As-forged WSTi6421 titanium alloy billet afterβannealing was investigated.Abnormally coarse grains larger than adjacent grains could be observed in the microstructures,forming abnormal grain structures with uneven si...As-forged WSTi6421 titanium alloy billet afterβannealing was investigated.Abnormally coarse grains larger than adjacent grains could be observed in the microstructures,forming abnormal grain structures with uneven size distribution.Through electron backscattered diffraction(EBSD),the forged microstructure at various locations of as-forged WSTi6421 titanium alloy billet was analyzed,revealing that the strength of theβphase cubic texture generated by forging significantly influences the grain size afterβannealing.Heat treatment experiments were conducted within the temperature range from T_(β)−50°C to T_(β)+10°C to observe the macro-and micro-morphologies.Results show that the cubic texture ofβphase caused by forging impacts the texture of the secondaryαphase,which subsequently influences theβphase formed during the post-βannealing process.Moreover,the pinning effect of the residual primaryαphase plays a crucial role in the growth ofβgrains during theβannealing process.EBSD analysis results suggest that the strength ofβphase with cubic texture formed during forging process impacts the orientation distribution differences ofβgrains afterβannealing.Additionally,the development of grains with large orientations within the cubic texture shows a certain degree of selectivity duringβannealing,which is affected by various factors,including the pinning effect of the primaryαphase,the strength of the matrix cubic texture,and the orientation relationship betweenβgrain and matrix.Comprehensively,the stronger the texture in a certain region,the less likely the large misoriented grains suffering secondary growth,thereby aggregating the difference in microstructure and grain orientation distribution across different regions afterβannealing.展开更多
目的系统评价不同驱动基因突变状态下非小细胞肺癌(NSCLC)相关静脉血栓栓塞症(VTE)发生率,并进一步探讨基因突变状态与VTE发病风险的关系。方法计算机检索PubMed、EMbase、Web of Science、Cochrane Library、中国知网、万方和维普数据...目的系统评价不同驱动基因突变状态下非小细胞肺癌(NSCLC)相关静脉血栓栓塞症(VTE)发生率,并进一步探讨基因突变状态与VTE发病风险的关系。方法计算机检索PubMed、EMbase、Web of Science、Cochrane Library、中国知网、万方和维普数据库,搜索NSCLC相关驱动基因突变状态与VTE发生率关系的相关研究,检索时限为建库至2023年7月3日,采用Stata 14.0软件进行分析。结果共纳入文献32篇,总样本量为18032例。Meta分析结果显示,在携带驱动基因突变的肺癌患者中VTE总发生率为19%[95%CI(15%~23%)];ROS1基因融合状态下VTE并发症发生率最高,为31%[95%CI(22%~39%)];ALK/ROS1基因融合/重排以及PD-L1表达阳性的存在与VTE发生风险增加有关[ALK:OR=2.28,95%CI(1.89~2.76);ROS1:OR=3.18,95%CI(1.89~5.35);PD-L1:OR=1.85,95%CI(1.25~2.72)],而EGFR/KRAS基因突变与VTE发生风险无相关性[EGFR:OR=1.16,95%CI(0.75~1.80);KRAS:OR=1.54,95%CI(0.98~2.43)]。结论不同驱动基因突变状态下NSCLC相关VTE并发症的发生率存在明显差异,ALK/ROS1基因融合/重排以及PD-L1表达阳性的存在与VTE发生风险增加有关,而EGFR/KRAS基因突变与VTE发生风险无明显相关性。展开更多
基金Key Research and Development Plan of Shaanxi Province(2023-YBGY-493)。
文摘As-forged WSTi6421 titanium alloy billet afterβannealing was investigated.Abnormally coarse grains larger than adjacent grains could be observed in the microstructures,forming abnormal grain structures with uneven size distribution.Through electron backscattered diffraction(EBSD),the forged microstructure at various locations of as-forged WSTi6421 titanium alloy billet was analyzed,revealing that the strength of theβphase cubic texture generated by forging significantly influences the grain size afterβannealing.Heat treatment experiments were conducted within the temperature range from T_(β)−50°C to T_(β)+10°C to observe the macro-and micro-morphologies.Results show that the cubic texture ofβphase caused by forging impacts the texture of the secondaryαphase,which subsequently influences theβphase formed during the post-βannealing process.Moreover,the pinning effect of the residual primaryαphase plays a crucial role in the growth ofβgrains during theβannealing process.EBSD analysis results suggest that the strength ofβphase with cubic texture formed during forging process impacts the orientation distribution differences ofβgrains afterβannealing.Additionally,the development of grains with large orientations within the cubic texture shows a certain degree of selectivity duringβannealing,which is affected by various factors,including the pinning effect of the primaryαphase,the strength of the matrix cubic texture,and the orientation relationship betweenβgrain and matrix.Comprehensively,the stronger the texture in a certain region,the less likely the large misoriented grains suffering secondary growth,thereby aggregating the difference in microstructure and grain orientation distribution across different regions afterβannealing.
文摘目的系统评价不同驱动基因突变状态下非小细胞肺癌(NSCLC)相关静脉血栓栓塞症(VTE)发生率,并进一步探讨基因突变状态与VTE发病风险的关系。方法计算机检索PubMed、EMbase、Web of Science、Cochrane Library、中国知网、万方和维普数据库,搜索NSCLC相关驱动基因突变状态与VTE发生率关系的相关研究,检索时限为建库至2023年7月3日,采用Stata 14.0软件进行分析。结果共纳入文献32篇,总样本量为18032例。Meta分析结果显示,在携带驱动基因突变的肺癌患者中VTE总发生率为19%[95%CI(15%~23%)];ROS1基因融合状态下VTE并发症发生率最高,为31%[95%CI(22%~39%)];ALK/ROS1基因融合/重排以及PD-L1表达阳性的存在与VTE发生风险增加有关[ALK:OR=2.28,95%CI(1.89~2.76);ROS1:OR=3.18,95%CI(1.89~5.35);PD-L1:OR=1.85,95%CI(1.25~2.72)],而EGFR/KRAS基因突变与VTE发生风险无相关性[EGFR:OR=1.16,95%CI(0.75~1.80);KRAS:OR=1.54,95%CI(0.98~2.43)]。结论不同驱动基因突变状态下NSCLC相关VTE并发症的发生率存在明显差异,ALK/ROS1基因融合/重排以及PD-L1表达阳性的存在与VTE发生风险增加有关,而EGFR/KRAS基因突变与VTE发生风险无明显相关性。
