High-entropy materials(HEMs)show exceptional mechanical properties,highly adjustable chemical characteristics,and outstanding stability,making them suitable for energy storage.However,the broad compositional space and...High-entropy materials(HEMs)show exceptional mechanical properties,highly adjustable chemical characteristics,and outstanding stability,making them suitable for energy storage.However,the broad compositional space and intricate chemical interactions in HEMs present challenges to traditional trial-and-error research methods,restricting their efficacy in swift screening and synthesis.Hence,the application of machine learning(ML)to the realm of high-entropy materials and energy storage becomes imperative.ML demonstrates its formidable capabilities for navigating the complexity of HEMs,with their diverse metal components,structures and property combinations,to advance energy storage applications.This review comprises the following sections:a concise introduction to the general process of ML in the energy materials field,a summary of HEMs in the energy storage field,a review of the latest achievements of ML in the HEMs and energy storage field,and finally,an exploration of current challenges and prospects in this interdisciplinary arena.With the advent of ML,the precision of its predictions and the efficiency of its screening methods have offered novel perspectives for material research,expediting the discovery and application of new materials.This article contributes to the advancement of research in related fields,hastening the development of novel materials to meet the escalating energy demands and promote sustainable development goals.展开更多
This study presents a detailed photometric and spectroscopic analysis of the W UMa-type binary NR Cam,using data from the Transiting Exoplanet Survey Satellite(TESS)and ground-based observations.The light curves exhib...This study presents a detailed photometric and spectroscopic analysis of the W UMa-type binary NR Cam,using data from the Transiting Exoplanet Survey Satellite(TESS)and ground-based observations.The light curves exhibit significant variable,with a negative correlation between the brightness of the two maxima—a characteristic of W UMa-type binaries typically attributed to magnetic activity.To explain this behavior,we incorporated a starspot model into our Wilson–Devinney analysis.Our results confirm that NR Cam is a W-subtype,moderately contact binary with a low mass ratio of q=5.75(±0.03)and a fill-out factor of f=33.4(±3.1)%.We also analyzed the orbital period variation using all available times of minima.The resulting O−C diagram reveals a long-term decreasing trend in the orbital period at a rate of dP/dt=−5.18(±0.02)×10^(-8) day yr^(-1),superimposed with a periodic oscillation characterized by an amplitude of A_(3)=0.0019(±0.0001)day and an oscillation period of P_(3)=7.776(±0.003)yr.The long-term decrease is likely due to mass transfer between the binary components,with an estimated mass transfer rate of dM_(2)/dt=1.33(±0.01)×10^(-8)M_(⊙)yr^(-1).The periodic oscillations are likely driven by the light-travel time effect caused by a tertiary companion,with a minimum mass of M_(3)=0.0956(1)M_(⊙)and a maximum separation of 3.841(6)au.Additionally,we considered the possibility that the periodic variation could result from changes in the gravitational quadrupole moment due to magnetic activity cycles,as described by the Applegate mechanism.Our findings confirm that NR Cam is an active binary system,where magnetic activity plays a significant role in its orbital evolution.These results contribute to our understanding of the magnetic dynamics and evolutionary processes in contact binary systems.展开更多
Light detection and ranging(LiDAR)has contributed immensely to forest mapping and 3D tree modelling.From the perspective of data acquisition,the integration of LiDAR data from different platforms would enrich forest i...Light detection and ranging(LiDAR)has contributed immensely to forest mapping and 3D tree modelling.From the perspective of data acquisition,the integration of LiDAR data from different platforms would enrich forest information at the tree and plot levels.This research develops a general framework to integrate ground-based and UAV-LiDAR(ULS)data to better estimate tree parameters based on quantitative structure modelling(QSM).This is accomplished in three sequential steps.First,the ground-based/ULS LiDAR data were co-registered based on the local density peaks of the clustered canopy.Next,redundancy and noise were removed for the ground-based/ULS LiDAR data fusion.Finally,tree modeling and biophysical parameter retrieval were based on QSM.Experiments were performed for Backpack/Handheld/UAV-based multi-platform mobile LiDAR data of a subtropical forest,including poplar and dawn redwood species.Generally,ground-based/ULS LiDAR data fusion outperforms ground-based LiDAR with respect to tree parameter estimation compared to field data.The fusion-derived tree height,tree volume,and crown volume significantly improved by up to 9.01%,5.28%,and 18.61%,respectively,in terms of rRMSE.By contrast,the diameter at breast height(DBH)is the parameter that has the least benefits from fusion,and rRMSE remains approximately the same,because stems are already well sampled from ground data.Additionally,particularly for dense forests,the fusion-derived tree parameters were improved compared to those derived from ground-based LiDAR.Ground-based LiDAR can potentially be used to estimate tree parameters in low-stand-density forests,whereby the improvement owing to fusion is not significant.展开更多
