BACKGROUND As the global population ages,the number of elderly patients with acute coronary syndrome(ACS)rises.However,prognostic assessment tools for elderly patients with ACS remain lacking,particularly in the Chine...BACKGROUND As the global population ages,the number of elderly patients with acute coronary syndrome(ACS)rises.However,prognostic assessment tools for elderly patients with ACS remain lacking,particularly in the Chinese population.This study aimed to develop and validate a nomogram to predict 2-year major adverse cardiovascular and cerebrovascular events(MACCE)in elderly Chinese patients with ACS.METHODS A retrospective analysis was conducted using two independent cohorts of ACS patients aged≥65 years who underwent percutaneous coronary intervention:the derivation cohort(n=1674)and the validation cohort(n=2333).Candidate predictors were selected using multivariable Cox proportional hazards regression and the Akaike information criterion.A final nomogram incorporating ten variables was constructed.Model performance was evaluated in terms of discrimination[concordance index(C-index)and area under the receiver operating characteristic curve(AUC)]and calibration(calibration plots).RESULTS The 2-year incidence of MACCE was 12.5%(n=210)in the derivation cohort and 15.6%(n=364)in the validation cohort.The nomogram demonstrated good discrimination,with C-index values of 0.727 and 0.661 and AUCs of 0.723 and 0.699 in the derivation cohort and the validation cohort,respectively;significantly outperforming the GRACE risk score(P<0.001).Calibration plots showed good agreement between the predicted and observed outcomes.Patients classified as the high-risk group by the nomogram had a significantly higher MACCE incidence compared to that of the low-risk group(log-rank P<0.001).CONCLUSIONS This newly developed nomogram provides a reliable tool for individualized prediction of the 2-year MACCE risk in elderly Chinese patients with ACS who underwent percutaneous coronary intervention.It outperformed the GRACE score in both discrimmination and calibration and may help improve clinical decision-making and personalized risk stratification in this vulnerable population.展开更多
Pigs have emerged as valuable large-animal models for cardiac xenotransplantation;however,the temporal dynamics of myocardial development in this species remains insufficiently defined.This study analyzed gene express...Pigs have emerged as valuable large-animal models for cardiac xenotransplantation;however,the temporal dynamics of myocardial development in this species remains insufficiently defined.This study analyzed gene expression patterns across four key developmental stages(neonatal,juvenile,sexual maturity,and adulthood)to delineate the molecular mechanisms driving porcine myocardial development.Increases in heart weight were accompanied by proportional expansion of myocardial fiber area and chamber size,reflecting coordinated structural development.Transcriptomic profiling of myocardial tissue by RNA sequencing(RNA-seq)identified 2189 differentially expressed genes(DEGs)across stage comparisons.Short time-series expression miner(STEM)analysis classified these DEGs into four major expression clusters enriched in pathways associated with myocardial development,immune responses,cell proliferation,and metabolic processes.Among 359 DEGs conserved across all developmental stages,six candidate genes were strongly associated with myocardial development.Reverse transcription-quantitative real-time polymerase chain reaction(RT-qPCR)confirmed a significant correlation between the expression of these candidate genes and myocardial development in porcine tissue.These findings establish a transcriptomic framework for porcine myocardial maturation and provide a molecular basis for advancing cardiac xenotransplantation.展开更多
