This study systematically addresses the limitations of traditional pest detection methods and proposes an optimized version of the YOLOv8 object detection model.By integrating the GhostConv convolution module and the ...This study systematically addresses the limitations of traditional pest detection methods and proposes an optimized version of the YOLOv8 object detection model.By integrating the GhostConv convolution module and the C3Ghost module,the Polarized Self-Attention(PSA)mechanism is incorporated to enhance the model’s capacity for extracting pest features.Experimental results demonstrate that the improved YOLOv8+Ghost+PSA model achieves outstanding performance in critical metrics such as precision,recall,and mean Average Precision(mAP),with a computational cost of only 5.3 GFLOPs,making it highly suitable for deployment in resource-constrained agricultural environments.展开更多
Chicoric acid(CA),a natural phenolic acid,has been used as a nutraceutical food ingredient due to its powerful antioxidant,anti-HIV and anti-diabetic bioactivities.CA could be partly metabolized into caffeic acid(CFA)...Chicoric acid(CA),a natural phenolic acid,has been used as a nutraceutical food ingredient due to its powerful antioxidant,anti-HIV and anti-diabetic bioactivities.CA could be partly metabolized into caffeic acid(CFA)and caftaric acid(CTA)on cytochrome P450s in rat liver microsomes.To compare the protective effects of CA and its metabolites on biomolecules and inflammatory responses,oxidative damage induced by free radicals in vitro and microglial inflammation triggered by lipopolysaccharide in BV2 cells were constructed.Results showed that CA,CTA and CFA all significantly inhibited protein degradation and carbonylation induced by hydroxyl radicals and alcoxyl radicals,and suppressed hemin/nitrite/H2O2 triggered-nitration.Moreover,CA,CTA and CFA all exerted remarkable inhibition capacities on linoleic acid and soybean lecithin liposomes peroxidation in a dose-dependent manner,and restrained the oxidation of herring sperm DNA,as well as the breakage of pBR322 plasmid DNA.Furthermore,CA and its metabolites suppressed lipopolysaccharide-induced decline of BV2 cell viability and the production of NO and ROS.However,bioactivities of CA were significantly stronger than those of its metabolites within a certain concentration range.This study provides scientific basis for the application of CA and its metabolites as nutrition and natural antioxidants.展开更多
The oxidized bamboo pulp fiber yarns were prepared by the HNO3?/H3PO4-NaNO2 oxidation system. The effects of the oxidation concentration and reaction time on the weight loss, the carboxyl content and the breaking stre...The oxidized bamboo pulp fiber yarns were prepared by the HNO3?/H3PO4-NaNO2 oxidation system. The effects of the oxidation concentration and reaction time on the weight loss, the carboxyl content and the breaking strength of the bamboo pulp fiber yarns were studied and the aggregation structure was investigated by Fourier transform infrared, X-ray and scanning electron microscopy. The results revealed an increase in carboxyl content and a decrease in breaking strength of oxidized bamboo pulp fiber yarns with increasing concentration of oxidant and reaction time. The breaking strength of oxidized bamboo fiber yarns was damaged seriously once the reaction time was more than 120 min or the concentration of oxidant was greater than 1.0%. The crystallinity of bamboo pulp fibers increased slightly under low oxidation degree but decreased with higher oxidation degree.展开更多
Sc-doped Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)(SFMSc)was successfully synthesized by partially substituting Mo in Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)(SFM)with Sc,resulting in a higher proton diffusion rate in the resultant SFMSc ...Sc-doped Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)(SFMSc)was successfully synthesized by partially substituting Mo in Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)(SFM)with Sc,resulting in a higher proton diffusion rate in the resultant SFMSc sample.Theoretical calculations showed that doping Sc into SFM lowered the oxygen vacancy formation energy,reduced the energy barrier for proton migration in the oxide,and increased the catalytic activity for oxygen reduction reaction.Next,a proton-conducting solid oxide fuel cell(H-SOFC)with a single-phase SFMSc cathode demonstrated significantly higher cell performance than that of cell based on an Sc-free SFM cathode,achieving 1258 mW cm^(−2)at 700℃.The performance also outperformed that of many other H-SOFCs based on single-phase cobalt-free cathodes.Furthermore,no trade-off between fuel cell performance and material stability was observed.The SFMSc material demonstrated good stability in both the CO_(2)-containing atmosphere and the fuel cell application.The combination of high performance and outstanding stability suggests that SFMSc is an excellent cathode material for H-SOFCs.展开更多
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be improved....Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be improved.This phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with RR-ENKTL.Expected objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 months.No dose-limiting events were observed,RP2D of chidamide was 30 mg twice a week.Twenty-nine patients were enrolled in phase 2.In the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,respectively.The most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)patients.Exploratory biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic role.STAT3 mutation shows an unfavorable prognosis.Although outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first time.It is a promising therapeutic option for this population.展开更多