Background:Head and neck squamous cancer(HNSC)frequently occurs in the clinic.Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and ...Background:Head and neck squamous cancer(HNSC)frequently occurs in the clinic.Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and tumor inhibition.Methods:The gene expression profiles and gene ontology of the proton-sensing G-protein-coupled receptor OGR1 were analyzed using the TCGA(The Cancer Genome Atlas)database.The effects of sex,age,race,and degree of malignancy on HNSC were investigated,and the survival times of HNSC patients with high or low/medium expression levels of OGR1 were compared.Methylation of the OGR1 promoter CpG sites was also investigated and OGR1-related genes were analyzed using gene set enrichment analysis.Results:OGR1 is overexpressed in HNSC patients.However,compared with the low/median expression group,the high OGR1 expression group did not have different survival rates.The OGR1 expression level differed across sex,age,race,and degree of malignancy,while the methylation of the OGR1 promoter CpG sites was maintained at a similar level.Gene set enrichment analysis revealed that OGR1 was positively correlated with head and neck cancer,cisplatin resistance,hypoxia,angiogenesis,cell migration,and TGF-β.Conclusion:The expression of OGR1 correlated with HNSC progression and survival and thus can serve as a potential treatment target and prognostic marker.展开更多
Objective To investigate the effect of insuline-like growth factor-Ⅰ （IGF-Ⅰ） on progesterone genesis and regulation. Methods Cytotrophoblast cells were collected by trypsin-collagenase digestion and percoll gradie...Objective To investigate the effect of insuline-like growth factor-Ⅰ （IGF-Ⅰ） on progesterone genesis and regulation. Methods Cytotrophoblast cells were collected by trypsin-collagenase digestion and percoll gradient centrifugation for primary culture. After stimulated with different concentrations（100 μg/ml, 10 μg/ml, 1 μg/ml, 0.1 μg/ml） of IGF-Ⅰ at the same time and with different duration（12 h,24 h,48 h, 72 h） of IGF-Ⅰ with the same concentration, progesterone levels in the media were measured by radioimmunoassay. Simultaneously, semiquantitative reverse transcriptase polymerase chain reaction （RT-PCR） was applied to determine the expression of low density lipoprotein receptor （LDLR） mRNA. Results Progesterone levels correlated positively with IGF-Ⅰ along with the IGF-Ⅰ concentration increasing, progesterone level began to increase at 12 h, and reached the climax at 48 h when cultured with 100 μg/L IGF-Ⅰ. The expression of LDLR mRNA was detectable in every group and accordant with variation of progesterone level. Conclusion Progesterone secretion has time- and dose-dependent effect on IGF-Ⅰ, and IGF-1 can up-regulate the expression of LDLR mRNA. IGF-Ⅰ may play an important role in promoting secretion of progesterone in trophoblast cells.展开更多
Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,whi...Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported before.Methods:The tumor,spleen,and thymus were weighed at the end of the experiment.Whole blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of NK cells was detected by LDH assay,and the proliferation index of lymphocytes was determined by CCK-8 assay.The overall and mean survival time and life extension rate were calculated using SPSS software.Results:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of mice.The underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and immunosuppression.Specifically,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of NK cells in mice treated with PTX.Conclusion:GLSO may enhance the efficacy of PTX by boosting the activity of immune NK cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving hematopoiesis.These findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.展开更多
Aim: To further evaluate the antifertility effects of tripchorolide, a derivative of triptolide produced at the extraction pro-cedure of Tripterygium wilfordii Hook. f., in male rats and to investigate its sites and p...Aim: To further evaluate the antifertility effects of tripchorolide, a derivative of triptolide produced at the extraction pro-cedure of Tripterygium wilfordii Hook. f., in male rats and to investigate its sites and possible mechanisms of action.Methods: In male rats, tripchlorolide was given by oral garage at a dose of 50 ug.kg～(-l).d～(-1) for 5 weeks, fertility wasassessed by mating tests, and biochemical indices and light microscopic observation of the epididymides and testes werealso performed. Results: Administration of tripchlorolide at 50 ugg.kg～(-l)-d～(-1) for 3 weeks did not influence the fertilityof male rats, but 5-week treatment rendered the rats infertile. The density and motility of spermatozoa collected fromcauda epididymides were reduced significantly. The epididymal weights, as well as the L-carnitine concentration and α-glucosidase content in the epididymal fluid were decreasd. There were no significant differences in α-glucosidase andacid phosphatase (ACP) in caput epididymal homogenates between the control and the experimental rats. Obvious mor-phological changes were observed in the epididymal spermatozoa, mainly including head and tail separation or acrosomecurving. Sloughed spermatids were found in the seminifeous and epididymal tubules. In tesficular homogenates,tripchlorolide had no influence on the lactate dehydrogenase-C_4 (LDH-C_4) and hyaluronidase activities. No apparentlesions were observed in the seminiferous and epididymal epithelium. Conclusion: At the dose level employed,tripchlorolide has a significant effect on the fertility in male rats and the primary sites of action may be spermatids and tes-ticular and epididymal spermatozoa. (Asian J Androl 1999 Sep ; 1: 121 - 125)展开更多
