Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the t...Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the type of fluid are conflicting and generally come from small single-center randomized controlled trials(RCTs).We therefore conducted a systematic review and meta-analysis to compare the effect of balanced solutions(BS)versus NS on patient-centered clinical outcomes in AP.Methods:From four databases searched up to October 2024,we included only RCTs of adult patients with AP that compared the use of BS(including LR,acetate Ringer’s,etc.)with NS.The primary out-come was the disease advances from AP to moderately severe and severe AP(MSAP/SAP).Trial sequential analyses(TSA)were conducted to control for type-I and type-II errors and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)was used to assess the quality of evidence.Results:Six RCTs were identified and included,involving 260 patients treated with BS and 298 patients with NS.Patients who received the BS had less MSAP/SAP[odds ratio(OR)=0.50,95%confidence in-terval(CI):0.29 to 0.85,P=0.01,I^(2)=0%;5 studies,299 patients],reduced the need of ICU admission(OR=0.60,95%CI:0.39 to 0.93,P=0.02,I^(2)=0%;5 studies,507 patients)and shorter length of hospital stay[mean difference(MD)=-0.88,95%CI:-1.48 to-0.28,P=0.004,I^(2)=0%;6 studies,558 patients;confirmed by TSA with high certainty]compared with those who received NS.The evidence for most of the clinical outcomes was rated as moderate to low due to the risk of bias,imprecision and inconsistency.Conclusions:BS,compared with NS,was associated with improved clinical outcomes in patients with AP.However,given the moderate to low quality of evidence for most of the outcomes assessed,further trials are warranted.展开更多
Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in ...Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC.展开更多
In general,self-healing dielectric composites are mainly composed of polar hydrogen bonds,which have high hydrophilicity and are unsuitable for humid environment.Dielectric composite with Diels-Alder(D-A)bond contains...In general,self-healing dielectric composites are mainly composed of polar hydrogen bonds,which have high hydrophilicity and are unsuitable for humid environment.Dielectric composite with Diels-Alder(D-A)bond contains covalent bonds,it can be adopted as an efficient self-healing material.Here,we construct self-healing barium titanate(BT)/polyurethane(PU)dielectric composites by adopting PU with D-A bond as matrix(BT/PU-DA).The prepared 10%BT/PU-DA composite exhibits superior self-healing ability than that of PUDA.Moreover,its dielectric constant can reach 9.3 with a loss of only 0.04 at 1000 Hz and maintain 93%repair efficiency of tensile strength.The experimental analysis suggests the introduction of D-A bond can enhance the thermostability and self-healing ability of BT/PU-DA composite.In addition,the incorporation of BT nanoparticles and D-A bond in the self-healing composite contributes to the lower dielectric loss and excellent tensile strength after healing.The adopted strategy is a promising and facile approach to develop highly efficient selfhealing dielectric material,which will be conducive to reuse and sustainable development of the electronic packaging material in aqueous medium or wet environment.展开更多
Mobile Edge Computing(MEC)is a promising solution to tackle the upcoming computing tsunami in 5G/6G era by effectively utilizing the idle resource at the mobile edge.In this work,a multi⁃hop D2D⁃enabled MEC scenario w...Mobile Edge Computing(MEC)is a promising solution to tackle the upcoming computing tsunami in 5G/6G era by effectively utilizing the idle resource at the mobile edge.In this work,a multi⁃hop D2D⁃enabled MEC scenario was studied,where mobile devices at network edge connect and share resources with each other via multi⁃hop D2D.The research focus was on the micro⁃task scheduling problem in the multi⁃hop D2D⁃enabled MEC system,where each task was divided into multiple sequential micro⁃tasks,such as data downloading micro⁃task,data processing micro⁃task,and data uploading micro⁃task,according to their functionalities as well as resource requirements.A joint Task Failure Probability and Energy Consumption Minimization(TFP⁃ECM)problem was proposed,aiming at minimizing the task failure probability and the energy consumption jointly.To solve the problem,several linearization methods were proposed to relax the constraints and convert the original problem into an integer linear programming(ILP).Simulation results show that the proposed solution outperformed the existing solutions(with indivisible tasks or without resource sharing)in terms of both total cost and task failure probability.展开更多