OBJECTIVE:To evaluate the efficacy and safety of Qingchang suppository(清肠栓,QCS),a preparation of Chinese herbal medicine,in the induction of remission in patients with mild-to-moderate ulcerative proctitis(UP).METH...OBJECTIVE:To evaluate the efficacy and safety of Qingchang suppository(清肠栓,QCS),a preparation of Chinese herbal medicine,in the induction of remission in patients with mild-to-moderate ulcerative proctitis(UP).METHODS:We performed a multicenter,prospective,randomized,parallel-controlled trial to evaluate the efficacy of QCS induction therapy in 140 adult patients with mild-to-moderate UP and TCM syndrome of dampness-heat in large intestine.The patients were randomized to receive QCS(study group)or Salicylazosulfapyridine(SASP)suppository(control group)one piece each time,twice a day,per anum for 12 weeks.Mayo score and main symptoms score were evaluated at weeks 0,2,4,8 and 12,rectosigmoidscopy was taken at weeks 0,4,8 and 12,Geboes score,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and safety indexes were assessed at weeks 0 and 12.The primary efficacy endpoint is clinical remission rate,the secondary efficacy endpoints are clinical response rate,mucosa healing rate,Geboes score,the remission rates of the main symptoms,the median day to the remission of the symptom,etc.RESULTS:There were no statistical difference in the clinical remission rates,the clinical response rates,the mucosa healing rates,Geboes score,ESR and CRP between the two groups.The remission rates of tenesmus and anal burning sensation of the study group were significantly higher than those of the control group(76.5%vs 25.0%,P=0.009;74.51%vs 29.63%,P=0.003).The median day to the remission of purulent bloody stool of the study group was significantly less than that of control group[11(1,64)vs 19(2,67),P=0.007].The patients receiving QCS had a significantly higher mucosa healing rate at week 4 than the patients receiving SASP suppository(71.42%vs 52.85%,P=0.023).No adverse event occurred in the study group while the adverse events incidence of the control group was 5.7%(P=0.049).CONCLUSIONS:QCS could induce the remission of UP as effectively and safely as SASP suppository,and was superior to SASP suppository in relieving the symptoms of tenesmus,anal burning sensation and purulent bloody stool and the time to reach mucosa healing.展开更多
Non-blind audio bandwidth extension is a standard technique within contemporary audio codecs to efficiently code audio signals at low bitrates. In existing methods, in most cases high frequencies signal is usually gen...Non-blind audio bandwidth extension is a standard technique within contemporary audio codecs to efficiently code audio signals at low bitrates. In existing methods, in most cases high frequencies signal is usually generated by a duplication of the corresponding low frequencies and some parameters of high frequencies. However, the perception quality of coding will significantly degrade if the correlation between high frequencies and low frequencies becomes weak. In this paper, we quantitatively analyse the correlation via computing mutual information value. The analysis results show the correlation also exists in low frequency signal of the context dependent frames besides the current frame. In order to improve the perception quality of coding, we propose a novel method of high frequency coarse spectrum generation to improve the conventional replication method. In the proposed method, the coarse high frequency spectrums are generated by a nonlinear mapping model using deep recurrent neural network. The experiments confirm that the proposed method shows better performance than the reference methods.展开更多