The diameter at breast height(DBH) of trees and stands is not only a widely used plant functional trait in ecology and biodiversity but also one of the most fundamental measurements in managing forests. However, syste...The diameter at breast height(DBH) of trees and stands is not only a widely used plant functional trait in ecology and biodiversity but also one of the most fundamental measurements in managing forests. However, systematically measuring the DBH of individual trees over large areas using conventional ground-based approaches is labour-intensive and costly. Here, we present an improved area-based approach to estimate plot-level tree DBH from airborne Li DAR data using the relationship between tree height and DBH, which is widely available for most forest types and many individual tree species. We first determined optimal functional forms for modelling heightDBH relationships using field-measured tree height and DBH. Then we estimated plot-level mean DBH by inverting the height-DBH relationships using the tree height predicted by Li DAR. Finally, we compared the predictive performance of our approach with a classical area-based method of DBH. The results showed that our approach significantly improved the prediction accuracy of tree DBH(R^(2)=0.85–0.90, rRMSE=9.57%–11.26%)compared to the classical area-based approach(R^(2)=0.80–0.83, rRMSE=11.98%–14.97%). Our study demonstrates the potential of using height-DBH relationships to improve the estimation of the plot-level DBH from airborne Li DAR data.展开更多
In order to solve the friction,wear and lubrication problems of titanium,a series of TaN/ployether−ether−ketone(PEEK)coatings were developed by electrophoretic deposition,and the effects of TaN nanoparticles on the mi...In order to solve the friction,wear and lubrication problems of titanium,a series of TaN/ployether−ether−ketone(PEEK)coatings were developed by electrophoretic deposition,and the effects of TaN nanoparticles on the microstructure,mechanical properties and tribological performance of coatings were explored.Results manifest that the introduction of TaN nanoparticles into PEEK coatings could improve the deposition efficiency,enhance the resistant deform capacity,increase the hardness,elastic modulus and adhesive bonding strength.Compared with the pure PEEK coating,the friction coefficient of P-TN-3 was greatly reduced by 31.25%.The wear resistance of P-TN-3 was also improved in huge boost,and its specific wear rate was decreased from 9.42×10^(−5) to 1.62×10^(−5) mm^(3)·N^(−1)·m^(−1).The homogeneous composite TaN/PEEK coatings prepared by electrophoretic deposition were well-adhered to the titanium alloy substrate,TaN nanoparticles could improve the strength of PEEK coating,and provide wear-resistance protection for titanium alloys.展开更多
A theoretical framework of nonlinear flight control for a flexible air-breathing hypersonic vehicle(FAHV)is proposed in this paper.In order to suppress the system uncertainty and external disturbance,an uncertainty an...A theoretical framework of nonlinear flight control for a flexible air-breathing hypersonic vehicle(FAHV)is proposed in this paper.In order to suppress the system uncertainty and external disturbance,an uncertainty and disturbance estimator(UDE)based back-stepping control strategy is designed for a dynamic state-feedback controller to provide stable velocity and altitude tracking.Firstly,the longitudinal dynamics of FAHV is simplified into a closure loop form with lumped uncertainty and disturbance.Then the UDE is applied to estimate the lumped uncertainty and disturbance for the purpose of control input compensation.While a nonlinear tracking differentiator is introduced to solve the problem of“explosion of term”in the back-stepping control.The stability of the UDE-based control strategy is proved by using Lyapunov stability theorem.Finally,simulation results are presented to demonstrate the capacity of the proposed control strategy.展开更多
After preparing the EU^3＋-doped scheelite nano-material by Pechini method with the nanoparticles of 30-50 nm in diameter, X-ray diffraction （XRD）, transmission electron microscopy （TEM） and high resolution transm...After preparing the EU^3＋-doped scheelite nano-material by Pechini method with the nanoparticles of 30-50 nm in diameter, X-ray diffraction （XRD）, transmission electron microscopy （TEM） and high resolution transmission electron microscopy （HRTEM） were used to show a microcosmic description of the particle morphology and crystal structure. The spectrum signature of the nano-scheelite, which was taken by fluorescence spectrometer, was used to discuss the difference of luminescent performance between the nano-scheelite and bulk scheelite. The atomic site of the nano-scheelite was intuitively shown through HRTEM images and HRTEM simulated images from the relation between luminescent properties and crystal structure, which was analyzed by spectrum probe. The results of antitumor activity examined by the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） method show that the inhibition of human promyelocytic leukemia cell line （HL60） is enhanced immediately with increasing the concentration and presents a reliance on the quantity. The results of fluorescence spectra and structure show that the antitumor activity has something to do with micro-structure and surface charge.展开更多
