BACKGROUND Middle meningeal artery embolization(MMAE)is emerging as a promising treatment for chronic subdural hematoma(CSDH),serving both as an adjunct to surgery and as a primary therapeutic option depending on pati...BACKGROUND Middle meningeal artery embolization(MMAE)is emerging as a promising treatment for chronic subdural hematoma(CSDH),serving both as an adjunct to surgery and as a primary therapeutic option depending on patient presentation.Due to its low recurrence rate and minimal complications,MMAE has gained increasing acceptance among clinicians in recent years.This report presents a case of diplopia following MMAE due to the presence of a potential anastomotic artery,aiming to enhance awareness of this complication.CASE SUMMARY A 60-year-old male patient presented with a headache following head trauma,and cranial computed tomography revealed a left-sided CSDH.The patient underwent left MMAE;however,polyvinyl alcohol particles inadvertently flowed into the lacrimal artery through an anastomotic artery,resulting in diplopia due to impaired abduction of the left eye.The diplopia resolved by postoperative day 40.The patient’s headache resolved by postoperative day 7,and the hematoma completely resolved by postoperative day 108.CONCLUSION Potential anastomotic arteries in the middle meningeal artery(MMA)can lead to serious complications.Superselective angiography of the MMA or its branches prior to embolization is essential.Performing embolization distal to potential anastomotic sites can reduce risks,and the presence of an anastomosis may warrant coil embolization or termination of the procedure.展开更多
目的:比较局部晚期宫颈癌采用标准三管施源器的腔内后装(tandem and ovoid)与腔内结合组织间插植后装的剂量学差异。方法:CT引导下的三维适形近距离治疗局部晚期宫颈癌患者20例,间隔采用三管式腔内后装与腔内结合组织间插植共72次。按...目的:比较局部晚期宫颈癌采用标准三管施源器的腔内后装(tandem and ovoid)与腔内结合组织间插植后装的剂量学差异。方法:CT引导下的三维适形近距离治疗局部晚期宫颈癌患者20例,间隔采用三管式腔内后装与腔内结合组织间插植共72次。按照施源器的不同分成2个组,每组36次,对靶区剂量、危及器官等进行比较。结果:在给予A点相同处方剂量的情况下,HR-CTV D90、D100在三管式腔内后装组与腔内结合组织间插植后装组中分别为(590.0±46.4)cGy、(471.2±66.2)cGy,(502.8±67.7)cGy、(335.9±46.0)cGy,P<0.05),膀胱、直肠、乙状结肠D2cc均相近(P=0.85、0.28、0.53)。结论:采用腔内结合插植后装治疗局部晚期宫颈癌比三管式腔内后装可获得更高的靶区剂量,但长期疗效及晚期反应仍需进一步研究。展开更多
We demonstrate a reinforcement learning(RL)-based control framework for optimizing evaporative cooling in the preparation of strongly interacting degenerate Fermi gases of 6Li.Using a Soft Actor-Critic(SAC)algorithm,t...We demonstrate a reinforcement learning(RL)-based control framework for optimizing evaporative cooling in the preparation of strongly interacting degenerate Fermi gases of 6Li.Using a Soft Actor-Critic(SAC)algorithm,the system autonomously explores a high-dimensional parameter space to learn optimal cooling trajectories.Compared to conventional exponential ramps,our method achieves up to 130%improvement in atomic density within 0.5 second,revealing non-trivial control strategies that balance fast evaporation and thermalization.While our current optimization focuses on the evaporation stage,future integration of other cooling stages,such as gray molasses cooling,could further extend RL to the full preparation pipeline.Our result highlights the promise of RL as a general tool for closed-loop quantum control and automated calibration in complex atomic physics experiments.展开更多
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the...Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.展开更多
INTRODUCTION With the expansion of the ageing population,cognitive decline has become an increas-ingly pressing challenge.1 As life expectancy increases,its socioeconomic burden is also increasing,highlighting the urg...INTRODUCTION With the expansion of the ageing population,cognitive decline has become an increas-ingly pressing challenge.1 As life expectancy increases,its socioeconomic burden is also increasing,highlighting the urgent need for effective interventions.Numerous studies suggest that specific dietary patterns and nutritional interventions may help mitigate cognitive decline associated with ageing.展开更多
Advertisement calls are essential for communication among anuran amphibians,with their production influenced by a range of environmental factors and morphological traits.To understand the primary sources of variation ...Advertisement calls are essential for communication among anuran amphibians,with their production influenced by a range of environmental factors and morphological traits.To understand the primary sources of variation of advertisement calls in male Leptobrachium liui,we recorded their advertisement calls during the breeding season and analyzed two primary acoustic parameters: call duration(CD) and dominant frequency(DF),along with their within-individual coefficients of variation.Additionally,we collected