This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus ...This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus current cases are compared with the random wave-only case,the forward current promotes wave propagation,whereas the reversed backward current inhibits wave propagation.Furthermore,the wave pressure on the downstream pipeline decreases as the relative spacing ratio increases and increases as the diameter increases.However,alterations in the relative spacing ratio or dimensions of the downstream pipeline exert a negligible influence on the wave pressure of the upstream pipeline.Moreover,the relative spacing ratio between the pipelines and the dimensions of the pipelines considerably influence the pore pressure in the sand bed.When the relative spacing ratio remains constant,increasing the downstream pipeline diameter will increase the pore-water pressure of the soil below the downstream pipeline.展开更多
Persistent flows are defined as network flows that persist over multiple time intervals and continue to exhibit activity over extended periods,which are critical for identifying long-term behaviors and subtle security...Persistent flows are defined as network flows that persist over multiple time intervals and continue to exhibit activity over extended periods,which are critical for identifying long-term behaviors and subtle security threats.Programmable switches provide line-rate packet processing to meet the requirements of high-speed network environments,yet they are fundamentally limited in computational and memory resources.Accurate and memoryefficient persistent flow detection on programmable switches is therefore essential.However,existing approaches often rely on fixed-window sketches or multiple sketches instances,which either suffer from insufficient temporal precision or incur substantial memory overhead,making them ineffective on programmable switches.To address these challenges,we propose SP-Sketch,an innovative sliding-window-based sketch that leverages a probabilistic update mechanism to emulate slot expiration without maintaining multiple sketch instances.This innovative design significantly reduces memory consumption while preserving high detection accuracy across multiple time intervals.We provide rigorous theoretical analyses of the estimation errors,deriving precise error bounds for the proposed method,and validate our approach through comprehensive implementations on both P4 hardware switches(with Intel Tofino ASIC)and software switches(i.e.,BMv2).Experimental evaluations using real-world traffic traces demonstrate that SP-Sketch outperforms traditional methods,improving accuracy by up to 20%over baseline sliding window approaches and enhancing recall by 5%compared to non-sliding alternatives.Furthermore,SP-Sketch achieves a significant reduction in memory utilization,reducing memory consumption by up to 65%compared to traditional methods,while maintaining a robust capability to accurately track persistent flow behavior over extended time periods.展开更多
Objective:The aim of the study was to investigate the efficacy of three-dimensional conformal radiotherapy (3D-CRT) combined with Temozolomide (TMZ) concurrent chemotherapy in treatment of postoperative cerebral gliom...Objective:The aim of the study was to investigate the efficacy of three-dimensional conformal radiotherapy (3D-CRT) combined with Temozolomide (TMZ) concurrent chemotherapy in treatment of postoperative cerebral gliomas by prospective randomized controlled trials. Methods: Sixty-two patients with cerebral glioma who had residual tumor were divided into 3D-CRT group (radiotherapy group, n=31) and 3D-CRT with concurrent chemotherapy group (chemoradiotherapy group, n=31) prospectively. All patients received a dose of 50-60 Gy/25-30 F/5-6 weeks by 6 MV-X ray, three-dimensional conformal radiotherapy, 1 f/d, 5 times a week. Chemotherapy regimen was Temozolomide:75 mg/m2/d, concomitantly with radiotherapy, followed by 150-200 mg/m2/d, 5 days, 28 days per cycle, totally 3-6 cycles. Results: The total response rate was 35.3% (11/31) in radiotherapy group. The response rate was 61.3% (19/31) in chemoradiotherapy group. There was significant difference in curative effect (P=0.042). There was no significant difference in survival comparison of two groups (P=0.263). Stratified analysis showed the patients with grade Ⅲ gliomas of chemoradiotherapy group had better prognosis than ones of radiotherapy group (P=0.043). Conclusion: The 3D-CRT with concurrent chemotherapy can improve the survival of cerebral gliomas with pathological grade Ⅲ.展开更多