Biofunctionalization of artificial nerve implants by incorporation of specific bioactive factors has greatly enhanced the success of grafting procedures for peripheral nerve regeneration.However,most studies on novel ...Biofunctionalization of artificial nerve implants by incorporation of specific bioactive factors has greatly enhanced the success of grafting procedures for peripheral nerve regeneration.However,most studies on novel biofunctionalized implants have emphasized the promotion of neuronal and axonal repair over vascularization,a process critical for long-term functional restoration.We constructed a dual-biofunctionalized chitosan/collagen composite scaffold with Ile-Lys-Val-Ala-Val(IKVAV)and vascular endothelial growth factor(VEGF)by combining solution blending,in situ lyophilization,and surface biomodification.Immobilization of VEGF and IKVAV on the scaffolds was confirmed both qualitatively by staining and quantitatively by ELISA.Various single-and dual-biofunctionalized scaffolds were compared for the promotion of endothelial cell(EC)and Schwann cell(SC)proliferation as well as the induction of angiogenic and neuroregeneration-associated genes by these cells in culture.The efficacy of these scaffolds for vascularization was evaluated by implantation in chicken embryos,while functional repair capacity in vivo was assessed in rats subjected to a 10mm sciatic nerve injury.Dual-biofunctionalized scaffolds supported robust EC and SC proliferation and upregulated the expression levels of multiple genes and proteins related to neuroregeneration and vascularization.Dual-biofunctionalized scaffolds demonstrated superior vascularization induction in embryos and greater promotion of vascularization,myelination,and functional recovery in rats.These findings support the clinical potential of VEGF/IKVAV dual-biofunctionalized chitosan/collagen composite scaffolds for facilitating peripheral nerve regeneration,making it an attractive candidate for repairing critical nerve defect.The study may provide a critical experimental and theoretical basis for the development and design of new artificial nerve implants with excellent biological performance.展开更多
文摘This study systematically addresses the limitations of traditional pest detection methods and proposes an optimized version of the YOLOv8 object detection model.By integrating the GhostConv convolution module and the C3Ghost module,the Polarized Self-Attention(PSA)mechanism is incorporated to enhance the model’s capacity for extracting pest features.Experimental results demonstrate that the improved YOLOv8+Ghost+PSA model achieves outstanding performance in critical metrics such as precision,recall,and mean Average Precision(mAP),with a computational cost of only 5.3 GFLOPs,making it highly suitable for deployment in resource-constrained agricultural environments.
基金This work was supported by the National Key Research and Development Program of China(No.2016YFD0400601)the Science and Technology Coordination Project of Innovation in Shaanxi province(NO.2014KTCL02-07).
文摘Chicoric acid(CA),a natural phenolic acid,has been used as a nutraceutical food ingredient due to its powerful antioxidant,anti-HIV and anti-diabetic bioactivities.CA could be partly metabolized into caffeic acid(CFA)and caftaric acid(CTA)on cytochrome P450s in rat liver microsomes.To compare the protective effects of CA and its metabolites on biomolecules and inflammatory responses,oxidative damage induced by free radicals in vitro and microglial inflammation triggered by lipopolysaccharide in BV2 cells were constructed.Results showed that CA,CTA and CFA all significantly inhibited protein degradation and carbonylation induced by hydroxyl radicals and alcoxyl radicals,and suppressed hemin/nitrite/H2O2 triggered-nitration.Moreover,CA,CTA and CFA all exerted remarkable inhibition capacities on linoleic acid and soybean lecithin liposomes peroxidation in a dose-dependent manner,and restrained the oxidation of herring sperm DNA,as well as the breakage of pBR322 plasmid DNA.Furthermore,CA and its metabolites suppressed lipopolysaccharide-induced decline of BV2 cell viability and the production of NO and ROS.However,bioactivities of CA were significantly stronger than those of its metabolites within a certain concentration range.This study provides scientific basis for the application of CA and its metabolites as nutrition and natural antioxidants.
文摘The oxidized bamboo pulp fiber yarns were prepared by the HNO3?/H3PO4-NaNO2 oxidation system. The effects of the oxidation concentration and reaction time on the weight loss, the carboxyl content and the breaking strength of the bamboo pulp fiber yarns were studied and the aggregation structure was investigated by Fourier transform infrared, X-ray and scanning electron microscopy. The results revealed an increase in carboxyl content and a decrease in breaking strength of oxidized bamboo pulp fiber yarns with increasing concentration of oxidant and reaction time. The breaking strength of oxidized bamboo fiber yarns was damaged seriously once the reaction time was more than 120 min or the concentration of oxidant was greater than 1.0%. The crystallinity of bamboo pulp fibers increased slightly under low oxidation degree but decreased with higher oxidation degree.
