Acceptorless dehydrogenative coupling of pyridinemethanol with ketones is one of the most reliable methodologies to access functionalized 1,8-naphthyridine derivatives.However,it is challenging to develop environmenta...Acceptorless dehydrogenative coupling of pyridinemethanol with ketones is one of the most reliable methodologies to access functionalized 1,8-naphthyridine derivatives.However,it is challenging to develop environmentally friendly catalytic systems,especially in constructing efficient and recyclable catalysts under water or solvent-free conditions.Here,we designed two novel coordination polymers Cd-CPs and Fe-CPs to investigate their catalytic performance in water.Gratifyingly,it was observed that Cd-CPs as a multifunctional catalyst was successfully applied to establish a universal pathway for direct fabrication of 1,8-naphthyridine derivatives under water conditions,while it was effective for the synthesis of1,3,5-triazines through acceptorless dehydrogenative coupling strategies.The features of broad substrate,high atom efficiency,and good catalyst reusability highlight the feasibility of this transformation.In additional,we demonstrated the spindle-like structures Fe-P,derived from the Fe-CPs via phosphorylation,which can be used as an efficient electrocatalyst for oxygen evolution reaction with good stability.This work provides two highly efficient non-noble metal catalysts for functionalized 1,8-naphthyridine derivatives production and oxygen evolution reaction,and opens a new avenue to further fabricate diverse metal catalysts with high catalytic performance in water.展开更多
A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalesce...A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been reported.Further,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current vaccines.Importantly,the mutations exhibit a trend of immune escape from the vaccination.Herein the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive.We performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of COVID-19.In addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation respectively.We found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 respectively.With the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S gene.Moreover,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control strategies.Hence,integrated vaccination and non-pharmacological interventions are critical to control the pandemic.Furthermore,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.展开更多
Graphene is a potential candidate for applications in biomedical field.It is inevitable that graphene is in contact with the ubiquitous bacterial environment.More attention has been paid to the antimicrobial activity ...Graphene is a potential candidate for applications in biomedical field.It is inevitable that graphene is in contact with the ubiquitous bacterial environment.More attention has been paid to the antimicrobial activity of graphene derivatives(graphene oxide,reduced graphene oxide)than the interaction between graphene and bacteria.Herein,we explore interaction between graphene micron-sheet and bacteria from micro(gene expression)and macro(colonies)perspectives.Results demonstrate that graphene micron-sheet accelerates the biofilm forming thus promoting pathogen expansion toward both Gram-negative bacteria E.coli and Gram-positive bacteria S.aureus.The graphene micron-sheet acts as a“habitat”for increasing bacterial attachment and biofilm forming.For E.coli,graphene micron-sheet,firstly changes the integrity of periplasmic and outer membrane components,then makes membraneassociated and cell division genes increased,and finally promotes bacterial proliferation;For S.aureus,graphene micron-sheet can accelerate biofilm forming and develop bacterial expansion owing to the regulation of the quorum-sensing system and global regulatory proteins.The work can shed new light on the range of possible mode of actions,developing a better understanding of the capabilities of graphene micronstructures.展开更多
1.Introduction.The Immunization Agenda 2030 outlined the importance of capacity building for researchers,regulators and public health officials at national,regional and local levels in its multiple strategic prioritie...1.Introduction.The Immunization Agenda 2030 outlined the importance of capacity building for researchers,regulators and public health officials at national,regional and local levels in its multiple strategic priorities for building an effective immunization programme[1].The mission of University of Chinese Academy of Sciences focuses on frontier science and applied biotechnology to address the challenges for both the development of the country as well as world sustainability,facing the forefront of the global scientific and technological advances,to compete on the main economic battlefield,and to address the major needs of the country and for the lives and health of the people.展开更多
Climate change is one of the biggest issues facing humanity.Governments,private sectors,nongovernmental organizations,and individuals are working daily to find solutions to counter andmitigate its influence.An underdi...Climate change is one of the biggest issues facing humanity.Governments,private sectors,nongovernmental organizations,and individuals are working daily to find solutions to counter andmitigate its influence.An underdiscussed issue is the effect that climate has on health,and the impact that environmental and atmospheric change can have on communities,medical care access,and ecology.Here,AlanDangour from theWellcomeTrustmediates a discussion between George Fu Gao,hLife Editor-in-Chief,and the former Director-General of Chinese Center for Disease Control and Prevention,Desta Lakewfrom African Medical and Research Foundation,and Alaa Murabit from the Gates Foundation,on this area of health and climate.They discuss how a changing climate can affect health,thework that has already been done to address these problems,and the innovations and steps that need to be made to fully tackle climate-related health issues,with a consensus that health should be at the center of all considerations.展开更多
基金financial support of this work by the National Natural Science Foundation of China(No.21861039)Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX24_2530)the Fundamental Research Funds for the Central Universities。
文摘Acceptorless dehydrogenative coupling of pyridinemethanol with ketones is one of the most reliable methodologies to access functionalized 1,8-naphthyridine derivatives.However,it is challenging to develop environmentally friendly catalytic systems,especially in constructing efficient and recyclable catalysts under water or solvent-free conditions.Here,we designed two novel coordination polymers Cd-CPs and Fe-CPs to investigate their catalytic performance in water.Gratifyingly,it was observed that Cd-CPs as a multifunctional catalyst was successfully applied to establish a universal pathway for direct fabrication of 1,8-naphthyridine derivatives under water conditions,while it was effective for the synthesis of1,3,5-triazines through acceptorless dehydrogenative coupling strategies.The features of broad substrate,high atom efficiency,and good catalyst reusability highlight the feasibility of this transformation.In additional,we demonstrated the spindle-like structures Fe-P,derived from the Fe-CPs via phosphorylation,which can be used as an efficient electrocatalyst for oxygen evolution reaction with good stability.This work provides two highly efficient non-noble metal catalysts for functionalized 1,8-naphthyridine derivatives production and oxygen evolution reaction,and opens a new avenue to further fabricate diverse metal catalysts with high catalytic performance in water.
