In tunnel construction,tunnel boring machine(TBM)tunnelling typically relies on manual experience with sub-optimal control parameters,which can easily lead to inefficiency and high costs.This study proposed an intelli...In tunnel construction,tunnel boring machine(TBM)tunnelling typically relies on manual experience with sub-optimal control parameters,which can easily lead to inefficiency and high costs.This study proposed an intelligent decision-making method for TBM tunnelling control parameters based on multiobjective optimization(MOO).First,the effective TBM operation dataset is obtained through data preprocessing of the Songhua River(YS)tunnel project in China.Next,the proposed method begins with developing machine learning models for predicting TBM tunnelling performance parameters(i.e.total thrust and cutterhead torque),rock mass classification,and hazard risks(i.e.tunnel collapse and shield jamming).Then,considering three optimal objectives,(i.e.,penetration rate,rock-breaking energy consumption,and cutterhead hob wear),the MOO framework and corresponding mathematical expression are established.The Pareto optimal front is solved using DE-NSGA-II algorithm.Finally,the optimal control parameters(i.e.,advance rate and cutterhead rotation speed)are obtained by the satisfactory solution determination criterion,which can balance construction safety and efficiency with satisfaction.Furthermore,the proposed method is validated through 50 cases of TBM tunnelling,showing promising potential of application.展开更多
This study aimed to investigate the mediating role of knowledge,attitude,and practice(KAP)in the relationship between fatigue and kinesiophobia in 200 coronary heart disease patients from three Chinese tertiary hospit...This study aimed to investigate the mediating role of knowledge,attitude,and practice(KAP)in the relationship between fatigue and kinesiophobia in 200 coronary heart disease patients from three Chinese tertiary hospitals.Using validated scales(MFSI-SF,TSK-SV Heart,and the Rehabilitation Exercise Knowledge-Attitude-Practice Scale for Patients),data analysis via SPSS 25.0 and AMOS 24.0 structural equation modeling identified a significant KAP-mediated pathway(total indirect effect=0.377).KAP of rehabilitation was significantly negatively correlated with fatigue(r=-0.51,p<0.01)and kinesiophobia(r=-0.60,p<0.01),whereas fatigue was significantly positively correlated with kinesiophobia(r=0.678,p<0.01).Results indicate that fatigue amplifies kinesiophobia by compromising KAP of rehabilitation.A significant mediating effect of KAP of rehabilitation on the relationship between fatigue and kinesiophobia was found.Improving patient fatigue and the knowledge,attitudes,and practices of rehabilitation can help reduce kinesiophobia.展开更多
After spinal cord injury(SCI),astrocytes gradually migrate to and surround the lesion,depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar,which limits the spread of inflam...After spinal cord injury(SCI),astrocytes gradually migrate to and surround the lesion,depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar,which limits the spread of inflammation but hinders axon regeneration.Meanwhile,microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype.However,the effect of microglia polarization on astrocytes is unclear.Here,we found that both microglia(CX3 CR1^(+))and astrocytes(GFAP^(+))gathered at the lesion border at 14 days post-injury(dpi).The microglia accumulated along the inner border of and in direct contact with the astrocytes.M1-type microglia(i NOS^(+)CX3 CR1^(+))were primarily observed at 3 and 7 dpi,while M2-type microglia(Arg1^(+)CX3 CR1^(+))were present at larger numbers at 7 and 14 dpi.Transforming growth factor-β1(TGFβ1)was highly expressed in M1 microglia in vitro,consistent with strong expression of TGFβ1 by microglia in vivo at 3 and 7 dpi,when they primarily exhibited an M1 phenotype.Furthermore,conditioned media from M1-type microglia induced astrocytes to secrete chondroitin sulfate proteoglycan in vitro.This effect was eliminated by knocking down sex-determining region Y-box 9(SOX9)in astrocytes and could not be reversed by treatment with TGFβ1.Taken together,our results suggest that microglia undergo M1 polarization and express high levels of TGFβ1 at 3 and 7 dpi,and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFβ1/SOX9 pathway.The study was approved by the Institutional Animal Care and Use Committee of Anhui Medical University,China(approval No.LLSC20160052)on March 1,2016.展开更多
Herein,we report a unique approach towards the preparation of C-modified and N-doped TiO2 hollow spheres(C/N-TiO2).TEM,SEM,and XPS analyses were used to confirm that the carbon and nitrogen co-decorated TiO2 photocata...Herein,we report a unique approach towards the preparation of C-modified and N-doped TiO2 hollow spheres(C/N-TiO2).TEM,SEM,and XPS analyses were used to confirm that the carbon and nitrogen co-decorated TiO2 photocatalyst was formed.Carbon-decoration improves the visible-light absorption and speeds up the separation of the photo-generated electron-hole pairs.C/N-TiO2 not only narrows the band gap of TiO2,but also exhibits excellent photocatalytic activity for the degradation of tetracycline and tetracycline hydrochloride.In addition,the C/N-TiO2 photocatalyst shows excellent recyclability for water decontamination,making it a promising candidate to purify aquatic contaminants.展开更多
Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate ...Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52179105)China Postdoctoral Science Foundation(Grant No.2024M762193)。
文摘In tunnel construction,tunnel boring machine(TBM)tunnelling typically relies on manual experience with sub-optimal control parameters,which can easily lead to inefficiency and high costs.This study proposed an intelligent decision-making method for TBM tunnelling control parameters based on multiobjective optimization(MOO).First,the effective TBM operation dataset is obtained through data preprocessing of the Songhua River(YS)tunnel project in China.Next,the proposed method begins with developing machine learning models for predicting TBM tunnelling performance parameters(i.e.total thrust and cutterhead torque),rock mass classification,and hazard risks(i.e.tunnel collapse and shield jamming).Then,considering three optimal objectives,(i.e.,penetration rate,rock-breaking energy consumption,and cutterhead hob wear),the MOO framework and corresponding mathematical expression are established.The Pareto optimal front is solved using DE-NSGA-II algorithm.Finally,the optimal control parameters(i.e.,advance rate and cutterhead rotation speed)are obtained by the satisfactory solution determination criterion,which can balance construction safety and efficiency with satisfaction.Furthermore,the proposed method is validated through 50 cases of TBM tunnelling,showing promising potential of application.