The dynamic characteristics of hydraulic self servo swing cylinder were analyzed according to the hydraulic system natural frequency formula. Based on that,a method of the hydraulic self servo swing cylinder structure...The dynamic characteristics of hydraulic self servo swing cylinder were analyzed according to the hydraulic system natural frequency formula. Based on that,a method of the hydraulic self servo swing cylinder structure optimization based on genetic algorithm was proposed in this paper. By analyzing the four parameters that affect the dynamic characteristics, we had to optimize the structure to obtain as larger the Dm( displacement) as possible under the condition with the purpose of improving the dynamic characteristics of hydraulic self servo swing cylinder. So three state equations were established in this paper. The paper analyzed the effect of the four parameters in hydraulic self servo swing cylinder natural frequency equation and used the genetic algorithm to obtain the optimal solution of structure parameters. The model was simulated by substituting the parameters and initial value to the simulink model. Simulation results show that: using self servo hydraulic swing cylinder natural frequency equation to study its dynamic response characteristics is very effective.Compared with no optimization,the overall system dynamic response speed is significantly improved.展开更多
Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients wit...Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).展开更多
Objective The SYNTAX score(Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery,SS)is now broadly accepted to guide and predict mortality of complex coronary artery disease(CAD)patients un...Objective The SYNTAX score(Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery,SS)is now broadly accepted to guide and predict mortality of complex coronary artery disease(CAD)patients undergoing PCI or CABG.Recently,the clinical SYNTAX score which is a combination of age,ejection fraction,decrease in creatinine clearance and classic SYNTAX score,has been found to be superior in predicting adverse outcomes compared with the SYNTAX scores.Whether the clinical SS could help to determine which patients could be managed medically has never been explored.We sought to investigate the prognostic impact of the SS on long-term clinical outcomes in patients with three vessels disease undergoing medical therapy only.展开更多
Background and Objective Prediabetes(Pre-DM)is a serious condition that is associated with an increase in cardiovascular morbidity and mortality.We sought to explore the prevalence of prediabetes in patients admitted ...Background and Objective Prediabetes(Pre-DM)is a serious condition that is associated with an increase in cardiovascular morbidity and mortality.We sought to explore the prevalence of prediabetes in patients admitted with coronary artery disease who were not known to have diabetes and to determine the impact of prediabetes on 2-year clinical outcomes versus non-diabetic patients.展开更多
目的:评估超声内镜引导下细针穿刺(endoscopic ultrasound-guided fine needle aspiration,EUS-FNA)在胆管病变中的诊断效能和安全性,并探讨影响其准确性的因素。方法:回顾性分析2021年1月到2023年12月成都市第三人民医院因疑似胆管恶...目的:评估超声内镜引导下细针穿刺(endoscopic ultrasound-guided fine needle aspiration,EUS-FNA)在胆管病变中的诊断效能和安全性,并探讨影响其准确性的因素。方法:回顾性分析2021年1月到2023年12月成都市第三人民医院因疑似胆管恶性狭窄/占位而接受EUS-FNA的41例患者临床资料,其中男性22例,女性19例,平均年龄为65.9(35.0~89.0)岁。评估其诊断效能(敏感性、特异性、阳性预测值、阴性预测值和准确性)及影响因素。结果:EUS-FNA对于胆管病变的总体灵敏性为85%,特异性为100%,阳性预测值为100%,阴性预测值为33%,准确性为86%;25G穿刺针和是否存在实性占位是影响EUS-FNA诊断胆管病变准确性的重要因素,而穿刺部位并未对诊断效能产生影响,参与分析的41例患者在随访期间未发现与EUS-FNA相关不良事件。结论:EUS-FNA在诊断胆管病变时具有较高的准确性和安全性,特别是使用25G穿刺针及存在胆管实性占位时,EUSFNA的诊断准确性更高。展开更多
系统梳理中医药干预溃疡性结肠炎(UC)的随机对照试验(RCT),分析中医药临床试验的研究特征和结局指标,以期为后续开展中医药干预UC的RCT设计提供参考,为中医药在UC中的临床应用提供证据支持。计算机检索中国知网(CNKI)、万方(Wanfang)、...系统梳理中医药干预溃疡性结肠炎(UC)的随机对照试验(RCT),分析中医药临床试验的研究特征和结局指标,以期为后续开展中医药干预UC的RCT设计提供参考,为中医药在UC中的临床应用提供证据支持。计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library、EMbase、Web of Science数据库2021年1月至2024年8月中医药治疗UC的RCT,评估偏倚风险,定性分析结局指标。最终纳入555篇RCT,样本量44853例,样本量最大为218例,最小为28例,多集中在60~100例;386篇RCT明确报告了中医证型,排序前3的分别是大肠湿热证(31.05%)、脾肾阳虚证(12.47%)及脾虚湿蕴证(9.17%);干预措施使用频数由高到低包括内服中药复方/制剂(64.5%)、中药复方/制剂保留灌肠(18.2%)、内服中药复方/制剂+中医外治(5.95%)、中医外治(4.86%)等;治疗疗程多集中在4~8周(64.86%),61篇(10.99%)研究报告了随访时间;共使用了157种结局指标,使用频数3460次,分属6个指标域:中医证候/症状(346次,10%)、症状/体征(541次,15.64%)、理化检查(2119次,61.24%)、生活质量(107次,3.09%)、远期预后(61次,1.76%)、安全性事件(284次,8.21%)。结果表明,中医药治疗UC的结局指标面临样本量计算缺乏依据、中医辨证分型欠规范、试验方案的设计与注册缺失、盲法与分配隐藏不足、干预措施的依从性、替代指标与终点指标选择不平衡、结局指标测量时点不统一以及设计待规范、伦理与安全性问题的局限性。建议未来应积极构建一套涵盖中医证型的标准化分类、明确的疗效评价指标、关键的终点指标及合理的测量时点,同时强调对远期预后影响的追踪、患者生活质量的全面评估及经济学效益考量的UC核心指标集,为中医药治疗UC的临床实践提供依据。展开更多
