The production of hydrogen peroxide(H_(2)O_(2))via artificial photosynthesis using single-atom semiconductor photocatalysts represents a promising green and sustainable technology.However,its efficiency is still limit...The production of hydrogen peroxide(H_(2)O_(2))via artificial photosynthesis using single-atom semiconductor photocatalysts represents a promising green and sustainable technology.However,its efficiency is still limited by sluggish water oxidation kinetics,poor photogenerated charge separation,and insufficient O_(2)adsorption and activation capabilities.Herein,uniformly dispersed single-atom catalysts(SACs)with a Co-N_(4)coordination structure have been synthesized by thermally transforming cobalt phthalocyanine(CoPc)assemblies pre-anchored on phosphate functionalized reduced graphene oxide(Co@rGO-P),and then used to construct heterojunctions with perylenetetracarboxylic acid(PTA)nanosheets for photocatalytic H_(2)O_(2)production by an in-situ growth method.The optimized Co@rGO-P/PTA achieved an H_(2)O_(2)production rate of 1.4 mmol g^(-1)h^(-1)in pure water,with a 12.9-fold enhancement compared to pristine PTA nanosheets exhibiting competitive photoactivity among reported perylene-based materials.Femtosecond transient absorption spectra,in-situ diffuse reflectance infrared Fourier transform spectra and theoretical calculations reveal that the exceptional performance is attributed to the enhanced electron transfer from PTA to rGO via the phosphate bridge and then to the Co-N_(4),and to the promoted O_(2)adsorption and activation at Co-N_(4)active sites.This work provides a feasible and effective strategy for designing highly efficient single-atom semiconductor heterojunction photocatalysts for H_(2)O_(2)production.展开更多
Rib spalling is a highly severe issue during mining in deep-buried large-mining-height working faces.This study takes Zhaogu No.2 Coal Mine in Jiaozuo Coalfield,China,as the research background and carries out three f...Rib spalling is a highly severe issue during mining in deep-buried large-mining-height working faces.This study takes Zhaogu No.2 Coal Mine in Jiaozuo Coalfield,China,as the research background and carries out three focused works to address this problem.Firstly,field measurements were conducted to clarify rib spalling characteristics:the coal wall is dominated by shear failure,internal cracks are mainly distributed 3–6 m above the coal wall surface,and the maximum depth of crack development reaches 3 m.Secondly,Universal Distinct Element Code(UDEC)numerical simulation software was used to build a rib spalling model,with the Trigon model adopted to divide the coal wall into blocks.Analysis of four key factors shows that increased buried depth and mining height significantly raise the total length of coal wall internal cracks,increasing rib spalling risk,while higher coal body strength and support strength effectively alleviate this phenomenon.Finally,an orthogonal experiment was designed to quantitatively determine the influence degree of the four factors on rib spalling.Results show that coal body strength has the greatest impact,followed by support strength,mining height,and mining depth in order of influence.This study provides valuable theoretical guidance for on-site prevention and control of coal wall rib spalling.展开更多
