High-performance lead-free piezoelectric single crystals are urgently needed for next-generation actuators and transducers.In this study,we reveal that a compositionally driven tetragonal-pseudocubic(T-PC)phase bounda...High-performance lead-free piezoelectric single crystals are urgently needed for next-generation actuators and transducers.In this study,we reveal that a compositionally driven tetragonal-pseudocubic(T-PC)phase boundary,in conjunction with an octahedral order-disorder tilting transition,significantly enhances the piezoelectric response in Nb^(5+)-substitution(Bi_(0.48)Na_(0.425)K_(0.055)Ba_(0.04))(Ti_(0.98)Nb_(0.02))O_(3)(BNKBT-2Nb)single crystals.The crystal achieves an outstanding piezoelectric coefficient of d33=662 pC/N at room temperature.In situ X-ray diffraction confirms an electric field-induced transition from the PC to T phase.Atomic-resolution HADDF-STEM analysis reveals an increase in the c/a ratio(c/a>1.01)on the local scale and ordered octahe-dral tilting of the a^(0)a^(0)c+type driven by the poling field.The single crystals exhibit excellent piezoelectric per-formance over a broad temperature range,achieving a peak d_(33) of 920 pC/N at approximately 92℃.Furthermore,the polar states exhibit a pronounced frequency dependence near the depolarization temperature.These findings provide critical insight into the structure-property relationship and offer a promising pathway for designing advanced lead-free piezoelectric crystals for functional electromechanical applications.展开更多
China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic ...China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic groups,with limited research on the genetic formation of the hereditary elite family,especially considering their abundant archaeological record and clear material identity.In this study,we obtain the ancient genome of a hereditary elite family,Gao Bin(高宾,503 AD–572 AD),at 0.6473-fold coverage with 475,132 single-nucleotide polymorphisms(SNPs)on the 1240k panel.His mitochondrial haplogroup belongs to Z4 and Y-haplogroup to O1a1a2b-F2444∗.The genetic profile of Gao Bin is most similar to that of the northern Han Chinese.He can be modeled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia,Korea,or the Mongolian Plateau.Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.展开更多
In traditional trial-and-error method,enhancing the Young's modulus of magnesium alloys while maintaining a favorable ductility has consistently been a challenge.It is a need to explore more efficient and expedite...In traditional trial-and-error method,enhancing the Young's modulus of magnesium alloys while maintaining a favorable ductility has consistently been a challenge.It is a need to explore more efficient and expedited methods to design magnesium alloys with high modulus and ductility.In this study,machine learning(ML)and assisted microstructure control methods are used to design high modulus magnesium alloys.Six key features that influence stiffness and ductility have been extracted in this ML model based on abundant data from literature sources.As a result,predictive models for Young's modulus and elongation are established,with errors<2.4%and 4.5%through XGBoost machine learning model,respectively.Within the given range of six features,the magnesium alloys can be fabricated with the Young's modulus exceeding 50 GPa and an elongation surpassing 6%.As a validation,Mg-Al-Y alloys were experimentally prepared to meet the criteria of six features,achieving Young's modulus of 51.5 GPa,and the elongation of 7%.Moreover,the SHapley Additive exPlanation(SHAP)is introduced to boost the model interpretability.This indicates that balancing the volume fraction of reinforcement,the most important feature,is key to achieve Mg-Al-Y alloys with high Young's modulus and favorable elongation through the two models.Enhancing reinforcement dispersion and reducing the size of reinforcement and grain can further improve the elongation of high-stiffness Mg alloy.展开更多
