Infectious diseases are the common enemies of mankind.In the course of historical development,they persistently threaten human health and safety.Even today,despite the developments in medical science,we cannot escape ...Infectious diseases are the common enemies of mankind.In the course of historical development,they persistently threaten human health and safety.Even today,despite the developments in medical science,we cannot escape the fear and suffering caused by infectious diseases.Whether in ancient or modern times,the source of infection,route of transmission,and a susceptible population are the three key conditions for the prevalence and spread of infectious diseases.All factors closely related to these three conditions can affect the prevalence of infectious diseases.China is one of the cradles of world civilization.The ancient people accumulated a great deal of experience and lessons in the long struggle against infectious diseases.In the face of the current threat posed by widespread infectious disease,it is imperative to review and summarize ancient Chinese ideas and health policies on epidemic prevention and control to inspire contemporary efforts in the prevention and control of infectious disease.The combination of prevention-oriented epidemic prevention ideology and traditional medicine provides valuable insights,especially for impoverished and medically underserved regions.展开更多
Objective:To explore the effect of switching to sequential treatment of tenofovir disoproxil in patients with chronic hepatitis B HBeAg(+)who have a poor response to treatment,and to provide a theoretical basis for be...Objective:To explore the effect of switching to sequential treatment of tenofovir disoproxil in patients with chronic hepatitis B HBeAg(+)who have a poor response to treatment,and to provide a theoretical basis for better clinical treatment of chronic hepatitis B HBeAg(+)patients.Methods:Totally 90 patients with chronic hepatitis B HBeAg(+)treated in our hospital from December 2016 to December 2018 were selected as the research subjects and randomly divided into the extension group treated tenofovir disoproxil fumarate tablets and the diversion group treated with tenofovir disoproxil,45 cases in each group.Compare the statistical differences of the content of HBeAg and HBV-DNA,liver function indicators(TBIL,TC,INR ratio),serological and biochemical responses,adverse reactions(gastrointestinal symptoms and nausea/weakness,rash)in the two groups of patients before and after treatment.Results:Comparing the efficacy of the 12-month extension group with the diversion group.It was found that the HBeAg(0.69±0.10PEI/mL)and HBV-DNA(3.26±0.94IU/mL)in the diversion group were lower than those in the extension group(0.90±0.17 PEI/mL)and HBV-DNA(4.37±1.26IU/mL),and the differences were statistically significant(P<0.05).Comparing the efficacy of the 12-month extended group with the diversion group,it was found that the TBIL content in the diversion group(1035.72±92.44umol/L)was higher than that in the extension group(234.72±27.56umol/L)and the the TBILINR ratio was lower(2.70±0.39),and the differences were statistically significant(P<0.05).Comparing the 12-month difference between the extension and diversion groups,it was found that the HBeg reversion rate in the diversion group(36 cases,80.00%)was higher than that in the extended group(27 cases,60.00%),and the HBeg LT recovery rate It was also higher than the extended use group(22 cases,48.89%),and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the extension group(17 cases,37.78%)was higher than that in the diverted group(8 cases,17.78%),and the difference was statistically significant(P<0.05).Conclusion:For patients with chronic hepatitis B HBeAg(+)with poor response to treatment,switching to tenofovir disoproxil sequential treatment can not only improve the treatment effect,but also effectively reduce the occurrence of adverse reactions.展开更多
文摘Infectious diseases are the common enemies of mankind.In the course of historical development,they persistently threaten human health and safety.Even today,despite the developments in medical science,we cannot escape the fear and suffering caused by infectious diseases.Whether in ancient or modern times,the source of infection,route of transmission,and a susceptible population are the three key conditions for the prevalence and spread of infectious diseases.All factors closely related to these three conditions can affect the prevalence of infectious diseases.China is one of the cradles of world civilization.The ancient people accumulated a great deal of experience and lessons in the long struggle against infectious diseases.In the face of the current threat posed by widespread infectious disease,it is imperative to review and summarize ancient Chinese ideas and health policies on epidemic prevention and control to inspire contemporary efforts in the prevention and control of infectious disease.The combination of prevention-oriented epidemic prevention ideology and traditional medicine provides valuable insights,especially for impoverished and medically underserved regions.
基金Wuhan science and technology bureau(No.2015061701011646).
文摘Objective:To explore the effect of switching to sequential treatment of tenofovir disoproxil in patients with chronic hepatitis B HBeAg(+)who have a poor response to treatment,and to provide a theoretical basis for better clinical treatment of chronic hepatitis B HBeAg(+)patients.Methods:Totally 90 patients with chronic hepatitis B HBeAg(+)treated in our hospital from December 2016 to December 2018 were selected as the research subjects and randomly divided into the extension group treated tenofovir disoproxil fumarate tablets and the diversion group treated with tenofovir disoproxil,45 cases in each group.Compare the statistical differences of the content of HBeAg and HBV-DNA,liver function indicators(TBIL,TC,INR ratio),serological and biochemical responses,adverse reactions(gastrointestinal symptoms and nausea/weakness,rash)in the two groups of patients before and after treatment.Results:Comparing the efficacy of the 12-month extension group with the diversion group.It was found that the HBeAg(0.69±0.10PEI/mL)and HBV-DNA(3.26±0.94IU/mL)in the diversion group were lower than those in the extension group(0.90±0.17 PEI/mL)and HBV-DNA(4.37±1.26IU/mL),and the differences were statistically significant(P<0.05).Comparing the efficacy of the 12-month extended group with the diversion group,it was found that the TBIL content in the diversion group(1035.72±92.44umol/L)was higher than that in the extension group(234.72±27.56umol/L)and the the TBILINR ratio was lower(2.70±0.39),and the differences were statistically significant(P<0.05).Comparing the 12-month difference between the extension and diversion groups,it was found that the HBeg reversion rate in the diversion group(36 cases,80.00%)was higher than that in the extended group(27 cases,60.00%),and the HBeg LT recovery rate It was also higher than the extended use group(22 cases,48.89%),and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the extension group(17 cases,37.78%)was higher than that in the diverted group(8 cases,17.78%),and the difference was statistically significant(P<0.05).Conclusion:For patients with chronic hepatitis B HBeAg(+)with poor response to treatment,switching to tenofovir disoproxil sequential treatment can not only improve the treatment effect,but also effectively reduce the occurrence of adverse reactions.
