The high-pressure phase diagram of the Nb-Ti binary system at 0 K is explored by systematic crystal structure prediction.The results highlight a novel niobium-rich bcc phase,Nb_(7)Ti,which is the only dynamically stab...The high-pressure phase diagram of the Nb-Ti binary system at 0 K is explored by systematic crystal structure prediction.The results highlight a novel niobium-rich bcc phase,Nb_(7)Ti,which is the only dynamically stable ordered Nb-Ti compound under ambient pressure.Extensive first-principles calculations have provided insights into the electronic structure,bonding and superconducting properties of Nb_(7)Ti.The superconducting transition temperature(T_(c))for Nb_(7)Ti at ambient pressure is estimated within the framework of BCS theory to be about 17.5 K,which is significantly higher—nearly double—that of the widely utilized NbTi alloy.Furthermore,the results unveil that the high T_(c) is mainly attributed to the unique ordered lattice along with the strong electron-phonon coupling driven by interatomic interactions at mid-frequency and phonon softening induced by low-frequency Fermi surface nesting.Valuable insights are provided for the subsequent synthesis of application-oriented superconductors at low pressure.展开更多
In the context of reducing its carbon emissions,the Chinese steel industry is currently undergoing an intelligent transformation to enhance its profitability and sustainability.The optimization of production planning ...In the context of reducing its carbon emissions,the Chinese steel industry is currently undergoing an intelligent transformation to enhance its profitability and sustainability.The optimization of production planning and scheduling plays a pivotal role in realizing these objectives such as improving production efficiency,saving energy,reducing carbon emissions,and enhancing quality.However,current practices in steel enterprises are largely dependent on experience-driven manual decision approaches supported by information systems,which are inadequate to meet the complex requirements of the industry.This study explores the current situation in production planning and scheduling,analyzes the characteristics and limitations of existing methods,and emphasizes the necessity and trends of intelligent systems.It surveys the current literature on production planning and scheduling in steel enterprises and analyzes the theoretical advancements and practical challenges associated with combinatorial and sequential optimization in this field.A key focus is on the limitations of current models and algorithms in effectively addressing the multi-objective and multiconstraint characteristics of steel produc-tion.To overcome these challenges,a novel framework for intelligent production planning and scheduling is proposed.This framework leverages data-and knowledge-driven decision-making and scenario adaptability,enabling the system to respond dynamically to real-time production conditions and market fluctuations.By integrating artificial intelligence and advanced optimization methodologies,the proposed framework improves the efficiency,cost-effectiveness,and environmental sustainability of steel manufacturing.展开更多
L-Theanine(LTA)is a non-protein amino acid mainly found in tea plants with many beneficial effects.Exercise exerts a wide range of benefits in metabolic health.Here,we show that exercise or gastric lavage intervention...L-Theanine(LTA)is a non-protein amino acid mainly found in tea plants with many beneficial effects.Exercise exerts a wide range of benefits in metabolic health.Here,we show that exercise or gastric lavage intervention on mice with LTA improves diet-induced nonalcoholic steatohepatitis(NASH)in mice.Meanwhile,combinatory therapy shows that exercise and LTA synergistically improve obesity-related metabolic disorders and NASH phenotypes,including hepatic steatosis,inflammation,cell death and oxidative stress.In vivo studies indicate that LTA inhibits free fatty acid(FFA)-induced hepatocyte injury,including steatosis,oxidative stress and apoptosis.Knockdown of Nrf2 blunts the role of LTA in inhibiting FFA-induced hepatocyte oxidative stress and dysfunction.Mechanistically,LTA increases theα-ketoglutarate(α-KG)level in hepatocytes,which increases the transcription of Nrf2 by inducing active DNA demethylation on its promoter.Moreover,LTA promote the aboveα-KG/Nrf2 axis in synergy with exercise,thereby more efficiently inhibiting hepatic oxidative stress and ameliorating diet-induced NASH in mice.Our results suggest that,through promoting theα-KG/Nrf2 axis-mediated anti-oxidative pathway,the combination of LTA and exercise may provide an effective measure for the prevention and control of NASH.展开更多
BACKGROUND Knee osteoarthritis(KOA)is a chronic condition characterized by joint pain and dysfunction,driven by aging and obesity.Research indicates that the gut microbiota significantly influences KOA,potentially aff...BACKGROUND Knee osteoarthritis(KOA)is a chronic condition characterized by joint pain and dysfunction,driven by aging and obesity.Research indicates that the gut microbiota significantly influences KOA,potentially affecting inflammation and disease progression through the gut-joint axis.Traditional treatments like nonsteroidal anti-inflammatory drugs offer symptom relief but have adverse effects.Emerging therapies like electroacupuncture(EA)and Tuina(TN)have shown promise in alleviating pain and improving joint function by targeting the gut microbiota.AIM To clarify the efficacy of EA with TN in treating KOA and its effect on gut microbiota regulation.METHODS Sixty patients with KOA were allocated to EA or EA+TN(ET)group(n=30 each).Seven acupoints were punctured.The ET group received TN after each EA session.Both