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Revealing the exceptional cryogenic strength-ductility synergy of a solid solution 6063 alloy by in-situ EBSD experiments 被引量:1
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作者 Youhong Peng Li Wang +3 位作者 Chenglu Liu Chao Xu lin geng Guohua Fan 《Journal of Materials Science & Technology》 2025年第5期313-322,共10页
A solid solution 6063 aluminium alloy features an exceptional combination of strength and ductility at 77 K.Here,the deformation mechanisms responsible for superior strength-ductility synergy and excellent strain hard... A solid solution 6063 aluminium alloy features an exceptional combination of strength and ductility at 77 K.Here,the deformation mechanisms responsible for superior strength-ductility synergy and excellent strain hardening capacity at a cryogenic temperature of the alloy were comparatively investigated by insitu electron backscatter diffraction(EBSD)observations coupled with transmission electron microscopy(TEM)characterization and fracture morphologies at both 298 and 77 K.It is found that kernel average misorientation(KAM)mappings and quantified KAM in degree suggest a higher proportion of geometrically necessary dislocations(GNDs)at 77 K.The existence of orientation scatter partitions at 77 K implies the activation of multiple slip systems,which is consistent with the results of potential slip systems calculated by Taylor axes.Furthermore,dislocation tangles characterized by brief and curved dislocation cells and abundant small dimples have been observed at 77 K.This temperature-mediated activation of dislocations facilitates the increased dislocations,thus enhancing the strain hardening capacity and ductility of the alloy.This research enriches cryogenic deformation theory and provides valuable insights into the design of high-performance aluminium alloys that are suitable for cryogenic applications. 展开更多
关键词 Aluminium alloy Cryogenic temperature Strength-ductility synergy In-situ EBSD Deformation mechanisms
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Insights into the deformation mechanisms of an Al1Mg0.4Si alloy at cryogenic temperature:An integration of experiments and crystal plasticity modeling 被引量:1
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作者 Youhong Peng Danyang Li +8 位作者 He Wu Kesong Miao Chenglu Liu Li Wang Wei Liu Chao Xu lin geng Peidong Wu Guohua Fan 《Journal of Materials Science & Technology》 CSCD 2024年第33期69-82,共14页
In this work,we investigated the mechanical properties and corresponding deformation mechanisms of an Al1Mg0.4Si alloy,which exhibited significantly higher strength and outstanding strain hardening capacity at 77 K co... In this work,we investigated the mechanical properties and corresponding deformation mechanisms of an Al1Mg0.4Si alloy,which exhibited significantly higher strength and outstanding strain hardening capacity at 77 K compared to its counterparts at 298 K.The deformation mechanisms responsible for the excellent strength-ductility synergy and extraordinary strain hardening capacity at cryogenic temperature were elucidated through a combined experimental and simulation study.The results reveal the presence of numerous slip traces and microbands throughout grain surfaces during deformation at 298 K,whereas at 77 K,vague grain surfaces dominate,indicating the simultaneous operation of multiple slip systems.Transmission electron microscopy(TEM)analysis using the two-beam diffraction technique demonstrates the presence of dislocations with several different Burgers vectors inside a grain at cryogenic temperature,confirming the activation of multiple slip systems.The accumulation of dislocations facilitated by these multiple slip systems,combined