Objective:To characterize the tumor-suppressive role of LINC00936 in non-small cell lung cancer(NSCLC)through mechanistic exploration of its regulatory pathways.Methods:Bioinformatics interrogation of TCGA/NSCLC cohor...Objective:To characterize the tumor-suppressive role of LINC00936 in non-small cell lung cancer(NSCLC)through mechanistic exploration of its regulatory pathways.Methods:Bioinformatics interrogation of TCGA/NSCLC cohorts assessed LINC00936 expression,clinical correlations,and immune contexture.Functional enrichment analyses predicted pathway associations.In H1299 cells,LINC00936 overexpression(plasmid)and knockdown(siRNA)models were validated by RT-qPCR.Transcriptomic profiling identified differentially expressed genes(DEGs)subjected to KEGG pathway analysis.Results:LINC00936 was significantly downregulated in NSCLC tissues(TCGA,P<0.05)and cell lines(vs.16-HBE,P<0.05),correlating with poor prognosis and altered tumor-infiltrating immune subsets.DEG enrichment implicated Ras/MAPK signaling as the dominant pathway(FDR<0.05).Successful LINC00936 modulation(overexpression/knockdown,P<0.05)confirmed its regulatory capacity.Conclusion:LINC00936 acts as a tumor suppressor in NSCLC via Ras/MAPK pathway modulation,proposing its therapeutic candidacy for precision oncology strategies.展开更多
Dust removal from pyrolytic vapors at high temperatures is an obstacle to the industrialization of the coal pyrolysis process.In this work,a granular bed with expanded perlites as filtration media was designed and int...Dust removal from pyrolytic vapors at high temperatures is an obstacle to the industrialization of the coal pyrolysis process.In this work,a granular bed with expanded perlites as filtration media was designed and integrated into a 10 t·d^(–1)coal pyrolysis facility.The testing results showed that around 97.56%dust collection efficiency was achieved.As a result,dust content in tar was significantly lowered.The pressure drop of the granular bed maintained in the range of 356 Pa to 489 Pa.The dust size in the effluent after filtration exhibited a bimodal distribution,which was attributed to the heterogeneity of the dust components.The effects of filtration bed on pyrolytic product yields were also discussed.A modified filtration model based on the macroscopic phenomenological theory was proposed to describe the performance of the granular bed.The computation results were well agreed with the experimental data.展开更多
Sparse identification of nonlinear dynamics(SINDy)has made significant progress in data-driven dynamics modeling.However,determining appropriate hyperparameters and addressing the time-consuming symbolic regression pr...Sparse identification of nonlinear dynamics(SINDy)has made significant progress in data-driven dynamics modeling.However,determining appropriate hyperparameters and addressing the time-consuming symbolic regression process remain substantial challenges.This study proposes the adaptive backward stepwise selection of fast SINDy(ABSS-FSINDy),which integrates statistical learning-based estimation and technical advancements to significantly reduce simulation time.This approach not only provides insights into the conditions under which SINDy performs optimally but also highlights potential failure points,particularly in the context of backward stepwise selection(BSS).By decoding predefined features into textual expressions,ABSS-FSINDy significantly reduces the simulation time compared with conventional symbolic regression methods.We validate the proposed method through a series of numerical experiments involving both planar/spatial dynamics and high-dimensional chaotic systems,including Lotka-Volterra,hyperchaotic Rossler,coupled Lorenz,and Lorenz 96 benchmark systems.The experimental results demonstrate that ABSS-FSINDy autonomously determines optimal hyperparameters within the SINDy framework,overcoming the curse of dimensionality in high-dimensional simulations.This improvement is substantial across both lowand high-dimensional systems,yielding efficiency gains of one to three orders of magnitude.For instance,in a 20D dynamical system,the simulation time is reduced from 107.63 s to just 0.093 s,resulting in a 3-order-of-magnitude improvement in simulation efficiency.This advancement broadens the applicability of SINDy for the identification and reconstruction of high-dimensional dynamical systems.展开更多
Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury, and expression levels of specific proteins, including low-density lipoprotein receptor related protein-6...Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury, and expression levels of specific proteins, including low-density lipoprotein receptor related protein-6 phosphorylation, β-catenin, and glycogen synthase kinase-3β, are significantly altered. We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/β-catenin signaling pathway. In the current study, 30 mg/kg methylprednisolone was injected into rats with spinal cord injury immediately post-injury and at 1 and 2 days post-injury. Basso, Beattie, and Bresnahan scores showed that methylprednisolone treatment significantly promoted locomotor functional recovery between 2 and 6 weeks post-injury. The number of surviving motor neurons increased, whereas the lesion size significantly decreased following methylprednisolone treatment at 7 days post-injury. Additionally, caspase-3, caspase-9, and Bax protein expression levels and the number of apoptotic cells were reduced at 3 and 7 days post-injury, while Bcl-2 levels at 7 days post-injury were higher in methylprednisolone-treated rats compared with saline-treated rats. At 3 and 7 days post-injury, methylprednisolone up-regulated expression and activation of the Wnt/β-catenin signaling pathway, including low-density lipoprotein receptor related protein-6 phosphorylation, β-catenin, and glycogen synthase kinase-3β phosphorylation. These results indicate that methylprednisolone-induced neuroprotection may correlate with activation of the Wnt/β-catenin signaling pathway.展开更多
BACKGROUND Mesenteric lymphangioma(ML) in adults is a very rare disease. We report six hospitalized adult patients with ML in our hospital between January 2013 and July 2018 to investigate the characteristics and prog...BACKGROUND Mesenteric lymphangioma(ML) in adults is a very rare disease. We report six hospitalized adult patients with ML in our hospital between January 2013 and July 2018 to investigate the characteristics and prognosis of ML in adults.CASE SUMMARY The male-to-female ratio was 3:3, and the median age at diagnosis was 55.2 years. Clinical manifestations varied; however, most were acute cases(5/6). No history of trauma was reported. None(0/6) of the patients were accurately diagnosed with ML in the emergency and outpatient departments. Mesenteric cysts were identified in four patients(66.7%) by abdominal ultrasound and in five patients(83.3%) by computed tomography. ML was postoperatively confirmed by pathology. Most MLs(4/6) were associated with infection of other systems. ML was located in the mesentery of the small intestine(n = 4), ileum(n = 1) and rectum(n = 1). Cyst fluid was clear(n = 4), chylous(n = 1) and bloody(n = 1). Surgical procedures included complete tumor removal and partial intestinal excision(n = 6). Recurrence and adhesive intestinal obstruction were not observed during the 3-12 mo follow-up period.CONCLUSION ML in adults is a rare benign acquired disease that can be cured by surgical treatment. Infection may be a cause of ML.展开更多
