OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic stroke...OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic stroke.METHODS:Network pharmacology was used to determine the compatibility of TM,YLC,and BP,and their potential mechanism.The middle cerebral artery occlusion(MCAO)rat model was used to evaluate the curative effect of the six combinations of TM,YLC,and BP(TZB1-TZB6)on cerebral ischemia,by using the weight matching method to form.The potential component changes of TM and YLC in the blood and brains of rats were analyzed using ultra performance liquid chromatography-mass spectrometry.Finally,molecular docking linked the results of animal experiments and network pharmacology,determining the potential component contributors of TM and YLC to treating ischemic stroke.RESULTS:TZB reduced the cerebral infarct volume and protected the nerve cells in MCAO rats.The components of TM and YLC were also identified in the blood and brain homogenate,and BP can facilitate the entry of the components of TM and YLC into the blood and brain.Diosgenin,pennogenin,and gastrodin induced effective binding activities with adenosine receptor a1.CONCLUSION:We investigate an approach that improves the means of folk prescription combined with multi technology that maybe promote the transformation of Chinese medicinal prescription into component-based Chinese medicine.展开更多
由于水的吸收和悬浮粒子的散射作用,水下图像出现色偏、对比度降低以及细节模糊等问题,影响水下视觉同步定位与地图构建(Simultaneous localization and mapping,SLAM)前端特征提取和特征匹配。针对上述问题,提出一种用于水下视觉SLAM...由于水的吸收和悬浮粒子的散射作用,水下图像出现色偏、对比度降低以及细节模糊等问题,影响水下视觉同步定位与地图构建(Simultaneous localization and mapping,SLAM)前端特征提取和特征匹配。针对上述问题,提出一种用于水下视觉SLAM前端的多尺度融合与细节突显的图像增强算法。首先,提出一种改进颜色通道补偿的颜色校正方法,用于校正水下图像色偏;其次,利用曝光融合框架对颜色校正的水下图像对比度进行增强;然后,将颜色校正图像和对比度增强图像进行多尺度融合;最后,采用非锐化掩模对融合图像进行细节突显,进而得到视觉效果较好的增强图像。实验结果表明,与其他算法相比,该算法处理后的水下图像在颜色平衡、对比度、细节以及清晰度等方面的效果较好,同时还增加了特征点和特征匹配对数,显著改善了水下视觉SLAM前端的特征提取和特征匹配。展开更多
The basic environmental variables and adaptability ofphytoplankton communities to low light and salinity were stud- ied using incubation experiments in Kongsfjorden, a high Arctic fjord of Spitsbergen, in late summer ...The basic environmental variables and adaptability ofphytoplankton communities to low light and salinity were stud- ied using incubation experiments in Kongsfjorden, a high Arctic fjord of Spitsbergen, in late summer 2006. Chlorophyll a concentrations were steady or decreased slightly in darkness after one day or one week incubation. Chlorophyll a concentrations showed an initial decline when exposed to natural light after one week incubation in darkness, and then increased significantly. In a salinity experiment, the maximal growth rate was observed at a dilution ratio of 10%, however, higher dilution ratios （≥0%） had an obvious negative effect on phytoplankton growth. We suggest that the phytoplankton communities in fjords in late summer are dark- ness adapted, and the inflow of glacial melt water is favorable for phytoplankton growth in the outer fiords where the influence of freshwater is limited.展开更多
基金Supported by Natural Science Foundation of China:Study on the Mechanism of Adjusting Yin and Eliminating Toxicity in Tujia Medicine to Treat Vascular Dementia based on Angiogenesisregulation by Angiogemic Switch and Nrf2/ARE pathway(No.81473793)Youth Talent Project from Beijing Education Commission:Optimization of Prescription of Tianzhu San,a Tujia medicine,based on Identification and Targeted Separation of Active Ingredients(No.YETP1293)
文摘OBJECTIVE:To evaluate the compatibility of Tianma(Rhizoma Gastrodiae,TM),Yanlingcao(Trillium tschonoskii Maxim,YLC)and Bingpian(Borneolum Syntheticum,BP),and their efficacy in the treatment of cerebral ischemic stroke.METHODS:Network pharmacology was used to determine the compatibility of TM,YLC,and BP,and their potential mechanism.The middle cerebral artery occlusion(MCAO)rat model was used to evaluate the curative effect of the six combinations of TM,YLC,and BP(TZB1-TZB6)on cerebral ischemia,by using the weight matching method to form.The potential component changes of TM and YLC in the blood and brains of rats were analyzed using ultra performance liquid chromatography-mass spectrometry.Finally,molecular docking linked the results of animal experiments and network pharmacology,determining the potential component contributors of TM and YLC to treating ischemic stroke.RESULTS:TZB reduced the cerebral infarct volume and protected the nerve cells in MCAO rats.The components of TM and YLC were also identified in the blood and brain homogenate,and BP can facilitate the entry of the components of TM and YLC into the blood and brain.Diosgenin,pennogenin,and gastrodin induced effective binding activities with adenosine receptor a1.CONCLUSION:We investigate an approach that improves the means of folk prescription combined with multi technology that maybe promote the transformation of Chinese medicinal prescription into component-based Chinese medicine.
文摘由于水的吸收和悬浮粒子的散射作用,水下图像出现色偏、对比度降低以及细节模糊等问题,影响水下视觉同步定位与地图构建(Simultaneous localization and mapping,SLAM)前端特征提取和特征匹配。针对上述问题,提出一种用于水下视觉SLAM前端的多尺度融合与细节突显的图像增强算法。首先,提出一种改进颜色通道补偿的颜色校正方法,用于校正水下图像色偏;其次,利用曝光融合框架对颜色校正的水下图像对比度进行增强;然后,将颜色校正图像和对比度增强图像进行多尺度融合;最后,采用非锐化掩模对融合图像进行细节突显,进而得到视觉效果较好的增强图像。实验结果表明,与其他算法相比,该算法处理后的水下图像在颜色平衡、对比度、细节以及清晰度等方面的效果较好,同时还增加了特征点和特征匹配对数,显著改善了水下视觉SLAM前端的特征提取和特征匹配。
基金supported by the National Natural Science Foundation of China (Grant nos. 41076130, 40576002)the Youth Marine Science Foundation of SOA (Grant no. 2010116)
文摘The basic environmental variables and adaptability ofphytoplankton communities to low light and salinity were stud- ied using incubation experiments in Kongsfjorden, a high Arctic fjord of Spitsbergen, in late summer 2006. Chlorophyll a concentrations were steady or decreased slightly in darkness after one day or one week incubation. Chlorophyll a concentrations showed an initial decline when exposed to natural light after one week incubation in darkness, and then increased significantly. In a salinity experiment, the maximal growth rate was observed at a dilution ratio of 10%, however, higher dilution ratios （≥0%） had an obvious negative effect on phytoplankton growth. We suggest that the phytoplankton communities in fjords in late summer are dark- ness adapted, and the inflow of glacial melt water is favorable for phytoplankton growth in the outer fiords where the influence of freshwater is limited.
