Ustiloxins are the primary secondary metabolites of Ustilaginoidea virens(teleomorph:Villosiclava virens).While these toxins are known to exhibit toxicity in certain animals,their potential risks to human health requi...Ustiloxins are the primary secondary metabolites of Ustilaginoidea virens(teleomorph:Villosiclava virens).While these toxins are known to exhibit toxicity in certain animals,their potential risks to human health require further investigation.Therefore,this study was conducted using male mice as experimental animal to explore their potential health risks.We observed morphological changes in cells and structural lesions in mitochondria using electron microscopy,combined with Hematoxylin and Eosin(H&E)staining.We utilized transcriptomics,proteomics,and bioinformatics techniques to analyze the regulatory networks associated with ustiloxins in the context of liver damage and study the mechanism of liver injury caused by ustiloxins in mice.Differentially expressed genes(DEGs)were linked to terms such as‘metabolism of exogenous substances with cytochrome P450’,‘peroxisomes’,and‘negative regulation of the inflammatory response’.Western blotting and quantitative real-time PCR(qRT-PCR)demonstrated that ustiloxins can further activate the inflammatory pathways of Nrf2/HO-1 and NLRP3 by activating cytochrome P450(CYP450),leading to liver damage in mice.展开更多
Accurate identification of water sources is crucial for effective water management and safety in mining operations.However,imbalanced water sample datasets often lead to suboptimal classification accuracy.To address t...Accurate identification of water sources is crucial for effective water management and safety in mining operations.However,imbalanced water sample datasets often lead to suboptimal classification accuracy.To address this challenge,this study proposes a novel water source identification method integrating Synthetic Minority Over-Sampling Technique(SMOTE),Zebra Optimization Algorithm(ZOA),and Light Gradient Boosting Machine(LightGBM).Initially,SMOTE is utilized to synthesize samples for the minority class within the imbalanced dataset,thereby generating a balanced water sample dataset and mitigating class distribution disparities.Subsequently,an efficient water source identification model is constructed by combining ZOA with LightGBM,leveraging the strengths of both algorithms.The model’s performance is validated using a test set and compared with other common classification models.Results demonstrate that SMOTE significantly alleviates class imbalance and enhances the classification accuracy of LightGBM for minority class water samples.ZOA parameter tuning accelerates model convergence and further improves classification accuracy,optimizing the model’s overall performance.In experimental validation,the proposed SMOTE-ZOA-LightGBM model achieved an accuracy of 88.41%and a F1 score of 88.24%,outperforming six other classification models.The method proposed in this paper can accurately identify water source types,effectively addressing the issue of low classification accuracy caused by imbalanced water sample data.It provides reliable technical support and scientific basis for identifying and preventing water inrush sources in mines.展开更多
This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly a...This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly ash(FA),and analyzed its mechanical properties,hydration mechanism,and retardation mechanism.The effects of retarders on the hydration products,mechanical properties,and hydration kinetics of ACCM were investigated using XRD,SEM,FTIR,EDS,and thermoactive microcalorimetry.The results showed that Na_(2)B_(4)O_(7)·10H_(2)O(B)delayed the exotherm during the alkali activation process and could effectively delay the setting time of ACCM,but the mechanical properties were slightly decreased.The setting time of ACCM increased with the increase in SG content,but the mechanical properties of ACCM decreased with the increase in SG content.C1_(2)H_(22)O_(11)(CHO)could effectively delay the hydration reaction of ACCM and weakly enhanced the compressive strength.H_(3)PO_(4)(HP)at a concentration of 0.05 mol/L had a certain effect on ACCM retardation,but HP at a concentration of 0.07 and 0.09 mol/L had an effect of promoting the setting and hardening time of ACCM.展开更多