with the high dislocation density,contributes to strain hardening and remarkable uniform elongation at 77 K.A modified dislocation density-based crystal plasticity model,incorporating the effect of grain boundary hardening(GBH)and temperature,was developed to gain a better understanding of the underlying mechanisms governing alloy’s strength and plasticity.The GBH effect significantly enhances statistically stored dislocation(SSD)density and screw dislocation proportion,which promote homogeneous deformation and enhance strain hardening capacity at cryogenic temperature.These findings deepen the understanding of plastic deformation at cryogenic temperatures and pave the way for the development of ultrahigh-performance metallic materials for cryogenic applications. 展开更多
关键词 Aluminum alloy Cryogenic temperature Grain boundary hardening effect Deformation mechanism Crystal plasticity modeling
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用于推动AI算法临床应用的甲状腺超声-超声造影数据集
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作者 迟剑宁 李则蓝 +2 位作者 林庚 陈佳慧 黄瑛 《中国临床医学影像杂志》 北大核心 2025年第9期616-620,共5页
目的:基于数据驱动的医学图像深度学习算法面临数据集稀缺、标注困难以及模态单一等挑战。本文提出了一种适用于AI辅助诊断的甲状腺超声-超声造影多模态多任务数据集,旨在推动深度学习算法在甲状腺结节疾病诊断中的应用与发展。方法:本... 目的:基于数据驱动的医学图像深度学习算法面临数据集稀缺、标注困难以及模态单一等挑战。本文提出了一种适用于AI辅助诊断的甲状腺超声-超声造影多模态多任务数据集,旨在推动深度学习算法在甲状腺结节疾病诊断中的应用与发展。方法:本文回顾性收集2016年6月—2023年8月在中国医科大学附属盛京医院检查的患者数据。数据集包括498例超声检查怀疑甲状腺癌的可疑结节,包含超声图像序列和对应的超声造影。通过结合超声图像与造影视频,数据集整合了甲状腺结节的多模态信息,并由经验丰富的医生标注了良恶性分类和结节区域分割标签,以支持结节的良恶性分类与分割。结果:在该数据集上,我们训练并测试了甲状腺结节良恶性诊断模型和分割模型,并比较了单模态与多模态数据集下的表现。使用多模态数据集的智能算法诊断结节良恶性的准确率超过82%,分割精度Dice系数超过79%。结论:研究结果证明,提出的多模态数据集对开发基于AI的甲状腺结节诊断与分割模型的发展具有重要意义,可有效辅助医生提升诊断的效率。 展开更多
关键词 甲状腺结节 超声检查
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Interstitial-oxygen-inducedγ-phase precipitation and martensitic transformation behavior in Ni-Mn-Sn-Co alloy prepared through binder jetting and sintering 被引量:1
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作者 Shijiang Zhong Mingfang Qian +5 位作者 Xinxin Shen Shuhe Gong Liangbo Sun Ping Shen Xuexi Zhang lin geng 《Journal of Materials Science & Technology》 2025年第11期272-277,共6页
1.Introduction.Ni-Mn-X(X=Ga,In,Sn,or Sb)Heusler alloys have versatile properties[1-4],such as shape memory effect[1],superelastic-ity[5],magnetocaloric effect[3],elastocaloric effect[6],and even multicaloric effect[7]... 1.Introduction.Ni-Mn-X(X=Ga,In,Sn,or Sb)Heusler alloys have versatile properties[1-4],such as shape memory effect[1],superelastic-ity[5],magnetocaloric effect[3],elastocaloric effect[6],and even multicaloric effect[7],that indicate their potential for use in actu-ators,sensors,micropumps,energy harvesters,and solid-state re-frigeration[8-10].Among the alloys,Ni-Mn-Sn-based alloys are environment-friendly and cost-effective[6,7,11],and hence,they have received widespread attention. 展开更多
关键词 phase precipitation martensitic transformation SINTERING Ni Mn Sn Co alloy shape memory effect superelastic ity magnetocaloric effect elastocaloric effect interstitial oxygen binder jetting multicaloric effect
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基于ABS-Stacking算法的抑郁症预测模型
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作者 张梓坪 林耿 +1 位作者 龙素娟 陈梦 《闽江学院学报》 2025年第2期51-62,共12页
为了解决传统抑郁症预测模型因过于依赖单一模型而难以有效应对数据复杂性的问题,提出了一种基于ABS-Stacking算法的抑郁症预测模型。在传统Stacking模型基础上采用最佳优先搜索算法构建基分类器筛选层,以自适应选择最优的基分类器组合... 为了解决传统抑郁症预测模型因过于依赖单一模型而难以有效应对数据复杂性的问题,提出了一种基于ABS-Stacking算法的抑郁症预测模型。在传统Stacking模型基础上采用最佳优先搜索算法构建基分类器筛选层,以自适应选择最优的基分类器组合。通过5折交叉验证,根据各基模型在验证集上的AUC(area under curve)值对预测结果进行加权平均,使得表现较好的基模型在最终预测中贡献更大,从而提升模型的整体预测性能。在中老年结构化数据上的实验结果表明,ABS-Stacking模型在泛化能力和抑郁症预测效果上均优于单一模型和传统集成方法。该方法不仅有效解决了基分类器组合选择和性能加权的问题,还显著提高了模型的自适应性和泛化能力,为抑郁症预测提供了新的方法参考。 展开更多
关键词 抑郁症 特征选择 集成学习 模型融合 STACKING
