In 2021,approximately 537 million people suffered from diabetes mellitus(DM)globally,and this figure will increase to approximately 783 million within the next quarter-century.The increasing burden of DM is a pressing...In 2021,approximately 537 million people suffered from diabetes mellitus(DM)globally,and this figure will increase to approximately 783 million within the next quarter-century.The increasing burden of DM is a pressing global public health issue.Therefore,the early identification of high-risk groups and implementation of effective intervention measures is imperative.展开更多
Long-life energy storage batteries are integral to energy storage systems and electric vehicles,with lithium-ion batteries(LIBs)currently being the preferred option for extended usage-life energy storage.To further ex...Long-life energy storage batteries are integral to energy storage systems and electric vehicles,with lithium-ion batteries(LIBs)currently being the preferred option for extended usage-life energy storage.To further extend the life span of LIBs,it is essential to intensify investments in battery design,manufacturing processes,and the advancement of ancillary materials.The pursuit of long durability introduces new challenges for battery energy density.The advent of electrode material offers effective support in enhancing the battery’s long-duration performance.Often underestimated as part of the cathode composition,the binder plays a pivotal role in the longevity and electrochemical performance of the electrode.Maintaining the mechanical integrity of the electrode through judicious binder design is a fundamental requirement for achieving consistent long-life cycles and high energy density.This paper primarily concentrates on the commonly employed cathode systems in lithium-ion batteries,elucidates the significance of binders for both,discusses the application status,strengths,and weaknesses of novel binders,and ultimately puts forth corresponding optimization strategies.It underscores the critical function of binders in enhancing battery performance and advancing the sustainable development of lithium-ion batteries,aiming to offer fresh insights and perspectives for the design of high-performance LIBs.展开更多
Lithium-ion batteries(LIBs)face significant limitations in low-temperature environments,with the slow interfacial de-solvation process and the hindered Li+transport through the interphase layer emerging as key obstacl...Lithium-ion batteries(LIBs)face significant limitations in low-temperature environments,with the slow interfacial de-solvation process and the hindered Li+transport through the interphase layer emerging as key obstacles beyond the issue of ionic conductivity.This investigation unveils a novel formulation that constructs an anion-rich solvation sheath within strong solvents,effectively addressing all three of these challenges to bolster low-temperature performance.The developed electrolyte,characterized by an enhanced concentration of contact ion pairs(CIPs)and aggregates(AGGs),facilitates the formation of an inorganic-rich interphase layer on the anode and cathode particles.This promotes de-solvation at low temperatures and stabilizes the electrode-electrolyte interphase.Full cells composed of LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)and graphite,when equipped with this electrolyte,showcase remarkable cycle stability and capacity retention,with 93.3% retention after 500 cycles at room temperature(RT)and 95.5%after 120 cycles at -20℃.This study validates the utility of the anion-rich solvation sheath in strong solvents as a strategy for the development of low-temperature electrolytes.展开更多
The application of machine learning in alloy design is increasingly widespread,yet traditional models still face challenges when dealing with limited datasets and complex nonlinear relationships.This work proposes an ...The application of machine learning in alloy design is increasingly widespread,yet traditional models still face challenges when dealing with limited datasets and complex nonlinear relationships.This work proposes an interpretable machine learning method based on data augmentation and reconstruction,excavating high-performance low-alloyed magnesium(Mg)alloys.The data augmentation technique expands the original dataset through Gaussian noise.The data reconstruction method reorganizes and transforms the original data to extract more representative features,significantly improving the model's generalization ability and prediction accuracy,with a coefficient of determination(R^(2))of 95.9%for the ultimate tensile strength(UTS)model and a R^(2)of 95.3%for the elongation-to-failure(EL)model.The correlation coefficient assisted screening(CCAS)method is proposed to filter low-alloyed target alloys.A new Mg-2.2Mn-0.4Zn-0.2Al-0.2Ca(MZAX2000,wt%)alloy is designed and extruded into bar at given processing parameters,achieving room-temperature strength-ductility synergy showing an excellent UTS of 395 MPa and a high EL of 17.9%.This is closely related to its hetero-structured characteristic in the as-extruded MZAX2000 alloy consisting of coarse grains(16%),fine grains(75%),and fiber regions(9%).Therefore,this work offers new insights into optimizing alloy compositions and processing parameters for attaining new high strong and ductile low-alloyed Mg alloys.展开更多
The Li-Mg-N-H(Mg(NH_(2))_(2)-2LiH)system,as a high-capacity Mg-based metal hydrogen storage material(5.6 wt%),has broad prospects for in vehicle hydrogen storage applications,but it still has high hydrogen ab/desorpti...The Li-Mg-N-H(Mg(NH_(2))_(2)-2LiH)system,as a high-capacity Mg-based metal hydrogen storage material(5.6 wt%),has broad prospects for in vehicle hydrogen storage applications,but it still has high hydrogen ab/desorption barriers.To improve its hydrogen storage performance,a nanohydrogen storage alloy was innovatively combined with Mg(NH_(2))_(2)-2LiH,AB5 type nanohydrogen storage alloy LaNi_(5)was prepared by co-precipitation method.Nano LaNi_(5)and single-walled carbon nanotubes(SWCNTs)were co-doped into the Mg(NH_(2))_(2)-2LiH system at a ratio of 10 wt%and 2 wt%,significantly enhancing the hydrogen storage performance of Mg(NH_(2))_(2)-2LiH.The initial hydrogen ab/desorption temperatures of the co-doped system decreased from110/130℃to 45/85℃.The release of by-product ammonia is significantly inhibited.4.73 wt% H_(2)can be ab/desorption in 150 min at 180/170℃.Cycle tests show that the co-doped system can still maintain a hydrogen storage capacity of 4.75 wt% after ten hydrogen release cycles.Mechanism and density functional theory study have shown that during the hydrogen release process,partially hydrogenated LaNi_(5)weakens the chemical bonding in Mg(NH_(2))_(2),promoted the dissociation of hydrogen from the Mg(NH_(2))_(2)-2LiH system,while playing a dual role of"hydrogen overflow"and"hydrogen pump".SWCNTs act as auxiliary agents,helping to refine particle size and increase thermal conductivity.The synergistic effect of the two optimizes the comprehensive hydrogen storage performance of Mg(NH_(2))_(2)-2LiH.This study provides a new research method for improving the comprehensive hydrogen storage performance of Mg-based metal hydrogen storage materials using rare earth element catalysts.展开更多
A solid solution 6063 aluminium alloy features an exceptional combination of strength and ductility at 77 K.Here,the deformation mechanisms responsible for superior strength-ductility synergy and excellent strain hard...A solid solution 6063 aluminium alloy features an exceptional combination of strength and ductility at 77 K.Here,the deformation mechanisms responsible for superior strength-ductility synergy and excellent strain hardening capacity at a cryogenic temperature of the alloy were comparatively investigated by insitu electron backscatter diffraction(EBSD)observations coupled with transmission electron microscopy(TEM)characterization and fracture morphologies at both 298 and 77 K.It is found that kernel average misorientation(KAM)mappings and quantified KAM in degree suggest a higher proportion of geometrically necessary dislocations(GNDs)at 77 K.The existence of orientation scatter partitions at 77 K implies the activation of multiple slip systems,which is consistent with the results of potential slip systems calculated by Taylor axes.Furthermore,dislocation tangles characterized by brief and curved dislocation cells and abundant small dimples have been observed at 77 K.This temperature-mediated activation of dislocations facilitates the increased dislocations,thus enhancing the strain hardening capacity and ductility of the alloy.This research enriches cryogenic deformation theory and provides valuable insights into the design of high-performance aluminium alloys that are suitable for cryogenic applications.展开更多