Insulin resistance(IR) has been considered to be an important causative factor of metabolic syndrome(Met S). The present study investigated whether pomegranate peel polyphenols(PPPs) could prevent the development of M...Insulin resistance(IR) has been considered to be an important causative factor of metabolic syndrome(Met S). The present study investigated whether pomegranate peel polyphenols(PPPs) could prevent the development of Met S by improving IR in rats. Male Sprague-Dawley(SD) rats were fed high fat diet(HFD) to induce Met S and supplemented with different dosages of PPPs for 12 weeks. The results showed that HFD-induced insulin resistant rats had disordered metabolism of blood glucose, blood lipid, and terrible muscle fiber morphology when compared with normal diet-fed rats, but PPPs treatment at a dosage of 300 mg/kg·day significantly reversed these negative effects. Moreover, in skeletal muscle tissue of insulin resistant rats, PPPs treatments significantly increased the protein expressions of insulin receptor(Ins R) and phosphorylated insulin receptor substrate 1(IRS-1), stimulated peroxisome proliferator activated receptor gamma(PPARγ) and phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT/PKB) signaling pathway, and aggrandized the protein levels of phosphorylated glycogen synthase kinase-3β(GSK-3β) and glucose transporter 4(GLUT4). Our results suggest that PPPs possess of the beneficial effects on alleviating IR by enhancing insulin sensitivity and regulating glucose metabolism.展开更多
Clinical experiments have proven that the pedunculopontine nucleus(PPN)plays a crucial role in the modulation of beta oscillations in Parkinson’s disease(PD).Here,we propose a new computational framework by introduci...Clinical experiments have proven that the pedunculopontine nucleus(PPN)plays a crucial role in the modulation of beta oscillations in Parkinson’s disease(PD).Here,we propose a new computational framework by introducing the PPN and related synaptic connections to the classic basal ganglia-thalamo-cortical model.Fascinatingly,the improved model can not only simulate the basic saturated and beta activities mentioned in previous studies but also produce the normal alpha rhythm that is much closer to physiological phenomena.Specifically,the results show that Parkinsonian oscillation activities can be controlled and modulated by the connection strength between the PPN and the globus pallidus internal nucleus(GPi)and the subthalamic nucleus(STN),supporting the fact that PPN is overinhibited in PD.Meanwhile,the internal mechanism underlying these state transitions is further explained from the perspective of dynamics.Additionally,both deep brain stimulation(DBS)and optogenetic technology are considered effective in terms of abnormal oscillations.Especially when a low-frequency DBS is added to the PPN,beta oscillations can be suppressed,but it is excited again as the DBS’s frequency gradually increases to a larger value.These results coincide with the experimental results that low-frequency stimulation of the PPN is effective,and verify the rationality of the model.Furthermore,we show that optogenetic stimulation of the globus pallidus external(GPe)expressing excitatory channelrhodopsin(ChR2)can effectively inhibit beta oscillations,whereas exciting the STN and PPN has a limited effect.These results are consistent with experimental reports suggesting that the symptoms of PD’s movement disorder can be alleviated under the GPe-ChR2,but not STN-ChR2,situation.Although the functional role of the PPN and the feasibility of optogenetic stimulation remain to be clinically explored,the results obtained help us understand the mechanisms of beta oscillations in PD.展开更多
CO_(2)-responsive gels,which swell upon contact with CO_(2),are widely used for profile control to plug high-permeability gas flow channels in carbon capture,utilization,and storage(CCUS)applications in oil reser-voir...CO_(2)-responsive gels,which swell upon contact with CO_(2),are widely used for profile control to plug high-permeability gas flow channels in carbon capture,utilization,and storage(CCUS)applications in oil reser-voirs.However,the use of these gels in high-temperature CCUS applications is limited due to their rever-sible swelling behavior at elevated temperatures.In this study,a novel dispersed particle gel(DPG)suspension is developed for high-temperature profile control in CCUS applications.First,we synthesize a double-network hydrogel consisting of a crosslinked polyacrylamide(PAAm)network and a crosslinked sodium alginate(SA)network.The hydrogel is then sheared in water to form a pre-prepared DPG suspen-sion.To enhance its performance,the gel particles are modified by introducing potassium methylsilan-etriolate(PMS)upon CO_(2) exposure.Comparing the particle size distributions of the modified and pre-prepared DPG suspension reveals a significant swelling of gel particles,over twice their original size.Moreover,subjecting the new DPG suspension to a 100℃ environment for 24 h demonstrates that its gel particle sizes do not decrease,confirming irreversible swelling,which is a significant advantage over the traditional CO_(2)-responsive gels.Thermogravimetric analysis further indicates improved thermal sta-bility compared to the pre-prepared DPG particles.Core flooding experiments show that the new DPG suspension achieves a high plugging efficiency of 95.3%in plugging an ultra-high permeability sandpack,whereas the pre-prepared DPG suspension achieves only 82.8%.With its high swelling ratio,irreversible swelling at high temperatures,enhanced thermal stability,and superior plugging performance,the newly developed DPG suspension in this work presents a highly promising solution for profile control in high-temperature CCUS applications.展开更多
BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of...BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of the pharyngeal airway during sleep;however,the relationship between these two conditions remains unexplored.We hypothesized that a higher TyG-BMI is associated with the occurrence of OSA.AIM To assess the association between TyG-BMI and OSA in adults in the United States.METHODS A cross-sectional study was conducted utilizing data from the National Health and Nutrition Examination Surveys spanning from 2005-2008 to 2015-2018.TyGBMI was calculated as Ln[triglyceride(mg/dL)×fasting blood glucose(mg/dL)/2]×BMI.Restricted cubic splines were used to analyze the risk of TyG-BMI and OSA occurrence.To identify potential nonlinear relationships,we combined Cox proportional hazard regression with smooth curve fitting.We also conducted sensitivity and subgroup analyses to verify the robustness of our findings.RESULTS We included 16794 participants in the final analysis.Multivariate regression analysis showed that participants with a higher TyG-BMI had a higher OSA incidence.After adjusting for all covariates,TyG-BMI was positively correlated with the prevalence of OSA(odds ratio:1.28;95%confidence interval:1.17,1.40;P<0.001);no significant nonlinear relationship was observed.Subgroup analysis showed no strong correlation between TyG-BMI and OSA in patients with diabetes.The correlation between TyG-BMI and OSA was influenced by age,sex,smoking status,marital status,hypertensive stratification,and obesity;these subgroups played a moderating role between TyGBMI and OSA.Even after adjusting for all covariates,there was a positive association between TYG-BMI and OSA prevalence.CONCLUSION A higher TyG-BMI index is linked to higher chances of developing OSA.As TyG-BMI is an indicator of IR,managing IR may help reduce the risk of OSA.展开更多
Enhanced mass concentrations of aromatic-derived secondary organic aerosol(SOA)are frequently observed during humid-haze events.However,the influencing mechanism of relative humidity(RH)in aromatic-derived SOA formati...Enhanced mass concentrations of aromatic-derived secondary organic aerosol(SOA)are frequently observed during humid-haze events.However,the influencing mechanism of relative humidity(RH)in aromatic-derived SOA formation remains incompletely understood.Here,the RH dependence of SOA formation in the presence of NOx was explored by a series of chamber experiments for toluene(TOL)and 1,3,5-trimethylbenzene(TMB)photooxidation.The yield of TOL SOA and TMB SOA increased by 221%and 52%with increasing RH from~8%to~70%,respectively.Analytical results from a high-resolution mass spectrometer showed that SOA constituents with high oxygen content(O/C>0.6)were more abundant in SOA formed in the~70%RH experiment.The elevated yields and O/C of SOA could be attributed to the promoted formation and particle-phase diffusivity of highly oxidized molecules.In addition,in comparison with TMB,TOL could produce more unsaturated aldehydes,which are oxidized into carboxylic acids with high O/C,leading to a more sensitive response of TOL SOA formation to the change in RH.Our work provides mechanistic insights into RH roles in aromatic SOA formation and is helpful for a better understanding of humid-haze events.展开更多
With the rapid development of the world economy,complex air pollution has increasingly become a serious threat;for example,with haze events occurring frequently in various regions of the globe.Recent evidence has indi...With the rapid development of the world economy,complex air pollution has increasingly become a serious threat;for example,with haze events occurring frequently in various regions of the globe.Recent evidence has indicated that secondary aerosols play an important role in haze formation,and that heterogeneous processes are among the main forces driving their explosive growth.In this regard,this paper reviews recent advances in the understanding of the impact of heterogeneous processes on haze chemistry,including the impact on NO_(2)chemistry,marine aerosols,and the hygroscopicity and optical properties of atmospheric aerosols.It is distinguished from past reviews on this topic by focusing mainly on new insights from the past five years.We summarize the main findings of the impacts of heterogeneous processes on NO_(2)chemistry,marine aerosols,and the physicochemical properties of atmospheric aerosols,and propose several future research directions.展开更多
Conventional open-loop deep brain stimulation(DBS)systems with fixed parameters fail to accommodate interindividual pathological differences in Parkinson's disease(PD)management while potentially inducing adverse ...Conventional open-loop deep brain stimulation(DBS)systems with fixed parameters fail to accommodate interindividual pathological differences in Parkinson's disease(PD)management while potentially inducing adverse effects and causing excessive energy consumption.In this paper,we present an adaptive closed-loop framework integrating a Yogi-optimized proportional–integral–derivative neural network(Yogi-PIDNN)controller.The Yogi-augmented gradient adaptation mechanism accelerates the convergence of general PIDNN controllers in high-dimensional nonlinear control systems while reducing control energy usage.In addition,a system identification method establishes input–output dynamics for pre-training stimulation waveforms,bypassing real-time parameter-tuning constraints and thereby enhancing closed-loop adaptability.Finally,a theoretical analysis based on Lyapunov stability criteria establishes a sufficient condition for closed-loop stability within the identified model.Computational validations demonstrate that our approach restores thalamic relay reliability while reducing energy consumption by(81.0±0.7)%across multi-frequency tests.This study advances adaptive neuromodulation by synergizing data-driven pre-training with stability-guaranteed real-time control,offering a novel framework for energy-efficient and personalized Parkinson's therapy.展开更多
Recently, deep eutectic solvents (DES) have received great attention in assisting water flooding and surfactant flooding to improve oil recovery because they can reduce the interfacial tension (IFT) between oil and wa...Recently, deep eutectic solvents (DES) have received great attention in assisting water flooding and surfactant flooding to improve oil recovery because they can reduce the interfacial tension (IFT) between oil and water, inhibit surfactant adsorption, and change the wettability of rock. However, the effects of DES on the wettability of rock surface have not been thoroughly investigated in the reported studies. In this study, the effects of various DES samples on the wettability of sandstone samples are investigated using the Amott wettability measurement method. Three DES samples and several DES solutions and DES-surfactant solutions are firstly synthesized. Then, the wettability of the sandstone samples is measured using pure saline water, DES solutions, and DES-surfactant solutions, respectively. The effects of the DES samples on the wettability of the sandstone samples are investigated by comparing the measured wettability parameters, including oil displacement ratio (I_(o)), water displacement ratio (I_(w)), and wettability index (I_(A)). The Berea rock sample used in this study is weakly hydrophilic with I_(o), I_(w), and I_(A) of 0.318, 0.032, and 0.286, respectively. Being processed by the prepared DES samples, the wettability of the Berea sandstone samples is altered to hydrophilic (0.7 > I_(A) > 0.3) by increasing I_(w) but lowering Io. Similarly, DES-surfactant solutions can also modify the wettability of the Berea sandstone samples from weakly hydrophilic to hydrophilic. However, some DES-surfactant solutions can not only increase I_(w) but also increase I_(o), suggesting that the lipophilicity of those sandstone samples will be improved by the DES-surfactant solutions. In addition, micromodel flooding tests confirm the promising performance of a DES-surfactant solution in improving oil recovery and altering wettability. Moreover, the possible mechanisms of DES and DES-surfactant solutions in altering the wettability of the Berea sandstone samples are proposed. DES samples may improve the hydrophilicity by forming hydrogen bonds between rock surface and water molecules. For DES-surfactant solutions, surfactant micelles can capture oil molecules to improve the lipophilicity of those sandstone samples.展开更多