基金supported by the National Natural Science Foundation of China(51972183)the Startup Funding for Talents at the University of South China。
文摘Sc-doped Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)(SFMSc)was successfully synthesized by partially substituting Mo in Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)(SFM)with Sc,resulting in a higher proton diffusion rate in the resultant SFMSc sample.Theoretical calculations showed that doping Sc into SFM lowered the oxygen vacancy formation energy,reduced the energy barrier for proton migration in the oxide,and increased the catalytic activity for oxygen reduction reaction.Next,a proton-conducting solid oxide fuel cell(H-SOFC)with a single-phase SFMSc cathode demonstrated significantly higher cell performance than that of cell based on an Sc-free SFM cathode,achieving 1258 mW cm^(−2)at 700℃.The performance also outperformed that of many other H-SOFCs based on single-phase cobalt-free cathodes.Furthermore,no trade-off between fuel cell performance and material stability was observed.The SFMSc material demonstrated good stability in both the CO_(2)-containing atmosphere and the fuel cell application.The combination of high performance and outstanding stability suggests that SFMSc is an excellent cathode material for H-SOFCs.
基金supported by the National Natural Science Foundation of China(grant numbers 82170188 and 81970176)Guangdong Basic and Applied Basic Research Foundation(grant number 2021A1515110012).
文摘Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be improved.This phase 1b/2 study investigated the safety and efficacy of sintilimab,a fully human anti-PD-1 antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with RR-ENKTL.Expected objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sintilimab in 21-days cycles up to 12 months.No dose-limiting events were observed,RP2D of chidamide was 30 mg twice a week.Twenty-nine patients were enrolled in phase 2.In the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 25.3,23.2,and 32.9 months,respectively.The most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(28.9%)and thrombocytopenia(10.5%),immune-related AEs were reported in 18(47.3%)patients.Exploratory biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic role.STAT3 mutation shows an unfavorable prognosis.Although outcome of anticipate ORR was not achieved,sintilimab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first time.It is a promising therapeutic option for this population.
基金the financial support of the National Natural Science Foundation of China(31771054,81871472,and 31830028)Academy of Finland Research Fellow(328933)+5 种基金Sigrid Jusélius Foundation grant(28002247k1)Natural Key Science Research Program of Jiangsu Provincial Department of Education(19KJA320006)National Key Research and Development Program of China(2016YFC1101600)Directive Project of Science and Technology Plan of Nantong City(MS12018028)226 High-Level Talent Training Project(2nd level,2018 II-182)of Nantong CityQinglan Project of Jiangsu Province(2018).
文摘Biofunctionalization of artificial nerve implants by incorporation of specific bioactive factors has greatly enhanced the success of grafting procedures for peripheral nerve regeneration.However,most studies on novel biofunctionalized implants have emphasized the promotion of neuronal and axonal repair over vascularization,a process critical for long-term functional restoration.We constructed a dual-biofunctionalized chitosan/collagen composite scaffold with Ile-Lys-Val-Ala-Val(IKVAV)and vascular endothelial growth factor(VEGF)by combining solution blending,in situ lyophilization,and surface biomodification.Immobilization of VEGF and IKVAV on the scaffolds was confirmed both qualitatively by staining and quantitatively by ELISA.Various single-and dual-biofunctionalized scaffolds were compared for the promotion of endothelial cell(EC)and Schwann cell(SC)proliferation as well as the induction of angiogenic and neuroregeneration-associated genes by these cells in culture.The efficacy of these scaffolds for vascularization was evaluated by implantation in chicken embryos,while functional repair capacity in vivo was assessed in rats subjected to a 10mm sciatic nerve injury.Dual-biofunctionalized scaffolds supported robust EC and SC proliferation and upregulated the expression levels of multiple genes and proteins related to neuroregeneration and vascularization.Dual-biofunctionalized scaffolds demonstrated superior vascularization induction in embryos and greater promotion of vascularization,myelination,and functional recovery in rats.These findings support the clinical potential of VEGF/IKVAV dual-biofunctionalized chitosan/collagen composite scaffolds for facilitating peripheral nerve regeneration,making it an attractive candidate for repairing critical nerve defect.The study may provide a critical experimental and theoretical basis for the development and design of new artificial nerve implants with excellent biological performance.