In drilling ultra-deep wells,the drilling fluid circulation usually causes erosion damage to downhole casing and drilling tools.However,the extent and process of this damage to the downhole tools is intricate and less...In drilling ultra-deep wells,the drilling fluid circulation usually causes erosion damage to downhole casing and drilling tools.However,the extent and process of this damage to the downhole tools is intricate and less understood.In order to systematically evaluate and clarify this damage process for different types of drilling fluid contamination,this research uses a high-temperature drilling fluid damage device to simulate the damage caused to the casing/drilling tools by various drilling fluid under a field thermal gradient.The results show that the drilling fluid residues are mainly solid-phase particles and organic components.The degree of casing/tool damage decreases with an increase in bottom hole temperature,and the casing/tool is least damaged within a temperature range of 150–180°C.Moreover,the surface of the casing/tool damaged by different types of drilling fluid shows different roughness,and the wettability of drilling fluid on the casing/tool surface increases with an increase in the degree of roughness.Oil-based drilling fluid have the strongest adhesion contamination on casing/drilling tools.In contrast,polysulfonated potassium drilling fluid and super-micro drilling fluid have the most potent erosion damage on casing/drilling tools.By analyzing the damage mechanism,it was established that the damage was mainly dominated by the abrasive wearing from solid-phase particles in concert with corrosion ions in drilling fluid,with solids producing many abrasion marks and corrosive ions causing a large number of pits.Clarifying drilling fluid's contamination and damage mechanism is significant in guiding the wellbore cleaning process and cutting associated costs.展开更多
The magnesium based metal hydrogen storage composite system Mg(NH_(2))_(2)-2LiH has a theoretical hydro-gen storage capacity of 5.6 wt.%and is a promising hydrogen storage material for vehicles.However,its application...The magnesium based metal hydrogen storage composite system Mg(NH_(2))_(2)-2LiH has a theoretical hydro-gen storage capacity of 5.6 wt.%and is a promising hydrogen storage material for vehicles.However,its application is limited due to serious thermodynamic and kinetic barriers.Introducing efficient catalysts is an effective method to improve the hydrogen storage performance of Mg(NH_(2))_(2)-2LiH.This article in-vestigates for the first time the use of nano rare earth oxide CeO_(2)(~44.5 nm)as an efficient modifier,achieving comprehensive regulation of the hydrogen storage performance of Mg(NH_(2))_(2)-2LiH composite system through oxygen vacancy driven catalysis.The modification mechanism of nano CeO_(2) is also sys-tematically studied using density functional theory(DFT)calculations and experimental results.Research has shown that the comprehensive hydrogen storage performance of the Mg(NH_(2))_(2)-2LiH-5 wt.%CeO_(2) composite system is optimal,with high hydrogen absorption and desorption kinetics and reversible per-formance.The initial hydrogen absorption and desorption temperatures of the composite system were significantly reduced from 110/130℃to 65/80℃,and the release of by-product ammonia was signifi-cantly inhibited.Under the conditions of 170℃/50 min and 180℃/100 min,4.37 wt.%of hydrogen can be rapidly absorbed and released.After 10 cycles of hydrogen release,the hydrogen cycle retention rate increased from 85%to nearly 100%.Further mechanistic studies have shown that the nano CeO_(2-x) gen-erated in situ during hydrogen evolution can effectively weaken the Mg-N and N-H bonds of Mg(NH_(2))_(2),exhibiting good catalytic effects.Meanwhile,oxygen vacancies provide a fast pathway for the diffusion of hydrogen atoms in the composite system.In addition,nano CeO_(2-x) can effectively inhibit the polycrys-talline transformation of the hydrogen evolving product Li_(2)MgN_(2)H_(2) in the system at high temperatures,reducing the difficulty of re-hydrogenation of the system.This study provides an innovative perspective for the efficient modification of magnesium based metal hydrogen storage composite materials using rare earth based catalysts,and also provides a reference for regulating the comprehensive hydrogen storage performance of hydrogen storage materials using rare earth catalysts with oxygen vacancies.展开更多
Graphite-silicon species(Gr-Si)hybrid anodes have merged as potential candidates for high-energy lithium-ion batteries(LIBs),yet long been plagued by rapid capacity fading due to their unstable mechano-electrochemistr...Graphite-silicon species(Gr-Si)hybrid anodes have merged as potential candidates for high-energy lithium-ion batteries(LIBs),yet long been plagued by rapid capacity fading due to their unstable mechano-electrochemistry.The dominant approach to enhance electrochemical stability of the Gr-Si hybrid anodes typically involves the optimization of the electrode material structures and the employment of low active Si species content in electrode(<10 wt%in most instances).However,the electrode structure design,a factor of equal importance in determining the electrochemical performance of Gr-Si hybrid anodes,has received scant attention.In this study,three Gr-Si hybrid anodes with the identical material composition but distinct electrode structures are designed to investigate the mechanoelectrochemistry of the electrodes.It is revealed that the substantial volume change of Si species particles in Gr-Si hybrid anodes led to the local lattice stress of Gr at their contact interface during the charge/discharge processes,thereby increasing thermodynamic and kinetic barrier of Li-ion migration.Furthermore,the huge disparity in volume change of Si species and Gr particles trigger the separate agglomeration of these two materials,resulting in a considerable electrode volume change and increased electrochemical resistance.An advanced Gr/Si hybrid anode with upper Gr and lower Si species layer structure design addresses the above challenges using photovoltaic waste silicon sources under high Si species content(17 wt%)and areal capacity(2.0 mA h cm^(-2))in Ah-level full pouch cells with a low negative/positive(N/P)ratio of 1.09.The cell shows stable cycling for 100 cycles at 0.3 C with an impressively low capacity decay rate of 0.0546%per cycle,outperforming most reported Gr-Si hybrid anodes.展开更多
Overexpression of Sperm Acrosomal SLLP1 Binding protein (SAS1B) in various cancer types, including uterine cancer cells, was discovered a few years ago, and different monoclonal antibodies (anti-SAS1B) that specifical...Overexpression of Sperm Acrosomal SLLP1 Binding protein (SAS1B) in various cancer types, including uterine cancer cells, was discovered a few years ago, and different monoclonal antibodies (anti-SAS1B) that specifically bind to SAS1B antigens were developed. Labeling of these antibodies with radionuclides can provide an opportunity for imaging and radioimmunotherapy. The objective of this study was to label anti-SAS1B (SB5) with Zirconium-89 (<sup>89</sup>Zr) for PET imaging and determine its biodistribution. Anti-SAS1B (SB5) antibody was labeled with <sup>89</sup>Zr indirectly using the chelator desferrioxamine B (DFO), which is currently a best linker for<sup> 89</sup>Zr. The antibody, SB5, was first conjugated to DFO with a ratio of 1:5 and then labeled with 250 μCi of <sup>89</sup>Zr. Results of PET imaging in mouse-bearing uterine cancer tumor showed a limited uptake. The bio-distribution study matched the PET imaging and confirmed the uptake by the tumor, and the accumulation in bones. In conclusion, labeling of anti-SAS1B could provide an effective way of uterine cancer detection and treatment progression.展开更多
<p align="justify"> <span style="font-family:Verdana;"><strong>Objective:</strong> To observe the clinical efficacy and safety of berberine in treating patients with prediab...<p align="justify"> <span style="font-family:Verdana;"><strong>Objective:</strong> To observe the clinical efficacy and safety of berberine in treating patients with prediabetes. <strong>Methods:</strong> A total of 76 patients with prediabetes were enrolled, and at the end of a one-month run-in period, 70 patients were eligible to participate in the clinical trial and randomly assigned to two groups in a 1:1 ratio, namely a treatment group (n = 35) and a control group (n = 35). Members of the control group underwent lifestyle interventions, including dietary interventions and exercise prescriptions, while participants of the treatment group received both lifestyle interventions and oral administration of 300 mg berberine, three times daily for three months. Subsequently, the treatment group entered a washout period of two months, during which time the medication was stopped, and the lifestyle interventions continued. Following the washout period, the oral administration of berberine was resumed at the same dose and lasted for three months. Blood glucose parameters were evaluated after different treatment periods. <strong>Results: </strong>1) Intra-group comparison: Following the first and the second treatment periods, the treatment group experienced a significant decrease in fasting plasma glucose (FPG), 2-hour PG (2hPG) based on oral glucose tolerance test (OGTT), HbA1c, and HOMA-IR (P < 0.05);for the control group, although the blood glucose parameters exhibited a downward trend, the differences lacked statistical significance. 2) Intergroup comparison: Compared to the control group, the treatment group showed a significant decline in the levels of FPG, 2hPG, and HbA1c, whereas the decrease in HOMA-IR had no statistical significance. 3) Safety evaluation: No serious adverse events occurred in either group. <strong>Conc</strong><strong>lusion: </strong>Berberine is safe and effective in controlling blood glucose levels in patients with prediabetes and deserves to be promoted in clinical practice.</span> </p>展开更多