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Effects of La and Ce on the microstructure,thermal conductivity and strength synergy of the as-extruded Mg-Mn-RE alloys 被引量:1
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作者 Huafeng Liu Taiki Nakata +6 位作者 Chao Xu Guangze Tang Danyang Li Xiaojun Wang Guisong Wang Shigeharu Kamado lin geng 《Journal of Magnesium and Alloys》 2025年第2期654-667,共14页
High thermal conductivity and high strength Mg-1.5Mn-2.5Ce alloy with a tensile yield strength of 387.0 MPa,ultimate tensile strength of 395.8 MPa,and thermal conductivity of 142.1 W/(m·K)was successfully fabrica... High thermal conductivity and high strength Mg-1.5Mn-2.5Ce alloy with a tensile yield strength of 387.0 MPa,ultimate tensile strength of 395.8 MPa,and thermal conductivity of 142.1 W/(m·K)was successfully fabricated via hot extrusion.The effects of La and Ce additions on the microstructure,thermal conductivity,and mechanical properties of the Mg-1.5Mn alloy were investigated.The results indicated that both the as-extruded Mg-1.5Mn-2.5La and Mg-1.5Mn-2.5Ce alloys exhibited a bimodal grain structure,with dynamically precipitated nano-scaleα-Mn phases.In comparison with La,the addition of Ce enhanced the dynamic precipitation more effectively during hot extrusion,while its influence on promoting the dynamic recrystallization was relatively weaker.The high tensile strength obtained in the as-extruded Mg-1.5Mn-2.5RE alloys can be attributed to the combined influence of the bimodal grain structure(with fine dynamic recrystallized(DRXed)grain size and high proportion of un-dynamic recrystallized(unDRXed)grains),dense nano-scale precipitates,and broken Mg12RE phases,while the remarkable thermal conductivity was due to the precipitation of Mn-rich phases from the Mg matrix. 展开更多
关键词 Mg-Mn-RE alloys Thermal conductivity Mechanical properties Dynamic precipitation
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Q开关Nd:YAG激光、谷胱甘肽和氢醌乳膏联合治疗黄褐斑的临床疗效
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作者 张园程 林庚 +3 位作者 张士发 周大鹏 任帅 杜红阳 《江苏医药》 2025年第1期21-24,共4页
目的探讨Q开关Nd:YAG激光、谷胱甘肽和氢醌乳膏联合治疗黄褐斑的临床疗效。方法124例黄褐斑患者随机分为四组,每组31例,分别采用Q开关Nd:YAG激光(A组)、Q开关Nd:YAG激光+谷胱甘肽(B组)、Q开关Nd:YAG激光+氢醌乳膏(C组)和Q开关Nd:YAG激光... 目的探讨Q开关Nd:YAG激光、谷胱甘肽和氢醌乳膏联合治疗黄褐斑的临床疗效。方法124例黄褐斑患者随机分为四组,每组31例,分别采用Q开关Nd:YAG激光(A组)、Q开关Nd:YAG激光+谷胱甘肽(B组)、Q开关Nd:YAG激光+氢醌乳膏(C组)和Q开关Nd:YAG激光+谷胱甘肽和氢醌乳膏(D组)治疗,连续治疗5个月。治疗结束后1个月,分析肉眼疗效、皮损积分和患者满意度。结果D组治疗显效率高于A、B和C组(P<0.05)。治疗结束后1个月,四组皮损积分均低于治疗前,且D组下降更明显(P<0.05)。B、C、D组患者满意度高于A组,D组患者满意度高于C组(P<0.05)。结论Q开关Nd:YAG激光、谷胱甘肽和氢醌乳膏联合治疗黄褐斑有较好的疗效,能够改善皮损,提高患者满意度。 展开更多
关键词 黄褐斑 Q开关ND:YAG激光 谷胱甘肽 氢醌
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Dalian Shipbuilding Makes Innovative Breakthroughs in LNG and FPSO Construction
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作者 Qian Ping Zhang Tuo +2 位作者 lin geng Zhang Dingshan Jiang Bingshang 《船舶经济贸易》 2025年第10期70-74,共5页
The 175,000 cm^(3) Mark III Flex membrane LNG carrier "SEA SPIRIT"built hy Dalian Shipbuilding Intlustry Co.,Ltd.(DLS),a suhsirliary of China State Shipbuilding Corporation(CSSC),and China Shipbuilding Tradi... The 175,000 cm^(3) Mark III Flex membrane LNG carrier "SEA SPIRIT"built hy Dalian Shipbuilding Intlustry Co.,Ltd.(DLS),a suhsirliary of China State Shipbuilding Corporation(CSSC),and China Shipbuilding Trading Co.,Ltd.(CSTC)for China Merchants Energy Shipping and CSTS1 shipbuilding and offshore engineering brokerage joint venture was offirially named and delivered on September 24.marking a new stage of strategic cooperation lietween DLS and China Merchants Shipping in the high-end equipment manufarturing field. 展开更多
关键词 strategic cooperation cm mark iii flex membrane lng carrier sea spirit LNG FPSO innovative breakthroughs flex membrane lng carrier