OBJECTIVE:To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system(NNCS) in rats with ulcerative colitis(UC).METHODS:UC rat model was established by administering 4% dextran s...OBJECTIVE:To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system(NNCS) in rats with ulcerative colitis(UC).METHODS:UC rat model was established by administering 4% dextran sulfate sodium.After 7 d,mild moxibustion,α7 nicotinic acetylcholine receptors(α7nAchRs) antagonist(α-bungarotoxin,α-BGT),vesicular acetylcholine transport inhibitor(vesamicol hydrochloride,VH) and organic cation transporters inhibitor(quinine,Qu) treatments were performed once daily for 7 d.Haematoxylin and eosin staining was used for morphological evaluation of colon tissues.Enzymelinked immunosorbent assay(ELISA) was used to measure the protein expressions of interleukin-1β(IL-1β) and choline acetyltransferase(ChAT) in colon tissue.Reverse transcription quantitative real-time polymerase chain reaction(RT-q PCR) was used to detect the mRNA expressions of IL-1β,carnosine acetyltransferase(CarAT),ChAT,and nuclear factor kappa-B p65 subunit(NF-κB p65) in colon tissue.Western blot was used to detect NF-κB p65 protein expression in colon tissue.Immunofluorescence was used to detect the expressions of neuronal acetylcholine(nAch) and non-neuronal acetylcholine(nnAch,released by NNCS) in colon tissue.RESULTS:Mild moxibustion inhibited colon inflammation and repaired mucosal damage to the colon in UC rats.Meanwhile,mild moxibustion could downregulate the expressions of IL-1β,NF-κB p65 protein and mRNA(P < 0.01),and upregulate the expressions of ChAT protein and CarAT mRNA(P < 0.05,P < 0.01).The α7nAChR antagonist α-BGT can reverse the protective effect of mild moxibustion on the UC and the inhibitory effect on the inflammatory factors.VH cannot affect the effect of mild moxibustion on the expressions of IL-1β and nnAch,while Qu can reverse the effect of mild moxibustion on the expression of IL-1β and nnAch.CONCLUSIONS:Mild moxibustion can inhibite colon inflammation in UC rats,which is closely related to the release of acetylcholine by NNCS and its mediated mechanism of cholinergic anti-inflammation pathway.展开更多
目的:分析深静脉血栓病人生活质量的研究现状、热点和发展趋势。方法:检索Web of Science核心合集数据库中科学引文索引扩展版和社会科学引文索引建库至2024年收录的深静脉血栓病人生活质量的相关文献,利用VOSviewer软件对发文作者、期...目的:分析深静脉血栓病人生活质量的研究现状、热点和发展趋势。方法:检索Web of Science核心合集数据库中科学引文索引扩展版和社会科学引文索引建库至2024年收录的深静脉血栓病人生活质量的相关文献,利用VOSviewer软件对发文作者、期刊、国家、文献共被引分析、作者共被引及关键词共现进行可视化分析,采用CiteSpace软件,基于对数似然率(LLR)算法开展文献共被引聚类及关键词突现分析。结果:共纳入304篇文献,涉及40个国家的1 391名作者,该领域的发文量呈上升趋势;美国的发文量居全球首位;高产学者主要来自加拿大和美国;发文量排名居前2位的期刊为Thrombosis Research和Phlebology;研究热点包括深静脉血栓病人的症状管理及风险因素、生活质量与心理健康的关系、不同治疗干预及结果对生活质量的影响,长期并发症(如血栓后综合征)的管理及其经济负担、深静脉血栓管理指南及预测因素;研究趋势包括深静脉血栓病人生活质量评估工具的验证、导管定向性溶栓治疗(CaVenT)对深静脉血栓病人生活质量的影响、深静脉血栓疾病的严重程度与生活质量的关联等。结论:深静脉血栓病人生活质量的研究处于发展阶段,国外已形成核心作者群,研究成果和方法备受关注,我国学者可学习借鉴国外的研究经验和方法,加强这一领域的研究,促进我国在深静脉血栓病人生活质量方面的进步与发展。展开更多
In contrast to the predominant mono or difunctionalization of alkenes,the multi-site functionalization of alkenes involving the synergistic formation of more than two new C–C or C–X bonds is much challenging,especia...In contrast to the predominant mono or difunctionalization of alkenes,the multi-site functionalization of alkenes involving the synergistic formation of more than two new C–C or C–X bonds is much challenging,especially for developing new reaction pathway to afford the functional heterocycle compounds with aggregation-induced emission(AIE)property has been rarely reported.In present work,the multi-site functionalization of in situ generated alkenes with indoles has been developed for the synthesis of diversely functionalized carbazoles through the synergistic construction of multiple C–C bonds and C=O bond.A proposed reaction sequence involving C–H alkenylation/radical oxygen atom transfer/Diels-Alder cycloaddition/dehydrogenative aromatization was supported by experiments and density functional theory calculations.Further derivative carbazole-linked-quinoxaline skeletons represent a class of AIEgens with acceptor-donor-acceptor configuration,which generated the desired twisted intramolecular charge transfer(TICT)AIE properties and could be used as fluorescent probes for detecting the micrometer-sized phase separation of polymer blends.The protocol provides a concise route for the synthesis and application of carbazole-based AIE luminogens.展开更多
Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic...Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic anisotropy(OA)are two typical categories of anisotropic media in exploration geophysics.In comparison of the elastic wave equations in both TI and OA media,pseudo-acoustic wave equations(PWEs)based on the acoustic assumption can markedly reduce computational cost and complexity.However,the presently available PWEs may experience SV-wave contamination and instability when anisotropic parameters cannot satisfy the approximated condition.Exploiting pure-mode wave equations can effectively resolve the above-mentioned issues and generate pure P-wave events without any artifacts.To further improve the computational accuracy and efficiency,we develop two novel pure qP-wave equations(PPEs)and illustrate the corresponding numerical solutions in