In the process of grinding carbon fiber reinforced polymer(CFRP),the changing state of acceleration vibration signal is closely related to the grinding surface quality.Therefore,the time domain and frequency domain si...In the process of grinding carbon fiber reinforced polymer(CFRP),the changing state of acceleration vibration signal is closely related to the grinding surface quality.Therefore,the time domain and frequency domain signal changes in acceleration can be used to monitor and control the grinding process to improve machining quality and efficiency.In this paper,changes in acceleration frequency domain signals under different grinding angles are studied,and the relationship between the vibration forms of acceleration frequency domain signals at the beginning,middle and end of grinding as well as the surface morphology and quality of the corresponding grinding position is studied.Combined with the micro-morphology of the grinding area,it can be seen that,a high frequency and low amplitude vibration can improve the grinding surface quality,but a high amplitude will have a negative impact on the grinding quality.The acceleration vibration during grinding is more stable and the corresponding surface quality is better.With an increase in grinding angle,the maximum amplitude of acceleration first increases and then decreases.The length of the surface fiber also initially decreases and then increases.Lastly,the resin residue first increases and then decreases.The purpose of this study is to provide a theoretical basis for the subsequent grinding state adjustment.展开更多
The divalent metal cations promote new bone formation through modulation of sensory and sympathetic nervous systems(SNS)activities.In addition,acetylcholine(Ach),as a chief neurotransmitter released by the parasympath...The divalent metal cations promote new bone formation through modulation of sensory and sympathetic nervous systems(SNS)activities.In addition,acetylcholine(Ach),as a chief neurotransmitter released by the parasympathetic nervous system(PNS),also affects bone remodeling,so it is of worth to investigate if the divalent cations influence PNS activity.Of note,these cations are key co-enzymes modulating glucose metabolism.Aerobic glycolysis rather than oxidative phosphorylation favors osteogenesis of mesenchymal stem cells(MSCs),so it is of interest to study the effects of these cations on glucose metabolic pathway.Prior to biological function assessment,the tolerance limits of the divalent metal cations(Mg^(2+),Zn^(2+),and Ca^(2+))and their combinations were profiled.In terms of direct effects,these divalent cations potentially enhanced migration and adhesion capability of MSCs through upregulating Tgf-β1 and Integrin-β1 levels.Interestingly,the divalent cations alone did not influence osteogenesis and aerobic glycolysis of undifferentiated MSCs.However,once the osteogenic differentiation of MSCs was initiated by neurotransmitters or osteogenic differentiation medium,the osteogenesis of MSCs could be significantly promoted by the divalent cations,which was accompanied by the improved aerobic glycolysis.In terms of indirect effects,the divalent cations significantly upregulated levels of sensory nerve derived CGRP,PNS produced choline acetyltransferase and type H vessels,while significantly tuned down sympathetic activity in the defect zone in rats,thereby contributing to significantly increased bone formation relative to the control group.Together,the divalent cations favor bone regeneration via modulation of sensory-autonomic nervous systems and promotion of aerobic glycolysis-driven osteogenesis of MSCs after osteogenic initiation by neurotransmitters.展开更多
基金Supported by the Qingdao Municipal Natural Science Foundation(Grant No.23-2-1-246-zyyd-jch)Lianyungang Municipal Key Research and Development Plan(Grant No.CG2310)。
文摘In the process of grinding carbon fiber reinforced polymer(CFRP),the changing state of acceleration vibration signal is closely related to the grinding surface quality.Therefore,the time domain and frequency domain signal changes in acceleration can be used to monitor and control the grinding process to improve machining quality and efficiency.In this paper,changes in acceleration frequency domain signals under different grinding angles are studied,and the relationship between the vibration forms of acceleration frequency domain signals at the beginning,middle and end of grinding as well as the surface morphology and quality of the corresponding grinding position is studied.Combined with the micro-morphology of the grinding area,it can be seen that,a high frequency and low amplitude vibration can improve the grinding surface quality,but a high amplitude will have a negative impact on the grinding quality.The acceleration vibration during grinding is more stable and the corresponding surface quality is better.With an increase in grinding angle,the maximum amplitude of acceleration first increases and then decreases.The length of the surface fiber also initially decreases and then increases.Lastly,the resin residue first increases and then decreases.The purpose of this study is to provide a theoretical basis for the subsequent grinding state adjustment.
基金supported by the National Natural Science Foundation of China(Grant Nos.:32271381,32471378 and 81971760)the Science and Technology Innovation Commission of Shenzhen(Grant No.:JCYJ20220530145601004)+4 种基金Guangdong Basic and Applied Basic Research Foundation(Grant No.:2024A1515010311)Dalian Medical Science Research Project(Grant NO.:2111038)State Key R&D Program(Grant NO.:2020JH2/10300093)Liaoning Provincial Department of Education Key Research Project(Grant NO.:LJKZZ20220148)Liaoning Provincial Health Commission,"Xingliao Plan of Excellence"Medical Masters Program(Grant NO.:YXMJ-QN-21).
文摘The divalent metal cations promote new bone formation through modulation of sensory and sympathetic nervous systems(SNS)activities.In addition,acetylcholine(Ach),as a chief neurotransmitter released by the parasympathetic nervous system(PNS),also affects bone remodeling,so it is of worth to investigate if the divalent cations influence PNS activity.Of note,these cations are key co-enzymes modulating glucose metabolism.Aerobic glycolysis rather than oxidative phosphorylation favors osteogenesis of mesenchymal stem cells(MSCs),so it is of interest to study the effects of these cations on glucose metabolic pathway.Prior to biological function assessment,the tolerance limits of the divalent metal cations(Mg^(2+),Zn^(2+),and Ca^(2+))and their combinations were profiled.In terms of direct effects,these divalent cations potentially enhanced migration and adhesion capability of MSCs through upregulating Tgf-β1 and Integrin-β1 levels.Interestingly,the divalent cations alone did not influence osteogenesis and aerobic glycolysis of undifferentiated MSCs.However,once the osteogenic differentiation of MSCs was initiated by neurotransmitters or osteogenic differentiation medium,the osteogenesis of MSCs could be significantly promoted by the divalent cations,which was accompanied by the improved aerobic glycolysis.In terms of indirect effects,the divalent cations significantly upregulated levels of sensory nerve derived CGRP,PNS produced choline acetyltransferase and type H vessels,while significantly tuned down sympathetic activity in the defect zone in rats,thereby contributing to significantly increased bone formation relative to the control group.Together,the divalent cations favor bone regeneration via modulation of sensory-autonomic nervous systems and promotion of aerobic glycolysis-driven osteogenesis of MSCs after osteogenic initiation by neurotransmitters.