基金We thank the important work of SARS-CoV-2 genome data producers globally and especially the COVID-19 genomics UK(COG-UK)consortium contributing sequence data to the GISAID database.This work was supported by the Beijing Natural Science Foundation(M22029)National Key R&D Program of China(2021YFC2301300)+5 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29010102)and National Natural Science Foundation of China(NSFC)(82161148010)J.Y.is supported by Special Program of China Postdoctoral Science Foundation(2020T130123ZX)Y.B.is supported by the NSFC Outstanding Young Scholars(31822055)Youth Innovation Promotion Association of CAS(Y2021034)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202208).
文摘A series of stringent non-pharmacological and pharmacological interventions were implemented to contain the pandemic but the pandemic continues.Moreover,vaccination breakthrough infection and reinfection in convalescent coronavirus disease 2019(COVID-19)cases have been reported.Further,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants emerged with mutations in spike(S)gene,the target of most current vaccines.Importantly,the mutations exhibit a trend of immune escape from the vaccination.Herein the scientific question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive.We performed correlation analyses to uncover the impacts of wide vaccination on epidemiological characteristics of COVID-19.In addition,we investigated the evolutionary dynamics and genetic diversity of SARS-CoV-2 under immune pressure by utilizing the Bayesian phylodynamic inferences and the lineage entropy calculation respectively.We found that vaccination coverage was negatively related to the infections,severe cases,and deaths of COVID-19 respectively.With the increasing vaccination coverage,the lineage diversity of SARS-CoV-2 dampened,but the rapid mutation rates of the S gene were identified,and the vaccination could be one of the explanations for driving mutations in S gene.Moreover,new epidemics resurged in several countries with high vaccination coverage,questioning their current pandemic control strategies.Hence,integrated vaccination and non-pharmacological interventions are critical to control the pandemic.Furthermore,novel vaccine preparation should enhance its capabilities to curb both disease severity and infection possibility.
基金supported by the National Natural Science Foundation of China(Grant No.51473175)the National Key Research and Development Program(2016YFC1000900)the Youth Innovation Promotion Association CAS.
文摘Graphene is a potential candidate for applications in biomedical field.It is inevitable that graphene is in contact with the ubiquitous bacterial environment.More attention has been paid to the antimicrobial activity of graphene derivatives(graphene oxide,reduced graphene oxide)than the interaction between graphene and bacteria.Herein,we explore interaction between graphene micron-sheet and bacteria from micro(gene expression)and macro(colonies)perspectives.Results demonstrate that graphene micron-sheet accelerates the biofilm forming thus promoting pathogen expansion toward both Gram-negative bacteria E.coli and Gram-positive bacteria S.aureus.The graphene micron-sheet acts as a“habitat”for increasing bacterial attachment and biofilm forming.For E.coli,graphene micron-sheet,firstly changes the integrity of periplasmic and outer membrane components,then makes membraneassociated and cell division genes increased,and finally promotes bacterial proliferation;For S.aureus,graphene micron-sheet can accelerate biofilm forming and develop bacterial expansion owing to the regulation of the quorum-sensing system and global regulatory proteins.The work can shed new light on the range of possible mode of actions,developing a better understanding of the capabilities of graphene micronstructures.
基金supported by the University of Chinese Academy of Sciences Education Foundation and the Bill&Melinda Gates Foundation(INV-008950)。
文摘1.Introduction.The Immunization Agenda 2030 outlined the importance of capacity building for researchers,regulators and public health officials at national,regional and local levels in its multiple strategic priorities for building an effective immunization programme[1].The mission of University of Chinese Academy of Sciences focuses on frontier science and applied biotechnology to address the challenges for both the development of the country as well as world sustainability,facing the forefront of the global scientific and technological advances,to compete on the main economic battlefield,and to address the major needs of the country and for the lives and health of the people.
文摘Climate change is one of the biggest issues facing humanity.Governments,private sectors,nongovernmental organizations,and individuals are working daily to find solutions to counter andmitigate its influence.An underdiscussed issue is the effect that climate has on health,and the impact that environmental and atmospheric change can have on communities,medical care access,and ecology.Here,AlanDangour from theWellcomeTrustmediates a discussion between George Fu Gao,hLife Editor-in-Chief,and the former Director-General of Chinese Center for Disease Control and Prevention,Desta Lakewfrom African Medical and Research Foundation,and Alaa Murabit from the Gates Foundation,on this area of health and climate.They discuss how a changing climate can affect health,thework that has already been done to address these problems,and the innovations and steps that need to be made to fully tackle climate-related health issues,with a consensus that health should be at the center of all considerations.