The Mini-SiTian project,which is a pathfinder for the SiTian project,utilizes three 30 cm telescopes equipped with commercial CMOS cameras(ZWO ASI6200MM Pro)to simulate a large-area time-domain survey.Due to the avoid...The Mini-SiTian project,which is a pathfinder for the SiTian project,utilizes three 30 cm telescopes equipped with commercial CMOS cameras(ZWO ASI6200MM Pro)to simulate a large-area time-domain survey.Due to the avoidance of the traditional mechanical shutter,the CMOS camera is favorable in time-domain survey projects.In the future,the SiTian telescope array will employ a two-by-two scientific-grade mosaic CMOS camera to survey a10,000 degree square area every 30 minutes.Therefore,the performance of CMOS directly determines the detection capability of SiTian telescopes for transient sources,and a comprehensive understanding of the performance of CMOS cameras is crucial.In this research,laboratory testing was conducted to thoroughly evaluate three cameras by assessing several critical parameters,including bias stability,dark current,pixel anomalies,linearity,gain,and read noise.We find exceptional short-term bias stability with standard deviations below 0.02 ADU,negligible dark current of approximately 0.002 e-pixel^(-1)s^(-1)at 0℃,and excellent linearity with nonlinearity consistently below±0.5%,and a small proportion(0.06%-0.08%)of pixels with anomalous responses.Furthermore,our analysis demonstrates uniform gain values across all cameras,ranging from 0.252 to 0.255 e-ADU^(-1),with low readout noise,measured to be below 1.6 e-using conventional methods.We also propose a novel method for pixel-level gain and read noise calculation for CMOS sensors,which revealed a narrow gain distribution and a low median read noise of 1.028 e-for one of the cameras.The laboratory testing of the ZWO ASI6200MM Pro cameras indicates their potential to meet the requirements of time-domain surveys for the Mini-SiTian project.展开更多
Many ＂rich - connected＂ topologies with multiple parallel paths between smwers have been proposed for data center networks recently to provide high bisection bandwidth, but it re mains challenging to fully utilize t...Many ＂rich - connected＂ topologies with multiple parallel paths between smwers have been proposed for data center networks recently to provide high bisection bandwidth, but it re mains challenging to fully utilize the high network capacity by appropriate multi- path routing algorithms. As flow-level path splitting may lead to trafl＇ic imbalance between paths due to flow- size difference, packet-level path splitting attracts more attention lately, which spreads packets from flows into multiple available paths and significantly improves link utilizations. However, it may cause packet reordering, confusing the TCP congestion control algorithm and lowering the throughput of flows. In this paper, we design a novel packetlevel multi-path routing scheme called SOPA, which leverag- es OpenFlow to perform packet-level path splitting in a round- robin fashion, and hence significantly mitigates the packet reordering problem and improves the network throughput. Moreover, SOPA leverages the topological feature of data center networks to encode a very small number of switches along the path into the packet header, resulting in very light overhead. Compared with random packet spraying （RPS）, Hedera and equal-cost multi-path routing （ECMP）, our simulations demonstrate that SOPA achieves 29.87%, 50.41% and 77.74% higher network throughput respectively under permutation workload, and reduces average data transfer completion time by 53.65%, 343.31% and 348.25% respectively under production workload.展开更多
In this study, concentrations of tritiated water(HTO) and non-exchangeable organically bound tritium(NE-OBT) and the NE-OBT/HTO ratios were determined in soil around Qinshan Nuclear Power Plant(NPP), Zhejiang, China, ...In this study, concentrations of tritiated water(HTO) and non-exchangeable organically bound tritium(NE-OBT) and the NE-OBT/HTO ratios were determined in soil around Qinshan Nuclear Power Plant(NPP), Zhejiang, China, and their vertical profile and spatial distribution were investigated. Results showed variations in both the HTO and NE-OBT concentrations in the vertical profile. The HTO concentrations generally decreased firstly and then increased with the increasing depths, but the trend was not significant. The NE-OBT concentrations in the surface soils(0–5 cm) were considerably lower than those in the deep soils(5–25 cm) at all the sites. The NE-OBT/HTO ratios also show a variable vertical profile, initially increasing and then decreasing with increasing soil depth.Both the HTO and NE-OBT concentrations decreased with the increasing distance to the HWRs in deep soil layers(5–25 cm), revealing that the released tritium from the NPP affected the spatial distribution.展开更多
文摘Objective:To characterize the tumor-suppressive role of LINC00936 in non-small cell lung cancer(NSCLC)through mechanistic exploration of its regulatory pathways.Methods:Bioinformatics interrogation of TCGA/NSCLC cohorts assessed LINC00936 expression,clinical correlations,and immune contexture.Functional enrichment analyses predicted pathway associations.In H1299 cells,LINC00936 overexpression(plasmid)and knockdown(siRNA)models were validated by RT-qPCR.Transcriptomic profiling identified differentially expressed genes(DEGs)subjected to KEGG pathway analysis.Results:LINC00936 was significantly downregulated in NSCLC tissues(TCGA,P<0.05)and cell lines(vs.16-HBE,P<0.05),correlating with poor prognosis and altered tumor-infiltrating immune subsets.DEG enrichment implicated Ras/MAPK signaling as the dominant pathway(FDR<0.05).Successful LINC00936 modulation(overexpression/knockdown,P<0.05)confirmed its regulatory capacity.Conclusion:LINC00936 acts as a tumor suppressor in NSCLC via Ras/MAPK pathway modulation,proposing its therapeutic candidacy for precision oncology strategies.
