Ultra-high dose rate flash radiotherapy(FLASH-RT)has attracted wide attention in the field of radiotherapy in recent years.For FLASH-RT,radiation is delivered at a very high dose rate[usually thousands of times compar...Ultra-high dose rate flash radiotherapy(FLASH-RT)has attracted wide attention in the field of radiotherapy in recent years.For FLASH-RT,radiation is delivered at a very high dose rate[usually thousands of times compared with conventional radiotherapy(CONV-RT)]in an extremely short time.This novel irradiation technique shows a protective effect on normal tissues,also known as the flash effect.At the same time,FLASH-RT is comparable to CONV-RT in terms of tumorkilling efficacy.As basic research dedicates to uncover the mechanisms by which FLASH-RT reduces radiation-induced normal tissue damage,clinical trials of FLASH-RT have been gradually conducted worldwide.This article systematically reviews the evidence of the feasibility and safety of FLASH-RT in clinical practice and offers insights into the future translation of this technology in clinic.展开更多
Genetic factors play a critical role in autoimmune hepatitis (AIH), and numerous studies have been conducted to identify variants associated with the risk of AIH. However, our knowledge of these genetic risk factors i...Genetic factors play a critical role in autoimmune hepatitis (AIH), and numerous studies have been conducted to identify variants associated with the risk of AIH. However, our knowledge of these genetic risk factors is still limited. In this study, we aim to provide a comprehensive synopsis of the genetic architecture of this disease. A systematic search was conducted to identify published studies on the associations between genetic variants and the risk of AIH. Meta-analyses were conducted to calculate the pooled odds ratio (OR) and 95% confidence interval (CI). Then, the cumulative evidence was evaluated for significant associations according to the Venice criteria and false-positive report probability. Finally, functional annotations and pathway analyses were conducted to identify potential pathogenic loci and related pathways. In total, 62 studies involving 11,068 cases and 45,482 controls were included to assess the association between 75 genetic variants and the risk of AIH. Among them, 24 variants were associated with the risk of AIH, and there is strong cumulative evidence supporting these associations. Importantly, HLA DRB1*0301 (OR: 3.023, 95% CI: 2.443 - 1.678, P = 2.81 × 10?24) and DRB3*0101 (OR: 3.667, 95% CI: 2.649 - 5.075, P = 4.69 × 10?15) are newly identified genome-wide significant risk loci. In addition, the rs3184504 variant (OR: 1.305, 95% CI: 1.122 - 1.516, P = 0.001) in the SH2B3 gene is a potential functional mutation. GO pathway analysis suggests that these genes are enriched in antigen processing and presentation, response to interferon-gamma, and immune response-regulating signaling pathways. This study comprehensively summarizes the genetic architecture of AIH and provides cumulative evidence. We have identified two new loci that exceed genome-wide significance. The findings from this study will offer new insights into the pathogenesis of AIH.展开更多
Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for...Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence.展开更多
Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracel...Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracellular materials or damaged organelles,is generated.The autophagosome is transported toward and eventually fuses with the lysosome(or the vacuole in yeast and plant cells).展开更多
Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rare...Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rarely focused on hypopharyngeal carcinoma(HPC).In our study,the effect of FST expression on HPC tissues and cell lines was investigated.Methods:A total of 60 patients with HPC were recruited for this study.Levels of FST mRNA and protein were measured by quantitative polymerase chain reaction(PCR)and immunohistochemistry in HPC tissue samples and by qPCR in the HPC FaDu cells,as well as immortal nasopharyngeal epithelial cell line NP-69 cells.After silencing the FST expression in FaDu cells using lentivirus-mediated siRNA that was specific for FST mRNA,cell proliferation was determined by a Celigo assay.Tumor growth was monitored in nude mice and viability was determined by a methylthiazoletetrazolium assay.The ratio of cell cycle arrest and apoptosis was evaluated by flow cytometry.The colony formation ability was performed using Giemsa staining.In addition,wound healing and Transwell migration and invasion assays were performed for the analysis of cell motility.Results:FST expression was significantly higher in human HPC tissue and FaDu cells than in normal tissue and NP-69 cells.A higher expression of FST in HPC samples was positively correlated with advanced tumors.Moreover,FST knockdown by shRNA significantly decreased cell growth,colony formation,migration and invasion.Furthermore,FST silencing increased the cell apoptosis percentage,and arrested cell cycle in the S phase in FaDu cells.In addition,FST silencing suppressed tumor growth in vivo.Conclusions:Our results indicated that the FST gene was associated with HPC progression and may serve as a potential therapeutic target for the treatment of HPC.展开更多