A thermal-responsive photonic crystal material was fabricated by forming an inverse opal nanocomposite hydrogel of poly(N-isopropylacrylamide)(IONHPNIPAm)within the interstitial space of a polystyrene photonic crystal...A thermal-responsive photonic crystal material was fabricated by forming an inverse opal nanocomposite hydrogel of poly(N-isopropylacrylamide)(IONHPNIPAm)within the interstitial space of a polystyrene photonic crystal template.In IONHPNIPAm,PNIPAm were physically cross-linked with two kinds of nanoparticles(carbon dots and laponite clays).The integration of carbon dots and laponite clays for physical crosslinking endowed IONHPNIPAm sufficient strength and self-healing property.IONHPNIPAm films can be completely peeled from the substrates to be utilized as an independent photonic crystal material.The structural color and optical diffraction of the IONHPNIPAm exhibits a rapid reversible change in response to external thermal stimuli due to its physical cross-linking feature.Moreover,the IONHPNIPAm shows clear fluorescence due to the introduction of carbon dots,which enables a convenient way for chemical detection(such as the detection of silver ions).This stimuli-responsive photonic crystal materials based on physically cross-linked inverse opal nanocomposite hydrogels with fast response and good mechanical stability are promising for applications in the fields of smart optical detectors,thermal-responsive sensors and chemical detectors.展开更多
The structural phase transitions and ferroelectric dynamics of lead-free AgNbO_(3)have attracted consid-erable attention owing to their potential in energy-storage device applications.Here,we examine the impact of Li+...The structural phase transitions and ferroelectric dynamics of lead-free AgNbO_(3)have attracted consid-erable attention owing to their potential in energy-storage device applications.Here,we examine the impact of Li+doping on the phase transitions and polarization behavior of(Ag_(1-x)Li_(x))NbO_(3)(x=0-7%)ceramics through comprehensive dielectric and ferroelectric analyses.Rietveld refinement reveals a Li+-induced phase transition from Pbcm to R3c,with x=5%and x=6%compositions near the morphotropic phase boundary(MPB).Dielectric anomalies identify key characteristic temperatures,supporting the con-struction of a low-field phase diagram.High-field studies uncover a direct relationship between phase structure and polarization behavior,culminating in a high-field phase diagram.Near-MPB compositions exhibit distinct structural states,elucidating the mechanisms of reversible and irreversible phase transi-tions.This work provides a comprehensive explanation of the evolution of hysteresis loop profiles,capturing their progression from double hysteresis loops to square loops and their subsequent reversion to double loops under varying electric field and temperature conditions.These temperature-composition(T-x)and temperature-electric field(T-E)phase diagrams provide a robust framework for understanding phase evolution,offering critical insights into optimizing AgNbO_(3)-based ceramics for advanced functional applications.展开更多
Under the rapid impetus of artificial intelligence(AI)technology,human society is stepping into the age of intelligence at an unprecedented speed.A new generation of information technology such as AI is not only a new...Under the rapid impetus of artificial intelligence(AI)technology,human society is stepping into the age of intelligence at an unprecedented speed.A new generation of information technology such as AI is not only a new engine of economic development,but also a gas pedal of social development,which has had a profound impact on the field of education.In the face of the opportunities and challenges of the AI era,it is particularly urgent to build a scientific and reasonable education evaluation system.This paper combines the context of the times with the new technology of AI to discuss the opportunities,challenges,and implementation strategies of educational evaluation reform in the era of AI,with a view to providing references for the construction of the educational evaluation system and the development of high-quality education in the new era.展开更多
Facial morphology,a complex trait influenced by genetics,holds great significance in evolutionary research.However,due to limited fossil evidence,the facial characteristics of Neanderthals and Denisovans have remained...Facial morphology,a complex trait influenced by genetics,holds great significance in evolutionary research.However,due to limited fossil evidence,the facial characteristics of Neanderthals and Denisovans have remained largely unknown.In this study,we conduct a large-scale multi-ethnic meta-analysis of the genome-wide association study(GWAS),including 9674 East Asians and 10,115 Europeans,quantitatively assessing 78 facial traits using 3D facial images.We identify 71 genomic loci associated with facial features,including 21 novel loci.We develop a facial polygenic