To achieve advanced nitrogen removal from actual municipal sewage,a novel multistage anoxic/aerobic process with sludge regeneration zone(R-MAO)was developed.The reactor was used to treat actual domestic sewage and th...To achieve advanced nitrogen removal from actual municipal sewage,a novel multistage anoxic/aerobic process with sludge regeneration zone(R-MAO)was developed.The reactor was used to treat actual domestic sewage and the nitrogen removal capacity of the sludge regeneration zone(R zone)was investigated during the long-term operation.The best performance was obtained at the R zone’s Oxidation-Reduction Potential(ORP)of-50±30 mV and hydraulic residence times(HRT)of 1.2 hr.The average effluent COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N of the R-MAO process were 18.0±2.3,7.5±0.6,1.0±0.5 and 4.6±0.4 mg/L,respectively,with the corresponding removal efficiency of COD,TN and NH_(4)^(+)-N were 92.9%±1.0%,84.1%±1.5% and 97.5%±1.1%.Compared to the sole MAO system,the TN removal efficiency of the R-MAO increased by 10.1%.Besides,under the optimal conditions,the contribution of the R zone in the R-MAO that removal COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N were 0.36,0.15,0.032 and 0.82 g/day.High-throughput sequencing results showed that uncultured_bacterium_f_Burkholderiaceae(5.20%),OLB8(1.04%)and Ottowia(1.03%)played an important role in denitrification in the R zone.This study provided effective guidance for the design and operation of the R-MAO process in domestic sewage treatment.展开更多
Background:Myelodysplastic syndrome(MDS)is a group of disorders involving he-mopoietic dysfunction leading to leukemia.Although recently progress has been made in identifying underlying genetic mutations,many question...Background:Myelodysplastic syndrome(MDS)is a group of disorders involving he-mopoietic dysfunction leading to leukemia.Although recently progress has been made in identifying underlying genetic mutations,many questions still remain.Animal models of MDS have been produced by introduction of specific mutations.However,there is no spontaneous mouse model of MDS,and an animal model to simulate natu-ral MDS pathogenesis is urgently needed.Methods:In characterizing the genetically diverse mouse strains of the Collaborative Cross(CC)we observed that one,designated JUN,had abnormal hematological traits.This strain was thus further analyzed for phenotypic and pathological iden-tification,comparing the changes in each cell population in peripheral blood and in bone marrow.Results:In a specific-pathogen free environment,mice of the JUN strain are rela-tively thin,with healthy appearance.However,in a conventional environment,they become lethargic,develop wrinkled yellow hair,have loose and light stools,and are prone to infections.We found that the mice were cytopenic,which was due to abnor-mal differentiation of multipotent bone marrow progenitor cells.These are common characteristics of MDS.Conclusions:A mouse strain,JUN,was found displaying spontaneous myelodysplas-tic syndrome.This strain has the advantage over existing models in that it develops MDS spontaneously and is more similar to human MDS than genetically modified mouse models.JUN mice will be an important tool for pathogenesis research of MDS and for evaluation of new drugs and treatments.展开更多
Background: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently...Background: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed.Method: We established a new mouse model in which the specific gene HNRNPK(heterogeneous nuclear ribonucleoprotein K) was downregulated after administration of doxycycline. The lung metastatic nodules were investigated using bioluminescence imaging, micro-CT, and autopsy quantification.Results: Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group.Conclusion: Downregulation of HNRNPK in cancer cells can inhibit lung metastasis.展开更多
The average size of the sand of dune in the vicinity of Tumen River is 0.12～0.30 mm, its standard deviation is 0.45～0.99 φ and the frequency cumulative distribution curve is divided into the single peak and the dou...The average size of the sand of dune in the vicinity of Tumen River is 0.12～0.30 mm, its standard deviation is 0.45～0.99 φ and the frequency cumulative distribution curve is divided into the single peak and the double peak. The Ski of the single peak is negative and the double peak is positive. There are two different areas in the plot of the Ski versus σi* It is shown that the sedimentary environment of the dunes is neritic deposit by the expressions of the grain-size parameters. All of the characters show that the sand dunes in Estuary of Tumen River may be the dunes of sea facies which were changed again by weathering and fluvialaction.展开更多
基金supported by the National Natural Science Foundation of China(22005072,21965006)Guiyang Guian science and Technology Personnel Training Project(2024-2-13)+1 种基金Guizhou Provincial Key Technology R&D Program(Qian Ke He support(2023)General 122)Guizhou Provincial Science and Technology Foundation(ZD2025049,KXJZ2024029).