nest-related environmental parameters and morphological traits to investigate how these factors influence the variation in advertisement calls.Our analyses revealed that both nest-related environmental parameters(particularly water temperature) and individual morphological traits(especially head morphology) significantly influenced advertisement call characteristics in male L.liui.Water temperature showed a negative relationship with CD,while head morphology was positively associated with both CD and DF.These findings enhance our understanding of the factors shaping acoustic communication in L.liui during the breeding season and highlight the importance of both environmental and morphological factors in anuran vocalization.展开更多
Single-phase high-entropy carbides(HECs)are emerging as promising electrocatalysts for the hydrogen evolution reaction(HER)due to their widely tunable electronic configurations and the synergistic effects of multimeta...Single-phase high-entropy carbides(HECs)are emerging as promising electrocatalysts for the hydrogen evolution reaction(HER)due to their widely tunable electronic configurations and the synergistic effects of multimetallic sites.However,their controllable synthesis and mechanistic understanding remain significant challenges due to the thermodynamic immiscibility of the multi-metallic elements within the carbide structure.In this study,we demonstrate the first successful synthesis of single-phase HECs based on Mo and W systems through an innovative high-entropy design strategy.Guided by comprehensive thermodynamic predictions,the single-phase solid solution formation temperatures were determined for the HEC-n(n=2-9)series of high-entropy carbides.We achieved the configurational-entropy driven formation of HEC nanoparticles containing 4-9 transition metal elements via an ultra-fast joule heating process(i.e.,(TiZrHfVNbTaCrWMo)C).Through rapid synthesis and screening,we obtained(VNbCrWMo)C nanoparticles exhibiting the best HER activities and exceptional longterm stability over 168 h due to high-entropy composition design and synthesis strategies,outperforming unary,binary,ternary,quaternary carbides and carbides with more than six metallic elements.Theoretical calculations and X-ray photoelectron spectroscopy analysis reveal that the(VNbCrWMo)C high-entropy carbide achieves enhanced HER activity through multi-metallic synergy,where constituent elements cooperatively redistribute electron density at catalytic sites.This work provides a new pathway for the rational design of advanced metal carbide electrocatalysts,highlighting the potential of high-entropy effects in tailoring material properties for energy conversion applications.展开更多
This work demonstrates that once a large number of pion is condensed in a high-energy hadron collision, the gamma-ray spectrum from π0decay takes on a typical broken power-law shape, which has been documented in many...This work demonstrates that once a large number of pion is condensed in a high-energy hadron collision, the gamma-ray spectrum from π0decay takes on a typical broken power-law shape, which has been documented in many astronomical observations, but we have not yet recognized it. We show that this pion condensation is caused by a large number of soft gluons condensed in protons.展开更多
文摘BACKGROUND Middle meningeal artery embolization(MMAE)is emerging as a promising treatment for chronic subdural hematoma(CSDH),serving both as an adjunct to surgery and as a primary therapeutic option depending on patient presentation.Due to its low recurrence rate and minimal complications,MMAE has gained increasing acceptance among clinicians in recent years.This report presents a case of diplopia following MMAE due to the presence of a potential anastomotic artery,aiming to enhance awareness of this complication.CASE SUMMARY A 60-year-old male patient presented with a headache following head trauma,and cranial computed tomography revealed a left-sided CSDH.The patient underwent left MMAE;however,polyvinyl alcohol particles inadvertently flowed into the lacrimal artery through an anastomotic artery,resulting in diplopia due to impaired abduction of the left eye.The diplopia resolved by postoperative day 40.The patient’s headache resolved by postoperative day 7,and the hematoma completely resolved by postoperative day 108.CONCLUSION Potential anastomotic arteries in the middle meningeal artery(MMA)can lead to serious complications.Superselective angiography of the MMA or its branches prior to embolization is essential.Performing embolization distal to potential anastomotic sites can reduce risks,and the presence of an anastomosis may warrant coil embolization or termination of the procedure.