the timespace domain for 3D tilted TI(TTI)and tilted OA(TOA)media.First,the rational polynomials are adopted to estimate the exact pure qP-wave dispersion relations,which contain complicated pseudo-differential operators with irrational forms.The polynomial coefficients are produced by applying a linear optimization algorithm to minimize the objective function difference between the expansion formula and the exact one.Then,the developed optimized PPEs are efficiently implemented using the finite-difference(FD)method in the time-space domain by introducing a scalar operator,which can help avoid the problem of spectral-based algorithms and other calculation burdens.Structures of the new equations are concise and corresponding implementation processes are straightforward.Phase velocity analyses indicate that our proposed optimized equations can lead to reliable approximation results.3D synthetic examples demonstrate that our proposed FD-based PPEs can produce accurate and stable P-wave responses,and effectively describe the wavefield features in complicated TTI and TOA media.展开更多
Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining s...Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining samples do not correspond one-to-one correctly.Mismatched datasets caused by missing samples make the industrial data unavailable for further machine learning.In order to align the mismatched samples,this article presents a cooperative iteration matching method(CIMM)based on the modified dynamic time warping(DTW).The proposed method regards the sequentially accumulated industrial data as the time series.Mismatched samples are aligned by the DTW.In addition,dynamic constraints are applied to the warping distance of the DTW process to make the alignment more efficient.Then a series of models are trained with the cumulated samples iteratively.Several groups of numerical experiments on different missing patterns and missing locations are designed and analyzed to prove the effectiveness and the applicability of the proposed method.展开更多
Polar marine equipment plays an important role in Arctic engineering,especially in the development of polar ships and ice-class propellers.When polar ships navigate in brash ice channels,the brash ice not only increas...Polar marine equipment plays an important role in Arctic engineering,especially in the development of polar ships and ice-class propellers.When polar ships navigate in brash ice channels,the brash ice not only increases resistance but also has adverse effects on their propulsion performance.On the basis of coupled computational fluid dynamics(CFD)and the discrete element method(DEM),this paper aims to numerically investigate the resistance and propulsion performance of a polar in a brash ice channel while considering the rotation status of the propeller by both experimental and numerical methods.Both ship resistance and ice motion under Froude numbers of 0.0557,0.0696,0.0836,0.975,and 0.1114 are studied when the propeller does not rotate.The influences of the rotating propeller on the ice brash resistance and flow are discussed.The thrust due to the propeller and ice resistance in the equilibrium state are also predicted.The errors between the thrust and total resistance are approximately 1.0%,and the maximum error between the simulated and predicted total resistance is 3.7%,which validates the CFD-DEM coupling method quite well.This work could provide a theoretical basis for the initial design of polar ships with low ice class notation and assist in planning navigation for merchant polar ships in brash ice fields.展开更多
Integrated urban-rural development is a crucial stage in the development of China’s urban-rural relations and is essential for Chinese modernization.In the digital era,the cultural tourism industry has the potential ...Integrated urban-rural development is a crucial stage in the development of China’s urban-rural relations and is essential for Chinese modernization.In the digital era,the cultural tourism industry has the potential to promote integrated urban-rural development through multidimensional integration mechanisms,including cultural exchanges,resource sharing,and industrial linkages.Specifically,by innovating cultural tourism development models,the efficiency of labor allocation between urban and rural areas can be improved,fostering the transformation of rural cultural tourism and its related industries.By expanding the cultural tourism scenarios,new spaces for rural cultural consumption can be constructed,which would help to reduce urban and rural consumption disparities.By establishing cultural tourism development platforms and facilitating the sharing of data elements,the coordinated development of urban and rural public cultural services can be promoted,which would reduce the service gaps between urban and rural areas.By leveraging smart city construction to drive the development of the rural digital infrastructure,integrated urban-rural development,guided by a“digital+”approach,can then be fostered and help to reduce urban and rural development gaps.Building on this foundation,the digital transformation of cultural tourism will advance industrial linkages,resource sharing,factor mobility,and spatial co-creation within urban and rural cultural tourism,gradually realizing integrated urban-rural development and ultimately driving rural revitalization and fostering common prosperity.展开更多