基金financial support from the National Key Research and Development Program of China(2018YFB0605003).
文摘Dust removal from pyrolytic vapors at high temperatures is an obstacle to the industrialization of the coal pyrolysis process.In this work,a granular bed with expanded perlites as filtration media was designed and integrated into a 10 t·d^(–1)coal pyrolysis facility.The testing results showed that around 97.56%dust collection efficiency was achieved.As a result,dust content in tar was significantly lowered.The pressure drop of the granular bed maintained in the range of 356 Pa to 489 Pa.The dust size in the effluent after filtration exhibited a bimodal distribution,which was attributed to the heterogeneity of the dust components.The effects of filtration bed on pyrolytic product yields were also discussed.A modified filtration model based on the macroscopic phenomenological theory was proposed to describe the performance of the granular bed.The computation results were well agreed with the experimental data.
基金Project supported by the National Natural Science Foundation of China(Nos.12172291,12472357,and 12232015)the Shaanxi Province Outstanding Youth Fund Project(No.2024JC-JCQN-05)the 111 Project(No.BP0719007)。
文摘Sparse identification of nonlinear dynamics(SINDy)has made significant progress in data-driven dynamics modeling.However,determining appropriate hyperparameters and addressing the time-consuming symbolic regression process remain substantial challenges.This study proposes the adaptive backward stepwise selection of fast SINDy(ABSS-FSINDy),which integrates statistical learning-based estimation and technical advancements to significantly reduce simulation time.This approach not only provides insights into the conditions under which SINDy performs optimally but also highlights potential failure points,particularly in the context of backward stepwise selection(BSS).By decoding predefined features into textual expressions,ABSS-FSINDy significantly reduces the simulation time compared with conventional symbolic regression methods.We validate the proposed method through a series of numerical experiments involving both planar/spatial dynamics and high-dimensional chaotic systems,including Lotka-Volterra,hyperchaotic Rossler,coupled Lorenz,and Lorenz 96 benchmark systems.The experimental results demonstrate that ABSS-FSINDy autonomously determines optimal hyperparameters within the SINDy framework,overcoming the curse of dimensionality in high-dimensional simulations.This improvement is substantial across both lowand high-dimensional systems,yielding efficiency gains of one to three orders of magnitude.For instance,in a 20D dynamical system,the simulation time is reduced from 107.63 s to just 0.093 s,resulting in a 3-order-of-magnitude improvement in simulation efficiency.This advancement broadens the applicability of SINDy for the identification and reconstruction of high-dimensional dynamical systems.
基金supported by the National Natural Science Foundation of China,No.81471854
文摘Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury, and expression levels of specific proteins, including low-density lipoprotein receptor related protein-6 phosphorylation, β-catenin, and glycogen synthase kinase-3β, are significantly altered. We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/β-catenin signaling pathway. In the current study, 30 mg/kg methylprednisolone was injected into rats with spinal cord injury immediately post-injury and at 1 and 2 days post-injury. Basso, Beattie, and Bresnahan scores showed that methylprednisolone treatment significantly promoted locomotor functional recovery between 2 and 6 weeks post-injury. The number of surviving motor neurons increased, whereas the lesion size significantly decreased following methylprednisolone treatment at 7 days post-injury. Additionally, caspase-3, caspase-9, and Bax protein expression levels and the number of apoptotic cells were reduced at 3 and 7 days post-injury, while Bcl-2 levels at 7 days post-injury were higher in methylprednisolone-treated rats compared with saline-treated rats. At 3 and 7 days post-injury, methylprednisolone up-regulated expression and activation of the Wnt/β-catenin signaling pathway, including low-density lipoprotein receptor related protein-6 phosphorylation, β-catenin, and glycogen synthase kinase-3β phosphorylation. These results indicate that methylprednisolone-induced neuroprotection may correlate with activation of the Wnt/β-catenin signaling pathway.
基金Supported by the National Natural Science Foundation of China,No.81572343
文摘BACKGROUND Mesenteric lymphangioma(ML) in adults is a very rare disease. We report six hospitalized adult patients with ML in our hospital between January 2013 and July 2018 to investigate the characteristics and prognosis of ML in adults.CASE SUMMARY The male-to-female ratio was 3:3, and the median age at diagnosis was 55.2 years. Clinical manifestations varied; however, most were acute cases(5/6). No history of trauma was reported. None(0/6) of the patients were accurately diagnosed with ML in the emergency and outpatient departments. Mesenteric cysts were identified in four patients(66.7%) by abdominal ultrasound and in five patients(83.3%) by computed tomography. ML was postoperatively confirmed by pathology. Most MLs(4/6) were associated with infection of other systems. ML was located in the mesentery of the small intestine(n = 4), ileum(n = 1) and rectum(n = 1). Cyst fluid was clear(n = 4), chylous(n = 1) and bloody(n = 1). Surgical procedures included complete tumor removal and partial intestinal excision(n = 6). Recurrence and adhesive intestinal obstruction were not observed during the 3-12 mo follow-up period.CONCLUSION ML in adults is a rare benign acquired disease that can be cured by surgical treatment. Infection may be a cause of ML.