目的:探讨Gremlin-1、血尿酸(SUA)及骨代谢指标表达水平与骨质疏松患者疾病严重程度的相关性及其联合诊断价值。方法:选取我院2019年1月到2020年12月收治的80例骨质疏松患者,对所有患者依照双X线吸收法诊断结果进行严重程度分组,将骨密...目的:探讨Gremlin-1、血尿酸(SUA)及骨代谢指标表达水平与骨质疏松患者疾病严重程度的相关性及其联合诊断价值。方法:选取我院2019年1月到2020年12月收治的80例骨质疏松患者,对所有患者依照双X线吸收法诊断结果进行严重程度分组,将骨密度-2.5<T<-1患者分为骨量减少组(n=23),将骨密度T≤-2.5患者分为骨质疏松症组(n=37),将骨密度T≤-2.5,且发生过骨质疏松性骨折的患者分为严重骨质疏松症组(n=20)。对比三组患者Gremlin-1、SUA表达水平与骨代谢指标表达水平,采用Spearman相关分析Gremlin-1、SUA及骨代谢指标表达水平与骨质疏松患者疾病严重程度的相关性。最后建立ROC曲线,Gremlin-1、SUA及骨代谢指标联合对骨质疏松症的诊断价值。结果:三组患者Gremlin-1、SUA水平对比差异显著,骨量减少组Gremlin-1高于骨质疏松症组和严重骨质疏松症组,SUA低于骨质疏松症组和严重骨质疏松症组(P<0.05);三组患者维生素D3[25-(OD)-D3]、β-胶原特殊序列(β-CTX)、甲状旁腺激素(PTH)、I型前胶原N端肽(N-terminal peptide of type I procollagen,PINP)、骨钙素(OC)相关骨代谢指标水平对比差异显著,骨量减少组25-(OD)-D3、PINP、OC高于骨质疏松症组和严重骨质疏松症组,β-CTX、PTH低于骨质疏松症组和严重骨质疏松症组(P<0.05);SUA(r=-0.636)、β-CTX(r=00.626)、PTH(r=0.625)的表达与骨质疏松患者疾病严重程度呈正相关,Gremlin-1(r=-0.452)、25-(OD)-D3(r=-0.462)、PINP(r=-0.622)、OC(r=-0.426)的表达与骨质疏松患者疾病严重程度呈负相关(P<0.05);Gremlin-1、SUA及骨代谢指标联合对骨质疏松症诊断的曲线下面积为0.688,敏感度为92.53%、特异度为87.49%,显著高于单一指标诊断(P<0.05)。结论:Gremlin-1、SUA及骨代谢指标与骨质疏松病情严重程度具有密切关系,且联合诊断骨质疏松症敏感度及特异度较高。展开更多
目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法...目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法:回顾性选取我院2020年5月至2022年4月就诊的85例HBV感染患者,并采用CMIA法、ELISA法分析HBV感染的准确率、血清学标志物检测结果[乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)、乙肝e抗体(Hepatitis B e antibody,HBeAb)、乙肝e抗原(Hepatitis B e antigen,HBeAg)、乙肝核心抗体(Hepatitis B core antibody,HBcAb)浓度]、HBsAb、HBsAg回收率.结果:CMIA法诊断准确率,检测HBsAg、HBeAb、HBcAb阳性率高于ELISA法(P<0.05);两组平均回收率无统计学差异.结论:与ELISA法相比,CMIA法用于检测HBV感染患者血清学标志物具有较高准确度、回收率.展开更多
文摘The production of hydrogen peroxide(H_(2)O_(2))via artificial photosynthesis using single-atom semiconductor photocatalysts represents a promising green and sustainable technology.However,its efficiency is still limited by sluggish water oxidation kinetics,poor photogenerated charge separation,and insufficient O_(2)adsorption and activation capabilities.Herein,uniformly dispersed single-atom catalysts(SACs)with a Co-N_(4)coordination structure have been synthesized by thermally transforming cobalt phthalocyanine(CoPc)assemblies pre-anchored on phosphate functionalized reduced graphene oxide(Co@rGO-P),and then used to construct heterojunctions with perylenetetracarboxylic acid(PTA)nanosheets for photocatalytic H_(2)O_(2)production by an in-situ growth method.The optimized Co@rGO-P/PTA achieved an H_(2)O_(2)production rate of 1.4 mmol g^(-1)h^(-1)in pure water,with a 12.9-fold enhancement compared to pristine PTA nanosheets exhibiting competitive photoactivity among reported perylene-based materials.Femtosecond transient absorption spectra,in-situ diffuse reflectance infrared Fourier transform spectra and theoretical calculations reveal that the exceptional performance is attributed to the enhanced electron transfer from PTA to rGO via the phosphate bridge and then to the Co-N_(4),and to the promoted O_(2)adsorption and activation at Co-N_(4)active sites.This work provides a feasible and effective strategy for designing highly efficient single-atom semiconductor heterojunction photocatalysts for H_(2)O_(2)production.
基金supported by the National Key Research and Development Program of China(No.2023YFC2907501)the National Natural Science Foundation of China(No.52374106)+1 种基金the China Postdoctoral Science Foundation(Grant no.2024T171006)the National Natural Science Foundation of China(Grant no.52204163).