The 91 measured values of the development height of the water-conducting fracture zone(WCFZ)in deep and thick coal seam mining faces under thick loose layer conditions were collected.Five key characteristic variables ...The 91 measured values of the development height of the water-conducting fracture zone(WCFZ)in deep and thick coal seam mining faces under thick loose layer conditions were collected.Five key characteristic variables influencing the WCFZ height were identified.After removing outliers from the dataset,a Random Forest(RF)regression model optimized by the Sparrow Search Algorithm(SSA)was constructed.The hyperparameters of the RF model were iteratively optimized by minimizing the Out-of-Bag(OOB)error,resulting in the rapid deter-mination of optimal parameters.Specifically,the SSA-RF model achieved an OOB error of 0.148,with 20 de-cision trees,a maximum depth of 8,a minimum split sample size of 2,and a minimum leaf node sample size of 1.Cross-validation experiments were performed using the trained optimal model and compared against other prediction methods.The results showed that the mining height had the most significant correlation with the development height of the WCFZ.The SSA-RF model outperformed all other models,with R2 values exceeding 0.9 across the training,validation,and test datasets.Compared to other models,the SSA-RF model demonstrates a simpler structure,stronger fitting capacity,higher predictive accuracy,and superior stability and generaliza-tion ability.It also exhibits the smallest variation in relative error across datasets,indicating excellent adapt-ability to different data conditions.Furthermore,a numerical model was developed using the hydrogeological data from the 1305 working face at Wanfukou Coal Mine,Shandong Province,China,to simulate the dynamic development of the WCFZ during mining.The SSA-RF model predicted the WCFZ height to be 69.7 m,closely aligning with the PFC2D simulation result of 65 m,with an error of less than 5%.Compared to traditional methods and numerical simulations,the SSA-RF model provides more accurate predictions,showing only a 7.23% deviation from the PFC2D simulation,while traditional empirical formulas yield deviations as large as 19.97%.These results demonstrate the SSA-RF model’s superior predictive capability,reinforcing its reliability and engineering applicability for real-world mining operations.This model holds significant potential for enhancing mining safety and optimizing planning processes,offering a more accurate and efficient approach for WCFZ height prediction.展开更多
Type 2 diabetes mellitus(T2DM)is one of the most prevalent chronic metabolic disorder characterized by insulin resistance and relative insulin deficiency.PPARδactivation has been reported to have several beneficial e...Type 2 diabetes mellitus(T2DM)is one of the most prevalent chronic metabolic disorder characterized by insulin resistance and relative insulin deficiency.PPARδactivation has been reported to have several beneficial effects in alleviating dyslipidemia and insulin resistance.GW501516,a synthetic PPARδagonist,was developed to target hyperlipidemia and reported to alleviating insulin resistance in T2DM.Studies indicate that PPARδactivation by GW501516 can reduce adiposity,enhanceβ-oxidation of fatty acids,and improve insulin sensitivity in T2DM animal models.Despite its therapeutic promise,potential carcinogenic effects also have been reported.Therefore,a comprehensive non-targeted and targeted lipidomics study was carried out to evaluate the regulatory effect of GW501516 in the plasma of db/db mice.The results revealed that GW501516 is effective in reducing the accumulation of lipids in the fatty acid metabolism pathway and lipid classes including triglycerides and phosphatidylglycerols.Furthermore,activation of PPARδby GW501516 demonstrated a beneficial effect on improving circulating cholesterol homeostasis.However,while the levels of hexosylceramides and sphingomyelin were partially reversed,ceramide levels,which are negatively associated with insulin sensitivity,were significantly elevated by GW501516.Despite these mixed outcomes,the study highlights both the promising therapeutic potential of PPARδactivation in metabolic disorders and the safety concerns regarding long-term clinical use.The findings provide valuable insights into the impact of GW501516-induced PPARδactivation on lipid metabolism in T2DM,contributing to a better understanding of its therapeutic potential and risks.展开更多
Background:In recent years,the increase of pollen allergy encourages people to do a lot of research on the disease.This paper conducted a bibliometric study on pollen allergy,to explore the risk factors,as well as the...Background:In recent years,the increase of pollen allergy encourages people to do a lot of research on the disease.This paper conducted a bibliometric study on pollen allergy,to explore the risk factors,as well as the current status,hotspots and development trends,so as to provide reference for researchers in related fields.Method:The visual analysis method was used to analyze the related literature of pollen allergy-related based on CiteSpace(6.2.R4)software,which were searched in the database of Web of Science Core Collection(WoSCC)from 2005 to 24 February 2025.Results:Finally,5318 documents were included in this study.Results showed that the country with the most published articles is USA.The research institution with the most publications is Medical University of Vienna.The analysis demonstrates strong international research collaboration,with particularly intensive connections observed within Europe.Professor Valenta Rudolf from the Medical University of Vienna is the most prolific author.High frequency keywords in this field include“asthma”,“allergic rhinitis”,“children”,“sensitization”and“food allergy”.It is worth noting that the emerging terms up to 2025 include“allergen immunotherapy”,“air pollution”,“risk”,“allergenic pollen”,“airborne pollen”,“exposure”,and“climate change”.Allergy and the Journal of Allergy and Clinical Immunology(JACI)are the two most-cited journals,both exhibiting high impact factors and centrality.The review article by Bousquet J.(2018)published in Allergy has been cited 137 times,representing the most cited publication with a betweenness centrality of 0.17.The research focus in the field has shifted to using research methods based on protein and peptides and DNA vaccines for the prevention and treatment of immune reactions induced by tree pollen.The study of recombinant fragments of purified proteins with specific allergens for preventive treatment has broad application prospects.Conclusion:Its conclusion provides comprehensive and beneficial reference information for the prevention and treatment of pollen allergy.展开更多
A series of as-cast Si_(x)Al_(0.43)CoCrFeNi_(2.1)(x=0,0.1,0.2,and 0.3)high-entropy alloys(HEAs)was successfully fabricated by va-cuum-assisted melting.The phase constituents,microstructural features,and mechanical pro...A series of as-cast Si_(x)Al_(0.43)CoCrFeNi_(2.1)(x=0,0.1,0.2,and 0.3)high-entropy alloys(HEAs)was successfully fabricated by va-cuum-assisted melting.The phase constituents,microstructural features,and mechanical properties(including hardness,tensile behavior,and wear behavior)of alloys with various Si contents were evaluated.The results revealed that the addition of Si promoted the precipita-tion of a body-centered cubic 1(BCC1)phase enriched in Al,Ni,and Si with a B2-ordered structure.Furthermore,the secondary BCC2 phase was enriched with Cr,Fe,and Si precipitates within the BCC1 matrix.Ultimately,a multiphase face-centered cubic(FCC)/(BCC1/BCC2)structure was formed.The microstructural evolution driven by Si addition significantly enhanced the mechanical properties of the Si_(x)Al_(0.43)CoCrFeNi_(2.1) HEAs.As the Si content increased,the microhardness and tensile strength improved by approxim-ately 42%and 55%,reaching 2.359 GPa and 785 MPa,respectively.The quantitative evaluation of the various strengthening mechanisms indicated that the intrinsic hardness of the FCC matrix and hardening due to BCC1/BCC2 precipitation dominated the overall microhard-ness.The comparison of the energy barriers indicates that BCC2 primarily strengthens the alloy through a shear mechanism rather than an Orowan bypass mechanism.Furthermore,with increasing Si content,reduced friction and wear,together with smoother worn surfaces,re-flect a greatly enhanced wear resistance.After the optimal cold-rolling and 1 h annealing at 800℃,the Si_(0.3)Al_(0.43)CoCrFeNi_(2.1) alloy showed 56%and 62%increases in microhardness and tensile strength,respectively,compared to the as-cast state,reaching 3.68 GPa and 1270 MPa.The enhanced mechanical properties are attributed to the synergistic effects of residual strain hardening by FCC ordering and L1_(2)/BCC precipitation strengthening.展开更多