The advent of Network Function Virtualization(NFV)and Service Function Chains(SFCs)unleashes the power of dynamic creation of network services using Virtual Network Functions(VNFs).This is of great interest to network...The advent of Network Function Virtualization(NFV)and Service Function Chains(SFCs)unleashes the power of dynamic creation of network services using Virtual Network Functions(VNFs).This is of great interest to network operators since poor service quality and resource wastage can potentially hurt their revenue in the long term.However,the study shows with a set of test-bed experiments that packet loss at certain positions(i.e.,different VNFs)in an SFC can cause various degrees of resource wastage and performance degradation because of repeated upstream processing and transmission of retransmitted packets.To overcome this challenge,this study focuses on resource scheduling and deployment of SFCs while considering packet loss positions.This study developed a novel SFC packet dropping cost model and formulated an SFC scheduling problem that aims to minimize overall packet dropping cost as a Mixed-Integer Linear Programming(MILP)and proved that it is NP-hard.In this study,Palos is proposed as an efficient scheme in exploiting the functional characteristics of VNFs and their positions in SFCs for scheduling resources and deployment to optimize packet dropping cost.Extensive experiment results show that Palos can achieve up to 42.73%improvement on packet dropping cost and up to 33.03%reduction on average SFC latency when compared with two other state-of-the-art schemes.展开更多
目的:探讨OCTA检查在视网膜静脉阻塞诊疗中的重要应用价值。方法:采用回顾性病例对照研究,选取2018-01/10于大连市第三人民医院眼科门诊确诊为视网膜静脉阻塞的患者38例38眼,其患病眼为A组,对侧健康眼为B组。所有患者均接受OCTA对黄斑...目的:探讨OCTA检查在视网膜静脉阻塞诊疗中的重要应用价值。方法:采用回顾性病例对照研究,选取2018-01/10于大连市第三人民医院眼科门诊确诊为视网膜静脉阻塞的患者38例38眼,其患病眼为A组,对侧健康眼为B组。所有患者均接受OCTA对黄斑区视网膜行3mm×3mm范围的模式扫描,获得表层视网膜、深层视网膜、外层视网膜及脉络膜毛细血管层4个层面黄斑血流密度图,测量表层视网膜中心凹无血管区面积(FAZ),Image J软件计算4个层面黄斑区血流密度(MVD),OCT模式测量黄斑中心凹的水平厚度与垂直厚度(CFT)。结果: A组和B组浅层视网膜FAZ、水平CFT及垂直CFT测量均有差异( P <0.01)。A组和B组表层视网膜及深层视网MVD均有差异( P <0.01),外层视网膜层MVD、脉络膜毛细血管层MVD结果无差异( P =0.542、0.489)。BCVA(LogMAR)分别与表层视网膜FAZ、水平CFT及垂直CFT呈正相关( r =0.482、0.652、0.621,均 P <0.01),与表层视网膜MVD及深层视网膜MVD呈负相关( r =-0.486 、-0.465,均 P <0.01)。结论:应用OCTA检查对提示视网膜静脉阻塞患者黄斑区视网膜的微循环障碍和视力预后有重要指导意义。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52271281)Shandong Provincial High-Level Talent Workstation,Shandong Province Natural Science Foundation Youth project(Grant No.ZR2023QE190)an Open funding project from the Key Laboratory of Ministry of Education for Coastal Disaster and Protection,Hohai University,China(Grant No.202206).
文摘This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus current cases are compared with the random wave-only case,the forward current promotes wave propagation,whereas the reversed backward current inhibits wave propagation.Furthermore,the wave pressure on the downstream pipeline decreases as the relative spacing ratio increases and increases as the diameter increases.However,alterations in the relative spacing ratio or dimensions of the downstream pipeline exert a negligible influence on the wave pressure of the upstream pipeline.Moreover,the relative spacing ratio between the pipelines and the dimensions of the pipelines considerably influence the pore pressure in the sand bed.When the relative spacing ratio remains constant,increasing the downstream pipeline diameter will increase the pore-water pressure of the soil below the downstream pipeline.
基金supported by the National Undergraduate Innovation and Entrepreneurship Training Program of China(Project No.202510559076)at Jinan University,a nationwide initiative administered by the Ministry of Educationthe National Natural Science Foundation of China(NSFC)under Grant No.62172189.
文摘Persistent flows are defined as network flows that persist over multiple time intervals and continue to exhibit activity over extended periods,which are critical for identifying long-term behaviors and subtle security threats.Programmable switches provide line-rate packet processing to meet the requirements of high-speed network environments,yet they are fundamentally limited in computational and memory resources.Accurate and memoryefficient persistent flow detection on programmable switches is therefore essential.However,existing approaches often rely on fixed-window sketches or multiple sketches instances,which either suffer from insufficient temporal precision or incur substantial memory overhead,making them ineffective on programmable switches.To address these challenges,we propose SP-Sketch,an innovative sliding-window-based sketch that leverages a probabilistic update mechanism to emulate slot expiration without maintaining multiple sketch instances.This innovative design significantly reduces memory consumption while preserving high detection accuracy across multiple time intervals.We provide rigorous theoretical analyses of the estimation errors,deriving precise error bounds for the proposed method,and validate our approach through comprehensive implementations on both P4 hardware switches(with Intel Tofino ASIC)and software switches(i.e.,BMv2).Experimental evaluations using real-world traffic traces demonstrate that SP-Sketch outperforms traditional methods,improving accuracy by up to 20%over baseline sliding window approaches and enhancing recall by 5%compared to non-sliding alternatives.Furthermore,SP-Sketch achieves a significant reduction in memory utilization,reducing memory consumption by up to 65%compared to traditional methods,while maintaining a robust capability to accurately track persistent flow behavior over extended time periods.