Objective:To observe the clinical effect of modified Yu Rong San gel eye mask in the treatment of dark circles.Methods:96 cases of patients with dark circles were randomly divided into treatment group and control grou...Objective:To observe the clinical effect of modified Yu Rong San gel eye mask in the treatment of dark circles.Methods:96 cases of patients with dark circles were randomly divided into treatment group and control group.In the control group and the treatment group,the common eye mask and the modified Yu Rong San gel eye mask were applied to the black circle area respectively.After 15min,water was used to wash the face,the application of the mask for one time a day,four weeks,one course,and three courses were observed.Results:After three courses of treatment,the total effective rate of the treatment group was higher than that of the control group(P<0.05);the area of black eye circles in the treatment group was smaller than that before treatment(P<0.05);compared with the control group,the score of black eye circles was lower than that before treatment,the difference was statistically significant(P<0.05).Conclusions Addition and reduction of Yu Rong San gel eye mask is effective in the treatment of dark circles.展开更多
Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenom...Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion(I/R)injury,which has recently gained the attention of researchers.Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury.This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury,focusing on the issues related to energy metabolism,mitochondrial quality control disorders,oxidative stress,and calcium.The mechanisms by which mitochondria mediate cell death have also been discussed.To develop a resource for the prevention and management of clinical myocardial I/R damage,we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.展开更多
In this paper, a smart home system based on ZigBee technology is designed. The system includes home network, home server and mobile terminal. The program is highly scalable and cost-effective. This paper developed the...In this paper, a smart home system based on ZigBee technology is designed. The system includes home network, home server and mobile terminal. The program is highly scalable and cost-effective. This paper developed the home server-side application based on MFC technology and the mobile terminal application. The mobile client can remotely control home devices and query the running state, electric energy information and historical data of home devices. At the same time, the home server-side application can store electric energy information and electricity consumption of home devices. Combined with household distributed photovoltaic generation system, the system can be applied to home energy management system. Through running tests and application, the results show that the system has realized basic functions of smart home and achieved the desired design goals.展开更多
Bluetongue (BT) is a serious hemorrhagic disease of ruminants caused by bluetongue virus (BTV). Inactive BTV vaccines have been successful in field trials in some areas, and inactivated vaccines are considered safer. ...Bluetongue (BT) is a serious hemorrhagic disease of ruminants caused by bluetongue virus (BTV). Inactive BTV vaccines have been successful in field trials in some areas, and inactivated vaccines are considered safer. However, information about the effect of the viral antigen level on the serological response and efficiency of the inactive BTV-16 vaccine is lacking. In the present study, the serological response and efficiency of the viral antigen concentration in the binary ethylenimine-inactivated Chinese BTV serotype-16 vaccine were investigated. The viral antigens in the viral suspension (VS) were quantified using a modified BTV AC-ELISA method. Four batches of vaccine containing 1, 5, 10, and 50 μg/ml of viral antigen were generated from the VS. Four groups of naive Chinese sheep were vaccinated with the different vaccine batches, and the serological response and vaccine efficiency were investigated before and after challenge infection. The vaccines containing 10 and 50 μg/ml of viral antigen induced significant ELISA and neutralizing antibody titers 14 days after vaccination, whereas the vaccines containing 1 and 5 μg/ml of viral antigen did not have these effects. A booster immunization at 21 days enhanced all groups’ antibody titers;however, the increased titer was related to the viral antigen level. In contrast to the serological response, the viral antigen level of the vaccines did not have a significant effect on the vaccine efficiency. With the exception of one sheep from the 5 μg/ml viral antigen group, all vaccinated sheep from the four antigen level groups showed strong resistance to infection based on their clinical symptoms, rectal temperatures and viremia. Collectively, these data suggested that viral antigen levels from 1 to 50 μg/ml had a significant effect on the serological response of the animals but a limited effect on the vaccine efficiency. The BTV-16 vaccine containing 1 μg/ml of viral antigen was sufficient to achieve high efficiency, but only the vaccines with more than 10 μg/ml of antigen induced a significant antibody response. To obtain a better serological response, we suggest the use of vaccines with more than 10 μg/ml of viral antigen. The findings in the study will be useful for BTV vaccine production.展开更多