The harmonic balance method(HBM)has been widely applied to get the periodic solution of nonlinear systems,however,its convergence rate as well as computation efficiency is dramatically degraded when the system is high...The harmonic balance method(HBM)has been widely applied to get the periodic solution of nonlinear systems,however,its convergence rate as well as computation efficiency is dramatically degraded when the system is highly non-smooth,e.g.,discontinuous.In order to accelerate the convergence,an enriched HBM is developed in this paper where the non-smooth Bernoulli bases are additionally introduced to enrich the conventional Fourier bases.The basic idea behind is that the convergence rate of the HB solution,as a truncated Fourier series,can be improved if the smoothness of the solution becomes finer.Along this line,using non-smooth Bernoulli bases can compensate the highly non-smooth part of the solution and then,the smoothness of the residual part for Fourier approximation is improved so as to achieve accelerated convergence.Numerical examples are conducted on systems with non-smooth restoring and/or external forces.The results confirm that the proposed enriched HBM indeed increases the convergence rate and the increase becomes more significant if more non-smooth bases are used.展开更多
BACKGROUND Proteins play a central role in regulating biological functions,and various pathways regulate their synthesis and secretion.Endoplasmic reticulum-associated protein degradation(ERAD)is crucial for monitorin...BACKGROUND Proteins play a central role in regulating biological functions,and various pathways regulate their synthesis and secretion.Endoplasmic reticulum-associated protein degradation(ERAD)is crucial for monitoring protein synthesis and processing unfolded or misfolded proteins in actively growing tumor cells.However,the role of the multiple ERAD complexes in liver cancer remains unclear.AIM To elucidate the effects of SEL1L-mediated ERAD on Huh7 and explore the underlying mechanisms in vivo and in vitro.METHODS Huh7 cells were treated with ERAD inhibitor to identify ERAD’s role.Cell counting kit-8,5-ethynyl-2’-deoxyuridine and colony formation experiments were performed.Apoptosis level and migration ability were assessed using fluorescence activated cell sorting and Transwell assay,respectively.Huh7 SEL1L knockout cell line was established via clustered regularly interspaced short palindromic repeats,proliferation,apoptosis,and migration were assessed through previous experiments.The role of SEL1L in vivo and the downstream target of SEL1L were identified using Xenograft and mass spectrometry,respectively.RESULTS The ERAD inhibitor suppressed cell proliferation and migration and promoted apoptosis.SEL1L-HRD1 significantly influenced Huh7 cell growth.SEL1L knockout suppressed tumor cell proliferation and migration and enhanced apoptosis.Mass spectrometry revealed EXT2 is a primary substrate of ERAD.SEL1L knockout significantly increased the protein expression of EXT2.Furthermore,EXT2 knockdown partially restored the effect of SEL1L knockout.CONCLUSION ERAD inhibition suppressed the proliferation and migration of Huh7 and promoted its apoptosis.EXT2 plays an important role and ERAD might be a potential treatment for Huh7 hepatocellular carcinoma.展开更多
Adjustment of the sowing date is a widely used measure in rice production for adapting to high-temperature conditions.However,the impact of a delayed sowing date(DS)on rice quality may vary by variety and ecological c...Adjustment of the sowing date is a widely used measure in rice production for adapting to high-temperature conditions.However,the impact of a delayed sowing date(DS)on rice quality may vary by variety and ecological conditions.In this study,we conducted experiments using four different sowing dates,the conventional sowing date 1(CS1),CS2(10 d later than CS1),DS1(30 d later than CS1),and DS2(30 d later than CS2),and three rice varieties,i.e.,Yixiangyou 2115,Fyou 498,and Chuanyou 6203.This experiment was conducted at four sites in the Sichuan Basin in 2018 and 2019 to evaluate the infuence of DS on the pasting properties of rice,which are a proxy for the eating and cooking quality(ECQ).In DS1 and DS2,the rice had a signifcantly greater amylose content(AC)but a lower protein content(PC),peak viscosity(PKV),cool paste viscosity(CPV),and hot paste viscosity(HPV)than in CS1 and CS2.Moreover,except for CS2 and DS1 in 2018,DS1 and DS2 led to 2.15-11.19%reductions in breakdown viscosity(BDV)and 23.46-108.47%increases in setback viscosity(SBV).However,the infuence of DS on rice pasting properties varied by study site and rice variety.In 2019,DS1 and DS2 led to BDV reductions of 2.35-9.33,2.61-8.61,10.03-17.78,and 2.06-8.93%,and SBV increases of 2.32-60.93,63.74-144.24,55.46-91.63,and-8.28-65.37%at the Dayi,Anzhou,Nanbu,and Shehong(except for SBV in CS2 and DS1)sites,respectively.DS resulted in greater reductions in PKV,HPV,CPV,and BDV and greater increases in the AC and SBV for Yixiangyou 2115 than for Chuanyou 6203 and Fyou 498.The correlation analysis indicated that PKV and HPV were signifcantly and positively related to the mean,maximum,and minimum temperatures after heading.These temperatures must be greater than 25.9,31.2,and 22.3℃,respectively,to increase the relative BDV and reduce the relative SBV of rice,thereby enhancing ECQ.In conclusion,DS might contribute to a signifcant deterioration in ECQ in machine-transplanted rice in the Sichuan Basin.A mean temperature above 25.9℃ after heading is required to improve the ECQ of rice.展开更多
In order to solve the black-box modeling problem and improve the prediction accuracy of model,two distinguished models for tensile strength(Ts)and yield strength(Ys)of hot-rolled strip steel are established based on t...In order to solve the black-box modeling problem and improve the prediction accuracy of model,two distinguished models for tensile strength(Ts)and yield strength(Ys)of hot-rolled strip steel are established based on the industrial hot-rolled data and the algorithm of gene expression programming(GEP).Firstly,the industrial data of hot-rolled strip steel are preprocessed using the Pauta criterion,so as to eliminate outliers.The key input variables that affect Ys and Ts are selected by using the method of the maximal information coefficient(MIC).Secondly,the explicit prediction models of Ys and Ts are established using GEP.Subsequently,the model results based on GEP are compared with those based on the support vector regression(SVR)and the back propagation neural network(BPNN).Finally,the mathematical expression models for Ys and Ts obtained by GEP are used to further analyse the specific relationships between the chemical composition and mechanical property.It is shown that the errors of Ys and Ts based on GEP are less than 4%,and the coefficient of determination(R^(2))of Ys and Ts based on GEP is above 0.9,which has strong prediction performance.The prediction accuracy of GEP can achieve the same level with SVR and BPNN.It is worth mentioning that the proposed model can not only show the explicit relationship between the chemical composition,production process,and mechanical property of strip steel,but also occupy high prediction accuracy,which can make reliable reference for strip steel product design and optimisation.展开更多
基金supported by the Research Funds of the Center for Big Data and Population Health of IHM(grant number JKS2022015)the Key Scientific Research Fund of the Anhui Provincial Education Department(grant number2023AH050610)the Anhui Natural Science Foundation(grant number 1808085QH252)。
文摘In 2021,approximately 537 million people suffered from diabetes mellitus(DM)globally,and this figure will increase to approximately 783 million within the next quarter-century.The increasing burden of DM is a pressing global public health issue.Therefore,the early identification of high-risk groups and implementation of effective intervention measures is imperative.