基金supported by the National High Level Hospital Clinical Research Funding(2025-GSP-QN-31&2022-GSP-QN-1)the Young Talent Program of the Academician Fund(YS-2022-002)the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS)(2023-I2M-1-002)。
文摘BACKGROUND As the global population ages,the number of elderly patients with acute coronary syndrome(ACS)rises.However,prognostic assessment tools for elderly patients with ACS remain lacking,particularly in the Chinese population.This study aimed to develop and validate a nomogram to predict 2-year major adverse cardiovascular and cerebrovascular events(MACCE)in elderly Chinese patients with ACS.METHODS A retrospective analysis was conducted using two independent cohorts of ACS patients aged≥65 years who underwent percutaneous coronary intervention:the derivation cohort(n=1674)and the validation cohort(n=2333).Candidate predictors were selected using multivariable Cox proportional hazards regression and the Akaike information criterion.A final nomogram incorporating ten variables was constructed.Model performance was evaluated in terms of discrimination[concordance index(C-index)and area under the receiver operating characteristic curve(AUC)]and calibration(calibration plots).RESULTS The 2-year incidence of MACCE was 12.5%(n=210)in the derivation cohort and 15.6%(n=364)in the validation cohort.The nomogram demonstrated good discrimination,with C-index values of 0.727 and 0.661 and AUCs of 0.723 and 0.699 in the derivation cohort and the validation cohort,respectively;significantly outperforming the GRACE risk score(P<0.001).Calibration plots showed good agreement between the predicted and observed outcomes.Patients classified as the high-risk group by the nomogram had a significantly higher MACCE incidence compared to that of the low-risk group(log-rank P<0.001).CONCLUSIONS This newly developed nomogram provides a reliable tool for individualized prediction of the 2-year MACCE risk in elderly Chinese patients with ACS who underwent percutaneous coronary intervention.It outperformed the GRACE score in both discrimmination and calibration and may help improve clinical decision-making and personalized risk stratification in this vulnerable population.
基金supported by the National Natural Science Foundation of China(32222079 to L.J.and 32202621 to D.D.W.)。
文摘Pigs have emerged as valuable large-animal models for cardiac xenotransplantation;however,the temporal dynamics of myocardial development in this species remains insufficiently defined.This study analyzed gene expression patterns across four key developmental stages(neonatal,juvenile,sexual maturity,and adulthood)to delineate the molecular mechanisms driving porcine myocardial development.Increases in heart weight were accompanied by proportional expansion of myocardial fiber area and chamber size,reflecting coordinated structural development.Transcriptomic profiling of myocardial tissue by RNA sequencing(RNA-seq)identified 2189 differentially expressed genes(DEGs)across stage comparisons.Short time-series expression miner(STEM)analysis classified these DEGs into four major expression clusters enriched in pathways associated with myocardial development,immune responses,cell proliferation,and metabolic processes.Among 359 DEGs conserved across all developmental stages,six candidate genes were strongly associated with myocardial development.Reverse transcription-quantitative real-time polymerase chain reaction(RT-qPCR)confirmed a significant correlation between the expression of these candidate genes and myocardial development in porcine tissue.These findings establish a transcriptomic framework for porcine myocardial maturation and provide a molecular basis for advancing cardiac xenotransplantation.