score(FPS)that enables the prediction of facial features based on genetic information.Interestingly,the distribution of FPSs among populations from diverse continental groups exhibits relevant correlations with observed facial features.Furthermore,we apply the FPS to predict the facial traits of seven Neanderthals and one Denisovan using ancient DNA and align predictions with the fossil records.Our results suggest that Neanderthals and Denisovans likely share similar facial features,such as a wider but shorter nose and a wider endocanthion distance.The decreased mouth width is characterized specifically in Denisovans.The integration of genomic data and facial trait analysis provides valuable insights into the evolutionary history and adaptive changes in human facial morphology.展开更多
BACKGROUND Primary liver cancer is a globally prevalent malignancy,with China accounting for approximately 55%of new cases,and is linked to hepatitis B,aflatoxin,and cirrhosis.Its rupture with hemorrhagic shock is a l...BACKGROUND Primary liver cancer is a globally prevalent malignancy,with China accounting for approximately 55%of new cases,and is linked to hepatitis B,aflatoxin,and cirrhosis.Its rupture with hemorrhagic shock is a lethal complication with high mortality,and traditional triage struggles with timely risk stratification,necessitating better tools,such as the integrated shock index(SI)-early warning score(EWS).AIM To study and analyze the combined effect of the SI and EWS in primary liver cancer patients with ruptured hemorrhage and shock.METHODS In total,118 patients who visited the Emergency Department of Nantong Third People's Hospital from January 2023 to December 2024 were selected and randomly divided into a control group(59 patients who received routine emergency treatment)and an observation group(59 patients who received condition assessment and intervention by combining the SI and EWS based on routine emergency treatment).The clinical treatment outcomes,respiratory function indicators,serological indicators,complications,and satisfaction with emergency intervention before and after the emergency intervention were compared between the two groups.RESULTS The emergency,triage,waiting,and hemostasis times,as well as hospital stay were shorter in the observation group than in the control group(P<0.05).After 48 hours of emergency intervention,blood oxygen saturation and partial pressure of oxygen in the observation group were higher than those in the control group(P<0.05).Seven days after emergency intervention,the hemoglobin,prealbumin,and albumin levels were higher in the observation group than in the control group(P<0.05).The complication rate in the observation group was 3.39%,lower than that in the control group(13.56%;P<0.05).Satisfaction with emergency intervention in the observation group was 94.92%,higher than 83.05%in the control group(P<0.05).CONCLUSION The combined application of the SI and EWS in patients with primary liver cancer rupture,hemorrhage,and shock can significantly shorten emergency treatment time,improve respiratory function and serological indicators,reduce the incidence of complications,and enhance patient satisfaction with emergency interventions,with higher clinical treatment efficiency and quality.Therefore,it is worthy of promotion and application.展开更多
Mitochondria play a key role in lipid metabolism,and mitochondrial DNA(mtDNA)mutations are thus considered to affect obesity susceptibility by altering oxidative phosphorylation and mitochondrial function.In this stud...Mitochondria play a key role in lipid metabolism,and mitochondrial DNA(mtDNA)mutations are thus considered to affect obesity susceptibility by altering oxidative phosphorylation and mitochondrial function.In this study,we investigate mtDNA variants that may affect obesity risk in 2877 Han Chinese individuals from 3 independent populations.The association analysis of 16 basal mtDNA haplogroups with body mass index,waist circumference,and waist-to-hip ratio reveals that only haplogroup M7 is significantly negatively correlated with all three adiposity-related anthropometric traits in the overall cohort,verified by the analysis of a single population,i.e.,the Zhengzhou population.Furthermore,subhaplogroup analysis suggests that M7b1a1 is the most likely haplogroup associated with a decreased obesity risk,and the variation T12811C(causing Y159H in ND5)harbored in M7b1a1 may be the most likely candidate for altering the mitochondrial function.Specifically,we find that proportionally more nonsynonymous mutations accumulate in M7b1a1 carriers,indicating that M7b1a1 is either under positive selection or subject to a relaxation of selective constraints.We also find that nuclear variants,especially in DACT2 and PIEZO1,may functionally interact with M7b1a1.展开更多