基金We would like to show gratitude to the Yunnan Province Basic Research Major Project(202501BC070006(Y.Wang))Key Industry Science and Technology Projects for University Services in Yunnan Province(FWCY ZNT2024002(Y.Wang))+3 种基金National Natural Science Foundation of China(22279070(L.Wang))and(U21A20170(X.He))the Ministry of Science and Technology of China(2019YFA0705703(L.Wang))Beijing Natural Science Foundation(L242005(X.He))Key Industry Science and Technology Projects for University Services in Yunnan Province(FWCY BSPY2024011(T.Lai)).
文摘Long-life energy storage batteries are integral to energy storage systems and electric vehicles,with lithium-ion batteries(LIBs)currently being the preferred option for extended usage-life energy storage.To further extend the life span of LIBs,it is essential to intensify investments in battery design,manufacturing processes,and the advancement of ancillary materials.The pursuit of long durability introduces new challenges for battery energy density.The advent of electrode material offers effective support in enhancing the battery’s long-duration performance.Often underestimated as part of the cathode composition,the binder plays a pivotal role in the longevity and electrochemical performance of the electrode.Maintaining the mechanical integrity of the electrode through judicious binder design is a fundamental requirement for achieving consistent long-life cycles and high energy density.This paper primarily concentrates on the commonly employed cathode systems in lithium-ion batteries,elucidates the significance of binders for both,discusses the application status,strengths,and weaknesses of novel binders,and ultimately puts forth corresponding optimization strategies.It underscores the critical function of binders in enhancing battery performance and advancing the sustainable development of lithium-ion batteries,aiming to offer fresh insights and perspectives for the design of high-performance LIBs.
基金the National Natural Science Foundation of China(No.22279070[L.Wang]and U21A20170[X.He])the Ministry of Science and Technology of China(No.2019YFA0705703[L.Wang])。
文摘Lithium-ion batteries(LIBs)face significant limitations in low-temperature environments,with the slow interfacial de-solvation process and the hindered Li+transport through the interphase layer emerging as key obstacles beyond the issue of ionic conductivity.This investigation unveils a novel formulation that constructs an anion-rich solvation sheath within strong solvents,effectively addressing all three of these challenges to bolster low-temperature performance.The developed electrolyte,characterized by an enhanced concentration of contact ion pairs(CIPs)and aggregates(AGGs),facilitates the formation of an inorganic-rich interphase layer on the anode and cathode particles.This promotes de-solvation at low temperatures and stabilizes the electrode-electrolyte interphase.Full cells composed of LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622)and graphite,when equipped with this electrolyte,showcase remarkable cycle stability and capacity retention,with 93.3% retention after 500 cycles at room temperature(RT)and 95.5%after 120 cycles at -20℃.This study validates the utility of the anion-rich solvation sheath in strong solvents as a strategy for the development of low-temperature electrolytes.
基金funded by the National Natural Science Foundation of China(No.52204407)the Natural Science Foundation of Jiangsu Province(No.BK20220595)+1 种基金the China Postdoctoral Science Foundation(No.2022M723689)the Industrial Collaborative Innovation Project of Shanghai(No.XTCX-KJ-2022-2-11)。
文摘The application of machine learning in alloy design is increasingly widespread,yet traditional models still face challenges when dealing with limited datasets and complex nonlinear relationships.This work proposes an interpretable machine learning method based on data augmentation and reconstruction,excavating high-performance low-alloyed magnesium(Mg)alloys.The data augmentation technique expands the original dataset through Gaussian noise.The data reconstruction method reorganizes and transforms the original data to extract more representative features,significantly improving the model's generalization ability and prediction accuracy,with a coefficient of determination(R^(2))of 95.9%for the ultimate tensile strength(UTS)model and a R^(2)of 95.3%for the elongation-to-failure(EL)model.The correlation coefficient assisted screening(CCAS)method is proposed to filter low-alloyed target alloys.A new Mg-2.2Mn-0.4Zn-0.2Al-0.2Ca(MZAX2000,wt%)alloy is designed and extruded into bar at given processing parameters,achieving room-temperature strength-ductility synergy showing an excellent UTS of 395 MPa and a high EL of 17.9%.This is closely related to its hetero-structured characteristic in the as-extruded MZAX2000 alloy consisting of coarse grains(16%),fine grains(75%),and fiber regions(9%).Therefore,this work offers new insights into optimizing alloy compositions and processing parameters for attaining new high strong and ductile low-alloyed Mg alloys.
基金financially supported by the National Natural Science Foundation of China(Nos.51971199 and 51771171)
文摘The Li-Mg-N-H(Mg(NH_(2))_(2)-2LiH)system,as a high-capacity Mg-based metal hydrogen storage material(5.6 wt%),has broad prospects for in vehicle hydrogen storage applications,but it still has high hydrogen ab/desorption barriers.To improve its hydrogen storage performance,a nanohydrogen storage alloy was innovatively combined with Mg(NH_(2))_(2)-2LiH,AB5 type nanohydrogen storage alloy LaNi_(5)was prepared by co-precipitation method.Nano LaNi_(5)and single-walled carbon nanotubes(SWCNTs)were co-doped into the Mg(NH_(2))_(2)-2LiH system at a ratio of 10 wt%and 2 wt%,significantly enhancing the hydrogen storage performance of Mg(NH_(2))_(2)-2LiH.The initial hydrogen ab/desorption temperatures of the co-doped system decreased from110/130℃to 45/85℃.The release of by-product ammonia is significantly inhibited.4.73 wt% H_(2)can be ab/desorption in 150 min at 180/170℃.Cycle tests show that the co-doped system can still maintain a hydrogen storage capacity of 4.75 wt% after ten hydrogen release cycles.Mechanism and density functional theory study have shown that during the hydrogen release process,partially hydrogenated LaNi_(5)weakens the chemical bonding in Mg(NH_(2))_(2),promoted the dissociation of hydrogen from the Mg(NH_(2))_(2)-2LiH system,while playing a dual role of"hydrogen overflow"and"hydrogen pump".SWCNTs act as auxiliary agents,helping to refine particle size and increase thermal conductivity.The synergistic effect of the two optimizes the comprehensive hydrogen storage performance of Mg(NH_(2))_(2)-2LiH.This study provides a new research method for improving the comprehensive hydrogen storage performance of Mg-based metal hydrogen storage materials using rare earth element catalysts.
基金supported by the National Natural Science Foundation of China(Grant Nos.92263201,51927801,and 52001160)the National Key Research and Development Program of China(Grant No.2020YFA0405900).
文摘A solid solution 6063 aluminium alloy features an exceptional combination of strength and ductility at 77 K.Here,the deformation mechanisms responsible for superior strength-ductility synergy and excellent strain hardening capacity at a cryogenic temperature of the alloy were comparatively investigated by insitu electron backscatter diffraction(EBSD)observations coupled with transmission electron microscopy(TEM)characterization and fracture morphologies at both 298 and 77 K.It is found that kernel average misorientation(KAM)mappings and quantified KAM in degree suggest a higher proportion of geometrically necessary dislocations(GNDs)at 77 K.The existence of orientation scatter partitions at 77 K implies the activation of multiple slip systems,which is consistent with the results of potential slip systems calculated by Taylor axes.Furthermore,dislocation tangles characterized by brief and curved dislocation cells and abundant small dimples have been observed at 77 K.This temperature-mediated activation of dislocations facilitates the increased dislocations,thus enhancing the strain hardening capacity and ductility of the alloy.This research enriches cryogenic deformation theory and provides valuable insights into the design of high-performance aluminium alloys that are suitable for cryogenic applications.