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Dispersion of nano-TiB in Ti64 based composite through plasma rotating electrode process followed by spark plasma sintering
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作者 Wen-qi LIU Shuai WANG +5 位作者 Xin CHEN Lu-jun HUANG Jia-yi JIN Feng-bo SUN Wei-hang LU lin geng 《Transactions of Nonferrous Metals Society of China》 2025年第11期3751-3760,共10页
In order to achieve the strength-ductility synergy and improve the work-hardening capacity,Ti64 based composites with dispersive nanoscaled TiB whiskers inside grains were fabricated by plasma rotating electrode proce... In order to achieve the strength-ductility synergy and improve the work-hardening capacity,Ti64 based composites with dispersive nanoscaled TiB whiskers inside grains were fabricated by plasma rotating electrode process coupled with spark plasma sintering.Based on the rapid eutectic reaction,the nanoscaled TiB whiskers exhibited ultra-fine network distribution in composite powders.During the spark plasma sintering process,the network dissolved,and TiB followed the Ostwald ripening mechanism and merged along the(100)plane.The intragranular TiB whiskers could significantly refine the primaryβgrain andαlath.The ultimate tensile strength of the composite with only 2 vol.%TiB whiskers was enhanced to(1123±17)MPa while the elongation was similar to that of the as-sintered Ti64 alloy with approximately 8%.The strength-ductility synergy effect was mainly attributed to the significant grain refinement and the work-hardening ability improvement contributed by intragranular nanoscaled TiB. 展开更多
关键词 titanium matrix composites nanoscaled TiB whisker spark plasma sintering thermodynamic calculation microstructure mechanical properties
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Improved resistance to creep and underlying mechanisms in TiB/(TA15−Si)composites with network structure
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作者 Shuai WANG Rui ZHANG +5 位作者 Ming JI Feng-bo SUN Zi-shuo MA Qi AN Lu-jun HUANG lin geng 《Transactions of Nonferrous Metals Society of China》 2025年第10期3357-3367,共11页
To assess the high-temperature creep properties of titanium matrix composites for aircraft skin,the TA15 alloy,TiB/TA15 and TiB/(TA15−Si)composites with network structure were fabricated using low-energy milling and v... To assess the high-temperature creep properties of titanium matrix composites for aircraft skin,the TA15 alloy,TiB/TA15 and TiB/(TA15−Si)composites with network structure were fabricated using low-energy milling and vacuum hot pressing sintering techniques.The results show that introducing TiB and Si can reduce the steady-state creep rate by an order of magnitude at 600℃ compared to the alloy.However,the beneficial effect of Si can be maintained at 700℃ while the positive effect of TiB gradually diminishes due to the pores near TiB and interface debonding.The creep deformation mechanism of the as-sintered TiB/(TA15−Si)composite is primarily governed by dislocation climbing.The high creep resistance at 600℃ can be mainly attributed to the absence of grain boundaryαphases,load transfer by TiB whisker,and the hindrance of dislocation movement by silicides.The low steady-state creep rate at 700℃ is mainly resulted from the elimination of grain boundaryαphases as well as increased dynamic precipitation of silicides andα_(2). 展开更多
关键词 discontinueously reinforced titanium matrix composite TiB whisker network structure SILICIDES creep properties
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Multi-scale dispersion strengthening for high-temperature titanium alloys: Strength preservation and softening mechanisms