BACKGROUND Spontaneous esophageal rupture or Boerhaave’s syndrome is a rare and acute disease with a high incidence of misdiagnosis and mortality.Here,we aimed to explore the clinical characteristics,diagnosis,treatm...BACKGROUND Spontaneous esophageal rupture or Boerhaave’s syndrome is a rare and acute disease with a high incidence of misdiagnosis and mortality.Here,we aimed to explore the clinical characteristics,diagnosis,treatment,and prognosis of spontaneous esophageal rupture,and to analyze the causes of misdiagnosis during the treatment of spontaneous esophageal rupture.CASE SUMMARY The clinical features of the patient with spontaneous esophageal rupture misdiagnosed earlier as pleural effusion were retrospectively analyzed and the reasons for misdiagnosis are discussed based on a current review of the literature.The patient was admitted to a local hospital due to shortness of breath accompanied by vomiting and abdominal distension for five hours.Based on the computed tomography(CT)scan analysis,clinically,right pleural effusion was diagnosed.However,the patient was unwilling to undergo right closed thoracic drainage.The patient also had intermittent fevers against infection,and during the course of treatment,he complained of chest pain,following which,he was transferred to our hospital.Grapefruit-like residue drainage fluid was observed.Re-examination of the chest CT scans suggested the presence of spontaneous perforation in the upper left esophagus.Therefore,the patient underwent an urgent esophageal hiatus repair.Unfortunately,the patient died of infection and respiratory failure due to progressive dyspnea after surgery.CONCLUSION Spontaneous esophageal rupture is a rare disease associated with high fatality.The patients do not present typical clinical symptoms and the disease progresses rapidly.This case report highlights the importance of a dynamic review of chest CT scan,not only for the initial identification of segmental injury but also for prioritizing subsequent treatment strategies.Moreover,we have presented some clues for clinicians to recognize and diagnose spontaneous esophageal rupture at rare sites(upper-esophageal segment)through this case report of spontaneous esophageal rupture that caused the patient’s death.We have also summarized the reasons for the misdiagnosis and lessons learned.展开更多
This corrigendum clarifies statement in the article"Biogenesis of autophagosomes from the ERGIC membrane system"by Han et al.(2023).In the"The role of ERGIC-equivalents and COPll vesicles in autophagy i...This corrigendum clarifies statement in the article"Biogenesis of autophagosomes from the ERGIC membrane system"by Han et al.(2023).In the"The role of ERGIC-equivalents and COPll vesicles in autophagy in yeast"section,the statement that"At least one answer is that they remove together components for membrane fusion."should be corrected into"At least one answer is that they bring components for membrane fusion.".展开更多
Spinal epidural hemorrhages(SEDH)caused by spinal epidural arteriovenous fistulas(SEAVFs)are rare;thus,their specific pathogenesis has not been explained.Furthermore,the standard treatment for SEAVFs has not yet been ...Spinal epidural hemorrhages(SEDH)caused by spinal epidural arteriovenous fistulas(SEAVFs)are rare;thus,their specific pathogenesis has not been explained.Furthermore,the standard treatment for SEAVFs has not yet been defined.Here we report the case of a 36-year-old Chinese man who experienced acute onset chest pain and tightness.His symptoms rapidly aggravated until the lower limbs were unable to support him.Spinal magnetic resonance angiography(MRA)revealed a localized SEAVF and a secondary spinal cord lesion at the T4 level.Digital subtraction angiography(DSA)confirmed the presence of the SEDH/SEAVF at the T3–4 level with the left radicular artery feeding the fistula.Based on DSA and MRA findings,SEDH,local spinal cord infarction,and spinal venous reflux disorder were conditionally diagnosed.Using the arterial route,Onyx-34 was injected into the fistula to embolize the feeding arteries and the venous system.Angiography was performed after the microcatheter was withdrawn,and no residual fistula or anterior spinal artery was observed.The six-week follow-up MRI showed acceptable healing of the SEAVF,and the patient improved neurologically.This case suggests that endovascular treatment with Onyx-34 embolization should be considered a promising treatment strategy for this type of complicated SEAVF.展开更多