基金supported by the National Natural Science Foundation of China (31871801, 32001679)the Science and Technology Research of Shaanxi Province (2020QFY08-03)+1 种基金Forestry Science and Technology Programs of Shaanxi Province (SXLK20200213)Fundamental Research Funds for the Central Universities (GK201604013)。
文摘Insulin resistance(IR) has been considered to be an important causative factor of metabolic syndrome(Met S). The present study investigated whether pomegranate peel polyphenols(PPPs) could prevent the development of Met S by improving IR in rats. Male Sprague-Dawley(SD) rats were fed high fat diet(HFD) to induce Met S and supplemented with different dosages of PPPs for 12 weeks. The results showed that HFD-induced insulin resistant rats had disordered metabolism of blood glucose, blood lipid, and terrible muscle fiber morphology when compared with normal diet-fed rats, but PPPs treatment at a dosage of 300 mg/kg·day significantly reversed these negative effects. Moreover, in skeletal muscle tissue of insulin resistant rats, PPPs treatments significantly increased the protein expressions of insulin receptor(Ins R) and phosphorylated insulin receptor substrate 1(IRS-1), stimulated peroxisome proliferator activated receptor gamma(PPARγ) and phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT/PKB) signaling pathway, and aggrandized the protein levels of phosphorylated glycogen synthase kinase-3β(GSK-3β) and glucose transporter 4(GLUT4). Our results suggest that PPPs possess of the beneficial effects on alleviating IR by enhancing insulin sensitivity and regulating glucose metabolism.
基金supported by the National Natural Science Foundation of China(Grant Nos.12072265 and 12372064).
文摘Clinical experiments have proven that the pedunculopontine nucleus(PPN)plays a crucial role in the modulation of beta oscillations in Parkinson’s disease(PD).Here,we propose a new computational framework by introducing the PPN and related synaptic connections to the classic basal ganglia-thalamo-cortical model.Fascinatingly,the improved model can not only simulate the basic saturated and beta activities mentioned in previous studies but also produce the normal alpha rhythm that is much closer to physiological phenomena.Specifically,the results show that Parkinsonian oscillation activities can be controlled and modulated by the connection strength between the PPN and the globus pallidus internal nucleus(GPi)and the subthalamic nucleus(STN),supporting the fact that PPN is overinhibited in PD.Meanwhile,the internal mechanism underlying these state transitions is further explained from the perspective of dynamics.Additionally,both deep brain stimulation(DBS)and optogenetic technology are considered effective in terms of abnormal oscillations.Especially when a low-frequency DBS is added to the PPN,beta oscillations can be suppressed,but it is excited again as the DBS’s frequency gradually increases to a larger value.These results coincide with the experimental results that low-frequency stimulation of the PPN is effective,and verify the rationality of the model.Furthermore,we show that optogenetic stimulation of the globus pallidus external(GPe)expressing excitatory channelrhodopsin(ChR2)can effectively inhibit beta oscillations,whereas exciting the STN and PPN has a limited effect.These results are consistent with experimental reports suggesting that the symptoms of PD’s movement disorder can be alleviated under the GPe-ChR2,but not STN-ChR2,situation.Although the functional role of the PPN and the feasibility of optogenetic stimulation remain to be clinically explored,the results obtained help us understand the mechanisms of beta oscillations in PD.
基金Lin Du acknowledges the financial support provided by China Scholarship Council(CSC)via a Ph.D.Scholarship(202008510128)supported by Core Technology Project of China National Petroleum Corporation(CNPC)"Research on Thermal Miscible Flooding Technology"(2023ZG18)。
文摘CO_(2)-responsive gels,which swell upon contact with CO_(2),are widely used for profile control to plug high-permeability gas flow channels in carbon capture,utilization,and storage(CCUS)applications in oil reser-voirs.However,the use of these gels in high-temperature CCUS applications is limited due to their rever-sible swelling behavior at elevated temperatures.In this study,a novel dispersed particle gel(DPG)suspension is developed for high-temperature profile control in CCUS applications.First,we synthesize a double-network hydrogel consisting of a crosslinked polyacrylamide(PAAm)network and a crosslinked sodium alginate(SA)network.The hydrogel is then sheared in water to form a pre-prepared DPG suspen-sion.To enhance its performance,the gel particles are modified by introducing potassium methylsilan-etriolate(PMS)upon CO_(2) exposure.Comparing the particle size distributions of the modified and pre-prepared DPG suspension reveals a significant swelling of gel particles,over twice their original size.Moreover,subjecting the new DPG suspension to a 100℃ environment for 24 h demonstrates that its gel particle sizes do not decrease,confirming irreversible swelling,which is a significant advantage over the traditional CO_(2)-responsive gels.Thermogravimetric analysis further indicates improved thermal sta-bility compared to the pre-prepared DPG particles.Core flooding experiments show that the new DPG suspension achieves a high plugging efficiency of 95.3%in plugging an ultra-high permeability sandpack,whereas the pre-prepared DPG suspension achieves only 82.8%.With its high swelling ratio,irreversible swelling at high temperatures,enhanced thermal stability,and superior plugging performance,the newly developed DPG suspension in this work presents a highly promising solution for profile control in high-temperature CCUS applications.