The code of the list of sea and island problems is the unique identification code of the regulatory files,which is accompanied by the whole life cycle of the regulatory"discovery,verification and disposal".S...The code of the list of sea and island problems is the unique identification code of the regulatory files,which is accompanied by the whole life cycle of the regulatory"discovery,verification and disposal".Standardized coding of problems found by supervision and tracking and recording the whole life cycle of supervision can quickly guide supervisors to find problems,identify problems,initiate responses and carry out follow-up disposal,which is a reflection of whole-process management of supervision.Combining with sea and island regulatory systems and mechanisms,combed the supervision business flow,divides the supervision link,based on the existing coding system,from the Angle of supervision refinement,puts forward a whole lifetime oriented regulatory system of sea and island issues list for coding,coding through to find and stop and disposal of the three links all process application scenarios,The implementation of the whole business"one code"association,the whole process of"one code"management,practice verification shows the effectiveness of the method,compared with the original coding rules for the supervision of all links and results reflect more intuitive,comprehensive,can be better applied to the practice of supervision.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.11704301)the Natural Science Basic Research Plan in Shaanxi Province of China(Program No.2022JM212)supported by the Ministry of Science and Higher Education of the Russian Federation(FSEG-2023-0016).
文摘High-performance lead-free piezoelectric single crystals are urgently needed for next-generation actuators and transducers.In this study,we reveal that a compositionally driven tetragonal-pseudocubic(T-PC)phase boundary,in conjunction with an octahedral order-disorder tilting transition,significantly enhances the piezoelectric response in Nb^(5+)-substitution(Bi_(0.48)Na_(0.425)K_(0.055)Ba_(0.04))(Ti_(0.98)Nb_(0.02))O_(3)(BNKBT-2Nb)single crystals.The crystal achieves an outstanding piezoelectric coefficient of d33=662 pC/N at room temperature.In situ X-ray diffraction confirms an electric field-induced transition from the PC to T phase.Atomic-resolution HADDF-STEM analysis reveals an increase in the c/a ratio(c/a>1.01)on the local scale and ordered octahe-dral tilting of the a^(0)a^(0)c+type driven by the poling field.The single crystals exhibit excellent piezoelectric per-formance over a broad temperature range,achieving a peak d_(33) of 920 pC/N at approximately 92℃.Furthermore,the polar states exhibit a pronounced frequency dependence near the depolarization temperature.These findings provide critical insight into the structure-property relationship and offer a promising pathway for designing advanced lead-free piezoelectric crystals for functional electromechanical applications.
基金funded by the National Natural Science Foundation of China(32070576,31801040,and 32270667)Lantai Young Scholars Program of Chinese History Institute(2022LTQN602)+11 种基金the National Social Science Fund of China(19VJX074 and 21CKG022)Priority Research Program of the Chinese Academy of Sciences:Pan-Third Pole Environment Study for a Green Silk Road(Pan-TPE)(XDA2004010101)the National Key Research and Development Program(2023YFC3303701-02)the Natural Science Foundation of Fujian Province of China(2023J06013)the Science and Technology Commission of Shanghai Municipality(18490750300)the National Key Research and Development Program(2020YFE0201600)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)the Major Project of National Social Science Foundation of China granted to C.C.W.(21&ZD285),S.W.(20&ZD212),and D.L.(21&ZD237)Major Special Project of Philosophy and Social Sciences Research of the Ministry of Education(2022JZDZ023)Open Research Fund of State Key Laboratory of Genetic Engineering at Fudan University(SKLGE-2310)Open Research Fund of Forensic Genetics Key Laboratory of the Ministry of Public Security(2023FGKFKT07)European Research Council(ERC)grant(ERC-2019-ADG-883700-TRAM).