基金Shanghai Municipal Administration of Traditional Chinese Medicine:Leadship Training Program of Inheritance and Innovation Team of Shanghai School of Traditional Chinese Medicine(No.2021WXGLP-007)。
文摘OBJECTIVE:To evaluate the efficacy and safety of Qingchang suppository(清肠栓,QCS),a preparation of Chinese herbal medicine,in the induction of remission in patients with mild-to-moderate ulcerative proctitis(UP).METHODS:We performed a multicenter,prospective,randomized,parallel-controlled trial to evaluate the efficacy of QCS induction therapy in 140 adult patients with mild-to-moderate UP and TCM syndrome of dampness-heat in large intestine.The patients were randomized to receive QCS(study group)or Salicylazosulfapyridine(SASP)suppository(control group)one piece each time,twice a day,per anum for 12 weeks.Mayo score and main symptoms score were evaluated at weeks 0,2,4,8 and 12,rectosigmoidscopy was taken at weeks 0,4,8 and 12,Geboes score,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and safety indexes were assessed at weeks 0 and 12.The primary efficacy endpoint is clinical remission rate,the secondary efficacy endpoints are clinical response rate,mucosa healing rate,Geboes score,the remission rates of the main symptoms,the median day to the remission of the symptom,etc.RESULTS:There were no statistical difference in the clinical remission rates,the clinical response rates,the mucosa healing rates,Geboes score,ESR and CRP between the two groups.The remission rates of tenesmus and anal burning sensation of the study group were significantly higher than those of the control group(76.5%vs 25.0%,P=0.009;74.51%vs 29.63%,P=0.003).The median day to the remission of purulent bloody stool of the study group was significantly less than that of control group[11(1,64)vs 19(2,67),P=0.007].The patients receiving QCS had a significantly higher mucosa healing rate at week 4 than the patients receiving SASP suppository(71.42%vs 52.85%,P=0.023).No adverse event occurred in the study group while the adverse events incidence of the control group was 5.7%(P=0.049).CONCLUSIONS:QCS could induce the remission of UP as effectively and safely as SASP suppository,and was superior to SASP suppository in relieving the symptoms of tenesmus,anal burning sensation and purulent bloody stool and the time to reach mucosa healing.
基金supported by the National Natural Science Foundation of China under Grant No. 61762005, 61231015, 61671335, 61702472, 61701194, 61761044, 61471271National High Technology Research and Development Program of China (863 Program) under Grant No. 2015AA016306+2 种基金 Hubei Province Technological Innovation Major Project under Grant No. 2016AAA015the Science Project of Education Department of Jiangxi Province under No. GJJ150585The Opening Project of Collaborative Innovation Center for Economics Crime Investigation and Prevention Technology, Jiangxi Province, under Grant No. JXJZXTCX-025
文摘Non-blind audio bandwidth extension is a standard technique within contemporary audio codecs to efficiently code audio signals at low bitrates. In existing methods, in most cases high frequencies signal is usually generated by a duplication of the corresponding low frequencies and some parameters of high frequencies. However, the perception quality of coding will significantly degrade if the correlation between high frequencies and low frequencies becomes weak. In this paper, we quantitatively analyse the correlation via computing mutual information value. The analysis results show the correlation also exists in low frequency signal of the context dependent frames besides the current frame. In order to improve the perception quality of coding, we propose a novel method of high frequency coarse spectrum generation to improve the conventional replication method. In the proposed method, the coarse high frequency spectrums are generated by a nonlinear mapping model using deep recurrent neural network. The experiments confirm that the proposed method shows better performance than the reference methods.
基金Sponsored by the National Natural Science Foundation of China(Grant No.61105086)Self-Planned Task of State Key Laboratory of Robotics and System(HIT)(Grant No.SKLRS-2010-MS-12)Hubei Province Natural Science Foundation(Grant No.2010CDB0 3405)
文摘The dynamic characteristics of hydraulic self servo swing cylinder were analyzed according to the hydraulic system natural frequency formula. Based on that,a method of the hydraulic self servo swing cylinder structure optimization based on genetic algorithm was proposed in this paper. By analyzing the four parameters that affect the dynamic characteristics, we had to optimize the structure to obtain as larger the Dm( displacement) as possible under the condition with the purpose of improving the dynamic characteristics of hydraulic self servo swing cylinder. So three state equations were established in this paper. The paper analyzed the effect of the four parameters in hydraulic self servo swing cylinder natural frequency equation and used the genetic algorithm to obtain the optimal solution of structure parameters. The model was simulated by substituting the parameters and initial value to the simulink model. Simulation results show that: using self servo hydraulic swing cylinder natural frequency equation to study its dynamic response characteristics is very effective.Compared with no optimization,the overall system dynamic response speed is significantly improved.
