[Objective]In this study,the feasibility of resins to extract antibacterial substances in ferrfientation broth of Micromonospora carbonacea JXNU-1 was investigated.Various parameters including the type of resin,the ti...[Objective]In this study,the feasibility of resins to extract antibacterial substances in ferrfientation broth of Micromonospora carbonacea JXNU-1 was investigated.Various parameters including the type of resin,the time of adsorption and the initial pH on the extraction efficiency were investigated and optimized.[Method]The antibacterial activity of antibiotics was determined by agar diffusion method.[Result]The 717 anion resin was selected as the optimal,and its adsorption capacity reached 1221 U/g within 2.5 h at the acidic range of pH(pH 5).The Freundlich model was fit for the adsorption model of the 717 anion resin for antibiotics.[Conclusion]The results laid the foundation for further separating and purifying antibiotics in fermentation broth of Micromonospora carbonacea JXNU-1.展开更多
文摘[Objective]In this study,the feasibility of resins to extract antibacterial substances in ferrfientation broth of Micromonospora carbonacea JXNU-1 was investigated.Various parameters including the type of resin,the time of adsorption and the initial pH on the extraction efficiency were investigated and optimized.[Method]The antibacterial activity of antibiotics was determined by agar diffusion method.[Result]The 717 anion resin was selected as the optimal,and its adsorption capacity reached 1221 U/g within 2.5 h at the acidic range of pH(pH 5).The Freundlich model was fit for the adsorption model of the 717 anion resin for antibiotics.[Conclusion]The results laid the foundation for further separating and purifying antibiotics in fermentation broth of Micromonospora carbonacea JXNU-1.