基金support and funding from the CNPC Project(2021ZG10)National Natural Science Foundation of China(No.52174047)Sinopec Project(No.P23138).
文摘In drilling ultra-deep wells,the drilling fluid circulation usually causes erosion damage to downhole casing and drilling tools.However,the extent and process of this damage to the downhole tools is intricate and less understood.In order to systematically evaluate and clarify this damage process for different types of drilling fluid contamination,this research uses a high-temperature drilling fluid damage device to simulate the damage caused to the casing/drilling tools by various drilling fluid under a field thermal gradient.The results show that the drilling fluid residues are mainly solid-phase particles and organic components.The degree of casing/tool damage decreases with an increase in bottom hole temperature,and the casing/tool is least damaged within a temperature range of 150–180°C.Moreover,the surface of the casing/tool damaged by different types of drilling fluid shows different roughness,and the wettability of drilling fluid on the casing/tool surface increases with an increase in the degree of roughness.Oil-based drilling fluid have the strongest adhesion contamination on casing/drilling tools.In contrast,polysulfonated potassium drilling fluid and super-micro drilling fluid have the most potent erosion damage on casing/drilling tools.By analyzing the damage mechanism,it was established that the damage was mainly dominated by the abrasive wearing from solid-phase particles in concert with corrosion ions in drilling fluid,with solids producing many abrasion marks and corrosive ions causing a large number of pits.Clarifying drilling fluid's contamination and damage mechanism is significant in guiding the wellbore cleaning process and cutting associated costs.
基金supported by the National Natural Science Foundation of China(Nos.51971199 and 51771171).
文摘The magnesium based metal hydrogen storage composite system Mg(NH_(2))_(2)-2LiH has a theoretical hydro-gen storage capacity of 5.6 wt.%and is a promising hydrogen storage material for vehicles.However,its application is limited due to serious thermodynamic and kinetic barriers.Introducing efficient catalysts is an effective method to improve the hydrogen storage performance of Mg(NH_(2))_(2)-2LiH.This article in-vestigates for the first time the use of nano rare earth oxide CeO_(2)(~44.5 nm)as an efficient modifier,achieving comprehensive regulation of the hydrogen storage performance of Mg(NH_(2))_(2)-2LiH composite system through oxygen vacancy driven catalysis.The modification mechanism of nano CeO_(2) is also sys-tematically studied using density functional theory(DFT)calculations and experimental results.Research has shown that the comprehensive hydrogen storage performance of the Mg(NH_(2))_(2)-2LiH-5 wt.%CeO_(2) composite system is optimal,with high hydrogen absorption and desorption kinetics and reversible per-formance.The initial hydrogen absorption and desorption temperatures of the composite system were significantly reduced from 110/130℃to 65/80℃,and the release of by-product ammonia was signifi-cantly inhibited.Under the conditions of 170℃/50 min and 180℃/100 min,4.37 wt.%of hydrogen can be rapidly absorbed and released.After 10 cycles of hydrogen release,the hydrogen cycle retention rate increased from 85%to nearly 100%.Further mechanistic studies have shown that the nano CeO_(2-x) gen-erated in situ during hydrogen evolution can effectively weaken the Mg-N and N-H bonds of Mg(NH_(2))_(2),exhibiting good catalytic effects.Meanwhile,oxygen vacancies provide a fast pathway for the diffusion of hydrogen atoms in the composite system.In addition,nano CeO_(2-x) can effectively inhibit the polycrys-talline transformation of the hydrogen evolving product Li_(2)MgN_(2)H_(2) in the system at high temperatures,reducing the difficulty of re-hydrogenation of the system.This study provides an innovative perspective for the efficient modification of magnesium based metal hydrogen storage composite materials using rare earth based catalysts,and also provides a reference for regulating the comprehensive hydrogen storage performance of hydrogen storage materials using rare earth catalysts with oxygen vacancies.
基金the financial support by the National Natural Science Foundation of China(52072137)the National Natural Science Foundation of China(22205068)the"CUG Scholar"Scientific Research Funds at China University of Geosciences(Wuhan)(2022118)。
文摘Graphite-silicon species(Gr-Si)hybrid anodes have merged as potential candidates for high-energy lithium-ion batteries(LIBs),yet long been plagued by rapid capacity fading due to their unstable mechano-electrochemistry.The dominant approach to enhance electrochemical stability of the Gr-Si hybrid anodes typically involves the optimization of the electrode material structures and the employment of low active Si species content in electrode(<10 wt%in most instances).However,the electrode structure design,a factor of equal importance in determining the electrochemical performance of Gr-Si hybrid anodes,has received scant attention.In this study,three Gr-Si hybrid anodes with the identical material composition but distinct electrode structures are designed to investigate the mechanoelectrochemistry of the electrodes.It is revealed that the substantial volume change of Si species particles in Gr-Si hybrid anodes led to the local lattice stress of Gr at their contact interface during the charge/discharge processes,thereby increasing thermodynamic and kinetic barrier of Li-ion migration.Furthermore,the huge disparity in volume change of Si species and Gr particles trigger the separate agglomeration of these two materials,resulting in a considerable electrode volume change and increased electrochemical resistance.An advanced Gr/Si hybrid anode with upper Gr and lower Si species layer structure design addresses the above challenges using photovoltaic waste silicon sources under high Si species content(17 wt%)and areal capacity(2.0 mA h cm^(-2))in Ah-level full pouch cells with a low negative/positive(N/P)ratio of 1.09.The cell shows stable cycling for 100 cycles at 0.3 C with an impressively low capacity decay rate of 0.0546%per cycle,outperforming most reported Gr-Si hybrid anodes.
文摘Overexpression of Sperm Acrosomal SLLP1 Binding protein (SAS1B) in various cancer types, including uterine cancer cells, was discovered a few years ago, and different monoclonal antibodies (anti-SAS1B) that specifically bind to SAS1B antigens were developed. Labeling of these antibodies with radionuclides can provide an opportunity for imaging and radioimmunotherapy. The objective of this study was to label anti-SAS1B (SB5) with Zirconium-89 (<sup>89</sup>Zr) for PET imaging and determine its biodistribution. Anti-SAS1B (SB5) antibody was labeled with <sup>89</sup>Zr indirectly using the chelator desferrioxamine B (DFO), which is currently a best linker for<sup> 89</sup>Zr. The antibody, SB5, was first conjugated to DFO with a ratio of 1:5 and then labeled with 250 μCi of <sup>89</sup>Zr. Results of PET imaging in mouse-bearing uterine cancer tumor showed a limited uptake. The bio-distribution study matched the PET imaging and confirmed the uptake by the tumor, and the accumulation in bones. In conclusion, labeling of anti-SAS1B could provide an effective way of uterine cancer detection and treatment progression.