基金Supported by Sanming Project of Medicine in Shenzhen,No.SZZYSM202202010。
文摘BACKGROUND The triglyceride glucose-body mass index(TyG-BMI)is a novel indicator of insulin resistance(IR).Obstructive sleep apnea(OSA)is a prevalent disorder characterized by recurrent complete or partial collapse of the pharyngeal airway during sleep;however,the relationship between these two conditions remains unexplored.We hypothesized that a higher TyG-BMI is associated with the occurrence of OSA.AIM To assess the association between TyG-BMI and OSA in adults in the United States.METHODS A cross-sectional study was conducted utilizing data from the National Health and Nutrition Examination Surveys spanning from 2005-2008 to 2015-2018.TyGBMI was calculated as Ln[triglyceride(mg/dL)×fasting blood glucose(mg/dL)/2]×BMI.Restricted cubic splines were used to analyze the risk of TyG-BMI and OSA occurrence.To identify potential nonlinear relationships,we combined Cox proportional hazard regression with smooth curve fitting.We also conducted sensitivity and subgroup analyses to verify the robustness of our findings.RESULTS We included 16794 participants in the final analysis.Multivariate regression analysis showed that participants with a higher TyG-BMI had a higher OSA incidence.After adjusting for all covariates,TyG-BMI was positively correlated with the prevalence of OSA(odds ratio:1.28;95%confidence interval:1.17,1.40;P<0.001);no significant nonlinear relationship was observed.Subgroup analysis showed no strong correlation between TyG-BMI and OSA in patients with diabetes.The correlation between TyG-BMI and OSA was influenced by age,sex,smoking status,marital status,hypertensive stratification,and obesity;these subgroups played a moderating role between TyGBMI and OSA.Even after adjusting for all covariates,there was a positive association between TYG-BMI and OSA prevalence.CONCLUSION A higher TyG-BMI index is linked to higher chances of developing OSA.As TyG-BMI is an indicator of IR,managing IR may help reduce the risk of OSA.
基金supported by the National Key Research and Development Program of China (Grant No. 2023YFC3706203)the National Natural Science Foundation of China (Grant Nos. 91644214, 22361162668, and 22406109)+1 种基金the China Postdoctoral Science Foundation (Grant No. 2024M751797)Shandong Postdoctoral Science Foundation (SDCX-ZG-202400178)
文摘Enhanced mass concentrations of aromatic-derived secondary organic aerosol(SOA)are frequently observed during humid-haze events.However,the influencing mechanism of relative humidity(RH)in aromatic-derived SOA formation remains incompletely understood.Here,the RH dependence of SOA formation in the presence of NOx was explored by a series of chamber experiments for toluene(TOL)and 1,3,5-trimethylbenzene(TMB)photooxidation.The yield of TOL SOA and TMB SOA increased by 221%and 52%with increasing RH from~8%to~70%,respectively.Analytical results from a high-resolution mass spectrometer showed that SOA constituents with high oxygen content(O/C>0.6)were more abundant in SOA formed in the~70%RH experiment.The elevated yields and O/C of SOA could be attributed to the promoted formation and particle-phase diffusivity of highly oxidized molecules.In addition,in comparison with TMB,TOL could produce more unsaturated aldehydes,which are oxidized into carboxylic acids with high O/C,leading to a more sensitive response of TOL SOA formation to the change in RH.Our work provides mechanistic insights into RH roles in aromatic SOA formation and is helpful for a better understanding of humid-haze events.
基金supported by the National Key Research and Development Program of China(No.2022YFC3701000)the National Natural Science Foundation of China(Nos.42130606 and 41931287)+1 种基金the Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202011)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.Y2021013).
文摘With the rapid development of the world economy,complex air pollution has increasingly become a serious threat;for example,with haze events occurring frequently in various regions of the globe.Recent evidence has indicated that secondary aerosols play an important role in haze formation,and that heterogeneous processes are among the main forces driving their explosive growth.In this regard,this paper reviews recent advances in the understanding of the impact of heterogeneous processes on haze chemistry,including the impact on NO_(2)chemistry,marine aerosols,and the hygroscopicity and optical properties of atmospheric aerosols.It is distinguished from past reviews on this topic by focusing mainly on new insights from the past five years.We summarize the main findings of the impacts of heterogeneous processes on NO_(2)chemistry,marine aerosols,and the physicochemical properties of atmospheric aerosols,and propose several future research directions.
基金supported by the National Natural Science Foundation of China(Grant Nos.12372064 and 12172291)the Youth and Middle-Aged Science and Technology Development Program of Shanghai Institute of Technology(Grant No.ZQ2024-10)。
文摘Conventional open-loop deep brain stimulation(DBS)systems with fixed parameters fail to accommodate interindividual pathological differences in Parkinson's disease(PD)management while potentially inducing adverse effects and causing excessive energy consumption.In this paper,we present an adaptive closed-loop framework integrating a Yogi-optimized proportional–integral–derivative neural network(Yogi-PIDNN)controller.The Yogi-augmented gradient adaptation mechanism accelerates the convergence of general PIDNN controllers in high-dimensional nonlinear control systems while reducing control energy usage.In addition,a system identification method establishes input–output dynamics for pre-training stimulation waveforms,bypassing real-time parameter-tuning constraints and thereby enhancing closed-loop adaptability.Finally,a theoretical analysis based on Lyapunov stability criteria establishes a sufficient condition for closed-loop stability within the identified model.Computational validations demonstrate that our approach restores thalamic relay reliability while reducing energy consumption by(81.0±0.7)%across multi-frequency tests.This study advances adaptive neuromodulation by synergizing data-driven pre-training with stability-guaranteed real-time control,offering a novel framework for energy-efficient and personalized Parkinson's therapy.
基金supported by the Scientific Research and Technology Development Projects of PetroChina(2023ZZ22-02)the Local Efficient Reform and Development Funds for Personnel Training Projectsthe China Scholarship Council(CSC)via a Ph.D.Scholarship(No.202008510128).