文摘High-entropy materials(HEMs)show exceptional mechanical properties,highly adjustable chemical characteristics,and outstanding stability,making them suitable for energy storage.However,the broad compositional space and intricate chemical interactions in HEMs present challenges to traditional trial-and-error research methods,restricting their efficacy in swift screening and synthesis.Hence,the application of machine learning(ML)to the realm of high-entropy materials and energy storage becomes imperative.ML demonstrates its formidable capabilities for navigating the complexity of HEMs,with their diverse metal components,structures and property combinations,to advance energy storage applications.This review comprises the following sections:a concise introduction to the general process of ML in the energy materials field,a summary of HEMs in the energy storage field,a review of the latest achievements of ML in the HEMs and energy storage field,and finally,an exploration of current challenges and prospects in this interdisciplinary arena.With the advent of ML,the precision of its predictions and the efficiency of its screening methods have offered novel perspectives for material research,expediting the discovery and application of new materials.This article contributes to the advancement of research in related fields,hastening the development of novel materials to meet the escalating energy demands and promote sustainable development goals.
基金supported by the College Students’ Innovation and Entrepreneurship Training Program (grant Nos.202410649025 and S202410649206)the Sichuan Science and Technology Program (grant No.2025Z NSFSC0315)+1 种基金the Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan at Leshan Normal University,Education Department of Sichuan Province (grant No.ZDXM202401002)supported by National Astronomical Observatories,Chinese Academy of Sciences
文摘This study presents a detailed photometric and spectroscopic analysis of the W UMa-type binary NR Cam,using data from the Transiting Exoplanet Survey Satellite(TESS)and ground-based observations.The light curves exhibit significant variable,with a negative correlation between the brightness of the two maxima—a characteristic of W UMa-type binaries typically attributed to magnetic activity.To explain this behavior,we incorporated a starspot model into our Wilson–Devinney analysis.Our results confirm that NR Cam is a W-subtype,moderately contact binary with a low mass ratio of q=5.75(±0.03)and a fill-out factor of f=33.4(±3.1)%.We also analyzed the orbital period variation using all available times of minima.The resulting O−C diagram reveals a long-term decreasing trend in the orbital period at a rate of dP/dt=−5.18(±0.02)×10^(-8) day yr^(-1),superimposed with a periodic oscillation characterized by an amplitude of A_(3)=0.0019(±0.0001)day and an oscillation period of P_(3)=7.776(±0.003)yr.The long-term decrease is likely due to mass transfer between the binary components,with an estimated mass transfer rate of dM_(2)/dt=1.33(±0.01)×10^(-8)M_(⊙)yr^(-1).The periodic oscillations are likely driven by the light-travel time effect caused by a tertiary companion,with a minimum mass of M_(3)=0.0956(1)M_(⊙)and a maximum separation of 3.841(6)au.Additionally,we considered the possibility that the periodic variation could result from changes in the gravitational quadrupole moment due to magnetic activity cycles,as described by the Applegate mechanism.Our findings confirm that NR Cam is an active binary system,where magnetic activity plays a significant role in its orbital evolution.These results contribute to our understanding of the magnetic dynamics and evolutionary processes in contact binary systems.
基金supported by the National Natural Science Foundation of China(Project No.42171361)the Research Grants Council of the Hong Kong Special Administrative Region,China,under Project PolyU 25211819the Hong Kong Polytechnic University under Projects 1-ZE8E and 1-ZVN6.
文摘Light detection and ranging(LiDAR)has contributed immensely to forest mapping and 3D tree modelling.From the perspective of data acquisition,the integration of LiDAR data from different platforms would enrich forest information at the tree and plot levels.This research develops a general framework to integrate ground-based and UAV-LiDAR(ULS)data to better estimate tree parameters based on quantitative structure modelling(QSM).This is accomplished in three sequential steps.First,the ground-based/ULS LiDAR data were co-registered based on the local density peaks of the clustered canopy.Next,redundancy and noise were removed for the ground-based/ULS LiDAR data fusion.Finally,tree modeling and biophysical parameter retrieval were based on QSM.Experiments were performed for Backpack/Handheld/UAV-based multi-platform mobile LiDAR data of a subtropical forest,including poplar and dawn redwood species.Generally,ground-based/ULS LiDAR data fusion outperforms ground-based LiDAR with respect to tree parameter estimation compared to field data.The fusion-derived tree height,tree volume,and crown volume significantly improved by up to 9.01%,5.28%,and 18.61%,respectively,in terms of rRMSE.By contrast,the diameter at breast height(DBH)is the parameter that has the least benefits from fusion,and rRMSE remains approximately the same,because stems are already well sampled from ground data.Additionally,particularly for dense forests,the fusion-derived tree parameters were improved compared to those derived from ground-based LiDAR.Ground-based LiDAR can potentially be used to estimate tree parameters in low-stand-density forests,whereby the improvement owing to fusion is not significant.
