To address the scheduling problem involving energy storage systems and uncertain energy,we propose a method based on multi-stage robust optimization.This approach aims to regulate the energy storage system by using a ...To address the scheduling problem involving energy storage systems and uncertain energy,we propose a method based on multi-stage robust optimization.This approach aims to regulate the energy storage system by using a multi-stage robust optimal control method,which helps overcome the limitations of traditional methods in terms of time scale.The goal is to effectively utilize the energy storage power station system to address issues caused by unpredictable variations in environmental energy and fluctuating load throughout the day.To achieve this,a mathematical model is constructed to represent uncertain energy sources such as photovoltaic and wind power.The generalized Benders Decomposition method is then employed to solve the multi-stage objective optimization problem.By decomposing the problem into a series of sub-objectives,the system scale is effectively reduced,and the algorithm’s convergence ability is improved.Compared with other algorithms,the multi-stage robust optimization model has better economy and convergence ability and can be used to guide the power dispatching of uncertain energy and energy storage systems.展开更多
Objective This study aimed to investigate the role of LSM12 in uveal melanoma(UM)oncogenesis and progression,examining its potential as both a prognostic biomarker and therapeutic target.Methods LSM12 expression was a...Objective This study aimed to investigate the role of LSM12 in uveal melanoma(UM)oncogenesis and progression,examining its potential as both a prognostic biomarker and therapeutic target.Methods LSM12 expression was analyzed in relation to RNA modification genes and tumor stemness in UM.UM cell lines were subjected to LSM12 knockdown using siRNA,followed by cell viability and migration assays.The therapeutic potential of targeting LSM12 was evaluated using a subcutaneous xenograft model.Additionally,the relationship between LSM12 and the PI3K/Akt/mTOR pathway was explored.Results LSM12 expression levels were significantly elevated in UM patients,correlating strongly with poor prognosis.Positive correlations were observed between LSM12 expression and multiple genes associated with RNA methylation modifications and cancer stem cell characteristics.Knockdown of LSM12 effectively disrupted UM cell viability and migration in vitro and inhibited OCM1 xenograft growth in vivo.Additionally,LSM12 knockdown resulted in notable inhibition of the PI3K/Akt/mTOR pathway both in vitro and in vivo.Conclusions Elevated LSM12 expression correlates with poor prognosis in UM and critically promotes oncogenic processes,including tumor cell viability,migration,and tumorigenesis.展开更多
What is already known about this topic?Pregnancy is associated with increased risk for severe illness and complications attributable to influenza infection.Information about the incidence of influenza hospitalization ...What is already known about this topic?Pregnancy is associated with increased risk for severe illness and complications attributable to influenza infection.Information about the incidence of influenza hospitalization among pregnant and early postpartum women in China is limited.What is added by this report?Population-based data from a large city in southern China estimated the annual influenza hospitalization rate to be 2.1 per 1,000 live births.Among hospitalized pregnant and postpartum women with influenza,86%were admitted to obstetrics rather than respiratory medicine wards;fewer than one third received antiviral treatment.Influenza vaccination coverage among hospitalized pregnant and postpartum women with influenza was<0.1%.What are the implications for public health practice?Increasing vaccination coverage among pregnant women can reduce influenza-associated morbidity.Raising awareness about early detection,treatment,and infection control of influenza in obstetrics wards is needed to reduce the adverse impact of influenza on pregnant women.展开更多
Background:The benefits of ideal cardiovascular-health metrics(ICVHMs)in patients with renal insufficiency remain unclear.This study aimed to investigate the associations between ICVHM and prognosis in a renal insuffi...Background:The benefits of ideal cardiovascular-health metrics(ICVHMs)in patients with renal insufficiency remain unclear.This study aimed to investigate the associations between ICVHM and prognosis in a renal insufficiency population.Methods:The trial enrolled 29,682 participants from the US National Health and Nutrition Examination Survey(NHANES),2007-2018,with mortality follow-up through December 31,2019.Participants were divided into three groups based on estimated glomerular filtration rates.Cardiovascular health was assessed using new"Life’s Essential 8"metrics.Cox regression analyses based on NHANES data were used to determine the associations between ICVHMs and cardiovascular mortality in patients with renal insufficiency.Results:During a mean follow-up of 6.58 years,ideal cardiovascular health(hazard ratio[HR]=0.42;95%confidence interval[CI];0.25-0.70)and ideal health behavior(HR=0.53;95%CI;0.39-0.73)reduced cardiovascular mortality in participants with renal insufficiency.For each one ICVHM increment,a 25%reduction in cardiovascular mortality was recorded(95%CI;0.69-0.82).When compared with participants with normal renal function,for those with mild renal insufficiency,the HR for cardiovascular mortality gradually decreased from 1.47(95%CI;0.85-2.52)in those who had≤1 ICVHMs to 0.30(95%CI;0.12-0.77)in participants who had>6 ICVHMs.Conclusions:From an ICVHM perspective,enhanced cardiovascular benefits were observed in individuals with renal insufficiency,coupled with a reduced risk of all-cause mortality.Furthermore,when compared with individuals with normal renal function,increased ICVHMs can mitigate adverse risks associated with renal impairment.展开更多
文摘To address the scheduling problem involving energy storage systems and uncertain energy,we propose a method based on multi-stage robust optimization.This approach aims to regulate the energy storage system by using a multi-stage robust optimal control method,which helps overcome the limitations of traditional methods in terms of time scale.The goal is to effectively utilize the energy storage power station system to address issues caused by unpredictable variations in environmental energy and fluctuating load throughout the day.To achieve this,a mathematical model is constructed to represent uncertain energy sources such as photovoltaic and wind power.The generalized Benders Decomposition method is then employed to solve the multi-stage objective optimization problem.By decomposing the problem into a series of sub-objectives,the system scale is effectively reduced,and the algorithm’s convergence ability is improved.Compared with other algorithms,the multi-stage robust optimization model has better economy and convergence ability and can be used to guide the power dispatching of uncertain energy and energy storage systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.82471068)Research Funds of the State Key Laboratory of Ophthalmology,China(Grant Nos.2025QZLH04).