文摘Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).
文摘Objective The SYNTAX score(Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery,SS)is now broadly accepted to guide and predict mortality of complex coronary artery disease(CAD)patients undergoing PCI or CABG.Recently,the clinical SYNTAX score which is a combination of age,ejection fraction,decrease in creatinine clearance and classic SYNTAX score,has been found to be superior in predicting adverse outcomes compared with the SYNTAX scores.Whether the clinical SS could help to determine which patients could be managed medically has never been explored.We sought to investigate the prognostic impact of the SS on long-term clinical outcomes in patients with three vessels disease undergoing medical therapy only.
文摘Background and Objective Prediabetes(Pre-DM)is a serious condition that is associated with an increase in cardiovascular morbidity and mortality.We sought to explore the prevalence of prediabetes in patients admitted with coronary artery disease who were not known to have diabetes and to determine the impact of prediabetes on 2-year clinical outcomes versus non-diabetic patients.
文摘目的:评估超声内镜引导下细针穿刺(endoscopic ultrasound-guided fine needle aspiration,EUS-FNA)在胆管病变中的诊断效能和安全性,并探讨影响其准确性的因素。方法:回顾性分析2021年1月到2023年12月成都市第三人民医院因疑似胆管恶性狭窄/占位而接受EUS-FNA的41例患者临床资料,其中男性22例,女性19例,平均年龄为65.9(35.0~89.0)岁。评估其诊断效能(敏感性、特异性、阳性预测值、阴性预测值和准确性)及影响因素。结果:EUS-FNA对于胆管病变的总体灵敏性为85%,特异性为100%,阳性预测值为100%,阴性预测值为33%,准确性为86%;25G穿刺针和是否存在实性占位是影响EUS-FNA诊断胆管病变准确性的重要因素,而穿刺部位并未对诊断效能产生影响,参与分析的41例患者在随访期间未发现与EUS-FNA相关不良事件。结论:EUS-FNA在诊断胆管病变时具有较高的准确性和安全性,特别是使用25G穿刺针及存在胆管实性占位时,EUSFNA的诊断准确性更高。
文摘系统梳理中医药干预溃疡性结肠炎(UC)的随机对照试验(RCT),分析中医药临床试验的研究特征和结局指标,以期为后续开展中医药干预UC的RCT设计提供参考,为中医药在UC中的临床应用提供证据支持。计算机检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library、EMbase、Web of Science数据库2021年1月至2024年8月中医药治疗UC的RCT,评估偏倚风险,定性分析结局指标。最终纳入555篇RCT,样本量44853例,样本量最大为218例,最小为28例,多集中在60~100例;386篇RCT明确报告了中医证型,排序前3的分别是大肠湿热证(31.05%)、脾肾阳虚证(12.47%)及脾虚湿蕴证(9.17%);干预措施使用频数由高到低包括内服中药复方/制剂(64.5%)、中药复方/制剂保留灌肠(18.2%)、内服中药复方/制剂+中医外治(5.95%)、中医外治(4.86%)等;治疗疗程多集中在4~8周(64.86%),61篇(10.99%)研究报告了随访时间;共使用了157种结局指标,使用频数3460次,分属6个指标域:中医证候/症状(346次,10%)、症状/体征(541次,15.64%)、理化检查(2119次,61.24%)、生活质量(107次,3.09%)、远期预后(61次,1.76%)、安全性事件(284次,8.21%)。结果表明,中医药治疗UC的结局指标面临样本量计算缺乏依据、中医辨证分型欠规范、试验方案的设计与注册缺失、盲法与分配隐藏不足、干预措施的依从性、替代指标与终点指标选择不平衡、结局指标测量时点不统一以及设计待规范、伦理与安全性问题的局限性。建议未来应积极构建一套涵盖中医证型的标准化分类、明确的疗效评价指标、关键的终点指标及合理的测量时点,同时强调对远期预后影响的追踪、患者生活质量的全面评估及经济学效益考量的UC核心指标集,为中医药治疗UC的临床实践提供依据。