Background:Infected pancreatic necrosis(IPN)is a highly morbid local complication following necrotizing pancreatitis.Early enteral nutrition has been proven to be effective in preventing IPN.This study aimed to assess...Background:Infected pancreatic necrosis(IPN)is a highly morbid local complication following necrotizing pancreatitis.Early enteral nutrition has been proven to be effective in preventing IPN.This study aimed to assess the association between the trajectory of prealbumin(PAB)during the early phase of acute pancreatitis(AP)and the incidence of IPN and other clinical outcomes.Methods:This retrospective,dual-centered study screened patients with AP admitted to the Center of Acute Pancreatitis,Jinling Hospital and the Affiliated Hospital of Zunyi Medical University from January 2018 to December 2022.The PAB levels during the first week after admission were collected.The primary outcome was the incidence of IPN within 90 days after AP onset.Group-based trajectory modelling was performed to describe the trajectory of PAB levels over time.A Cox proportional hazard model was used to facilitate the interpretation of the time-varying hazard ratio(HR)between PAB and outcomes.Fine-Gray sub-distribution hazard model was adopted for sensitivity analysis.Results:A total of 373 patients were included,of whom 82(22.0%)were diagnosed with IPN within 90 days.The trajectory model assigned 232 patients to the low-level PAB(L-PAB)group and 141 to the high-level PAB(H-PAB)group.The incidence of 90-day IPN in the L-PAB group was significantly higher than that in the H-PAB group(26.7%vs.14.2%,P=0.005).The multivariate Cox regression model showed that a high PAB trajectory was associated with a lower incidence of IPN(HR=0.52,95%CI:0.30-0.89;P=0.017)after adjustment for potential confounders.In the sensitivity analysis,taking death as a com-peting risk,high PAB trajectory remained significantly associated with a lower incidence of IPN in the Fine-Gray model(HR=0.55,95%CI:0.33-0.92;P=0.022).Conclusions:A high PAB trajectory within the first week of AP was significantly associated with a lower incidence of IPN within 90 days after AP onset.Dynamic monitoring of PAB levels in the early phase of AP may play an important role in stratifying patients at high risk of developing IPN.展开更多
文摘Background:Isotonic crystalloids are recommended as the first choice for fluid therapy in acute pan-creatitis(AP),with normal saline(NS)and lactate Ringer’s(LR)used most often.Evidence based recom-mendations on the type of fluid are conflicting and generally come from small single-center randomized controlled trials(RCTs).We therefore conducted a systematic review and meta-analysis to compare the effect of balanced solutions(BS)versus NS on patient-centered clinical outcomes in AP.Methods:From four databases searched up to October 2024,we included only RCTs of adult patients with AP that compared the use of BS(including LR,acetate Ringer’s,etc.)with NS.The primary out-come was the disease advances from AP to moderately severe and severe AP(MSAP/SAP).Trial sequential analyses(TSA)were conducted to control for type-I and type-II errors and Grading of Recommendations Assessment,Development,and Evaluation(GRADE)was used to assess the quality of evidence.Results:Six RCTs were identified and included,involving 260 patients treated with BS and 298 patients with NS.Patients who received the BS had less MSAP/SAP[odds ratio(OR)=0.50,95%confidence in-terval(CI):0.29 to 0.85,P=0.01,I^(2)=0%;5 studies,299 patients],reduced the need of ICU admission(OR=0.60,95%CI:0.39 to 0.93,P=0.02,I^(2)=0%;5 studies,507 patients)and shorter length of hospital stay[mean difference(MD)=-0.88,95%CI:-1.48 to-0.28,P=0.004,I^(2)=0%;6 studies,558 patients;confirmed by TSA with high certainty]compared with those who received NS.The evidence for most of the clinical outcomes was rated as moderate to low due to the risk of bias,imprecision and inconsistency.Conclusions:BS,compared with NS,was associated with improved clinical outcomes in patients with AP.However,given the moderate to low quality of evidence for most of the outcomes assessed,further trials are warranted.
基金supported by the National Natural Science Foundation of China(No.82170587)the National Natural Science Foundation of China(No.82100647)+3 种基金Luzhou Municipal People’s Government-Southwest Medical University Science and Technology Strategic Cooperation Project(No.2021LZXNYD-Z01)Sichuan Province International Science and Technology Innovation Cooperation Project(No.2023YFH0078)Sichuan Science and Technology Program(2022YFS0625)the Talent Development Project of the Affiliated Hospital of Southwest Medical University.
文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC.