文摘China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic groups,with limited research on the genetic formation of the hereditary elite family,especially considering their abundant archaeological record and clear material identity.In this study,we obtain the ancient genome of a hereditary elite family,Gao Bin(高宾,503 AD–572 AD),at 0.6473-fold coverage with 475,132 single-nucleotide polymorphisms(SNPs)on the 1240k panel.His mitochondrial haplogroup belongs to Z4 and Y-haplogroup to O1a1a2b-F2444∗.The genetic profile of Gao Bin is most similar to that of the northern Han Chinese.He can be modeled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia,Korea,or the Mongolian Plateau.Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.
基金financially supported by the National Natural Science Foundation of China(Nos.U2241231 and 52071206).
文摘In traditional trial-and-error method,enhancing the Young's modulus of magnesium alloys while maintaining a favorable ductility has consistently been a challenge.It is a need to explore more efficient and expedited methods to design magnesium alloys with high modulus and ductility.In this study,machine learning(ML)and assisted microstructure control methods are used to design high modulus magnesium alloys.Six key features that influence stiffness and ductility have been extracted in this ML model based on abundant data from literature sources.As a result,predictive models for Young's modulus and elongation are established,with errors<2.4%and 4.5%through XGBoost machine learning model,respectively.Within the given range of six features,the magnesium alloys can be fabricated with the Young's modulus exceeding 50 GPa and an elongation surpassing 6%.As a validation,Mg-Al-Y alloys were experimentally prepared to meet the criteria of six features,achieving Young's modulus of 51.5 GPa,and the elongation of 7%.Moreover,the SHapley Additive exPlanation(SHAP)is introduced to boost the model interpretability.This indicates that balancing the volume fraction of reinforcement,the most important feature,is key to achieve Mg-Al-Y alloys with high Young's modulus and favorable elongation through the two models.Enhancing reinforcement dispersion and reducing the size of reinforcement and grain can further improve the elongation of high-stiffness Mg alloy.
基金Funded by the National Natural Science Foundation of China(No.51873167)the National Innovation and Entrepreneurship Training Program for College Students(No.S202010497024)。
文摘A thermal-responsive photonic crystal material was fabricated by forming an inverse opal nanocomposite hydrogel of poly(N-isopropylacrylamide)(IONHPNIPAm)within the interstitial space of a polystyrene photonic crystal template.In IONHPNIPAm,PNIPAm were physically cross-linked with two kinds of nanoparticles(carbon dots and laponite clays).The integration of carbon dots and laponite clays for physical crosslinking endowed IONHPNIPAm sufficient strength and self-healing property.IONHPNIPAm films can be completely peeled from the substrates to be utilized as an independent photonic crystal material.The structural color and optical diffraction of the IONHPNIPAm exhibits a rapid reversible change in response to external thermal stimuli due to its physical cross-linking feature.Moreover,the IONHPNIPAm shows clear fluorescence due to the introduction of carbon dots,which enables a convenient way for chemical detection(such as the detection of silver ions).This stimuli-responsive photonic crystal materials based on physically cross-linked inverse opal nanocomposite hydrogels with fast response and good mechanical stability are promising for applications in the fields of smart optical detectors,thermal-responsive sensors and chemical detectors.
基金finically supported by the National Natural Science Foundation of China(Nos.52261135548,52302153,and 52402155)the China Postdoctoral Science Foundation(Nos.GZC20232075 and 2023M742767)+2 种基金The research was made possible by Russian Science Foundation(Project No 23-42-00116)The equipment of the Ural Center for Shared Use“Modern nanotech-nology”Ural Federal University(Reg.No2968)whichis supported by the Ministry of Science and Higher Education RF(Project No 075-15-2021-677)was usedThe SEM work was done at International Center for Dielectric Research(ICDR),Xi’an Jiaotong University,Xi’an,China.