文摘<p align="justify"> <span style="font-family:Verdana;"><strong>Objective:</strong> To observe the clinical efficacy and safety of berberine in treating patients with prediabetes. <strong>Methods:</strong> A total of 76 patients with prediabetes were enrolled, and at the end of a one-month run-in period, 70 patients were eligible to participate in the clinical trial and randomly assigned to two groups in a 1:1 ratio, namely a treatment group (n = 35) and a control group (n = 35). Members of the control group underwent lifestyle interventions, including dietary interventions and exercise prescriptions, while participants of the treatment group received both lifestyle interventions and oral administration of 300 mg berberine, three times daily for three months. Subsequently, the treatment group entered a washout period of two months, during which time the medication was stopped, and the lifestyle interventions continued. Following the washout period, the oral administration of berberine was resumed at the same dose and lasted for three months. Blood glucose parameters were evaluated after different treatment periods. <strong>Results: </strong>1) Intra-group comparison: Following the first and the second treatment periods, the treatment group experienced a significant decrease in fasting plasma glucose (FPG), 2-hour PG (2hPG) based on oral glucose tolerance test (OGTT), HbA1c, and HOMA-IR (P < 0.05);for the control group, although the blood glucose parameters exhibited a downward trend, the differences lacked statistical significance. 2) Intergroup comparison: Compared to the control group, the treatment group showed a significant decline in the levels of FPG, 2hPG, and HbA1c, whereas the decrease in HOMA-IR had no statistical significance. 3) Safety evaluation: No serious adverse events occurred in either group. <strong>Conc</strong><strong>lusion: </strong>Berberine is safe and effective in controlling blood glucose levels in patients with prediabetes and deserves to be promoted in clinical practice.</span> </p>
基金supported by the National Natural Science Foundation of China(51774199)the project of the educational department of Liaoning Province(No LJKMZ20220825).
文摘The 91 measured values of the development height of the water-conducting fracture zone(WCFZ)in deep and thick coal seam mining faces under thick loose layer conditions were collected.Five key characteristic variables influencing the WCFZ height were identified.After removing outliers from the dataset,a Random Forest(RF)regression model optimized by the Sparrow Search Algorithm(SSA)was constructed.The hyperparameters of the RF model were iteratively optimized by minimizing the Out-of-Bag(OOB)error,resulting in the rapid deter-mination of optimal parameters.Specifically,the SSA-RF model achieved an OOB error of 0.148,with 20 de-cision trees,a maximum depth of 8,a minimum split sample size of 2,and a minimum leaf node sample size of 1.Cross-validation experiments were performed using the trained optimal model and compared against other prediction methods.The results showed that the mining height had the most significant correlation with the development height of the WCFZ.The SSA-RF model outperformed all other models,with R2 values exceeding 0.9 across the training,validation,and test datasets.Compared to other models,the SSA-RF model demonstrates a simpler structure,stronger fitting capacity,higher predictive accuracy,and superior stability and generaliza-tion ability.It also exhibits the smallest variation in relative error across datasets,indicating excellent adapt-ability to different data conditions.Furthermore,a numerical model was developed using the hydrogeological data from the 1305 working face at Wanfukou Coal Mine,Shandong Province,China,to simulate the dynamic development of the WCFZ during mining.The SSA-RF model predicted the WCFZ height to be 69.7 m,closely aligning with the PFC2D simulation result of 65 m,with an error of less than 5%.Compared to traditional methods and numerical simulations,the SSA-RF model provides more accurate predictions,showing only a 7.23% deviation from the PFC2D simulation,while traditional empirical formulas yield deviations as large as 19.97%.These results demonstrate the SSA-RF model’s superior predictive capability,reinforcing its reliability and engineering applicability for real-world mining operations.This model holds significant potential for enhancing mining safety and optimizing planning processes,offering a more accurate and efficient approach for WCFZ height prediction.
基金the financial support by Hong Kong Research Grants Council(No.T12-101/23-N)National Natural Science Foundation of China(No.22206160)。
文摘Type 2 diabetes mellitus(T2DM)is one of the most prevalent chronic metabolic disorder characterized by insulin resistance and relative insulin deficiency.PPARδactivation has been reported to have several beneficial effects in alleviating dyslipidemia and insulin resistance.GW501516,a synthetic PPARδagonist,was developed to target hyperlipidemia and reported to alleviating insulin resistance in T2DM.Studies indicate that PPARδactivation by GW501516 can reduce adiposity,enhanceβ-oxidation of fatty acids,and improve insulin sensitivity in T2DM animal models.Despite its therapeutic promise,potential carcinogenic effects also have been reported.Therefore,a comprehensive non-targeted and targeted lipidomics study was carried out to evaluate the regulatory effect of GW501516 in the plasma of db/db mice.The results revealed that GW501516 is effective in reducing the accumulation of lipids in the fatty acid metabolism pathway and lipid classes including triglycerides and phosphatidylglycerols.Furthermore,activation of PPARδby GW501516 demonstrated a beneficial effect on improving circulating cholesterol homeostasis.However,while the levels of hexosylceramides and sphingomyelin were partially reversed,ceramide levels,which are negatively associated with insulin sensitivity,were significantly elevated by GW501516.Despite these mixed outcomes,the study highlights both the promising therapeutic potential of PPARδactivation in metabolic disorders and the safety concerns regarding long-term clinical use.The findings provide valuable insights into the impact of GW501516-induced PPARδactivation on lipid metabolism in T2DM,contributing to a better understanding of its therapeutic potential and risks.
文摘Background:In recent years,the increase of pollen allergy encourages people to do a lot of research on the disease.This paper conducted a bibliometric study on pollen allergy,to explore the risk factors,as well as the current status,hotspots and development trends,so as to provide reference for researchers in related fields.Method:The visual analysis method was used to analyze the related literature of pollen allergy-related based on CiteSpace(6.2.R4)software,which were searched in the database of Web of Science Core Collection(WoSCC)from 2005 to 24 February 2025.Results:Finally,5318 documents were included in this study.Results showed that the country with the most published articles is USA.The research institution with the most publications is Medical University of Vienna.The analysis demonstrates strong international research collaboration,with particularly intensive connections observed within Europe.Professor Valenta Rudolf from the Medical University of Vienna is the most prolific author.High frequency keywords in this field include“asthma”,“allergic rhinitis”,“children”,“sensitization”and“food allergy”.It is worth noting that the emerging terms up to 2025 include“allergen immunotherapy”,“air pollution”,“risk”,“allergenic pollen”,“airborne pollen”,“exposure”,and“climate change”.Allergy and the Journal of Allergy and Clinical Immunology(JACI)are the two most-cited journals,both exhibiting high impact factors and centrality.The review article by Bousquet J.(2018)published in Allergy has been cited 137 times,representing the most cited publication with a betweenness centrality of 0.17.The research focus in the field has shifted to using research methods based on protein and peptides and DNA vaccines for the prevention and treatment of immune reactions induced by tree pollen.The study of recombinant fragments of purified proteins with specific allergens for preventive treatment has broad application prospects.Conclusion:Its conclusion provides comprehensive and beneficial reference information for the prevention and treatment of pollen allergy.
基金supported by the National Natural Science Foundation of China(No.52071012)Open Research Fund of the National Key Laboratory of Advanced Casting Technologies(No.CAT2023-004)+2 种基金Key Research and Development Program of Shandong Province,China(No.2022JMRH0209)Hebei Province Innovation Capability Enhancement Plan Project,China(No.244A7607D)the Open Foundation of the State Key Laboratory for Advanced Metals and Materials(No.2022-Z01).
文摘A series of as-cast Si_(x)Al_(0.43)CoCrFeNi_(2.1)(x=0,0.1,0.2,and 0.3)high-entropy alloys(HEAs)was successfully fabricated by va-cuum-assisted melting.The phase constituents,microstructural features,and mechanical properties(including hardness,tensile behavior,and wear behavior)of alloys with various Si contents were evaluated.The results revealed that the addition of Si promoted the precipita-tion of a body-centered cubic 1(BCC1)phase enriched in Al,Ni,and Si with a B2-ordered structure.Furthermore,the secondary BCC2 phase was enriched with Cr,Fe,and Si precipitates within the BCC1 matrix.Ultimately,a multiphase face-centered cubic(FCC)/(BCC1/BCC2)structure was formed.The microstructural evolution driven by Si addition significantly enhanced the mechanical properties of the Si_(x)Al_(0.43)CoCrFeNi_(2.1) HEAs.As the Si content increased,the microhardness and tensile strength improved by approxim-ately 42%and 55%,reaching 2.359 GPa and 785 MPa,respectively.The quantitative evaluation of the various strengthening mechanisms indicated that the intrinsic hardness of the FCC matrix and hardening due to BCC1/BCC2 precipitation dominated the overall microhard-ness.The comparison of the energy barriers indicates that BCC2 primarily strengthens the alloy through a shear mechanism rather than an Orowan bypass mechanism.Furthermore,with increasing Si content,reduced friction and wear,together with smoother worn surfaces,re-flect a greatly enhanced wear resistance.After the optimal cold-rolling and 1 h annealing at 800℃,the Si_(0.3)Al_(0.43)CoCrFeNi_(2.1) alloy showed 56%and 62%increases in microhardness and tensile strength,respectively,compared to the as-cast state,reaching 3.68 GPa and 1270 MPa.The enhanced mechanical properties are attributed to the synergistic effects of residual strain hardening by FCC ordering and L1_(2)/BCC precipitation strengthening.