文摘目的:比较局部晚期宫颈癌采用标准三管施源器的腔内后装(tandem and ovoid)与腔内结合组织间插植后装的剂量学差异。方法:CT引导下的三维适形近距离治疗局部晚期宫颈癌患者20例,间隔采用三管式腔内后装与腔内结合组织间插植共72次。按照施源器的不同分成2个组,每组36次,对靶区剂量、危及器官等进行比较。结果:在给予A点相同处方剂量的情况下,HR-CTV D90、D100在三管式腔内后装组与腔内结合组织间插植后装组中分别为(590.0±46.4)cGy、(471.2±66.2)cGy,(502.8±67.7)cGy、(335.9±46.0)cGy,P<0.05),膀胱、直肠、乙状结肠D2cc均相近(P=0.85、0.28、0.53)。结论:采用腔内结合插植后装治疗局部晚期宫颈癌比三管式腔内后装可获得更高的靶区剂量,但长期疗效及晚期反应仍需进一步研究。
基金supported by the Innovation Program for Quantum Science and Technology of China(Grant No.2024ZD0300100)the National Basic Research Program of China(Grant No.2021YFA1400900)+1 种基金Shanghai Municipal Science and Technology(Grant Nos.25TQ003,2019SHZDZX01,and 24DP2600100)the National Natural Science Foundation of China(Grant No.12304555).
文摘We demonstrate a reinforcement learning(RL)-based control framework for optimizing evaporative cooling in the preparation of strongly interacting degenerate Fermi gases of 6Li.Using a Soft Actor-Critic(SAC)algorithm,the system autonomously explores a high-dimensional parameter space to learn optimal cooling trajectories.Compared to conventional exponential ramps,our method achieves up to 130%improvement in atomic density within 0.5 second,revealing non-trivial control strategies that balance fast evaporation and thermalization.While our current optimization focuses on the evaporation stage,future integration of other cooling stages,such as gray molasses cooling,could further extend RL to the full preparation pipeline.Our result highlights the promise of RL as a general tool for closed-loop quantum control and automated calibration in complex atomic physics experiments.
基金supported by the STI2030-Major Projects(2021ZD0204001)the National Natural Science Foundation of China(92049120,81870897,81271424,81671111,and 62475179)+8 种基金the Sino German Cooperation and Exchange Project(M-0679)the Guangdong Key Project in the Development of New Tools for the Diagnosis and Treatment of Autism(2018B030335001)the Natural Science Foundation of Jiangsu Province(BK20181436)the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases(BM2013003)Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research(SKY2022161)the Research Project of Neurological Diseases in the Second Affiliated Hospital of Soochow University Research Center(ND2023A01)Boxi clinical research project of The First Affiliated Hospital of Soochow University(BXQN202204)Suzhou Science&Technology Projects for People's Livelihood(SKY2021065)Wuxi Municipal Health Commission(M202204).
文摘Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.