A solid,fast-dissolving sodium silicate was used as an alkaline activator.Granulated blast furnace slag(GGBS),metakaolin(MK),and steel slag(SS)were used as the cementious components to prepare a ternary composite ceme...A solid,fast-dissolving sodium silicate was used as an alkaline activator.Granulated blast furnace slag(GGBS),metakaolin(MK),and steel slag(SS)were used as the cementious components to prepare a ternary composite cementitious material known as alkali-activated steel slag composite cementitious material(ASCM)by the"one-step method".The impacts of cementitious components,alkali activator modulus,and Na_(2)O%on the mechanical strength were investigated,and the hydration products and hydration kinetics of ASCM were analyzed.The experimental results reveal that XRD,FTIR,SEM,EDS,and exothermic heat of hydration show that when GGBS:MK:SS=60wt%:10wt%:30wt%,the activator modulus is 1.2,and the alkali content is 5.5wt%,the 28 d flexural strength of ASCM mortar is 12.6 MPa,and the compressive strength is 53.3 MPa,the hydration products consist of C-S-H gel/C-A-S-H gel,mullite(3Al_(2)O_(3)-2SiO_(2)),calcite(CaCO_(3)),quartz,etc.ASCM has a large initial hydration exotherm rate but a small cumulative exotherm.展开更多
Aim: This study evaluates the impact of Enhanced Recovery After Surgery (ERAS) nursing on postoperative complications and quality of life in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE)....Aim: This study evaluates the impact of Enhanced Recovery After Surgery (ERAS) nursing on postoperative complications and quality of life in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE). Methods: A total of 150 patients who underwent RAMIE from January 2020 to January 2022 at our hospital were randomly assigned to either the observation group or the control group, with 75 patients in each. The control group received standard perioperative management and nursing care, while the observation group was treated with ERAS nursing strategies. Interventions continued until discharge, and outcomes such as postoperative complications, quality of life, and nutritional status were compared between the groups. Results: The observation group exhibited a significantly lower incidence of postoperative adverse reactions compared to the control group (P ionally, all dimension scores of the Short-Form 36 Health Survey (SF-36), including the total score, were higher in the observation group (P < 0.05). Furthermore, the Nutritional Risk Screening (NRS) scores for impaired nutritional status and disease severity, along with the total NRS score, were significantly lower in the observation group compared to the control group (P Conclusion: Implementing ERAS nursing in the perioperative care of patients undergoing RAMIE is associated with reduced postoperative complications and enhanced postoperative quality of life and nutritional status. .展开更多
基金supported by the General Scientific Research Project of the Zhejiang Education Department,China(Grant No.Y202249221).
文摘Ustiloxins are the primary secondary metabolites of Ustilaginoidea virens(teleomorph:Villosiclava virens).While these toxins are known to exhibit toxicity in certain animals,their potential risks to human health require further investigation.Therefore,this study was conducted using male mice as experimental animal to explore their potential health risks.We observed morphological changes in cells and structural lesions in mitochondria using electron microscopy,combined with Hematoxylin and Eosin(H&E)staining.We utilized transcriptomics,proteomics,and bioinformatics techniques to analyze the regulatory networks associated with ustiloxins in the context of liver damage and study the mechanism of liver injury caused by ustiloxins in mice.Differentially expressed genes(DEGs)were linked to terms such as‘metabolism of exogenous substances with cytochrome P450’,‘peroxisomes’,and‘negative regulation of the inflammatory response’.Western blotting and quantitative real-time PCR(qRT-PCR)demonstrated that ustiloxins can further activate the inflammatory pathways of Nrf2/HO-1 and NLRP3 by activating cytochrome P450(CYP450),leading to liver damage in mice.