A general framework for observatory control software would help to improve the efficiency of observation and operation of telescopes, and would also be advantageous for remote and joint observations. We describe a gen...A general framework for observatory control software would help to improve the efficiency of observation and operation of telescopes, and would also be advantageous for remote and joint observations. We describe a general framework for observatory control software, which considers principles of flexibility and inheritance to meet the expectations from observers and technical personnel. This framework includes observation scheduling, device control and data storage. The design is based on a finite state machine that controls the whole process.展开更多
The Si Tian project,designed to utilize 60 telescopes distributed across multiple sites in China,is a next-generation timedomain survey initiative.As a pathfinder for the Si Tian project,the Mini-Si Tian(MST)has been ...The Si Tian project,designed to utilize 60 telescopes distributed across multiple sites in China,is a next-generation timedomain survey initiative.As a pathfinder for the Si Tian project,the Mini-Si Tian(MST)has been proposed and implemented to test the Si Tian’s brain and data pipeline,and to evaluate the feasibility of its technology and science cases.Mounted at the Xinglong Observatory,the MST project comprises three 30 cm telescopes and has been operated since 2022 November.Each telescope of the MST possesses a large field of view,covering 2°.29×1°.53 FOV,and is equipped withg',r'andi'filters,respectively.Acting as the pioneer of the forthcoming Si Tian project,the MST is dedicated to the discovery of variable stars,transients,and outburst events,and has already obtained some interesting scientific results.In this paper,we will summarize the first-two-year operation of the MST project.展开更多
This paper presents a comprehensive analysis of the photometric system of the University of Chinese Academy of Sciences 70 cm Telescope located at the Yan-qi Lake campus of the University of Chinese Academy of Science...This paper presents a comprehensive analysis of the photometric system of the University of Chinese Academy of Sciences 70 cm Telescope located at the Yan-qi Lake campus of the University of Chinese Academy of Sciences.We evaluated the linearity,bias stability,and dark current of the camera.Utilizing the Johnson-Cousins Blue-Visible-Red-Infrared filter system and an Andor DZ936 charge-coupled device camera,we conducted extensive observations of Landolt standard stars to determine the color terms,atmospheric extinction coefficients,photometric zero-points,and the sky background brightness.The results indicate that this telescope demonstrates excellent performance in photometric calibration and good system performance overall,meeting the requirements for limited scientific research and teaching purposes.展开更多
The SiTian Project represents a groundbreaking initiative in astronomy,aiming to deploy a global network of telescopes,each with a 1 m aperture,for comprehensive time-domain sky surveys.The network's innovative ar...The SiTian Project represents a groundbreaking initiative in astronomy,aiming to deploy a global network of telescopes,each with a 1 m aperture,for comprehensive time-domain sky surveys.The network's innovative architecture features multiple observational nodes,each comprising three strategically aligned telescopes equipped with filters.This design enables three-color(g,r,i)channel imaging within each node,facilitating precise and coordinated observations.As a pathfinder to the full-scale project,the Mini-SiTian Project serves as the scientific and technological validation platform,utilizing three 30 cm aperture telescopes to validate the methodologies and technologies planned for the broader SiTian network.This paper focuses on the development and implementation of the Master Control System(MCS),and the central command hub for the Mini-SiTian Array.The MCS is designed to facilitate seamless communication with the SiTian Brain,the project's central processing and decisionmaking unit,while ensuring accurate task allocation,real-time status monitoring,and optimized observational workflows.The system adopts a