth in the outer fiords where the influence of freshwater is limited.
文摘Information hiding in Joint Photographic Experts Group （JPEG） compressed images are investigated in this paper. Quantization is the source of information loss in JPEG compression process. Therefore, information hidden in images is probably destroyed by JPEG compression. This paper presents an algorithm to reliably embed information into the JPEG bit streams in the process of JPEG encoding. Information extraction is performed in the process of JPEG decoding. The basic idea of our algorithm is to modify the quantized direct current （DC） coefficients and non zero alternating currenl （AC） coefficients to represent one bit information （0 or 1 ）. Experimental results on gray images using baseline sequential JPEG encoding show that the cover images （images without scoret information） and the stego-images （images with secret information） are perceptually indiscernible.