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作者 Xin Chen Lujun Huang +3 位作者 Shuo Ma Fengbo Sun Shuai Wang lin geng 《Journal of Materials Science & Technology》 2025年第3期1-14,共14页
The long-lasting expectation“the hotter the engine,the better”calls for the development of high-temperature metallic alloys.Although the high specific strengths of titanium alloys are compelling for such application... The long-lasting expectation“the hotter the engine,the better”calls for the development of high-temperature metallic alloys.Although the high specific strengths of titanium alloys are compelling for such applications,their deleterious softening beyond 600℃ imposes serious limitations.Much has been known for decades regarding the phase metallurgy for precipitation strengthening design in titanium alloys,however,the other facile strength promotion mechanism,dispersion strengthening,remains comparatively less-explored and unutilized.The present research concerns the multi-scale dispersion strengthening in titanium alloys,with mechanistic emphases on the critical plasticity micro-events that affect strength preservation.Due to the simultaneous introduction of intragranular dispersoids and intergranular reinforcers,the current titanium alloys present superior engineering tensile strength of 519 MPa at 700℃.Throughout the examined 25-800℃ temperature range,noticeable softening induced by the thermal activation occurs above 600℃,accompanied by evident strength loss.The temperature-dependence transition of dominated softening mechanisms from dynamic recovery to dynamic recrystallization has been clarified by theoretical calculations.Furthermore,the strengthening effect of multi-scale architectures is underpinned as the enhanced dislocation strengthening owing to the introduction of thermally-stable heterointerfaces,which could generically guide the design of similar heat-resistant titanium alloys. 展开更多
关键词 Titanium-based alloys Multi-scale architectures Mechanical properties Temperature dependence Dislocation strengthening
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寒冷地区装配式农宅模块化设计方法研究
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作者 李反宁 林耕 刘立 《华中建筑》 2025年第3期56-60,共5页
我国大多数农村住宅建设依旧处于传统手工业建造阶段。传统建筑虽多因地制宜,适应性强且具有地域特色,但其功能布局比较单一,物理与安全性能也得不到保障,无法适应现代化村镇需求。为了提高住宅质量和建造效率,提高室内舒适度,以河北南... 我国大多数农村住宅建设依旧处于传统手工业建造阶段。传统建筑虽多因地制宜,适应性强且具有地域特色,但其功能布局比较单一,物理与安全性能也得不到保障,无法适应现代化村镇需求。为了提高住宅质量和建造效率,提高室内舒适度,以河北南宫市的农村住宅为研究对象,从建筑设计角度出发,结合模块化理论,设计寒冷地区装配式农村住宅典型户型。总结寒冷地区装配式住宅的设计策略,为寒冷地区装配式建筑设计提供参考,完善相关设计理论与设计方法。 展开更多
关键词 寒冷地区 装配式农宅 调查研究 模块化设计 平面组合
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Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes
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作者 lin geng Ting-Ting Sun +3 位作者 Wen-Bo Xia Yin Qin Di Huo Guang-Jing Qu 《World Journal of Diabetes》 2025年第7期289-307,共19页
BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disorder linked to high blood glucose and gut dysbiosis.Probiotics like Lactobacillus rhamnosus LRa05 may im-prove glycemic control and gut microbiota.AIM To exp... BACKGROUND Type 2 diabetes mellitus(T2DM)is a metabolic disorder linked to high blood glucose and gut dysbiosis.Probiotics like Lactobacillus rhamnosus LRa05 may im-prove glycemic control and gut microbiota.AIM To explore the impact of LRa05 with hypoglycemic medications on glycemic control and intestinal flora in T2DM patients with gut dysbiosis.METHODS Seventy-six participants were randomly assigned to receive either LRa05(0.1 g 2×10^(10) CFU)(n=38)or a placebo(n=38)for 12 weeks.Baseline characteristics were recorded,and changes in glycated hemoglobin,fasting blood glucose,and other biochemical indices were assessed using repeated measures one-way analysis of variance.Additionally,gut microbiota diversity was analyzed