基金funding from the Natural Science Foundation of Henan Province(252300421852)the State Key Laboratory of Development and Comprehensive Utilization of Coking Coal Resources(41040220201308)+4 种基金the National Natural Science Foundation of China(41972254)the China Postdoctoral Science Foundation(2019M662494)Supported by the Key Scientific Research Projects of Higher Education Institutions of Henan Province(19A170005)the Fundamental Research Funds for the Universities of Henan Province(NSFRF200337,NSFRF200103)Key Research and Development Project of Henan Province(251111322300).
文摘Accurate identification of water sources is crucial for effective water management and safety in mining operations.However,imbalanced water sample datasets often lead to suboptimal classification accuracy.To address this challenge,this study proposes a novel water source identification method integrating Synthetic Minority Over-Sampling Technique(SMOTE),Zebra Optimization Algorithm(ZOA),and Light Gradient Boosting Machine(LightGBM).Initially,SMOTE is utilized to synthesize samples for the minority class within the imbalanced dataset,thereby generating a balanced water sample dataset and mitigating class distribution disparities.Subsequently,an efficient water source identification model is constructed by combining ZOA with LightGBM,leveraging the strengths of both algorithms.The model’s performance is validated using a test set and compared with other common classification models.Results demonstrate that SMOTE significantly alleviates class imbalance and enhances the classification accuracy of LightGBM for minority class water samples.ZOA parameter tuning accelerates model convergence and further improves classification accuracy,optimizing the model’s overall performance.In experimental validation,the proposed SMOTE-ZOA-LightGBM model achieved an accuracy of 88.41%and a F1 score of 88.24%,outperforming six other classification models.The method proposed in this paper can accurately identify water source types,effectively addressing the issue of low classification accuracy caused by imbalanced water sample data.It provides reliable technical support and scientific basis for identifying and preventing water inrush sources in mines.
基金Funded by Key Laboratory for Comprehensive Energy Saving of Cold Regions Architecture of Ministry of Education(No.JLJZHDKF202204)。
文摘This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly ash(FA),and analyzed its mechanical properties,hydration mechanism,and retardation mechanism.The effects of retarders on the hydration products,mechanical properties,and hydration kinetics of ACCM were investigated using XRD,SEM,FTIR,EDS,and thermoactive microcalorimetry.The results showed that Na_(2)B_(4)O_(7)·10H_(2)O(B)delayed the exotherm during the alkali activation process and could effectively delay the setting time of ACCM,but the mechanical properties were slightly decreased.The setting time of ACCM increased with the increase in SG content,but the mechanical properties of ACCM decreased with the increase in SG content.C1_(2)H_(22)O_(11)(CHO)could effectively delay the hydration reaction of ACCM and weakly enhanced the compressive strength.H_(3)PO_(4)(HP)at a concentration of 0.05 mol/L had a certain effect on ACCM retardation,but HP at a concentration of 0.07 and 0.09 mol/L had an effect of promoting the setting and hardening time of ACCM.