robust architecture that separates front-end and back-end functionalities.A key innovation of the MCS is its ability to dynamically adjust observation plans in response to transient source alerts,enabling rapid and coordinated scans of target sky regions.The paper provides an in-depth analysis of the system's internal components,including the communication system,which is critical for seamless network operation.Extensive testing has validated the functionality,reliability,and compatibility of these components within the overall system architecture.The successful deployment of the MCS in managing the Mini-SiTian Array has demonstrated its practicality and efficacy in collaborative observation and distributed control.By simplifying cluster management and ensuring data integrity,the MCS represents a significant advancement in astronomical observation control systems.Its scalable and adaptable design not only supports the future expansion of the SiTian network but also provides a blueprint for other large-scale telescope arrays,marking a transformative step forward in time-domain astronomy.展开更多
We assess the detectability of tidal disruption events(TDEs)using mock observations from the Mini-SiTian Array.We select 100 host galaxy samples from a simulated galaxy catalog based on specific criteria such as redsh...We assess the detectability of tidal disruption events(TDEs)using mock observations from the Mini-SiTian Array.We select 100 host galaxy samples from a simulated galaxy catalog based on specific criteria such as redshift,black hole mass,and event rate.Taking into account the site conditions and survey strategy,we simulate observations over a 440 deg^(2)field.The results indicate that 0.53±0.73 TDEs can be detected per year when observing in both g and r bands with 300 s exposures every 3 days.Applying this method to the SiTian project,we expect to discover approximately 204 TDEs annually,heralding a new era in TDE science.展开更多
文摘Ultra-high dose rate flash radiotherapy(FLASH-RT)has attracted wide attention in the field of radiotherapy in recent years.For FLASH-RT,radiation is delivered at a very high dose rate[usually thousands of times compared with conventional radiotherapy(CONV-RT)]in an extremely short time.This novel irradiation technique shows a protective effect on normal tissues,also known as the flash effect.At the same time,FLASH-RT is comparable to CONV-RT in terms of tumorkilling efficacy.As basic research dedicates to uncover the mechanisms by which FLASH-RT reduces radiation-induced normal tissue damage,clinical trials of FLASH-RT have been gradually conducted worldwide.This article systematically reviews the evidence of the feasibility and safety of FLASH-RT in clinical practice and offers insights into the future translation of this technology in clinic.
文摘Genetic factors play a critical role in autoimmune hepatitis (AIH), and numerous studies have been conducted to identify variants associated with the risk of AIH. However, our knowledge of these genetic risk factors is still limited. In this study, we aim to provide a comprehensive synopsis of the genetic architecture of this disease. A systematic search was conducted to identify published studies on the associations between genetic variants and the risk of AIH. Meta-analyses were conducted to calculate the pooled odds ratio (OR) and 95% confidence interval (CI). Then, the cumulative evidence was evaluated for significant associations according to the Venice criteria and false-positive report probability. Finally, functional annotations and pathway analyses were conducted to identify potential pathogenic loci and related pathways. In total, 62 studies involving 11,068 cases and 45,482 controls were included to assess the association between 75 genetic variants and the risk of AIH. Among them, 24 variants were associated with the risk of AIH, and there is strong cumulative evidence supporting these associations. Importantly, HLA DRB1*0301 (OR: 3.023, 95% CI: 2.443 - 1.678, P = 2.81 × 10?24) and DRB3*0101 (OR: 3.667, 95% CI: 2.649 - 5.075, P = 4.69 × 10?15) are newly identified genome-wide significant risk loci. In addition, the rs3184504 variant (OR: 1.305, 95% CI: 1.122 - 1.516, P = 0.001) in the SH2B3 gene is a potential functional mutation. GO pathway analysis suggests that these genes are enriched in antigen processing and presentation, response to interferon-gamma, and immune response-regulating signaling pathways. This study comprehensively summarizes the genetic architecture of AIH and provides cumulative evidence. We have identified two new loci that exceed genome-wide significance. The findings from this study will offer new insights into the pathogenesis of AIH.