文摘Recently, deep eutectic solvents (DES) have received great attention in assisting water flooding and surfactant flooding to improve oil recovery because they can reduce the interfacial tension (IFT) between oil and water, inhibit surfactant adsorption, and change the wettability of rock. However, the effects of DES on the wettability of rock surface have not been thoroughly investigated in the reported studies. In this study, the effects of various DES samples on the wettability of sandstone samples are investigated using the Amott wettability measurement method. Three DES samples and several DES solutions and DES-surfactant solutions are firstly synthesized. Then, the wettability of the sandstone samples is measured using pure saline water, DES solutions, and DES-surfactant solutions, respectively. The effects of the DES samples on the wettability of the sandstone samples are investigated by comparing the measured wettability parameters, including oil displacement ratio (I_(o)), water displacement ratio (I_(w)), and wettability index (I_(A)). The Berea rock sample used in this study is weakly hydrophilic with I_(o), I_(w), and I_(A) of 0.318, 0.032, and 0.286, respectively. Being processed by the prepared DES samples, the wettability of the Berea sandstone samples is altered to hydrophilic (0.7 > I_(A) > 0.3) by increasing I_(w) but lowering Io. Similarly, DES-surfactant solutions can also modify the wettability of the Berea sandstone samples from weakly hydrophilic to hydrophilic. However, some DES-surfactant solutions can not only increase I_(w) but also increase I_(o), suggesting that the lipophilicity of those sandstone samples will be improved by the DES-surfactant solutions. In addition, micromodel flooding tests confirm the promising performance of a DES-surfactant solution in improving oil recovery and altering wettability. Moreover, the possible mechanisms of DES and DES-surfactant solutions in altering the wettability of the Berea sandstone samples are proposed. DES samples may improve the hydrophilicity by forming hydrogen bonds between rock surface and water molecules. For DES-surfactant solutions, surfactant micelles can capture oil molecules to improve the lipophilicity of those sandstone samples.
基金supported by the National Key R&D Program of China(grant Nos.2023YFA1609700,2023YFA1608304,and2023YFA1608303)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550103)+1 种基金the National Natural Science Foundation of China(NSFC,Nos.12090040 and 12090041)supported from the Strategic Pioneer Program of the Astronomy Large-Scale Scientific Facility,Chinese Academy of Sciences,and the Science and Education Integration Funding of the University of Chinese Academy of Sciences。
文摘The Mini-SiTian project,which is a pathfinder for the SiTian project,utilizes three 30 cm telescopes equipped with commercial CMOS cameras(ZWO ASI6200MM Pro)to simulate a large-area time-domain survey.Due to the avoidance of the traditional mechanical shutter,the CMOS camera is favorable in time-domain survey projects.In the future,the SiTian telescope array will employ a two-by-two scientific-grade mosaic CMOS camera to survey a10,000 degree square area every 30 minutes.Therefore,the performance of CMOS directly determines the detection capability of SiTian telescopes for transient sources,and a comprehensive understanding of the performance of CMOS cameras is crucial.In this research,laboratory testing was conducted to thoroughly evaluate three cameras by assessing several critical parameters,including bias stability,dark current,pixel anomalies,linearity,gain,and read noise.We find exceptional short-term bias stability with standard deviations below 0.02 ADU,negligible dark current of approximately 0.002 e-pixel^(-1)s^(-1)at 0℃,and excellent linearity with nonlinearity consistently below±0.5%,and a small proportion(0.06%-0.08%)of pixels with anomalous responses.Furthermore,our analysis demonstrates uniform gain values across all cameras,ranging from 0.252 to 0.255 e-ADU^(-1),with low readout noise,measured to be below 1.6 e-using conventional methods.We also propose a novel method for pixel-level gain and read noise calculation for CMOS sensors,which revealed a narrow gain distribution and a low median read noise of 1.028 e-for one of the cameras.The laboratory testing of the ZWO ASI6200MM Pro cameras indicates their potential to meet the requirements of time-domain surveys for the Mini-SiTian project.
基金supported by the National Basic Research Program of China(973 program)under Grant No.2014CB347800 and No.2012CB315803the National High-Tech R&D Program of China(863 program)under Grant No.2013AA013303+1 种基金the Natural Science Foundation of China under Grant No.61170291,No.61133006,and No.61161140454ZTE IndustryAcademia-Research Cooperation Funds
文摘Many ＂rich - connected＂ topologies with multiple parallel paths between smwers have been proposed for data center networks recently to provide high bisection bandwidth, but it re mains challenging to fully utilize the high network capacity by appropriate multi- path routing algorithms. As flow-level path splitting may lead to trafl＇ic imbalance between paths due to flow- size difference, packet-level path splitting attracts more attention lately, which spreads packets from flows into multiple available paths and significantly improves link utilizations. However, it may cause packet reordering, confusing the TCP congestion control algorithm and lowering the throughput of flows. In this paper, we design a novel packetlevel multi-path routing scheme called SOPA, which leverag- es OpenFlow to perform packet-level path splitting in a round- robin fashion, and hence significantly mitigates the packet reordering problem and improves the network throughput. Moreover, SOPA leverages the topological feature of data center networks to encode a very small number of switches along the path into the packet header, resulting in very light overhead. Compared with random packet spraying （RPS）, Hedera and equal-cost multi-path routing （ECMP）, our simulations demonstrate that SOPA achieves 29.87%, 50.41% and 77.74% higher network throughput respectively under permutation workload, and reduces average data transfer completion time by 53.65%, 343.31% and 348.25% respectively under production workload.
文摘In this study, concentrations of tritiated water(HTO) and non-exchangeable organically bound tritium(NE-OBT) and the NE-OBT/HTO ratios were determined in soil around Qinshan Nuclear Power Plant(NPP), Zhejiang, China, and their vertical profile and spatial distribution were investigated. Results showed variations in both the HTO and NE-OBT concentrations in the vertical profile. The HTO concentrations generally decreased firstly and then increased with the increasing depths, but the trend was not significant. The NE-OBT concentrations in the surface soils(0–5 cm) were considerably lower than those in the deep soils(5–25 cm) at all the sites. The NE-OBT/HTO ratios also show a variable vertical profile, initially increasing and then decreasing with increasing soil depth.Both the HTO and NE-OBT concentrations decreased with the increasing distance to the HWRs in deep soil layers(5–25 cm), revealing that the released tritium from the NPP affected the spatial distribution.