基金This work was supported by grants from the National Natural Science Foundation of China(no.81372253)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2016-I2M-3-019).
文摘Background:Head and neck squamous cancer(HNSC)frequently occurs in the clinic.Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and tumor inhibition.Methods:The gene expression profiles and gene ontology of the proton-sensing G-protein-coupled receptor OGR1 were analyzed using the TCGA(The Cancer Genome Atlas)database.The effects of sex,age,race,and degree of malignancy on HNSC were investigated,and the survival times of HNSC patients with high or low/medium expression levels of OGR1 were compared.Methylation of the OGR1 promoter CpG sites was also investigated and OGR1-related genes were analyzed using gene set enrichment analysis.Results:OGR1 is overexpressed in HNSC patients.However,compared with the low/median expression group,the high OGR1 expression group did not have different survival rates.The OGR1 expression level differed across sex,age,race,and degree of malignancy,while the methylation of the OGR1 promoter CpG sites was maintained at a similar level.Gene set enrichment analysis revealed that OGR1 was positively correlated with head and neck cancer,cisplatin resistance,hypoxia,angiogenesis,cell migration,and TGF-β.Conclusion:The expression of OGR1 correlated with HNSC progression and survival and thus can serve as a potential treatment target and prognostic marker.
基金This study was supported by the Foundation of Scientific and Technological Development of Shanghai (02DZ19115) and Chinese Post-doctor Fund
文摘Objective To investigate the effect of insuline-like growth factor-Ⅰ （IGF-Ⅰ） on progesterone genesis and regulation. Methods Cytotrophoblast cells were collected by trypsin-collagenase digestion and percoll gradient centrifugation for primary culture. After stimulated with different concentrations（100 μg/ml, 10 μg/ml, 1 μg/ml, 0.1 μg/ml） of IGF-Ⅰ at the same time and with different duration（12 h,24 h,48 h, 72 h） of IGF-Ⅰ with the same concentration, progesterone levels in the media were measured by radioimmunoassay. Simultaneously, semiquantitative reverse transcriptase polymerase chain reaction （RT-PCR） was applied to determine the expression of low density lipoprotein receptor （LDLR） mRNA. Results Progesterone levels correlated positively with IGF-Ⅰ along with the IGF-Ⅰ concentration increasing, progesterone level began to increase at 12 h, and reached the climax at 48 h when cultured with 100 μg/L IGF-Ⅰ. The expression of LDLR mRNA was detectable in every group and accordant with variation of progesterone level. Conclusion Progesterone secretion has time- and dose-dependent effect on IGF-Ⅰ, and IGF-1 can up-regulate the expression of LDLR mRNA. IGF-Ⅰ may play an important role in promoting secretion of progesterone in trophoblast cells.
基金Authors of this research are in deep gratitude toward Professor Qin Wang from the Nanchang Research Institute,Sun Yat-sen University for her dedicated guidance and support to this work.This work was supported by the National Key R&D Program of China(2022YFC3500302)the Ministry of Science and Technology of China(No.2017YFC1703104)+1 种基金the Key Laboratory Project of Pharmaceutical Lipids in Guangdong Province(No.2020B1212070024)the Guangdong Province Key Areas R&D Program Project(No.2020B1111120002).
文摘Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported before.Methods:The tumor,spleen,and thymus were weighed at the end of the experiment.Whole blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of NK cells was detected by LDH assay,and the proliferation index of lymphocytes was determined by CCK-8 assay.The overall and mean survival time and life extension rate were calculated using SPSS software.Results:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of mice.The underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and immunosuppression.Specifically,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of NK cells in mice treated with PTX.Conclusion:GLSO may enhance the efficacy of PTX by boosting the activity of immune NK cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving hematopoiesis.These findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.