基金supported by the National Natural Science Foundation of China (Nos. 81572978 and 81760638)Special Science and Frontier Technology Research Project of Chongqing(No. cstc2016jcyj A0520)+1 种基金Innovative Technology in Military and Clinical Medicine (No. 2018JSLC0035)Natural Science Foundation of Xinjiang Province (No. 2017D01C200)。
文摘Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for drug delivery. In this study, we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX) using a p H-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions, while disassemble under the tumor microenvironment. Especially, at p H 5.8, its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure, which enhanced cellular uptake of DOX. In addition, FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sustained drug release and improve antitumor efficacy. This octapeptide opens up new avenues for promoting the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence.
基金funded by Beijing Natural Science Foundation(JQ20028)the National Natural Science Foundation of China(32130023,91854114,32061143009)Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602,2021YFA0804802)。
文摘Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracellular materials or damaged organelles,is generated.The autophagosome is transported toward and eventually fuses with the lysosome(or the vacuole in yeast and plant cells).
基金supported by the Project of Young and Middle-aged Scientific Research Fund of Wannan Medical College(No.WK2019F11).
文摘Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its receptor.Although the prognostic value of FST in various cancers has been investigated previously,studies rarely focused on hypopharyngeal carcinoma(HPC).In our study,the effect of FST expression on HPC tissues and cell lines was investigated.Methods:A total of 60 patients with HPC were recruited for this study.Levels of FST mRNA and protein were measured by quantitative polymerase chain reaction(PCR)and immunohistochemistry in HPC tissue samples and by qPCR in the HPC FaDu cells,as well as immortal nasopharyngeal epithelial cell line NP-69 cells.After silencing the FST expression in FaDu cells using lentivirus-mediated siRNA that was specific for FST mRNA,cell proliferation was determined by a Celigo assay.Tumor growth was monitored in nude mice and viability was determined by a methylthiazoletetrazolium assay.The ratio of cell cycle arrest and apoptosis was evaluated by flow cytometry.The colony formation ability was performed using Giemsa staining.In addition,wound healing and Transwell migration and invasion assays were performed for the analysis of cell motility.Results:FST expression was significantly higher in human HPC tissue and FaDu cells than in normal tissue and NP-69 cells.A higher expression of FST in HPC samples was positively correlated with advanced tumors.Moreover,FST knockdown by shRNA significantly decreased cell growth,colony formation,migration and invasion.Furthermore,FST silencing increased the cell apoptosis percentage,and arrested cell cycle in the S phase in FaDu cells.In addition,FST silencing suppressed tumor growth in vivo.Conclusions:Our results indicated that the FST gene was associated with HPC progression and may serve as a potential therapeutic target for the treatment of HPC.
基金Supported by the Natural Science Foundation of Hubei Province,No.2019CFB798。
文摘BACKGROUND Spontaneous esophageal rupture or Boerhaave’s syndrome is a rare and acute disease with a high incidence of misdiagnosis and mortality.Here,we aimed to explore the clinical characteristics,diagnosis,treatment,and prognosis of spontaneous esophageal rupture,and to analyze the causes of misdiagnosis during the treatment of spontaneous esophageal rupture.CASE SUMMARY The clinical features of the patient with spontaneous esophageal rupture misdiagnosed earlier as pleural effusion were retrospectively analyzed and the reasons for misdiagnosis are discussed based on a current review of the literature.The patient was admitted to a local hospital due to shortness of breath accompanied by vomiting and abdominal distension for five hours.Based on the computed tomography(CT)scan analysis,clinically,right pleural effusion was diagnosed.However,the patient was unwilling to undergo right closed thoracic drainage.The patient also had intermittent fevers against infection,and during the course of treatment,he complained of chest pain,following which,he was transferred to our hospital.Grapefruit-like residue drainage fluid was observed.Re-examination of the chest CT scans suggested the presence of spontaneous perforation in the upper left esophagus.Therefore,the patient underwent an urgent esophageal hiatus repair.Unfortunately,the patient died of infection and respiratory failure due to progressive dyspnea after surgery.CONCLUSION Spontaneous esophageal rupture is a rare disease associated with high fatality.The patients do not present typical clinical symptoms and the disease progresses rapidly.This case report highlights the importance of a dynamic review of chest CT scan,not only for the initial identification of segmental injury but also for prioritizing subsequent treatment strategies.Moreover,we have presented some clues for clinicians to recognize and diagnose spontaneous esophageal rupture at rare sites(upper-esophageal segment)through this case report of spontaneous esophageal rupture that caused the patient’s death.We have also summarized the reasons for the misdiagnosis and lessons learned.