groups completed 12 sessions.The visual analog scale(VAS)for assessing pain and the Western Ontario and McMaster Universities osteoarthritis index(WOMAC)for measuring pain intensity,joint stiffness,and functional capacity were employed to assess clinical outcomes.Pre-and post-treatment fecal specimens underwent 16S ribosomal RNA sequencing to analyze the gut microbiota.RESULTS The ET group showed higher rates of“effective”and“markedly effective”outcomes.The VAS score of the ET group remained significantly lower than that of the EA group(P<0.001)immediately after treatment and 1 week post-treatment.The total WOMAC score(P<0.001),pain(P=0.191),stiffness(P=0.015),and function scores(P<0.001)decreased significantly in the ET group post-treatment.The gut microbiota analysis revealed no significant changes in alpha diversity in either group.Beta-diversity analysis indicated distinct patterns in the ET group before and after treatment.Significant changes in microbial abundance were detected in both groups,highlighting variations in Firmicutes,Actinobacteria,Proteobacteria,and Bacteroidetes.CONCLUSION ET outperforms EA alone in improving KOA pain,stiffness,and function,potentially via gut microbiota modulation,intestinal barrier protection,and inflammation reduction.展开更多
Obtaining inertial fusion energy requires higher gain in laser indirect drive inertial confinement fusion(ICF),but traditional cylindrical hohlraums face two persistent challenges:low energy coupling efficiency from t...Obtaining inertial fusion energy requires higher gain in laser indirect drive inertial confinement fusion(ICF),but traditional cylindrical hohlraums face two persistent challenges:low energy coupling efficiency from the hohlraum to the capsule and severe inner beam interception by outer gold bubbles,both needing optimization for improved ICF performance.In this paper,a new domed-rugby hohlraum design is proposed.The novel and optimized hohlraum configuration increases the energy coupling efficiency by reducing the wall surface and energy loss with a rugby-shaped geometry,thereby enhancing the radiation source temperature.Simultaneously,through a special toroidal dome structure,the interaction between the outer bubble plasma and inner laser beams is mitigated,allowing the inner laser beams to reach the waist of the hohlraum.As a result,more spherical implosions are obtained and the quality of the radiation source is improved.It has been simulated that on the 100 kJ class laser facility,there is a 20%higher neutron yield.The integrated implosion performance is expected to be significantly advanced in such a novel configuration,providing a new concept for hohlraum configuration designs with a high-temperature and high-quality radiation source.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.12122405,12274169,and 11574109)the Fundamental Research Funds for the Central Universities。
文摘The high-pressure phase diagram of the Nb-Ti binary system at 0 K is explored by systematic crystal structure prediction.The results highlight a novel niobium-rich bcc phase,Nb_(7)Ti,which is the only dynamically stable ordered Nb-Ti compound under ambient pressure.Extensive first-principles calculations have provided insights into the electronic structure,bonding and superconducting properties of Nb_(7)Ti.The superconducting transition temperature(T_(c))for Nb_(7)Ti at ambient pressure is estimated within the framework of BCS theory to be about 17.5 K,which is significantly higher—nearly double—that of the widely utilized NbTi alloy.Furthermore,the results unveil that the high T_(c) is mainly attributed to the unique ordered lattice along with the strong electron-phonon coupling driven by interatomic interactions at mid-frequency and phonon softening induced by low-frequency Fermi surface nesting.Valuable insights are provided for the subsequent synthesis of application-oriented superconductors at low pressure.
基金supported by the Key Program of the National Natural Science Foundation of China(Nos.52334008 and 51734004).
文摘In the context of reducing its carbon emissions,the Chinese steel industry is currently undergoing an intelligent transformation to enhance its profitability and sustainability.The optimization of production planning and scheduling plays a pivotal role in realizing these objectives such as improving production efficiency,saving energy,reducing carbon emissions,and enhancing quality.However,current practices in steel enterprises are largely dependent on experience-driven manual decision approaches supported by information systems,which are inadequate to meet the complex requirements of the industry.This study explores the current situation in production planning and scheduling,analyzes the characteristics and limitations of existing methods,and emphasizes the necessity and trends of intelligent systems.It surveys the current literature on production planning and scheduling in steel enterprises and analyzes the theoretical advancements and practical challenges associated with combinatorial and sequential optimization in this field.A key focus is on the limitations of current models and algorithms in effectively addressing the multi-objective and multiconstraint characteristics of steel produc-tion.To overcome these challenges,a novel framework for intelligent production planning and scheduling is proposed.This framework leverages data-and knowledge-driven decision-making and scenario adaptability,enabling the system to respond dynamically to real-time production conditions and market fluctuations.By integrating artificial intelligence and advanced optimization methodologies,the proposed framework improves the efficiency,cost-effectiveness,and environmental sustainability of steel manufacturing.