through species accumulation and alpha and beta diversity metrics.RESULTS The intervention group showed statistically significant improvements in lipid profiles,particularly in high-density lipoprotein cholesterol levels,which in-creased significantly over time(P<0.001).Additionally,fasting blood glucose was significantly reduced in the LRa05 group compared with the placebo group(P<0.001).No significant changes were observed in glycated hemoglobin,insulin sensitivity,or systemic inflammatory markers such as C-reactive protein.Fur-thermore,gut microbiota analysis revealed significant shifts in composition following the intervention,particularly an increase in Bifidobacterium and a de-crease in Bacillota,indicating beneficial effects on gut health.CONCLUSION This study demonstrated that the combination of Lactobacillus rhamnosus LRa05 and hypoglycemic medications positively impacted glycemic control,specifically reflected in improved levels of high-density lipoprotein and fasting blood glucose.Additionally,significant alterations in gut microbiota composition were observed in patients with T2DM,indicating a potential synergistic effect between gut health and blood glucose regulation. 展开更多
关键词 Lactobacillus rhamnosus Type 2 diabetes Glycated hemoglobin Gut microbiota
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High damping capacity of Ni-Mn-Ga-Cu microwires prepared by melt-extraction technique
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作者 Xue-Xi Zhang Ming-Fang Qian +3 位作者 Guang-Wei Wang Peng-Fei Xu lin geng Jian-Fei Sun 《Rare Metals》 2025年第10期7889-7894,共6页
Ni-Mn-Ga-Cu microwires,with diameter of 20-80 μm,length of 30-150 mm and fined columnar grains,were produced by melt-extraction technique.The damping capacity of the extracted micro wires was investigated by stretchi... Ni-Mn-Ga-Cu microwires,with diameter of 20-80 μm,length of 30-150 mm and fined columnar grains,were produced by melt-extraction technique.The damping capacity of the extracted micro wires was investigated by stretching a micro wire under a tensile stress using dynamic mechanical analyzer.The damping capacity of the martensite and austenite phases shows a weak frequency dependence but a strong strain amplitude dependence.The damping capacity(Tanδ) of the martensite and austenite phases reaches 0.08 and 0.04,respectively,under strain amplitude of 0.5% and frequency of 1 Hz.The high damping capacity of the martensite phase is related to the high mobility of martensite twin boudaries,while that of austenite phase to the motion of dislocations.The ferromagnetic Ni-Mn-Ga-Cu micro wires,with high ductility and damping capacity,may act as promising materials for microscale devices,systems and composite fillers for passive dissipation of undesired vibrations and noises. 展开更多
关键词 Shape memory alloys Phase transformation Damping capacity Ni-Mn-Ga-Cu alloy
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Light-switchable 1D CsPbI_(3)@SWCNTs van der Waals heterostructures for negative photodetection and photosynapse devices
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作者 Yong Zhang Zishen Zhao +8 位作者 Xu Zhang Kunjie Wang lin geng Yanyan Zhao Shuaiwei Huang Jiadong Shen Xiujun Wang Chun Zhao lin Wang 《Nano Research》 2025年第11期63-72,共10页