基金National Natural Science Foundation of China:Study for the Mechanism of Moxibustion in Ulcerative Colitis based on the α7 Nicotinic Acetylcholine Receptor Mediated Cholinergic Antiinflammatory Pathway (No.82205293)National Natural Science Foundation of China:Study of the Central Nervous System Regulatory Mechanism of Moxibustion Repair of Ulcerative Colitis Gut Vascular Barrier Based on Ubiquitin Specific Peptidase 14 Deubiquitination (No.82274641)+3 种基金National Natural Science Foundation of China:Moxibustion Regulates P300-mediated Histone H3K27 Acetylation Modification in the Treatment of Crohn's Disease (No.82205262)National Natural Science Foundation of China:Study on the Protective Mechanism of Moxibustion on Intestinal Mucosal Barrier in Ulcerative Colitis based on GABAergic System (No.82105012)Shanghai Sailing Program:to Study the Protective Effect of Moxibustion on Intestinal Mucosal Barrier in Crohn's Disease Based on Histone H3 Acetylation Modification (No.22YF1444100)State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project (No.zyyzdxk-2023068)。
文摘OBJECTIVE:To investigate the effect and mechanism of mild moxibustion on the non-neuronal cholinergic system(NNCS) in rats with ulcerative colitis(UC).METHODS:UC rat model was established by administering 4% dextran sulfate sodium.After 7 d,mild moxibustion,α7 nicotinic acetylcholine receptors(α7nAchRs) antagonist(α-bungarotoxin,α-BGT),vesicular acetylcholine transport inhibitor(vesamicol hydrochloride,VH) and organic cation transporters inhibitor(quinine,Qu) treatments were performed once daily for 7 d.Haematoxylin and eosin staining was used for morphological evaluation of colon tissues.Enzymelinked immunosorbent assay(ELISA) was used to measure the protein expressions of interleukin-1β(IL-1β) and choline acetyltransferase(ChAT) in colon tissue.Reverse transcription quantitative real-time polymerase chain reaction(RT-q PCR) was used to detect the mRNA expressions of IL-1β,carnosine acetyltransferase(CarAT),ChAT,and nuclear factor kappa-B p65 subunit(NF-κB p65) in colon tissue.Western blot was used to detect NF-κB p65 protein expression in colon tissue.Immunofluorescence was used to detect the expressions of neuronal acetylcholine(nAch) and non-neuronal acetylcholine(nnAch,released by NNCS) in colon tissue.RESULTS:Mild moxibustion inhibited colon inflammation and repaired mucosal damage to the colon in UC rats.Meanwhile,mild moxibustion could downregulate the expressions of IL-1β,NF-κB p65 protein and mRNA(P < 0.01),and upregulate the expressions of ChAT protein and CarAT mRNA(P < 0.05,P < 0.01).The α7nAChR antagonist α-BGT can reverse the protective effect of mild moxibustion on the UC and the inhibitory effect on the inflammatory factors.VH cannot affect the effect of mild moxibustion on the expressions of IL-1β and nnAch,while Qu can reverse the effect of mild moxibustion on the expression of IL-1β and nnAch.CONCLUSIONS:Mild moxibustion can inhibite colon inflammation in UC rats,which is closely related to the release of acetylcholine by NNCS and its mediated mechanism of cholinergic anti-inflammation pathway.
文摘目的:分析深静脉血栓病人生活质量的研究现状、热点和发展趋势。方法:检索Web of Science核心合集数据库中科学引文索引扩展版和社会科学引文索引建库至2024年收录的深静脉血栓病人生活质量的相关文献,利用VOSviewer软件对发文作者、期刊、国家、文献共被引分析、作者共被引及关键词共现进行可视化分析,采用CiteSpace软件,基于对数似然率(LLR)算法开展文献共被引聚类及关键词突现分析。结果:共纳入304篇文献,涉及40个国家的1 391名作者,该领域的发文量呈上升趋势;美国的发文量居全球首位;高产学者主要来自加拿大和美国;发文量排名居前2位的期刊为Thrombosis Research和Phlebology;研究热点包括深静脉血栓病人的症状管理及风险因素、生活质量与心理健康的关系、不同治疗干预及结果对生活质量的影响,长期并发症(如血栓后综合征)的管理及其经济负担、深静脉血栓管理指南及预测因素;研究趋势包括深静脉血栓病人生活质量评估工具的验证、导管定向性溶栓治疗(CaVenT)对深静脉血栓病人生活质量的影响、深静脉血栓疾病的严重程度与生活质量的关联等。结论:深静脉血栓病人生活质量的研究处于发展阶段,国外已形成核心作者群,研究成果和方法备受关注,我国学者可学习借鉴国外的研究经验和方法,加强这一领域的研究,促进我国在深静脉血栓病人生活质量方面的进步与发展。
文摘In contrast to the predominant mono or difunctionalization of alkenes,the multi-site functionalization of alkenes involving the synergistic formation of more than two new C–C or C–X bonds is much challenging,especially for developing new reaction pathway to afford the functional heterocycle compounds with aggregation-induced emission(AIE)property has been rarely reported.In present work,the multi-site functionalization of in situ generated alkenes with indoles has been developed for the synthesis of diversely functionalized carbazoles through the synergistic construction of multiple C–C bonds and C=O bond.A proposed reaction sequence involving C–H alkenylation/radical oxygen atom transfer/Diels-Alder cycloaddition/dehydrogenative aromatization was supported by experiments and density functional theory calculations.Further derivative carbazole-linked-quinoxaline skeletons represent a class of AIEgens with acceptor-donor-acceptor configuration,which generated the desired twisted intramolecular charge transfer(TICT)AIE properties and could be used as fluorescent probes for detecting the micrometer-sized phase separation of polymer blends.The protocol provides a concise route for the synthesis and application of carbazole-based AIE luminogens.