文摘The structural phase transitions and ferroelectric dynamics of lead-free AgNbO_(3)have attracted consid-erable attention owing to their potential in energy-storage device applications.Here,we examine the impact of Li+doping on the phase transitions and polarization behavior of(Ag_(1-x)Li_(x))NbO_(3)(x=0-7%)ceramics through comprehensive dielectric and ferroelectric analyses.Rietveld refinement reveals a Li+-induced phase transition from Pbcm to R3c,with x=5%and x=6%compositions near the morphotropic phase boundary(MPB).Dielectric anomalies identify key characteristic temperatures,supporting the con-struction of a low-field phase diagram.High-field studies uncover a direct relationship between phase structure and polarization behavior,culminating in a high-field phase diagram.Near-MPB compositions exhibit distinct structural states,elucidating the mechanisms of reversible and irreversible phase transi-tions.This work provides a comprehensive explanation of the evolution of hysteresis loop profiles,capturing their progression from double hysteresis loops to square loops and their subsequent reversion to double loops under varying electric field and temperature conditions.These temperature-composition(T-x)and temperature-electric field(T-E)phase diagrams provide a robust framework for understanding phase evolution,offering critical insights into optimizing AgNbO_(3)-based ceramics for advanced functional applications.
文摘Under the rapid impetus of artificial intelligence(AI)technology,human society is stepping into the age of intelligence at an unprecedented speed.A new generation of information technology such as AI is not only a new engine of economic development,but also a gas pedal of social development,which has had a profound impact on the field of education.In the face of the opportunities and challenges of the AI era,it is particularly urgent to build a scientific and reasonable education evaluation system.This paper combines the context of the times with the new technology of AI to discuss the opportunities,challenges,and implementation strategies of educational evaluation reform in the era of AI,with a view to providing references for the construction of the educational evaluation system and the development of high-quality education in the new era.
基金funded by the following grants and contracts:Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38020400 to S.W.)the National Natural Science Foundation of China(32325013 to S.W.,32271186 to J.T.,31900408 to M.Z.)+5 种基金the CAS Project for Young Scientists in Basic Research(YSBR-077 to S.W.)Shanghai Science and Technology Commission Excellent Academic Leaders Program(22XD1424700 to S.W.)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-066 to L.J.and J.W.)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01 to L.J.and S.W.)the National Science and Technology Basic Research Project(2015FY111700 to L.J.)the 111 Project(B13016 to L.J.).
文摘Facial morphology,a complex trait influenced by genetics,holds great significance in evolutionary research.However,due to limited fossil evidence,the facial characteristics of Neanderthals and Denisovans have remained largely unknown.In this study,we conduct a large-scale multi-ethnic meta-analysis of the genome-wide association study(GWAS),including 9674 East Asians and 10,115 Europeans,quantitatively assessing 78 facial traits using 3D facial images.We identify 71 genomic loci associated with facial features,including 21 novel loci.We develop a facial polygenic score(FPS)that enables the prediction of facial features based on genetic information.Interestingly,the distribution of FPSs among populations from diverse continental groups exhibits relevant correlations with observed facial features.Furthermore,we apply the FPS to predict the facial traits of seven Neanderthals and one Denisovan using ancient DNA and align predictions with the fossil records.Our results suggest that Neanderthals and Denisovans likely share similar facial features,such as a wider but shorter nose and a wider endocanthion distance.The decreased mouth width is characterized specifically in Denisovans.The integration of genomic data and facial trait analysis provides valuable insights into the evolutionary history and adaptive changes in human facial morphology.