The applications of one-dimensional(1D)halide perovskite heterostructures based on single-walled carbon nanotubes(SWCNTs)remain an unresolved challenge.Herein,1D van der Waals heterostructures composed of CsPbI_(3)(CP... The applications of one-dimensional(1D)halide perovskite heterostructures based on single-walled carbon nanotubes(SWCNTs)remain an unresolved challenge.Herein,1D van der Waals heterostructures composed of CsPbI_(3)(CPI)encapsulated within semiconducting SWCNTs(CPI@s-SWCNTs)are designed for negative photodetectors and photosynapse devices via modulable photocarrier engineering.A single CPI@SWCNT device demonstrates a notable n-doping effect and exhibits negative photoresponse.Theoretical simulations reveal that the electrons transferred from CPI to SWCNT amount to 0.73e/cell.Large-area CPI@s-SWCNTs film can be obtained through the separation using the ultraviolet(UV)photosensitive polymer poly[9-(1-octyl-9H-carbazol-9-yl)-nonyl](PCz).Under visible light irradiation,the large-area film device exhibits remarkable negative photoresponse(−9.3 A/W)owing to the photoelectric effect of internally filled CPI.Under UV irradiation,the film device exhibits synaptic behavior of electrical writing and optical erasing due to the persistent photoconductivity effect of the surface polymer PCz.This work not only provides a general strategy for the separation and application of halide perovskite filled SWCNTs,but also paves the way for broader applications of 1D van der Waals heterostructures in multifunctional optoelectronic devices. 展开更多
关键词 halide perovskite single-walled carbon nanotubes PHOTODETECTORS photosynapse device
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Morphological adaptation strategy of invasive plant Ambrosia trifida seed distributed along rivers is closely related to soil nutrients
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作者 Yufeng Xu Chenyang Xue +6 位作者 Xuezhi Wang lin Meng Ying Gao Mengyang Yu lin geng Meini Shao Bo Qu 《Plant Diversity》 2025年第3期499-510,共12页
Rivers are crucial in the spread of invasive plants.Invasive plants alter their seed traits to adapt to environmental changes and promote invasion.Studying the trait changes in invasive plant seeds may improve the und... Rivers are crucial in the spread of invasive plants.Invasive plants alter their seed traits to adapt to environmental changes and promote invasion.Studying the trait changes in invasive plant seeds may improve the understanding of their propagation mechanisms along the river and provide appropriate control measures.In this study,seven Ambrosia trifida populations along the Liaohe River were used as study subjects.The results showed that the seven A.trifida populations were closely related and exhibited a certain gene exchange,but the absence of evidence of directed gene flow among populations did not confirm that rivers were the medium of seed dispersal of A.trifida.Along the Liaohe River,from top to bottom,the positive view area,length,width,perimeter,and thousand seed weight of A.trifida seeds showed an increasing trend.The total nitrogen and phosphorus contents in the river water of the A.trifida population in the lower reaches of the Liaohe River were higher than those at the other sites.Furthermore,along the river,from top to bottom,the available nitrogen,total nitrogen,total potassium,available potassium,and organic matter contents in the soil in which A.trifida populations grew showed significant increasing trends.River structure,water quality,and soil nutrients had direct and indirect effects on seed morphology.Soil total nitrogen,available potassium,and organic matter had significant positive effects on seed positive view area and perimeter,suggesting that the maternal effect played a critical role in shaping seed morphology.Our analysis showed that soil nutrients along the river may be the primary driver that governs changes in A.trifida seed traits. 展开更多
关键词 Biological invasion RIVER Seed morphology Genetic differentiation
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Correction to “Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes”