基金supported by the National Natural Science Foundation of China (Grant No. 12372028)the National Key Research and Development Program of China (Grant No. 2020YFC2201101)the Guangdong Basic and Applied Basic Research Foundation (Grant No.2022A1515011809)。
文摘The harmonic balance method(HBM)has been widely applied to get the periodic solution of nonlinear systems,however,its convergence rate as well as computation efficiency is dramatically degraded when the system is highly non-smooth,e.g.,discontinuous.In order to accelerate the convergence,an enriched HBM is developed in this paper where the non-smooth Bernoulli bases are additionally introduced to enrich the conventional Fourier bases.The basic idea behind is that the convergence rate of the HB solution,as a truncated Fourier series,can be improved if the smoothness of the solution becomes finer.Along this line,using non-smooth Bernoulli bases can compensate the highly non-smooth part of the solution and then,the smoothness of the residual part for Fourier approximation is improved so as to achieve accelerated convergence.Numerical examples are conducted on systems with non-smooth restoring and/or external forces.The results confirm that the proposed enriched HBM indeed increases the convergence rate and the increase becomes more significant if more non-smooth bases are used.
基金Supported by the National Natural Science Foundation of China,No.82241219,No.82127808 and No.81921004The Shenzhen Science and Technology Program,No.JCYJ20210324120813037.
文摘BACKGROUND Proteins play a central role in regulating biological functions,and various pathways regulate their synthesis and secretion.Endoplasmic reticulum-associated protein degradation(ERAD)is crucial for monitoring protein synthesis and processing unfolded or misfolded proteins in actively growing tumor cells.However,the role of the multiple ERAD complexes in liver cancer remains unclear.AIM To elucidate the effects of SEL1L-mediated ERAD on Huh7 and explore the underlying mechanisms in vivo and in vitro.METHODS Huh7 cells were treated with ERAD inhibitor to identify ERAD’s role.Cell counting kit-8,5-ethynyl-2’-deoxyuridine and colony formation experiments were performed.Apoptosis level and migration ability were assessed using fluorescence activated cell sorting and Transwell assay,respectively.Huh7 SEL1L knockout cell line was established via clustered regularly interspaced short palindromic repeats,proliferation,apoptosis,and migration were assessed through previous experiments.The role of SEL1L in vivo and the downstream target of SEL1L were identified using Xenograft and mass spectrometry,respectively.RESULTS The ERAD inhibitor suppressed cell proliferation and migration and promoted apoptosis.SEL1L-HRD1 significantly influenced Huh7 cell growth.SEL1L knockout suppressed tumor cell proliferation and migration and enhanced apoptosis.Mass spectrometry revealed EXT2 is a primary substrate of ERAD.SEL1L knockout significantly increased the protein expression of EXT2.Furthermore,EXT2 knockdown partially restored the effect of SEL1L knockout.CONCLUSION ERAD inhibition suppressed the proliferation and migration of Huh7 and promoted its apoptosis.EXT2 plays an important role and ERAD might be a potential treatment for Huh7 hepatocellular carcinoma.
基金supported by the National Natural Science Foundation of China(U20A2022 and 32372217)the National Key Research and Development Program of China(2022YFD2300700)the Free Exploration Program of State Key Laboratory of Crop Gene Exploration and Utilization in Sichuan Basin,China(SKL-ZY202216)。
文摘Adjustment of the sowing date is a widely used measure in rice production for adapting to high-temperature conditions.However,the impact of a delayed sowing date(DS)on rice quality may vary by variety and ecological conditions.In this study,we conducted experiments using four different sowing dates,the conventional sowing date 1(CS1),CS2(10 d later than CS1),DS1(30 d later than CS1),and DS2(30 d later than CS2),and three rice varieties,i.e.,Yixiangyou 2115,Fyou 498,and Chuanyou 6203.This experiment was conducted at four sites in the Sichuan Basin in 2018 and 2019 to evaluate the infuence of DS on the pasting properties of rice,which are a proxy for the eating and cooking quality(ECQ).In DS1 and DS2,the rice had a signifcantly greater amylose content(AC)but a lower protein content(PC),peak viscosity(PKV),cool paste viscosity(CPV),and hot paste viscosity(HPV)than in CS1 and CS2.Moreover,except for CS2 and DS1 in 2018,DS1 and DS2 led to 2.15-11.19%reductions in breakdown viscosity(BDV)and 23.46-108.47%increases in setback viscosity(SBV).However,the infuence of DS on rice pasting properties varied by study site and rice variety.In 2019,DS1 and DS2 led to BDV reductions of 2.35-9.33,2.61-8.61,10.03-17.78,and 2.06-8.93%,and SBV increases of 2.32-60.93,63.74-144.24,55.46-91.63,and-8.28-65.37%at the Dayi,Anzhou,Nanbu,and Shehong(except for SBV in CS2 and DS1)sites,respectively.DS resulted in greater reductions in PKV,HPV,CPV,and BDV and greater increases in the AC and SBV for Yixiangyou 2115 than for Chuanyou 6203 and Fyou 498.The correlation analysis indicated that PKV and HPV were signifcantly and positively related to the mean,maximum,and minimum temperatures after heading.These temperatures must be greater than 25.9,31.2,and 22.3℃,respectively,to increase the relative BDV and reduce the relative SBV of rice,thereby enhancing ECQ.In conclusion,DS might contribute to a signifcant deterioration in ECQ in machine-transplanted rice in the Sichuan Basin.A mean temperature above 25.9℃ after heading is required to improve the ECQ of rice.
基金supported by the National Natural Science Foundation of China(Grant Nos.52074187 and 52274388)Liaoning Province Artificial Intelligence Innovation and Development Plan Project(Major Science and Technology Project)(2023JH26-10100002)the National Key Research and Development Program of China(No.2022YFB3304800).
文摘In order to solve the black-box modeling problem and improve the prediction accuracy of model,two distinguished models for tensile strength(Ts)and yield strength(Ys)of hot-rolled strip steel are established based on the industrial hot-rolled data and the algorithm of gene expression programming(GEP).Firstly,the industrial data of hot-rolled strip steel are preprocessed using the Pauta criterion,so as to eliminate outliers.The key input variables that affect Ys and Ts are selected by using the method of the maximal information coefficient(MIC).Secondly,the explicit prediction models of Ys and Ts are established using GEP.Subsequently,the model results based on GEP are compared with those based on the support vector regression(SVR)and the back propagation neural network(BPNN).Finally,the mathematical expression models for Ys and Ts obtained by GEP are used to further analyse the specific relationships between the chemical composition and mechanical property.It is shown that the errors of Ys and Ts based on GEP are less than 4%,and the coefficient of determination(R^(2))of Ys and Ts based on GEP is above 0.9,which has strong prediction performance.The prediction accuracy of GEP can achieve the same level with SVR and BPNN.It is worth mentioning that the proposed model can not only show the explicit relationship between the chemical composition,production process,and mechanical property of strip steel,but also occupy high prediction accuracy,which can make reliable reference for strip steel product design and optimisation.