文摘This corrigendum clarifies statement in the article"Biogenesis of autophagosomes from the ERGIC membrane system"by Han et al.(2023).In the"The role of ERGIC-equivalents and COPll vesicles in autophagy in yeast"section,the statement that"At least one answer is that they remove together components for membrane fusion."should be corrected into"At least one answer is that they bring components for membrane fusion.".
基金the National Natural Science Foundation of China (Grant No. 81771242)。
文摘Spinal epidural hemorrhages(SEDH)caused by spinal epidural arteriovenous fistulas(SEAVFs)are rare;thus,their specific pathogenesis has not been explained.Furthermore,the standard treatment for SEAVFs has not yet been defined.Here we report the case of a 36-year-old Chinese man who experienced acute onset chest pain and tightness.His symptoms rapidly aggravated until the lower limbs were unable to support him.Spinal magnetic resonance angiography(MRA)revealed a localized SEAVF and a secondary spinal cord lesion at the T4 level.Digital subtraction angiography(DSA)confirmed the presence of the SEDH/SEAVF at the T3–4 level with the left radicular artery feeding the fistula.Based on DSA and MRA findings,SEDH,local spinal cord infarction,and spinal venous reflux disorder were conditionally diagnosed.Using the arterial route,Onyx-34 was injected into the fistula to embolize the feeding arteries and the venous system.Angiography was performed after the microcatheter was withdrawn,and no residual fistula or anterior spinal artery was observed.The six-week follow-up MRI showed acceptable healing of the SEAVF,and the patient improved neurologically.This case suggests that endovascular treatment with Onyx-34 embolization should be considered a promising treatment strategy for this type of complicated SEAVF.
文摘A general framework for observatory control software would help to improve the efficiency of observation and operation of telescopes, and would also be advantageous for remote and joint observations. We describe a general framework for observatory control software, which considers principles of flexibility and inheritance to meet the expectations from observers and technical personnel. This framework includes observation scheduling, device control and data storage. The design is based on a finite state machine that controls the whole process.
基金supported by the National Key R&D Program of China(grant No.2023YFA1608304 and No.2023YFA1608300)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550100 and XDB0550000)the National Natural Science Foundation of China(NSFC,grant Nos.12090041,12090040,11903054,12422303,and 12261141690)。
文摘The Si Tian project,designed to utilize 60 telescopes distributed across multiple sites in China,is a next-generation timedomain survey initiative.As a pathfinder for the Si Tian project,the Mini-Si Tian(MST)has been proposed and implemented to test the Si Tian’s brain and data pipeline,and to evaluate the feasibility of its technology and science cases.Mounted at the Xinglong Observatory,the MST project comprises three 30 cm telescopes and has been operated since 2022 November.Each telescope of the MST possesses a large field of view,covering 2°.29×1°.53 FOV,and is equipped withg',r'andi'filters,respectively.Acting as the pioneer of the forthcoming Si Tian project,the MST is dedicated to the discovery of variable stars,transients,and outburst events,and has already obtained some interesting scientific results.In this paper,we will summarize the first-two-year operation of the MST project.