基金supported by the Shandong Second Medical University Overseas Visiting Scholar Programthe National Medical Research Council of Singapore (grant numbers NMRC/TA/0053/2016 and NMRC/CSA/INV/0009/2022)
文摘INTRODUCTION With the expansion of the ageing population,cognitive decline has become an increas-ingly pressing challenge.1 As life expectancy increases,its socioeconomic burden is also increasing,highlighting the urgent need for effective interventions.Numerous studies suggest that specific dietary patterns and nutritional interventions may help mitigate cognitive decline associated with ageing.
基金supported by the County-School Cooperation Project in Suichang County (2024-HZ12)Ecological Discipline Construction Fund of Lishui University。
文摘Advertisement calls are essential for communication among anuran amphibians,with their production influenced by a range of environmental factors and morphological traits.To understand the primary sources of variation of advertisement calls in male Leptobrachium liui,we recorded their advertisement calls during the breeding season and analyzed two primary acoustic parameters: call duration(CD) and dominant frequency(DF),along with their within-individual coefficients of variation.Additionally,we collected nest-related environmental parameters and morphological traits to investigate how these factors influence the variation in advertisement calls.Our analyses revealed that both nest-related environmental parameters(particularly water temperature) and individual morphological traits(especially head morphology) significantly influenced advertisement call characteristics in male L.liui.Water temperature showed a negative relationship with CD,while head morphology was positively associated with both CD and DF.These findings enhance our understanding of the factors shaping acoustic communication in L.liui during the breeding season and highlight the importance of both environmental and morphological factors in anuran vocalization.
基金financially supported by the National Natural Science Foundation of China(No.22175077)the National Key R&D Program of China(No.2023YFA1507602)+4 种基金the Innovation Team Project in Guangdong Colleges and Universities(No.2021KCXTD009)the Natural Science Foundation of Guangdong Province(Nos.2024A1515010427,2022A1515010211 and 2021A1515012351)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515240081)the Natural Science Foundation of Guangzhou(No.SL2024A04J00660)the Fundamental Research Funds for the Central Universities(Nos.21623103 and 21624412)
文摘Single-phase high-entropy carbides(HECs)are emerging as promising electrocatalysts for the hydrogen evolution reaction(HER)due to their widely tunable electronic configurations and the synergistic effects of multimetallic sites.However,their controllable synthesis and mechanistic understanding remain significant challenges due to the thermodynamic immiscibility of the multi-metallic elements within the carbide structure.In this study,we demonstrate the first successful synthesis of single-phase HECs based on Mo and W systems through an innovative high-entropy design strategy.Guided by comprehensive thermodynamic predictions,the single-phase solid solution formation temperatures were determined for the HEC-n(n=2-9)series of high-entropy carbides.We achieved the configurational-entropy driven formation of HEC nanoparticles containing 4-9 transition metal elements via an ultra-fast joule heating process(i.e.,(TiZrHfVNbTaCrWMo)C).Through rapid synthesis and screening,we obtained(VNbCrWMo)C nanoparticles exhibiting the best HER activities and exceptional longterm stability over 168 h due to high-entropy composition design and synthesis strategies,outperforming unary,binary,ternary,quaternary carbides and carbides with more than six metallic elements.Theoretical calculations and X-ray photoelectron spectroscopy analysis reveal that the(VNbCrWMo)C high-entropy carbide achieves enhanced HER activity through multi-metallic synergy,where constituent elements cooperatively redistribute electron density at catalytic sites.This work provides a new pathway for the rational design of advanced metal carbide electrocatalysts,highlighting the potential of high-entropy effects in tailoring material properties for energy conversion applications.
基金partly supported by the National Key R&D Program of China (Grant No. 2023YFB3001502)the National Natural Science of China (Grant No. 12373002)。
文摘This work demonstrates that once a large number of pion is condensed in a high-energy hadron collision, the gamma-ray spectrum from π0decay takes on a typical broken power-law shape, which has been documented in many astronomical observations, but we have not yet recognized it. We show that this pion condensation is caused by a large number of soft gluons condensed in protons.