基金the State Major Research Program of China(2020YFF0406126,Junlong Yao)the National Natural Science Foundation of China(22102125,Huan Yang)+2 种基金the Scientific Research Foundation of Wuhan Institute of Technology(K2021040,Huan Yang)the Innovation Foundation of Key Laboratory of Green Chemical Engineering Process of Ministry of Education(GCX202108,Huan Yang)the Graduate Innovative Fund of Wuhan Institute of Technology(cx2021127,Wei Nie).
文摘In general,self-healing dielectric composites are mainly composed of polar hydrogen bonds,which have high hydrophilicity and are unsuitable for humid environment.Dielectric composite with Diels-Alder(D-A)bond contains covalent bonds,it can be adopted as an efficient self-healing material.Here,we construct self-healing barium titanate(BT)/polyurethane(PU)dielectric composites by adopting PU with D-A bond as matrix(BT/PU-DA).The prepared 10%BT/PU-DA composite exhibits superior self-healing ability than that of PUDA.Moreover,its dielectric constant can reach 9.3 with a loss of only 0.04 at 1000 Hz and maintain 93%repair efficiency of tensile strength.The experimental analysis suggests the introduction of D-A bond can enhance the thermostability and self-healing ability of BT/PU-DA composite.In addition,the incorporation of BT nanoparticles and D-A bond in the self-healing composite contributes to the lower dielectric loss and excellent tensile strength after healing.The adopted strategy is a promising and facile approach to develop highly efficient selfhealing dielectric material,which will be conducive to reuse and sustainable development of the electronic packaging material in aqueous medium or wet environment.
基金National Natural Science Foundation of China(Grant Nos.61831008,61525103 and 61972113)the Guangdong Science and Tech⁃nology Planning Project(Grant No.2018B030322004)the Basic Research Project of Shenzhen Science and Technology Program(Grant No.JCYJ20190806112215116).
文摘Mobile Edge Computing(MEC)is a promising solution to tackle the upcoming computing tsunami in 5G/6G era by effectively utilizing the idle resource at the mobile edge.In this work,a multi⁃hop D2D⁃enabled MEC scenario was studied,where mobile devices at network edge connect and share resources with each other via multi⁃hop D2D.The research focus was on the micro⁃task scheduling problem in the multi⁃hop D2D⁃enabled MEC system,where each task was divided into multiple sequential micro⁃tasks,such as data downloading micro⁃task,data processing micro⁃task,and data uploading micro⁃task,according to their functionalities as well as resource requirements.A joint Task Failure Probability and Energy Consumption Minimization(TFP⁃ECM)problem was proposed,aiming at minimizing the task failure probability and the energy consumption jointly.To solve the problem,several linearization methods were proposed to relax the constraints and convert the original problem into an integer linear programming(ILP).Simulation results show that the proposed solution outperformed the existing solutions(with indivisible tasks or without resource sharing)in terms of both total cost and task failure probability.
基金Jingmen science and technology research and development plan(2019yfzd024).
文摘Objective:To observe the clinical effect of modified Yu Rong San gel eye mask in the treatment of dark circles.Methods:96 cases of patients with dark circles were randomly divided into treatment group and control group.In the control group and the treatment group,the common eye mask and the modified Yu Rong San gel eye mask were applied to the black circle area respectively.After 15min,water was used to wash the face,the application of the mask for one time a day,four weeks,one course,and three courses were observed.Results:After three courses of treatment,the total effective rate of the treatment group was higher than that of the control group(P<0.05);the area of black eye circles in the treatment group was smaller than that before treatment(P<0.05);compared with the control group,the score of black eye circles was lower than that before treatment,the difference was statistically significant(P<0.05).Conclusions Addition and reduction of Yu Rong San gel eye mask is effective in the treatment of dark circles.
基金supported by the National Natural Science Foundation of China(Grant No.:82074235)the Central Universities in China(Grant No.:2023-JYB-JBQN-041)。
文摘Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion(I/R)injury,which has recently gained the attention of researchers.Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury.This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury,focusing on the issues related to energy metabolism,mitochondrial quality control disorders,oxidative stress,and calcium.The mechanisms by which mitochondria mediate cell death have also been discussed.To develop a resource for the prevention and management of clinical myocardial I/R damage,we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.