基金Guided Scientific Research Projects of Shiyan City(Project No.:24Y006)。
文摘This study aimed to investigate the mediating role of knowledge,attitude,and practice(KAP)in the relationship between fatigue and kinesiophobia in 200 coronary heart disease patients from three Chinese tertiary hospitals.Using validated scales(MFSI-SF,TSK-SV Heart,and the Rehabilitation Exercise Knowledge-Attitude-Practice Scale for Patients),data analysis via SPSS 25.0 and AMOS 24.0 structural equation modeling identified a significant KAP-mediated pathway(total indirect effect=0.377).KAP of rehabilitation was significantly negatively correlated with fatigue(r=-0.51,p<0.01)and kinesiophobia(r=-0.60,p<0.01),whereas fatigue was significantly positively correlated with kinesiophobia(r=0.678,p<0.01).Results indicate that fatigue amplifies kinesiophobia by compromising KAP of rehabilitation.A significant mediating effect of KAP of rehabilitation on the relationship between fatigue and kinesiophobia was found.Improving patient fatigue and the knowledge,attitudes,and practices of rehabilitation can help reduce kinesiophobia.
基金supported by the National Natural Science Foundation of China,Nos.81801220(to MGZ),81671204(to JHJ)Key Research and Development Projects of Anhui Province of China,No.202004j07020042(to JHJ)。
文摘After spinal cord injury(SCI),astrocytes gradually migrate to and surround the lesion,depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar,which limits the spread of inflammation but hinders axon regeneration.Meanwhile,microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype.However,the effect of microglia polarization on astrocytes is unclear.Here,we found that both microglia(CX3 CR1^(+))and astrocytes(GFAP^(+))gathered at the lesion border at 14 days post-injury(dpi).The microglia accumulated along the inner border of and in direct contact with the astrocytes.M1-type microglia(i NOS^(+)CX3 CR1^(+))were primarily observed at 3 and 7 dpi,while M2-type microglia(Arg1^(+)CX3 CR1^(+))were present at larger numbers at 7 and 14 dpi.Transforming growth factor-β1(TGFβ1)was highly expressed in M1 microglia in vitro,consistent with strong expression of TGFβ1 by microglia in vivo at 3 and 7 dpi,when they primarily exhibited an M1 phenotype.Furthermore,conditioned media from M1-type microglia induced astrocytes to secrete chondroitin sulfate proteoglycan in vitro.This effect was eliminated by knocking down sex-determining region Y-box 9(SOX9)in astrocytes and could not be reversed by treatment with TGFβ1.Taken together,our results suggest that microglia undergo M1 polarization and express high levels of TGFβ1 at 3 and 7 dpi,and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFβ1/SOX9 pathway.The study was approved by the Institutional Animal Care and Use Committee of Anhui Medical University,China(approval No.LLSC20160052)on March 1,2016.
基金supported by the National Natural Science Foundation of China(21876069,21707054)the Six Talent Peaks Project in Jiangsu(XCL-018)the China Postdoctoral Science Foundation(2016M601744)~~
文摘Herein,we report a unique approach towards the preparation of C-modified and N-doped TiO2 hollow spheres(C/N-TiO2).TEM,SEM,and XPS analyses were used to confirm that the carbon and nitrogen co-decorated TiO2 photocatalyst was formed.Carbon-decoration improves the visible-light absorption and speeds up the separation of the photo-generated electron-hole pairs.C/N-TiO2 not only narrows the band gap of TiO2,but also exhibits excellent photocatalytic activity for the degradation of tetracycline and tetracycline hydrochloride.In addition,the C/N-TiO2 photocatalyst shows excellent recyclability for water decontamination,making it a promising candidate to purify aquatic contaminants.
基金the 1.3.5 Project for Disciplines of Excellence from West China Hospital of Sichuan University(No.ZYGD18027)。
文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events.