文摘Objective This study aimed to investigate the role of LSM12 in uveal melanoma(UM)oncogenesis and progression,examining its potential as both a prognostic biomarker and therapeutic target.Methods LSM12 expression was analyzed in relation to RNA modification genes and tumor stemness in UM.UM cell lines were subjected to LSM12 knockdown using siRNA,followed by cell viability and migration assays.The therapeutic potential of targeting LSM12 was evaluated using a subcutaneous xenograft model.Additionally,the relationship between LSM12 and the PI3K/Akt/mTOR pathway was explored.Results LSM12 expression levels were significantly elevated in UM patients,correlating strongly with poor prognosis.Positive correlations were observed between LSM12 expression and multiple genes associated with RNA methylation modifications and cancer stem cell characteristics.Knockdown of LSM12 effectively disrupted UM cell viability and migration in vitro and inhibited OCM1 xenograft growth in vivo.Additionally,LSM12 knockdown resulted in notable inhibition of the PI3K/Akt/mTOR pathway both in vitro and in vivo.Conclusions Elevated LSM12 expression correlates with poor prognosis in UM and critically promotes oncogenic processes,including tumor cell viability,migration,and tumorigenesis.
文摘What is already known about this topic?Pregnancy is associated with increased risk for severe illness and complications attributable to influenza infection.Information about the incidence of influenza hospitalization among pregnant and early postpartum women in China is limited.What is added by this report?Population-based data from a large city in southern China estimated the annual influenza hospitalization rate to be 2.1 per 1,000 live births.Among hospitalized pregnant and postpartum women with influenza,86%were admitted to obstetrics rather than respiratory medicine wards;fewer than one third received antiviral treatment.Influenza vaccination coverage among hospitalized pregnant and postpartum women with influenza was<0.1%.What are the implications for public health practice?Increasing vaccination coverage among pregnant women can reduce influenza-associated morbidity.Raising awareness about early detection,treatment,and infection control of influenza in obstetrics wards is needed to reduce the adverse impact of influenza on pregnant women.
基金This work was partially supported by the Leading Talents Plan,Beijing Municipal Health Commission(No.LJRC20240306).
文摘Background:The benefits of ideal cardiovascular-health metrics(ICVHMs)in patients with renal insufficiency remain unclear.This study aimed to investigate the associations between ICVHM and prognosis in a renal insufficiency population.Methods:The trial enrolled 29,682 participants from the US National Health and Nutrition Examination Survey(NHANES),2007-2018,with mortality follow-up through December 31,2019.Participants were divided into three groups based on estimated glomerular filtration rates.Cardiovascular health was assessed using new"Life’s Essential 8"metrics.Cox regression analyses based on NHANES data were used to determine the associations between ICVHMs and cardiovascular mortality in patients with renal insufficiency.Results:During a mean follow-up of 6.58 years,ideal cardiovascular health(hazard ratio[HR]=0.42;95%confidence interval[CI];0.25-0.70)and ideal health behavior(HR=0.53;95%CI;0.39-0.73)reduced cardiovascular mortality in participants with renal insufficiency.For each one ICVHM increment,a 25%reduction in cardiovascular mortality was recorded(95%CI;0.69-0.82).When compared with participants with normal renal function,for those with mild renal insufficiency,the HR for cardiovascular mortality gradually decreased from 1.47(95%CI;0.85-2.52)in those who had≤1 ICVHMs to 0.30(95%CI;0.12-0.77)in participants who had>6 ICVHMs.Conclusions:From an ICVHM perspective,enhanced cardiovascular benefits were observed in individuals with renal insufficiency,coupled with a reduced risk of all-cause mortality.Furthermore,when compared with individuals with normal renal function,increased ICVHMs can mitigate adverse risks associated with renal impairment.