文摘In this paper, a smart home system based on ZigBee technology is designed. The system includes home network, home server and mobile terminal. The program is highly scalable and cost-effective. This paper developed the home server-side application based on MFC technology and the mobile terminal application. The mobile client can remotely control home devices and query the running state, electric energy information and historical data of home devices. At the same time, the home server-side application can store electric energy information and electricity consumption of home devices. Combined with household distributed photovoltaic generation system, the system can be applied to home energy management system. Through running tests and application, the results show that the system has realized basic functions of smart home and achieved the desired design goals.
文摘Bluetongue (BT) is a serious hemorrhagic disease of ruminants caused by bluetongue virus (BTV). Inactive BTV vaccines have been successful in field trials in some areas, and inactivated vaccines are considered safer. However, information about the effect of the viral antigen level on the serological response and efficiency of the inactive BTV-16 vaccine is lacking. In the present study, the serological response and efficiency of the viral antigen concentration in the binary ethylenimine-inactivated Chinese BTV serotype-16 vaccine were investigated. The viral antigens in the viral suspension (VS) were quantified using a modified BTV AC-ELISA method. Four batches of vaccine containing 1, 5, 10, and 50 μg/ml of viral antigen were generated from the VS. Four groups of naive Chinese sheep were vaccinated with the different vaccine batches, and the serological response and vaccine efficiency were investigated before and after challenge infection. The vaccines containing 10 and 50 μg/ml of viral antigen induced significant ELISA and neutralizing antibody titers 14 days after vaccination, whereas the vaccines containing 1 and 5 μg/ml of viral antigen did not have these effects. A booster immunization at 21 days enhanced all groups’ antibody titers;however, the increased titer was related to the viral antigen level. In contrast to the serological response, the viral antigen level of the vaccines did not have a significant effect on the vaccine efficiency. With the exception of one sheep from the 5 μg/ml viral antigen group, all vaccinated sheep from the four antigen level groups showed strong resistance to infection based on their clinical symptoms, rectal temperatures and viremia. Collectively, these data suggested that viral antigen levels from 1 to 50 μg/ml had a significant effect on the serological response of the animals but a limited effect on the vaccine efficiency. The BTV-16 vaccine containing 1 μg/ml of viral antigen was sufficient to achieve high efficiency, but only the vaccines with more than 10 μg/ml of antigen induced a significant antibody response. To obtain a better serological response, we suggest the use of vaccines with more than 10 μg/ml of viral antigen. The findings in the study will be useful for BTV vaccine production.
基金supported by a grant from the National Natural Science Foundation of China(82470680).
文摘Background:Infected pancreatic necrosis(IPN)is a highly morbid local complication following necrotizing pancreatitis.Early enteral nutrition has been proven to be effective in preventing IPN.This study aimed to assess the association between the trajectory of prealbumin(PAB)during the early phase of acute pancreatitis(AP)and the incidence of IPN and other clinical outcomes.Methods:This retrospective,dual-centered study screened patients with AP admitted to the Center of Acute Pancreatitis,Jinling Hospital and the Affiliated Hospital of Zunyi Medical University from January 2018 to December 2022.The PAB levels during the first week after admission were collected.The primary outcome was the incidence of IPN within 90 days after AP onset.Group-based trajectory modelling was performed to describe the trajectory of PAB levels over time.A Cox proportional hazard model was used to facilitate the interpretation of the time-varying hazard ratio(HR)between PAB and outcomes.Fine-Gray sub-distribution hazard model was adopted for sensitivity analysis.Results:A total of 373 patients were included,of whom 82(22.0%)were diagnosed with IPN within 90 days.The trajectory model assigned 232 patients to the low-level PAB(L-PAB)group and 141 to the high-level PAB(H-PAB)group.The incidence of 90-day IPN in the L-PAB group was significantly higher than that in the H-PAB group(26.7%vs.14.2%,P=0.005).The multivariate Cox regression model showed that a high PAB trajectory was associated with a lower incidence of IPN(HR=0.52,95%CI:0.30-0.89;P=0.017)after adjustment for potential confounders.In the sensitivity analysis,taking death as a com-peting risk,high PAB trajectory remained significantly associated with a lower incidence of IPN in the Fine-Gray model(HR=0.55,95%CI:0.33-0.92;P=0.022).Conclusions:A high PAB trajectory within the first week of AP was significantly associated with a lower incidence of IPN within 90 days after AP onset.Dynamic monitoring of PAB levels in the early phase of AP may play an important role in stratifying patients at high risk of developing IPN.