文摘Rib spalling is a highly severe issue during mining in deep-buried large-mining-height working faces.This study takes Zhaogu No.2 Coal Mine in Jiaozuo Coalfield,China,as the research background and carries out three focused works to address this problem.Firstly,field measurements were conducted to clarify rib spalling characteristics:the coal wall is dominated by shear failure,internal cracks are mainly distributed 3–6 m above the coal wall surface,and the maximum depth of crack development reaches 3 m.Secondly,Universal Distinct Element Code(UDEC)numerical simulation software was used to build a rib spalling model,with the Trigon model adopted to divide the coal wall into blocks.Analysis of four key factors shows that increased buried depth and mining height significantly raise the total length of coal wall internal cracks,increasing rib spalling risk,while higher coal body strength and support strength effectively alleviate this phenomenon.Finally,an orthogonal experiment was designed to quantitatively determine the influence degree of the four factors on rib spalling.Results show that coal body strength has the greatest impact,followed by support strength,mining height,and mining depth in order of influence.This study provides valuable theoretical guidance for on-site prevention and control of coal wall rib spalling.
文摘目的:探讨Gremlin-1、血尿酸(SUA)及骨代谢指标表达水平与骨质疏松患者疾病严重程度的相关性及其联合诊断价值。方法:选取我院2019年1月到2020年12月收治的80例骨质疏松患者,对所有患者依照双X线吸收法诊断结果进行严重程度分组,将骨密度-2.5<T<-1患者分为骨量减少组(n=23),将骨密度T≤-2.5患者分为骨质疏松症组(n=37),将骨密度T≤-2.5,且发生过骨质疏松性骨折的患者分为严重骨质疏松症组(n=20)。对比三组患者Gremlin-1、SUA表达水平与骨代谢指标表达水平,采用Spearman相关分析Gremlin-1、SUA及骨代谢指标表达水平与骨质疏松患者疾病严重程度的相关性。最后建立ROC曲线,Gremlin-1、SUA及骨代谢指标联合对骨质疏松症的诊断价值。结果:三组患者Gremlin-1、SUA水平对比差异显著,骨量减少组Gremlin-1高于骨质疏松症组和严重骨质疏松症组,SUA低于骨质疏松症组和严重骨质疏松症组(P<0.05);三组患者维生素D3[25-(OD)-D3]、β-胶原特殊序列(β-CTX)、甲状旁腺激素(PTH)、I型前胶原N端肽(N-terminal peptide of type I procollagen,PINP)、骨钙素(OC)相关骨代谢指标水平对比差异显著,骨量减少组25-(OD)-D3、PINP、OC高于骨质疏松症组和严重骨质疏松症组,β-CTX、PTH低于骨质疏松症组和严重骨质疏松症组(P<0.05);SUA(r=-0.636)、β-CTX(r=00.626)、PTH(r=0.625)的表达与骨质疏松患者疾病严重程度呈正相关,Gremlin-1(r=-0.452)、25-(OD)-D3(r=-0.462)、PINP(r=-0.622)、OC(r=-0.426)的表达与骨质疏松患者疾病严重程度呈负相关(P<0.05);Gremlin-1、SUA及骨代谢指标联合对骨质疏松症诊断的曲线下面积为0.688,敏感度为92.53%、特异度为87.49%,显著高于单一指标诊断(P<0.05)。结论:Gremlin-1、SUA及骨代谢指标与骨质疏松病情严重程度具有密切关系,且联合诊断骨质疏松症敏感度及特异度较高。
文摘目的:分析化学发光微粒子免疫法(Chemiluminescence particle immunoassay,CMIA)和酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)对乙型肝炎病毒(Hepatitis B virus,HBV)感染患者血清学标志物诊断准确率的临床应用价值.方法:回顾性选取我院2020年5月至2022年4月就诊的85例HBV感染患者,并采用CMIA法、ELISA法分析HBV感染的准确率、血清学标志物检测结果[乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)、乙肝e抗体(Hepatitis B e antibody,HBeAb)、乙肝e抗原(Hepatitis B e antigen,HBeAg)、乙肝核心抗体(Hepatitis B core antibody,HBcAb)浓度]、HBsAb、HBsAg回收率.结果:CMIA法诊断准确率,检测HBsAg、HBeAb、HBcAb阳性率高于ELISA法(P<0.05);两组平均回收率无统计学差异.结论:与ELISA法相比,CMIA法用于检测HBV感染患者血清学标志物具有较高准确度、回收率.
