Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction,but morbidity and mortality of acute myocardial infarction are still high.Reperfusion injuries are inevitable due ...Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction,but morbidity and mortality of acute myocardial infarction are still high.Reperfusion injuries are inevitable due to the generation of reactive oxygen species(ROS)and apoptosis of cardiac muscle cells.However,many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration,such as short half-life,low stability,low bioavailability,and side effects for treatment myocardial ischemia reperfusion injury.Therefore,it is necessary to develop effective drugs and technologies to address this issue.Fortunately,nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury.Compared with traditional drugs,nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’size,shape,and material characteristics.In this review,the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed.Furthermore,we summarized the applications of ROS-based nanoparticles,highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury.展开更多
Molybdenum is a trace dietary element necessary for the survival of humans.Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body(such as xanthine oxidase,aldehyde oxidase and sulfi...Molybdenum is a trace dietary element necessary for the survival of humans.Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body(such as xanthine oxidase,aldehyde oxidase and sulfite oxidase).Many molybdenum-based compounds have been widely used in biomedical research.Especially,MoS_(2)-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties.MoS_(2)can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area,improving its tumor targeting and colloidal stability,as well as accuracy and sensitivity for detecting specific biomarkers.At the same time,in the near-infrared(NIR)window,MoS_(2)has excellent optical absorption and prominent photothermal conversion efficiency,which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release.Significantly,the modified MoS_(2)-nanocomposite can specifically respond to the tumor microenvironment,leading to drug accumulation in the tumor site increased,reducing its side effects on non-cancerous tissues,and improved therapeutic effect.In this review,we introduced the latest developments of MoS_(2)-nanocomposites in cancer diagnosis and therapy,mainly focusing on biosensors,bioimaging,chemotherapy,phototherapy,microwave hyperthermia,and combination therapy.Furthermore,we also discuss the current challenges and prospects of MoS_(2)-nanocomposites in cancer treatment.展开更多
基金This work was supported by the National Natural Science Foundation of China,China(No.21974134,81974508,81673492,81873581)Innovation-Driven Project of Central South University(No.202045005)+1 种基金Special Science and Technology Plan of Changsha City.(No.kq2001048)Key Research Project of Ningxia Hui Autonomous Region(Major Project)(2021BEG01001).
文摘Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction,but morbidity and mortality of acute myocardial infarction are still high.Reperfusion injuries are inevitable due to the generation of reactive oxygen species(ROS)and apoptosis of cardiac muscle cells.However,many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration,such as short half-life,low stability,low bioavailability,and side effects for treatment myocardial ischemia reperfusion injury.Therefore,it is necessary to develop effective drugs and technologies to address this issue.Fortunately,nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury.Compared with traditional drugs,nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’size,shape,and material characteristics.In this review,the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed.Furthermore,we summarized the applications of ROS-based nanoparticles,highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury.
基金the National Natural Science Foundation of China,China(No.21974134,81974508,81673492,81873581)Innovation-Driven Project of Central South University(No.202045005)Changsha Science and Technology Project(No.kq2001048).
文摘Molybdenum is a trace dietary element necessary for the survival of humans.Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body(such as xanthine oxidase,aldehyde oxidase and sulfite oxidase).Many molybdenum-based compounds have been widely used in biomedical research.Especially,MoS_(2)-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties.MoS_(2)can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area,improving its tumor targeting and colloidal stability,as well as accuracy and sensitivity for detecting specific biomarkers.At the same time,in the near-infrared(NIR)window,MoS_(2)has excellent optical absorption and prominent photothermal conversion efficiency,which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release.Significantly,the modified MoS_(2)-nanocomposite can specifically respond to the tumor microenvironment,leading to drug accumulation in the tumor site increased,reducing its side effects on non-cancerous tissues,and improved therapeutic effect.In this review,we introduced the latest developments of MoS_(2)-nanocomposites in cancer diagnosis and therapy,mainly focusing on biosensors,bioimaging,chemotherapy,phototherapy,microwave hyperthermia,and combination therapy.Furthermore,we also discuss the current challenges and prospects of MoS_(2)-nanocomposites in cancer treatment.
