Background: A two-compound product containing calcipotriol 50 μg/g and betamethasone dipropionate 0.5 mg/g (Daivobet., Dovobet.)hasbeendemonstratedtobeaneffective,oncedaily, treatment for psoriasis vulgaris. Objectiv...Background: A two-compound product containing calcipotriol 50 μg/g and betamethasone dipropionate 0.5 mg/g (Daivobet., Dovobet.)hasbeendemonstratedtobeaneffective,oncedaily, treatment for psoriasis vulgaris. Objective: To compare the efficacy and safety of treatment with the two-compound product for 4 weeks followed by calcipotriol for 4 weeks, with that of tacalcitol for 8 weeks in patients with stable psoriasis vulgaris. Methods: 501 patients were randomised to double-blind treatment with the two-compound product followed by calcipotriol 50 μg/g once daily, or to tacalcitol 4 μg/g once daily. Results: Treatment with the two-compound product/calcipotriol was significantly more effective than tacalcitol in terms of mean percentage PASI reduction (65.0 vs. 33.3%at week 4 and 59.0 vs. 38.4%at week 8; P < 0.001 for both). Conclusion: A treatment regimen comprising calcipotriol/betamethasone ointment (Daivobet) for 4 weeks followed by calcipotriol for 4 weeks is superior to tacalcitol ointment for 8 weeks in patients with psoriasis vulgaris.展开更多
文摘Background: A two-compound product containing calcipotriol 50 μg/g and betamethasone dipropionate 0.5 mg/g (Daivobet., Dovobet.)hasbeendemonstratedtobeaneffective,oncedaily, treatment for psoriasis vulgaris. Objective: To compare the efficacy and safety of treatment with the two-compound product for 4 weeks followed by calcipotriol for 4 weeks, with that of tacalcitol for 8 weeks in patients with stable psoriasis vulgaris. Methods: 501 patients were randomised to double-blind treatment with the two-compound product followed by calcipotriol 50 μg/g once daily, or to tacalcitol 4 μg/g once daily. Results: Treatment with the two-compound product/calcipotriol was significantly more effective than tacalcitol in terms of mean percentage PASI reduction (65.0 vs. 33.3%at week 4 and 59.0 vs. 38.4%at week 8; P < 0.001 for both). Conclusion: A treatment regimen comprising calcipotriol/betamethasone ointment (Daivobet) for 4 weeks followed by calcipotriol for 4 weeks is superior to tacalcitol ointment for 8 weeks in patients with psoriasis vulgaris.
