The dense alumina shell on the surface of aluminum powder will hinder the combustion of aluminum powder and increase its ignition temperature.In this study,the aluminum oxide shell layer on the surface of aluminum pow...The dense alumina shell on the surface of aluminum powder will hinder the combustion of aluminum powder and increase its ignition temperature.In this study,the aluminum oxide shell layer on the surface of aluminum powder was removed with hydrofluoric acid by one-pot method,and 3-Perfluorohexyl-1,2-epoxypropane(PFHP)(F3C(CF2)5CH2C2H3O)was coated to form a uniform and controllable core-shell Al@PFHP.The core-shell AI@PFHP showed better thermal reaction and ignition performance.The exothermic enthalpy of Al@0.15 PFHP was increased by about 1.9 times,with lower ignition temperature(reduced by about 140℃)and longer burning duration(increased by about 1.5 times)after coating with PFHP,compared with raw aluminum powder.In addition,the formation of PFHP coating shell can effectively improve the hydrophobicity and corrosion resistance of aluminum powder.展开更多
Neutrophils are crucial for immunity and play important roles in inflammatory diseases;however,mouse models selectively deficient in neutrophils are limited,and neutrophil-specific diphtheria toxin(DT)-based depletion...Neutrophils are crucial for immunity and play important roles in inflammatory diseases;however,mouse models selectively deficient in neutrophils are limited,and neutrophil-specific diphtheria toxin(DT)-based depletion system has not yet been established.In this study,we generated a novel knock-in mouse model expressing diphtheria toxin receptor(DTR)under control of the endogenous Ly6G promoter.We showed that DTR expression was restricted to Ly6G+neutrophils and complete depletion of neutrophils could be achieved by DT treatment at 24-48 h intervals.We characterized the effects of specific neutrophil depletion in mice at steady-state,with acute inflammation and during tumor growth.Our study presents a valuable new tool to study the roles of neutrophils in the immune system and during tumor progression.展开更多
Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in vivo.As key players in suppressing immune reactions,they help to preserve immune tolerance and...Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in vivo.As key players in suppressing immune reactions,they help to preserve immune tolerance and are thus crucial for preventing autoimmune diseases.Within the tumor microenvironment(TME),Tregs facilitate tumor immune evasion by impairing the activity of effector cells via multiple mechanisms,thus contributing to the initiation and progression of tumors[1].To perform this regulatory function,Tregs depend on the master transcription factor forkhead box protein p3(Foxp3)[2].The expression of Foxp3 has emerged as indispensable for the development and optimal function of Tregs[3].Interestingly,different posttranslational modifications,including phosphorylation,ubiquitination,glycosylation,and acetylation,exert significant regulatory effects on the biological function of Foxp3[4-8].展开更多
Multimedia data have become popularly transmitted content in opportunistic networks. A large amount of video data easily leads to a low delivery ratio. Breaking up these big data into small pieces or fragments is a re...Multimedia data have become popularly transmitted content in opportunistic networks. A large amount of video data easily leads to a low delivery ratio. Breaking up these big data into small pieces or fragments is a reasonable option. The size of the fragments is critical to transmission efficiency and should be adaptable to the communication capability of a network. We propose a novel communication capacity calculation model of opportunistic network based on the classical random direction mobile model, define the restrain facts model of overhead, and present an optimal fragment size algorithm. We also design and evaluate the methods and algorithms with video data fragments disseminated in a simulated environment. Experiment results verified the effectiveness of the network capability and the optimal fragment methods.展开更多
文摘The dense alumina shell on the surface of aluminum powder will hinder the combustion of aluminum powder and increase its ignition temperature.In this study,the aluminum oxide shell layer on the surface of aluminum powder was removed with hydrofluoric acid by one-pot method,and 3-Perfluorohexyl-1,2-epoxypropane(PFHP)(F3C(CF2)5CH2C2H3O)was coated to form a uniform and controllable core-shell Al@PFHP.The core-shell AI@PFHP showed better thermal reaction and ignition performance.The exothermic enthalpy of Al@0.15 PFHP was increased by about 1.9 times,with lower ignition temperature(reduced by about 140℃)and longer burning duration(increased by about 1.5 times)after coating with PFHP,compared with raw aluminum powder.In addition,the formation of PFHP coating shell can effectively improve the hydrophobicity and corrosion resistance of aluminum powder.
基金funded by the National Natural Science Foundation of China(81471595 to YL,81601360 to LZ,U1904157 to LL)The animal model development was supported by 111 Program(D20036).
文摘Neutrophils are crucial for immunity and play important roles in inflammatory diseases;however,mouse models selectively deficient in neutrophils are limited,and neutrophil-specific diphtheria toxin(DT)-based depletion system has not yet been established.In this study,we generated a novel knock-in mouse model expressing diphtheria toxin receptor(DTR)under control of the endogenous Ly6G promoter.We showed that DTR expression was restricted to Ly6G+neutrophils and complete depletion of neutrophils could be achieved by DT treatment at 24-48 h intervals.We characterized the effects of specific neutrophil depletion in mice at steady-state,with acute inflammation and during tumor growth.Our study presents a valuable new tool to study the roles of neutrophils in the immune system and during tumor progression.
基金supported by the National Natural Science Foundation of China(Grant no.32000491 to BHZ)projects 222300420015 and 2023DK2005 to YMLa start-up fund from Xinxiang Medical University(505483,to BHZ).
文摘Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in vivo.As key players in suppressing immune reactions,they help to preserve immune tolerance and are thus crucial for preventing autoimmune diseases.Within the tumor microenvironment(TME),Tregs facilitate tumor immune evasion by impairing the activity of effector cells via multiple mechanisms,thus contributing to the initiation and progression of tumors[1].To perform this regulatory function,Tregs depend on the master transcription factor forkhead box protein p3(Foxp3)[2].The expression of Foxp3 has emerged as indispensable for the development and optimal function of Tregs[3].Interestingly,different posttranslational modifications,including phosphorylation,ubiquitination,glycosylation,and acetylation,exert significant regulatory effects on the biological function of Foxp3[4-8].
基金supported by the Shaanxi Natural Science Foundation Research Plan (No. 2015JQ6238)the China Scholarship Council+3 种基金the National Natural Science Foundation of China(Nos. 61373083 and 61402273)the Fundamental Research Funds for the Central Universities of China (No. GK201401002)the Program of Shaanxi Science and Technology Innovation Team of China (No. 2014KTC18)the 111 Programme of Introducing Talents of Discipline to Universities (No. B16031)
文摘Multimedia data have become popularly transmitted content in opportunistic networks. A large amount of video data easily leads to a low delivery ratio. Breaking up these big data into small pieces or fragments is a reasonable option. The size of the fragments is critical to transmission efficiency and should be adaptable to the communication capability of a network. We propose a novel communication capacity calculation model of opportunistic network based on the classical random direction mobile model, define the restrain facts model of overhead, and present an optimal fragment size algorithm. We also design and evaluate the methods and algorithms with video data fragments disseminated in a simulated environment. Experiment results verified the effectiveness of the network capability and the optimal fragment methods.