基金supported by National Key R&D Program of China(2023YFA1609700)Research and Education Integration Funding。
文摘This paper presents a comprehensive analysis of the photometric system of the University of Chinese Academy of Sciences 70 cm Telescope located at the Yan-qi Lake campus of the University of Chinese Academy of Sciences.We evaluated the linearity,bias stability,and dark current of the camera.Utilizing the Johnson-Cousins Blue-Visible-Red-Infrared filter system and an Andor DZ936 charge-coupled device camera,we conducted extensive observations of Landolt standard stars to determine the color terms,atmospheric extinction coefficients,photometric zero-points,and the sky background brightness.The results indicate that this telescope demonstrates excellent performance in photometric calibration and good system performance overall,meeting the requirements for limited scientific research and teaching purposes.
基金Supported by National Key R&D Program of China(grant No.2023YFA1608304)Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550103)National Natural Science Foundation of China(NSFC,grant No.11903054)。
文摘The SiTian Project represents a groundbreaking initiative in astronomy,aiming to deploy a global network of telescopes,each with a 1 m aperture,for comprehensive time-domain sky surveys.The network's innovative architecture features multiple observational nodes,each comprising three strategically aligned telescopes equipped with filters.This design enables three-color(g,r,i)channel imaging within each node,facilitating precise and coordinated observations.As a pathfinder to the full-scale project,the Mini-SiTian Project serves as the scientific and technological validation platform,utilizing three 30 cm aperture telescopes to validate the methodologies and technologies planned for the broader SiTian network.This paper focuses on the development and implementation of the Master Control System(MCS),and the central command hub for the Mini-SiTian Array.The MCS is designed to facilitate seamless communication with the SiTian Brain,the project's central processing and decisionmaking unit,while ensuring accurate task allocation,real-time status monitoring,and optimized observational workflows.The system adopts a robust architecture that separates front-end and back-end functionalities.A key innovation of the MCS is its ability to dynamically adjust observation plans in response to transient source alerts,enabling rapid and coordinated scans of target sky regions.The paper provides an in-depth analysis of the system's internal components,including the communication system,which is critical for seamless network operation.Extensive testing has validated the functionality,reliability,and compatibility of these components within the overall system architecture.The successful deployment of the MCS in managing the Mini-SiTian Array has demonstrated its practicality and efficacy in collaborative observation and distributed control.By simplifying cluster management and ensuring data integrity,the MCS represents a significant advancement in astronomical observation control systems.Its scalable and adaptable design not only supports the future expansion of the SiTian network but also provides a blueprint for other large-scale telescope arrays,marking a transformative step forward in time-domain astronomy.
基金the support of the staff at the Xinglong Observatorysupported by the National Key R&D Program of China(grant No.2023YFA1609700)+10 种基金supported by the National Natural Science Foundation of China(NSFCgrant Nos.12090040,12090041,12403022 and 12273057)supported by the Strategic Priority Research Program of Chinese Academy of Sciences(grant Nos.XDB0550000,XDB0550100and XDB0550102)supported by the National Key R&D Program of China(grant No.2023YFA1608304)the supports from NSFC(grant Nos.12422303,12261141690)the National Key Basic R&D Program of China via2023YFA1608303the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550103)the supports of the NSFC(grant No.12403024)the Postdoctoral Fellowship Program of CPSF under grant No.GZB20240731the Young Data Scientist Project of the National Astronomical Data Centerthe China Post-doctoral Science Foundation(No.2023M743447)。
文摘We assess the detectability of tidal disruption events(TDEs)using mock observations from the Mini-SiTian Array.We select 100 host galaxy samples from a simulated galaxy catalog based on specific criteria such as redshift,black hole mass,and event rate.Taking into account the site conditions and survey strategy,we simulate observations over a 440 deg^(2)field.The results indicate that 0.53±0.73 TDEs can be detected per year when observing in both g and r bands with 300 s exposures every 3 days.Applying this method to the SiTian project,we expect to discover approximately 204 TDEs annually,heralding a new era in TDE science.
