Chondrocyte senescence is a critical pathological hallmark of osteoarthritis(OA).Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging;however,the precise underlying mechanism remains elu...Chondrocyte senescence is a critical pathological hallmark of osteoarthritis(OA).Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging;however,the precise underlying mechanism remains elusive.Our findings demonstrate that SPI1 plays a significant role in counteracting chondrocyte senescence and inhibiting OA progression.SPI1 binds to the PERK promoter,thereby promoting its transcriptional activity.Importantly,PERK,rather than GCN2,facilitates eIF2αphosphorylation,activating the mitochondrial unfolded protein response(UPRmt)and impeding chondrocyte senescence.Deficiency of SPI1 in mechanical overload-induced mice leads to diminished UPRmt activation and accelerated OA progression.Intra-articular injection of adenovirus vectors overexpressing SPI1 and PERK effectively mitigates cartilage degeneration.In summary,our study elucidates the crucial regulatory role of SPI1 in the pathogenesis of chondrocyte senescence by activating UPRmt signaling through PERK,which may present a novel therapeutic target for treating OA.展开更多
In parallel-batching machine scheduling, all jobs in a batch start and complete at the same time, and the processing time of the batch is the maximum processing time of any job in it. For the unbounded parallel-batchi...In parallel-batching machine scheduling, all jobs in a batch start and complete at the same time, and the processing time of the batch is the maximum processing time of any job in it. For the unbounded parallel-batching machine scheduling problem of minimizing the maximum lateness, denoted 1|p-batch|L_(max), a dynamic programming algorithm with time complexity O(n^2) is well known in the literature.Later, this algorithm is improved to be an O(n log n) algorithm. In this note, we present another O(n log n) algorithm with simplifications on data structure and implementation details.展开更多
基金supported by the Anhui Provincial Natural Science Foundation(Grant No.2308085MH250)the Natural Science Research Project of Anhui Educational Committee(Grant No.2023AH053327)the Scientific Research Fund Project of Anhui Medical University(2020xkj039).
文摘Chondrocyte senescence is a critical pathological hallmark of osteoarthritis(OA).Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging;however,the precise underlying mechanism remains elusive.Our findings demonstrate that SPI1 plays a significant role in counteracting chondrocyte senescence and inhibiting OA progression.SPI1 binds to the PERK promoter,thereby promoting its transcriptional activity.Importantly,PERK,rather than GCN2,facilitates eIF2αphosphorylation,activating the mitochondrial unfolded protein response(UPRmt)and impeding chondrocyte senescence.Deficiency of SPI1 in mechanical overload-induced mice leads to diminished UPRmt activation and accelerated OA progression.Intra-articular injection of adenovirus vectors overexpressing SPI1 and PERK effectively mitigates cartilage degeneration.In summary,our study elucidates the crucial regulatory role of SPI1 in the pathogenesis of chondrocyte senescence by activating UPRmt signaling through PERK,which may present a novel therapeutic target for treating OA.
基金Supported by NSFC(11571323 11201121)+1 种基金NSFSTDOHN(162300410221)NSFEDOHN(2013GGJS-079)
文摘In parallel-batching machine scheduling, all jobs in a batch start and complete at the same time, and the processing time of the batch is the maximum processing time of any job in it. For the unbounded parallel-batching machine scheduling problem of minimizing the maximum lateness, denoted 1|p-batch|L_(max), a dynamic programming algorithm with time complexity O(n^2) is well known in the literature.Later, this algorithm is improved to be an O(n log n) algorithm. In this note, we present another O(n log n) algorithm with simplifications on data structure and implementation details.