文摘Aim: To further evaluate the antifertility effects of tripchorolide, a derivative of triptolide produced at the extraction pro-cedure of Tripterygium wilfordii Hook. f., in male rats and to investigate its sites and possible mechanisms of action.Methods: In male rats, tripchlorolide was given by oral garage at a dose of 50 ug.kg～(-l).d～(-1) for 5 weeks, fertility wasassessed by mating tests, and biochemical indices and light microscopic observation of the epididymides and testes werealso performed. Results: Administration of tripchlorolide at 50 ugg.kg～(-l)-d～(-1) for 3 weeks did not influence the fertilityof male rats, but 5-week treatment rendered the rats infertile. The density and motility of spermatozoa collected fromcauda epididymides were reduced significantly. The epididymal weights, as well as the L-carnitine concentration and α-glucosidase content in the epididymal fluid were decreasd. There were no significant differences in α-glucosidase andacid phosphatase (ACP) in caput epididymal homogenates between the control and the experimental rats. Obvious mor-phological changes were observed in the epididymal spermatozoa, mainly including head and tail separation or acrosomecurving. Sloughed spermatids were found in the seminifeous and epididymal tubules. In tesficular homogenates,tripchlorolide had no influence on the lactate dehydrogenase-C_4 (LDH-C_4) and hyaluronidase activities. No apparentlesions were observed in the seminiferous and epididymal epithelium. Conclusion: At the dose level employed,tripchlorolide has a significant effect on the fertility in male rats and the primary sites of action may be spermatids and tes-ticular and epididymal spermatozoa. (Asian J Androl 1999 Sep ; 1: 121 - 125)
基金funded by the National Key Research and Development Program(No.2017YFD0600904)the National Natural Science Foundation of China(No.31922055)+3 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX21_0913)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)funded by the China Scholarship Council(Grant No.202108320285)partially supported by the Horizon 2020 Research and Innovation Programme—European Commission‘BIOSPACE Monitoring Biodiversity from Space’project(Grant Agreement ID 834709,H2020-EU.1.1)。
文摘The diameter at breast height(DBH) of trees and stands is not only a widely used plant functional trait in ecology and biodiversity but also one of the most fundamental measurements in managing forests. However, systematically measuring the DBH of individual trees over large areas using conventional ground-based approaches is labour-intensive and costly. Here, we present an improved area-based approach to estimate plot-level tree DBH from airborne Li DAR data using the relationship between tree height and DBH, which is widely available for most forest types and many individual tree species. We first determined optimal functional forms for modelling heightDBH relationships using field-measured tree height and DBH. Then we estimated plot-level mean DBH by inverting the height-DBH relationships using the tree height predicted by Li DAR. Finally, we compared the predictive performance of our approach with a classical area-based method of DBH. The results showed that our approach significantly improved the prediction accuracy of tree DBH(R^(2)=0.85–0.90, rRMSE=9.57%–11.26%)compared to the classical area-based approach(R^(2)=0.80–0.83, rRMSE=11.98%–14.97%). Our study demonstrates the potential of using height-DBH relationships to improve the estimation of the plot-level DBH from airborne Li DAR data.
基金supported by the National Key Research and Development Program of China (No. 2018YFB2002000)the Guangdong Basic and Applied Basic Research Foundation,China (Nos. 2021A515012271, 2019A1515011220, 2020B1515120027)
文摘In order to solve the friction,wear and lubrication problems of titanium,a series of TaN/ployether−ether−ketone(PEEK)coatings were developed by electrophoretic deposition,and the effects of TaN nanoparticles on the microstructure,mechanical properties and tribological performance of coatings were explored.Results manifest that the introduction of TaN nanoparticles into PEEK coatings could improve the deposition efficiency,enhance the resistant deform capacity,increase the hardness,elastic modulus and adhesive bonding strength.Compared with the pure PEEK coating,the friction coefficient of P-TN-3 was greatly reduced by 31.25%.The wear resistance of P-TN-3 was also improved in huge boost,and its specific wear rate was decreased from 9.42×10^(−5) to 1.62×10^(−5) mm^(3)·N^(−1)·m^(−1).The homogeneous composite TaN/PEEK coatings prepared by electrophoretic deposition were well-adhered to the titanium alloy substrate,TaN nanoparticles could improve the strength of PEEK coating,and provide wear-resistance protection for titanium alloys.
基金Supported by National Natural Science Foundation of China(11672235)。
文摘A theoretical framework of nonlinear flight control for a flexible air-breathing hypersonic vehicle(FAHV)is proposed in this paper.In order to suppress the system uncertainty and external disturbance,an uncertainty and disturbance estimator(UDE)based back-stepping control strategy is designed for a dynamic state-feedback controller to provide stable velocity and altitude tracking.Firstly,the longitudinal dynamics of FAHV is simplified into a closure loop form with lumped uncertainty and disturbance.Then the UDE is applied to estimate the lumped uncertainty and disturbance for the purpose of control input compensation.While a nonlinear tracking differentiator is introduced to solve the problem of“explosion of term”in the back-stepping control.The stability of the UDE-based control strategy is proved by using Lyapunov stability theorem.Finally,simulation results are presented to demonstrate the capacity of the proposed control strategy.