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作者 lin geng Ting-Ting Sun +3 位作者 Wen-Bo Xia Ying Qin Di Huo Guang-Jin Qu 《World Journal of Diabetes》 2025年第11期283-284,共2页
This is an erratum to the published paper titled “Lactobacillus rhamnosus LRa05 onglycemic control and gut microbiota in patients with type 2 diabetes”. We havenoticed that the names of the fourth author, Ms. Qin, a... This is an erratum to the published paper titled “Lactobacillus rhamnosus LRa05 onglycemic control and gut microbiota in patients with type 2 diabetes”. We havenoticed that the names of the fourth author, Ms. Qin, and the correspondingauthor, Dr. Qu, were spelled incorrectly. The correct names should be Ying Qinand Guang-Jin Qu, respectively. 展开更多
关键词 World Journal of Diabetes CORRECTION
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肠破裂修补术同时行疝修补术与择期行疝修补术治疗腹股沟疝合并肠破裂的临床效果、安全性比较
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作者 林庚 黄拔炎 高晖 《中外医学研究》 2024年第19期123-126,共4页
目的:比较肠破裂修补术同时行疝修补术与择期行疝修补术治疗腹股沟疝合并肠破裂的临床效果及安全性。方法:选择2019年1月—2022年1月在福建省立医院南院普外科住院的120例腹股沟疝合并肠破裂患者作为研究对象,以随机法将其分为两组,各6... 目的:比较肠破裂修补术同时行疝修补术与择期行疝修补术治疗腹股沟疝合并肠破裂的临床效果及安全性。方法:选择2019年1月—2022年1月在福建省立医院南院普外科住院的120例腹股沟疝合并肠破裂患者作为研究对象,以随机法将其分为两组,各60例。择期组于肠破裂修补术后3个月择期行疝修补术治疗,同期组在肠破裂修补术同时行疝修补术治疗。比较两组手术指标、血清炎症因子、并发症总发生率。结果:同期组手术时间、首次下床时间、住院时间均短于择期组,术中失血量少于择期组,差异有统计学意义(P<0.05)。术前,两组血清炎症因子比较,差异无统计学意义(P>0.05);术后5 d,两组血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于术前,且同期组低于择期组,差异有统计学意义(P<0.05)。同期组并发症总发生率为3.33%,低于择期组的15.00%,差异有统计学意义(P<0.05)。结论:肠破裂修补术同时行疝修补术可有效减轻腹股沟疝合并肠破裂患者机体炎症反应,降低并发症发生率,且具有耗时短、出血少、术后恢复快优点。 展开更多
关键词 肠破裂 疝修补术 腹股沟疝 肠破裂 治疗效果
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降解苯丙氨酸的工程益生菌构建及其喂养苯丙酮尿症小鼠的效果分析 被引量:2
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作者 马欣 付加芳 +2 位作者 林赓 张佩佩 曹广祥 《食品与发酵工业》 CAS CSCD 北大核心 2024年第17期75-81,共7页
苯丙酮尿症(phenylketonuria,PKU)是一种常染色体隐性遗传病,低蛋白饮食是目前临床治疗的主要方法,而采用工程益生菌治疗尚处于研发阶段。为了探究工程益生菌对PKU的治疗效果,该研究基于大肠埃希菌Nissle 1917(EcN)菌株,构建了一株表达... 苯丙酮尿症(phenylketonuria,PKU)是一种常染色体隐性遗传病,低蛋白饮食是目前临床治疗的主要方法,而采用工程益生菌治疗尚处于研发阶段。为了探究工程益生菌对PKU的治疗效果,该研究基于大肠埃希菌Nissle 1917(EcN)菌株,构建了一株表达苯丙氨酸裂解酶的工程益生菌EcN-PAL。通过λ-Red同源重组系统在EcN中导入经优化设计的苯丙氨酸裂解酶基因,并通过体外降解实验和小鼠喂养实验验证其功能性。实验结果表明,工程益生菌EcN-PAL成功表达苯丙氨酸裂解酶,并且可降解苯丙氨酸和有效降低PKU小鼠的血液苯丙氨酸浓度。该研究成功构建的工程益生菌EcN-PAL对苯丙氨酸有良好的降解效果,动物实验证实可有效治疗PKU小鼠,为用于PKU患者的益生菌治疗奠定了基础。 展开更多
关键词 苯丙酮尿症 λ-Red同源重组系统 工程益生菌 苯丙氨酸降解 苯丙酮尿症小鼠
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过表达肝细胞生长因子的人牙髓来源间充质干细胞通过调节Th2/Th1、Th17/Treg平衡改善变应性鼻炎的研究 被引量:1
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作者 王润生 林庚 +4 位作者 陶梦雨 张乐统 李妍 孙合强 徐国纲 《解放军医学院学报》 CAS 2024年第9期946-953,959,共9页
背景当前间充质干细胞治疗变应性鼻炎研究较多,过表达肝细胞生长因子的间充质干细胞在其中的作用和机制有待进一步探究。目的 构建过表达肝细胞生长因子的人牙髓来源间充质干细胞(hepatocyte growth factor-overexpressing human dental... 背景当前间充质干细胞治疗变应性鼻炎研究较多,过表达肝细胞生长因子的间充质干细胞在其中的作用和机制有待进一步探究。目的 构建过表达肝细胞生长因子的人牙髓来源间充质干细胞(hepatocyte growth factor-overexpressing human dental pulp-stem cells,HGF/hDPSCs),研究其对变应性鼻炎的作用和可能机制。方法 提取人牙髓来源间充质干细胞,利用腺病毒载体Ad5将靶基因HGF转入,以构建HGF/hDPSCs,并评估其HGF分泌能力和鼻黏膜分布。采取卵清蛋白腹腔注射致敏、滴鼻激发的方式构建变应性鼻炎小鼠模型。根据致敏、激发和干预措施的区别,将小鼠分为4组:WT-PBS组(阴性对照组),AR-PBS组(阳性对照组),AR-hDPSCs组(hDPSCs治疗组),AR-HGF/hDPSCs组(HGF/hDPSCs治疗组)。利用症状评分、病理学分析(HE、PAS染色)监测各组小鼠变应性鼻炎症状和鼻黏膜局部炎症情况。采取免疫组织化学染色(CD3、CD19)、ELISA(总IgE、OVA特异IgE)和PCR(IFN-γ、IL-5、IL-13、IL-17A、Foxp3)探究免疫应答机制。结果 HGF/hDPSCs可在体外和体内稳定表达HGF,经尾静脉注射后可迁移至小鼠鼻黏膜。症状评分显示,HGF/hDPSCs可改善变应性鼻炎小鼠挠鼻、喷嚏、流涕等过敏症状(P<0.05)。病理分析和免疫组化结果显示,变应性鼻炎小鼠鼻黏膜免疫反应以T淋巴细胞聚集为主要特征。应用HGF/hDPSCs可减少鼻黏膜淋巴细胞浸润和杯状细胞增生等鼻黏膜炎症表现,并降低病理损伤评分(P<0.01)。ELISA结果表明,HGF/hDPSCs可下调血清总IgE和OVA特异性IgE表达水平(P<0.01)。PCR结果表明,HGF/hDPSCs可抑制变应性鼻炎小鼠脾Th1细胞(IFN-γ)、Th2细胞(IL-5、IL-13)应答水平,改变了Th2/Th1平衡;下调Th17细胞(IL-17A)应答水平(P<0.05),不影响Treg细胞(Foxp3)应答水平(P>0.05),改变了Th17/Treg平衡。结论 HGF/hDPSCs可通过调节Th2/Th1、Th17/Treg平衡缓解变应性鼻炎小鼠的鼻部过敏症状,减轻鼻黏膜炎症。 展开更多
关键词 变应性鼻炎 间充质干细胞 肝细胞生长因子 CD4^(+)T细胞 细胞因子
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