基金Supported by Clinical Medicine Special Research Fund Project of Nantong University,No.2024HZ001 and No.2022HY009。
文摘BACKGROUND Primary liver cancer is a globally prevalent malignancy,with China accounting for approximately 55%of new cases,and is linked to hepatitis B,aflatoxin,and cirrhosis.Its rupture with hemorrhagic shock is a lethal complication with high mortality,and traditional triage struggles with timely risk stratification,necessitating better tools,such as the integrated shock index(SI)-early warning score(EWS).AIM To study and analyze the combined effect of the SI and EWS in primary liver cancer patients with ruptured hemorrhage and shock.METHODS In total,118 patients who visited the Emergency Department of Nantong Third People's Hospital from January 2023 to December 2024 were selected and randomly divided into a control group(59 patients who received routine emergency treatment)and an observation group(59 patients who received condition assessment and intervention by combining the SI and EWS based on routine emergency treatment).The clinical treatment outcomes,respiratory function indicators,serological indicators,complications,and satisfaction with emergency intervention before and after the emergency intervention were compared between the two groups.RESULTS The emergency,triage,waiting,and hemostasis times,as well as hospital stay were shorter in the observation group than in the control group(P<0.05).After 48 hours of emergency intervention,blood oxygen saturation and partial pressure of oxygen in the observation group were higher than those in the control group(P<0.05).Seven days after emergency intervention,the hemoglobin,prealbumin,and albumin levels were higher in the observation group than in the control group(P<0.05).The complication rate in the observation group was 3.39%,lower than that in the control group(13.56%;P<0.05).Satisfaction with emergency intervention in the observation group was 94.92%,higher than 83.05%in the control group(P<0.05).CONCLUSION The combined application of the SI and EWS in patients with primary liver cancer rupture,hemorrhage,and shock can significantly shorten emergency treatment time,improve respiratory function and serological indicators,reduce the incidence of complications,and enhance patient satisfaction with emergency interventions,with higher clinical treatment efficiency and quality.Therefore,it is worthy of promotion and application.
基金supported by the National Natural Science Foundation of China(32270670,32288101,32271186,and 32200482)the National Basic Research Program of China(2015FY111700)the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-066).
文摘Mitochondria play a key role in lipid metabolism,and mitochondrial DNA(mtDNA)mutations are thus considered to affect obesity susceptibility by altering oxidative phosphorylation and mitochondrial function.In this study,we investigate mtDNA variants that may affect obesity risk in 2877 Han Chinese individuals from 3 independent populations.The association analysis of 16 basal mtDNA haplogroups with body mass index,waist circumference,and waist-to-hip ratio reveals that only haplogroup M7 is significantly negatively correlated with all three adiposity-related anthropometric traits in the overall cohort,verified by the analysis of a single population,i.e.,the Zhengzhou population.Furthermore,subhaplogroup analysis suggests that M7b1a1 is the most likely haplogroup associated with a decreased obesity risk,and the variation T12811C(causing Y159H in ND5)harbored in M7b1a1 may be the most likely candidate for altering the mitochondrial function.Specifically,we find that proportionally more nonsynonymous mutations accumulate in M7b1a1 carriers,indicating that M7b1a1 is either under positive selection or subject to a relaxation of selective constraints.We also find that nuclear variants,especially in DACT2 and PIEZO1,may functionally interact with M7b1a1.
文摘The code of the list of sea and island problems is the unique identification code of the regulatory files,which is accompanied by the whole life cycle of the regulatory"discovery,verification and disposal".Standardized coding of problems found by supervision and tracking and recording the whole life cycle of supervision can quickly guide supervisors to find problems,identify problems,initiate responses and carry out follow-up disposal,which is a reflection of whole-process management of supervision.Combining with sea and island regulatory systems and mechanisms,combed the supervision business flow,divides the supervision link,based on the existing coding system,from the Angle of supervision refinement,puts forward a whole lifetime oriented regulatory system of sea and island issues list for coding,coding through to find and stop and disposal of the three links all process application scenarios,The implementation of the whole business"one code"association,the whole process of"one code"management,practice verification shows the effectiveness of the method,compared with the original coding rules for the supervision of all links and results reflect more intuitive,comprehensive,can be better applied to the practice of supervision.