基金supported by the National Natural Science Foundation of China(No.40072013)
文摘After preparing the EU^3＋-doped scheelite nano-material by Pechini method with the nanoparticles of 30-50 nm in diameter, X-ray diffraction （XRD）, transmission electron microscopy （TEM） and high resolution transmission electron microscopy （HRTEM） were used to show a microcosmic description of the particle morphology and crystal structure. The spectrum signature of the nano-scheelite, which was taken by fluorescence spectrometer, was used to discuss the difference of luminescent performance between the nano-scheelite and bulk scheelite. The atomic site of the nano-scheelite was intuitively shown through HRTEM images and HRTEM simulated images from the relation between luminescent properties and crystal structure, which was analyzed by spectrum probe. The results of antitumor activity examined by the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） method show that the inhibition of human promyelocytic leukemia cell line （HL60） is enhanced immediately with increasing the concentration and presents a reliance on the quantity. The results of fluorescence spectra and structure show that the antitumor activity has something to do with micro-structure and surface charge.
基金supported by a project of Shenzhen Science and Technology Plan (No. KCXFZ202002011006362)Project of Central and Southern China Municipal Engineering Design & Research Institute Co.,Ltd. (Technology Development 2019)
文摘To achieve advanced nitrogen removal from actual municipal sewage,a novel multistage anoxic/aerobic process with sludge regeneration zone(R-MAO)was developed.The reactor was used to treat actual domestic sewage and the nitrogen removal capacity of the sludge regeneration zone(R zone)was investigated during the long-term operation.The best performance was obtained at the R zone’s Oxidation-Reduction Potential(ORP)of-50±30 mV and hydraulic residence times(HRT)of 1.2 hr.The average effluent COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N of the R-MAO process were 18.0±2.3,7.5±0.6,1.0±0.5 and 4.6±0.4 mg/L,respectively,with the corresponding removal efficiency of COD,TN and NH_(4)^(+)-N were 92.9%±1.0%,84.1%±1.5% and 97.5%±1.1%.Compared to the sole MAO system,the TN removal efficiency of the R-MAO increased by 10.1%.Besides,under the optimal conditions,the contribution of the R zone in the R-MAO that removal COD,TN,NH_(4)^(+)-N and NO_(3)^(−)-N were 0.36,0.15,0.032 and 0.82 g/day.High-throughput sequencing results showed that uncultured_bacterium_f_Burkholderiaceae(5.20%),OLB8(1.04%)and Ottowia(1.03%)played an important role in denitrification in the R zone.This study provided effective guidance for the design and operation of the R-MAO process in domestic sewage treatment.
基金National Science and Technology Major Project,Grant/Award Number:2017ZX10304402Peking Union Medical College,Grant/Award Number:3332020050。
文摘Background:Myelodysplastic syndrome(MDS)is a group of disorders involving he-mopoietic dysfunction leading to leukemia.Although recently progress has been made in identifying underlying genetic mutations,many questions still remain.Animal models of MDS have been produced by introduction of specific mutations.However,there is no spontaneous mouse model of MDS,and an animal model to simulate natu-ral MDS pathogenesis is urgently needed.Methods:In characterizing the genetically diverse mouse strains of the Collaborative Cross(CC)we observed that one,designated JUN,had abnormal hematological traits.This strain was thus further analyzed for phenotypic and pathological iden-tification,comparing the changes in each cell population in peripheral blood and in bone marrow.Results:In a specific-pathogen free environment,mice of the JUN strain are rela-tively thin,with healthy appearance.However,in a conventional environment,they become lethargic,develop wrinkled yellow hair,have loose and light stools,and are prone to infections.We found that the mice were cytopenic,which was due to abnor-mal differentiation of multipotent bone marrow progenitor cells.These are common characteristics of MDS.Conclusions:A mouse strain,JUN,was found displaying spontaneous myelodysplas-tic syndrome.This strain has the advantage over existing models in that it develops MDS spontaneously and is more similar to human MDS than genetically modified mouse models.JUN mice will be an important tool for pathogenesis research of MDS and for evaluation of new drugs and treatments.
基金National Natural Science Foundation of China,Grant/Award Number:81602460
文摘Background: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed.Method: We established a new mouse model in which the specific gene HNRNPK(heterogeneous nuclear ribonucleoprotein K) was downregulated after administration of doxycycline. The lung metastatic nodules were investigated using bioluminescence imaging, micro-CT, and autopsy quantification.Results: Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group.Conclusion: Downregulation of HNRNPK in cancer cells can inhibit lung metastasis.
文摘The average size of the sand of dune in the vicinity of Tumen River is 0.12～0.30 mm, its standard deviation is 0.45～0.99 φ and the frequency cumulative distribution curve is divided into the single peak and the double peak. The Ski of the single peak is negative and the double peak is positive. There are two different areas in the plot of the Ski versus σi* It is shown that the sedimentary environment of the dunes is neritic deposit by the expressions of the grain-size parameters. All of the characters show that the sand dunes in Estuary of Tumen River may be the dunes of sea facies which were changed again by weathering and fluvialaction.