基金supported by the National Natural Science Foundation of China(82571021,32070751 and 31871435)the Shanghai Natural Science Foundation(25ZR1401328)the Program for Overseas High-level talents at Shanghai Institutions of Higher Learning(TP2022100)。
文摘L-Theanine(LTA)is a non-protein amino acid mainly found in tea plants with many beneficial effects.Exercise exerts a wide range of benefits in metabolic health.Here,we show that exercise or gastric lavage intervention on mice with LTA improves diet-induced nonalcoholic steatohepatitis(NASH)in mice.Meanwhile,combinatory therapy shows that exercise and LTA synergistically improve obesity-related metabolic disorders and NASH phenotypes,including hepatic steatosis,inflammation,cell death and oxidative stress.In vivo studies indicate that LTA inhibits free fatty acid(FFA)-induced hepatocyte injury,including steatosis,oxidative stress and apoptosis.Knockdown of Nrf2 blunts the role of LTA in inhibiting FFA-induced hepatocyte oxidative stress and dysfunction.Mechanistically,LTA increases theα-ketoglutarate(α-KG)level in hepatocytes,which increases the transcription of Nrf2 by inducing active DNA demethylation on its promoter.Moreover,LTA promote the aboveα-KG/Nrf2 axis in synergy with exercise,thereby more efficiently inhibiting hepatic oxidative stress and ameliorating diet-induced NASH in mice.Our results suggest that,through promoting theα-KG/Nrf2 axis-mediated anti-oxidative pathway,the combination of LTA and exercise may provide an effective measure for the prevention and control of NASH.
基金Supported by Chongqing Municipal Health and Family Planning Commission and Chongqing Municipal Science and Technology Commission Jointly Funded Key Research Projects in Traditional Chinese Medicine,No.ZY201801007。
文摘BACKGROUND Knee osteoarthritis(KOA)is a chronic condition characterized by joint pain and dysfunction,driven by aging and obesity.Research indicates that the gut microbiota significantly influences KOA,potentially affecting inflammation and disease progression through the gut-joint axis.Traditional treatments like nonsteroidal anti-inflammatory drugs offer symptom relief but have adverse effects.Emerging therapies like electroacupuncture(EA)and Tuina(TN)have shown promise in alleviating pain and improving joint function by targeting the gut microbiota.AIM To clarify the efficacy of EA with TN in treating KOA and its effect on gut microbiota regulation.METHODS Sixty patients with KOA were allocated to EA or EA+TN(ET)group(n=30 each).Seven acupoints were punctured.The ET group received TN after each EA session.Both groups completed 12 sessions.The visual analog scale(VAS)for assessing pain and the Western Ontario and McMaster Universities osteoarthritis index(WOMAC)for measuring pain intensity,joint stiffness,and functional capacity were employed to assess clinical outcomes.Pre-and post-treatment fecal specimens underwent 16S ribosomal RNA sequencing to analyze the gut microbiota.RESULTS The ET group showed higher rates of“effective”and“markedly effective”outcomes.The VAS score of the ET group remained significantly lower than that of the EA group(P<0.001)immediately after treatment and 1 week post-treatment.The total WOMAC score(P<0.001),pain(P=0.191),stiffness(P=0.015),and function scores(P<0.001)decreased significantly in the ET group post-treatment.The gut microbiota analysis revealed no significant changes in alpha diversity in either group.Beta-diversity analysis indicated distinct patterns in the ET group before and after treatment.Significant changes in microbial abundance were detected in both groups,highlighting variations in Firmicutes,Actinobacteria,Proteobacteria,and Bacteroidetes.CONCLUSION ET outperforms EA alone in improving KOA pain,stiffness,and function,potentially via gut microbiota modulation,intestinal barrier protection,and inflammation reduction.
基金supported by National Natural Science Foundation of China(Nos.12105269,12075218 and 12175210)。
文摘Obtaining inertial fusion energy requires higher gain in laser indirect drive inertial confinement fusion(ICF),but traditional cylindrical hohlraums face two persistent challenges:low energy coupling efficiency from the hohlraum to the capsule and severe inner beam interception by outer gold bubbles,both needing optimization for improved ICF performance.In this paper,a new domed-rugby hohlraum design is proposed.The novel and optimized hohlraum configuration increases the energy coupling efficiency by reducing the wall surface and energy loss with a rugby-shaped geometry,thereby enhancing the radiation source temperature.Simultaneously,through a special toroidal dome structure,the interaction between the outer bubble plasma and inner laser beams is mitigated,allowing the inner laser beams to reach the waist of the hohlraum.As a result,more spherical implosions are obtained and the quality of the radiation source is improved.It has been simulated that on the 100 kJ class laser facility,there is a 20%higher neutron yield.The integrated implosion performance is expected to be significantly advanced in such a novel configuration,providing a new concept for hohlraum configuration designs with a high-temperature and high-quality radiation source.