文摘Objective:The aim of the study was to investigate the efficacy of three-dimensional conformal radiotherapy (3D-CRT) combined with Temozolomide (TMZ) concurrent chemotherapy in treatment of postoperative cerebral gliomas by prospective randomized controlled trials. Methods: Sixty-two patients with cerebral glioma who had residual tumor were divided into 3D-CRT group (radiotherapy group, n=31) and 3D-CRT with concurrent chemotherapy group (chemoradiotherapy group, n=31) prospectively. All patients received a dose of 50-60 Gy/25-30 F/5-6 weeks by 6 MV-X ray, three-dimensional conformal radiotherapy, 1 f/d, 5 times a week. Chemotherapy regimen was Temozolomide:75 mg/m2/d, concomitantly with radiotherapy, followed by 150-200 mg/m2/d, 5 days, 28 days per cycle, totally 3-6 cycles. Results: The total response rate was 35.3% (11/31) in radiotherapy group. The response rate was 61.3% (19/31) in chemoradiotherapy group. There was significant difference in curative effect (P=0.042). There was no significant difference in survival comparison of two groups (P=0.263). Stratified analysis showed the patients with grade Ⅲ gliomas of chemoradiotherapy group had better prognosis than ones of radiotherapy group (P=0.043). Conclusion: The 3D-CRT with concurrent chemotherapy can improve the survival of cerebral gliomas with pathological grade Ⅲ.
基金supported by the National Natural Science Foundation of China(NSFC)No.62172189 and 61772235the Natural Science Foundation of Guangdong Province No.2020A1515010771+1 种基金the Science and Technology Program of Guangzhou No.202002030372the UK Engineering and Physical Sciences Research Council(EPSRC)grants EP/P004407/2 and EP/P004024/1,and Innovate UK grant 106199-47198.
文摘The advent of Network Function Virtualization(NFV)and Service Function Chains(SFCs)unleashes the power of dynamic creation of network services using Virtual Network Functions(VNFs).This is of great interest to network operators since poor service quality and resource wastage can potentially hurt their revenue in the long term.However,the study shows with a set of test-bed experiments that packet loss at certain positions(i.e.,different VNFs)in an SFC can cause various degrees of resource wastage and performance degradation because of repeated upstream processing and transmission of retransmitted packets.To overcome this challenge,this study focuses on resource scheduling and deployment of SFCs while considering packet loss positions.This study developed a novel SFC packet dropping cost model and formulated an SFC scheduling problem that aims to minimize overall packet dropping cost as a Mixed-Integer Linear Programming(MILP)and proved that it is NP-hard.In this study,Palos is proposed as an efficient scheme in exploiting the functional characteristics of VNFs and their positions in SFCs for scheduling resources and deployment to optimize packet dropping cost.Extensive experiment results show that Palos can achieve up to 42.73%improvement on packet dropping cost and up to 33.03%reduction on average SFC latency when compared with two other state-of-the-art schemes.
文摘目的:探讨OCTA检查在视网膜静脉阻塞诊疗中的重要应用价值。方法:采用回顾性病例对照研究,选取2018-01/10于大连市第三人民医院眼科门诊确诊为视网膜静脉阻塞的患者38例38眼,其患病眼为A组,对侧健康眼为B组。所有患者均接受OCTA对黄斑区视网膜行3mm×3mm范围的模式扫描,获得表层视网膜、深层视网膜、外层视网膜及脉络膜毛细血管层4个层面黄斑血流密度图,测量表层视网膜中心凹无血管区面积(FAZ),Image J软件计算4个层面黄斑区血流密度(MVD),OCT模式测量黄斑中心凹的水平厚度与垂直厚度(CFT)。结果: A组和B组浅层视网膜FAZ、水平CFT及垂直CFT测量均有差异( P <0.01)。A组和B组表层视网膜及深层视网MVD均有差异( P <0.01),外层视网膜层MVD、脉络膜毛细血管层MVD结果无差异( P =0.542、0.489)。BCVA(LogMAR)分别与表层视网膜FAZ、水平CFT及垂直CFT呈正相关( r =0.482、0.652、0.621,均 P <0.01),与表层视网膜MVD及深层视网膜MVD呈负相关( r =-0.486 、-0.465,均 P <0.01)。结论:应用OCTA检查对提示视网膜静脉阻塞患者黄斑区视网膜的微循环障碍和视力预后有重要指导意义。