基金supported by the National Key R&D Program of China(2021YFA0716902)National Natural Science Foundation of China(NSFC)under contract number 42374149 and 42004119National Science and Technology Major Project(2024ZD1002907)。
文摘Seismic anisotropy has been extensively acknowledged as a crucial element that influences the wave propagation characteristic during wavefield simulation,inversion and imaging.Transversely isotropy(TI)and orthorhombic anisotropy(OA)are two typical categories of anisotropic media in exploration geophysics.In comparison of the elastic wave equations in both TI and OA media,pseudo-acoustic wave equations(PWEs)based on the acoustic assumption can markedly reduce computational cost and complexity.However,the presently available PWEs may experience SV-wave contamination and instability when anisotropic parameters cannot satisfy the approximated condition.Exploiting pure-mode wave equations can effectively resolve the above-mentioned issues and generate pure P-wave events without any artifacts.To further improve the computational accuracy and efficiency,we develop two novel pure qP-wave equations(PPEs)and illustrate the corresponding numerical solutions in the timespace domain for 3D tilted TI(TTI)and tilted OA(TOA)media.First,the rational polynomials are adopted to estimate the exact pure qP-wave dispersion relations,which contain complicated pseudo-differential operators with irrational forms.The polynomial coefficients are produced by applying a linear optimization algorithm to minimize the objective function difference between the expansion formula and the exact one.Then,the developed optimized PPEs are efficiently implemented using the finite-difference(FD)method in the time-space domain by introducing a scalar operator,which can help avoid the problem of spectral-based algorithms and other calculation burdens.Structures of the new equations are concise and corresponding implementation processes are straightforward.Phase velocity analyses indicate that our proposed optimized equations can lead to reliable approximation results.3D synthetic examples demonstrate that our proposed FD-based PPEs can produce accurate and stable P-wave responses,and effectively describe the wavefield features in complicated TTI and TOA media.
基金the Key National Natural Science Foundation of China(No.U1864211)the National Natural Science Foundation of China(No.11772191)the Natural Science Foundation of Shanghai(No.21ZR1431500)。
文摘Industrial data mining usually deals with data from different sources.These heterogeneous datasets describe the same object in different views.However,samples from some of the datasets may be lost.Then the remaining samples do not correspond one-to-one correctly.Mismatched datasets caused by missing samples make the industrial data unavailable for further machine learning.In order to align the mismatched samples,this article presents a cooperative iteration matching method(CIMM)based on the modified dynamic time warping(DTW).The proposed method regards the sequentially accumulated industrial data as the time series.Mismatched samples are aligned by the DTW.In addition,dynamic constraints are applied to the warping distance of the DTW process to make the alignment more efficient.Then a series of models are trained with the cumulated samples iteratively.Several groups of numerical experiments on different missing patterns and missing locations are designed and analyzed to prove the effectiveness and the applicability of the proposed method.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFE0107000)the Fundamental Research Funds for the Central Universities(Grant No.HYGJXM202319).
文摘Polar marine equipment plays an important role in Arctic engineering,especially in the development of polar ships and ice-class propellers.When polar ships navigate in brash ice channels,the brash ice not only increases resistance but also has adverse effects on their propulsion performance.On the basis of coupled computational fluid dynamics(CFD)and the discrete element method(DEM),this paper aims to numerically investigate the resistance and propulsion performance of a polar in a brash ice channel while considering the rotation status of the propeller by both experimental and numerical methods.Both ship resistance and ice motion under Froude numbers of 0.0557,0.0696,0.0836,0.975,and 0.1114 are studied when the propeller does not rotate.The influences of the rotating propeller on the ice brash resistance and flow are discussed.The thrust due to the propeller and ice resistance in the equilibrium state are also predicted.The errors between the thrust and total resistance are approximately 1.0%,and the maximum error between the simulated and predicted total resistance is 3.7%,which validates the CFD-DEM coupling method quite well.This work could provide a theoretical basis for the initial design of polar ships with low ice class notation and assist in planning navigation for merchant polar ships in brash ice fields.
