γ-Hydroxy acid has widespread applications in materials,pharmaceuticals,food industries and organic synthesis.In this context,the CO_(2)-involved multi-component reaction of the C-C unsaturated bond represents one of...γ-Hydroxy acid has widespread applications in materials,pharmaceuticals,food industries and organic synthesis.In this context,the CO_(2)-involved multi-component reaction of the C-C unsaturated bond represents one of the most promising strategies for preparingγ-hydroxy acids from readily available feedstocks in one step.However,current reports mainly rely on the utilization of limited-access reagents and even stoichiometric metal catalysts,which suppress their application.Herein,we describe a novel example of γ-hydroxy acids enabled by photocatalyzed carboxylative alkylation of styrenes with easy-access aliphatic aldehydes and CO_(2).This protocol offers a facile tool to furnish a variety of γ-hydroxy acids with good functional group compatibility and can be further applied to the late-stage modification of biomolecules,as well as ligation of drug fragments.The developed reaction can be seamlessly scaled up using flow technology,rendering its practicality.Additionally,this platform enables the downstream synthesis of furan-2(5H)-one 67,which shows attractive anti-cancer efficacy against a set of tumor cells,further highlighting the significance of our protocol.展开更多
The anti-tumor effect of therapeutic carbon monoxide(CO)has been considered concerning the electron transport chain on the inner mitochondrial membrane.Herein,a tumor microenvironment and photo-responsive CO nanoplatf...The anti-tumor effect of therapeutic carbon monoxide(CO)has been considered concerning the electron transport chain on the inner mitochondrial membrane.Herein,a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles(NPs)were constructed through biomineralizing acryloyl-modified flavonol,which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion.The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca_(3)(PO_(4))_(2)acidolysis,resulting in mitochondrial dysfunction and cell apoptosis.In addition,the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo.This work provides new insight into the potential characteristics of CO,paving a new way to engineer more efficient treatment based on CO.展开更多
基金supported by the“Thousand Talents Plan”Youth Programthe National Natural Science Foundations of China(22101136,22478200)+1 种基金the Fundamental Research Funds for the Central Universities(DUT23LAB612,DUT25RC(3)049)the Foundation of Guizhou Educational Committee(qianjiaoji[2023]088)。
文摘γ-Hydroxy acid has widespread applications in materials,pharmaceuticals,food industries and organic synthesis.In this context,the CO_(2)-involved multi-component reaction of the C-C unsaturated bond represents one of the most promising strategies for preparingγ-hydroxy acids from readily available feedstocks in one step.However,current reports mainly rely on the utilization of limited-access reagents and even stoichiometric metal catalysts,which suppress their application.Herein,we describe a novel example of γ-hydroxy acids enabled by photocatalyzed carboxylative alkylation of styrenes with easy-access aliphatic aldehydes and CO_(2).This protocol offers a facile tool to furnish a variety of γ-hydroxy acids with good functional group compatibility and can be further applied to the late-stage modification of biomolecules,as well as ligation of drug fragments.The developed reaction can be seamlessly scaled up using flow technology,rendering its practicality.Additionally,this platform enables the downstream synthesis of furan-2(5H)-one 67,which shows attractive anti-cancer efficacy against a set of tumor cells,further highlighting the significance of our protocol.
基金the National Natural Science Foundation of China(Nos.21975121 and 22175089)Jiangsu Provincial key research and development plan(No.BE2021711)Taishan scholars’construction special fund of Shandong Province.
文摘The anti-tumor effect of therapeutic carbon monoxide(CO)has been considered concerning the electron transport chain on the inner mitochondrial membrane.Herein,a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles(NPs)were constructed through biomineralizing acryloyl-modified flavonol,which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion.The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca_(3)(PO_(4))_(2)acidolysis,resulting in mitochondrial dysfunction and cell apoptosis.In addition,the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo.This work provides new insight into the potential characteristics of CO,paving a new way to engineer more efficient treatment based on CO.