基金Research into the Spatiotemporal Patterns and Driving Mechanisms of the Deep Integration between the Cultural and Tourism Industries in the Digital Era(Project No.:2024SJZD124)a major project for the philosophy and social sciences research of Jiangsu universities,and the Research on the Mechanism and Practical Pathways for the High-Quality Development of Jiangsu’s Digital Cultural Industry Driven by the Humanistic Economy(Project No.:24EYB006)a project under the Jiangsu Social Science Fund.
文摘Integrated urban-rural development is a crucial stage in the development of China’s urban-rural relations and is essential for Chinese modernization.In the digital era,the cultural tourism industry has the potential to promote integrated urban-rural development through multidimensional integration mechanisms,including cultural exchanges,resource sharing,and industrial linkages.Specifically,by innovating cultural tourism development models,the efficiency of labor allocation between urban and rural areas can be improved,fostering the transformation of rural cultural tourism and its related industries.By expanding the cultural tourism scenarios,new spaces for rural cultural consumption can be constructed,which would help to reduce urban and rural consumption disparities.By establishing cultural tourism development platforms and facilitating the sharing of data elements,the coordinated development of urban and rural public cultural services can be promoted,which would reduce the service gaps between urban and rural areas.By leveraging smart city construction to drive the development of the rural digital infrastructure,integrated urban-rural development,guided by a“digital+”approach,can then be fostered and help to reduce urban and rural development gaps.Building on this foundation,the digital transformation of cultural tourism will advance industrial linkages,resource sharing,factor mobility,and spatial co-creation within urban and rural cultural tourism,gradually realizing integrated urban-rural development and ultimately driving rural revitalization and fostering common prosperity.
基金Funded by the Scientific Research Program of Jilin Provincial Science and Technology Development(No.20250203184SF)。
文摘A solid,fast-dissolving sodium silicate was used as an alkaline activator.Granulated blast furnace slag(GGBS),metakaolin(MK),and steel slag(SS)were used as the cementious components to prepare a ternary composite cementitious material known as alkali-activated steel slag composite cementitious material(ASCM)by the"one-step method".The impacts of cementitious components,alkali activator modulus,and Na_(2)O%on the mechanical strength were investigated,and the hydration products and hydration kinetics of ASCM were analyzed.The experimental results reveal that XRD,FTIR,SEM,EDS,and exothermic heat of hydration show that when GGBS:MK:SS=60wt%:10wt%:30wt%,the activator modulus is 1.2,and the alkali content is 5.5wt%,the 28 d flexural strength of ASCM mortar is 12.6 MPa,and the compressive strength is 53.3 MPa,the hydration products consist of C-S-H gel/C-A-S-H gel,mullite(3Al_(2)O_(3)-2SiO_(2)),calcite(CaCO_(3)),quartz,etc.ASCM has a large initial hydration exotherm rate but a small cumulative exotherm.
文摘Aim: This study evaluates the impact of Enhanced Recovery After Surgery (ERAS) nursing on postoperative complications and quality of life in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE). Methods: A total of 150 patients who underwent RAMIE from January 2020 to January 2022 at our hospital were randomly assigned to either the observation group or the control group, with 75 patients in each. The control group received standard perioperative management and nursing care, while the observation group was treated with ERAS nursing strategies. Interventions continued until discharge, and outcomes such as postoperative complications, quality of life, and nutritional status were compared between the groups. Results: The observation group exhibited a significantly lower incidence of postoperative adverse reactions compared to the control group (P ionally, all dimension scores of the Short-Form 36 Health Survey (SF-36), including the total score, were higher in the observation group (P < 0.05). Furthermore, the Nutritional Risk Screening (NRS) scores for impaired nutritional status and disease severity, along with the total NRS score, were significantly lower in the observation group compared to the control group (P Conclusion: Implementing ERAS nursing in the perioperative care of patients undergoing RAMIE is associated with reduced postoperative complications and enhanced postoperative quality of life and nutritional status. .
