Metal halide perovskite nanocrystals(MHP NCs)are of great candidates in photocatalytic applications due to their extreme light utilization efficiency.However,the instability towards humid environment severely restrict...Metal halide perovskite nanocrystals(MHP NCs)are of great candidates in photocatalytic applications due to their extreme light utilization efficiency.However,the instability towards humid environment severely restrict their practical application.Herein,the CsPbBr_(3)/CsPb_(2)Br_(5)heteronanocrystals(HNCs)were successfully encapsulated into ZIF-8 through a thermal injection method via controlling the molar ratio of Cs^(+)/Pb2^(+).The surface of ZIF-8 was then modified with hydrophobic copolymer of poly(methyl methacrylate)(PMMA)to improve the water stability.Benefiting from the intimate interfacial interaction and staggered energy band structure,the type-II heterojunction of CsPb Br_(3)/CsPb_(2)Br_(5)guarantees efficient separation and migration of photogenerated electron/hole pairs.Meanwhile,the formation of Z-scheme heterojunction between ZIF-8 and CsPbBr_(3)/CsPb_(2)Br_(5)HNCs contributes to the adsorption and enrichment of pollutants,further accelerates the photocatalytic antibiotic degradation efficiency towards tetracycline hydrochloride(TCH)in aqueous solution.Nearly 87%of TCH(40 mg/L,50 mL)was degraded by 40 mg catalyst within 100 min.This work offers a feasible approach in assembling high-performance MHP NCsbased efficient photocatalyst with expanding application in aqueous solution.展开更多
In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabiliti...In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabilities of simulating instability flow and lock-in phenomenon are verified on a transonic rotor and a NACA0012 airfoil by comparing with the test data,respectively.The lock-in phenomenon is first numerically confirmed that may occur to TCF instabilities when its frequency is close to the blade vibration frequency.The lock-in region becomes wider with the vibration amplitude increasing,and it is also affected by modal shapes.For the rotor at the simulation conditions in this study,the bending mode results in a wider lock-in region than the torsional mode.In the lock-in region,the phase difference between the Tip Clearance Vortex(TCV)and the blade vibration changes with the flow condition and the frequency ratio of the blade vibration and the TCV instabilities.The frequency of the TCV instabilities reduces with the mass flow decreasing.Therefore,reducing mass flow and increasing frequency ratio have similar effects on the TCV phase,which causes a significant variation on the unsteady pressure amplitude in the blade tip area.Thus,the aerodynamic damping changes significantly with the TCV phase.The aerodynamic damping displays a nonlinear relationship with the vibration amplitude,and it changes from negative to positive with the vibration amplitude increasing at the same frequency ratio.The negative damping is mainly provided by the tip area of the blade.For unlocked conditions,the period of the TCF instabilities fluctuates over time,and it cannot be directly separated by their frequency features.Inter Blade Phase Angle(IBPA)also has an important influence on the feature of the TCV instabilities.The occurrence of frequency lock-in also requires“appropriate”IBPA.For the examined working conditions,the frequency lock-in occurs under 0 ND(Nodal Diameter),but not under 8 ND.However,no matter 0 ND or 8 ND,the phase of TCV always locks onto the IBPA at the examined conditions.展开更多
Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health...Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health.As important mediators between the gut microbiota and the host,SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics,activating G protein-coupled receptors,and inhibiting pathogenic microbial infections.This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health,enhancing energy metabolism,mitigating diseases such as cancer,obesity,and diabetes,modulating the gut-brain axis and gut-l ung axis,and promoting bone health.展开更多
The divertor target components for the Chinese fusion engineering test reactor(CFETR)and the future experimental advanced superconducting tokamak(EAST)need to remove a heat flux of up to20 MW m-2.In view of such a hig...The divertor target components for the Chinese fusion engineering test reactor(CFETR)and the future experimental advanced superconducting tokamak(EAST)need to remove a heat flux of up to20 MW m-2.In view of such a high heat flux removal requirement,this study proposes a conceptual design for a flat-tile divertor target based on explosive welding and brazing technology.Rectangular water-cooled channels with a special thermal transfer structure(TTS)are designed in the heat sink to improve the flat-tile divertor target’s heat transfer performance(HTP).The parametric design and optimization methods are applied to study the influence of the TTS variation parameters,including height(H),width(W*),thickness(T),and spacing(L),on the HTP.The research results show that the flat-tile divertor target’s HTP is sensitive to the TTS parameter changes,and the sensitivity is T>L>W*>H.The HTP first increases and then decreases with the increase of T,L,and W*and gradually increases with the increase of H.The optimal design parameters are as follows:H=5.5 mm,W*=25.8 mm,T=2.2 mm,and L=9.7 mm.The HTP of the optimized flat-tile divertor target at different flow speeds and tungsten tile thicknesses is studied using the numerical simulation method.A flat-tile divertor mock-up is developed according to the optimized parameters.In addition,high heat flux(HHF)tests are performed on an electron beam facility to further investigate the mock-up HTP.The numerical simulation calculation results show that the optimized flat-tile divertor target has great potential for handling the steady-state heat load of 20 MW m-2under the tungsten tile thickness<5 mm and the flow speed7 m s^(-1).The heat transfer efficiency of the flat-tile divertor target with rectangular cooling channels improves by13%and30%compared to that of the flat-tile divertor target with circular cooling channels and the ITER-like monoblock,respectively.The HHF tests indicate that the flat-tile divertor mock-up can successfully withstand 1000 cycles of20 MW m-2of heat load without visible deformation,damage,and HTP degradation.The surface temperature of the flat-tile divertor mock-up at the 1000th cycle is only930℃.The flat-tile divertor target’s HTP is greatly improved by the parametric design and optimization method,and is better than the ITER-like monoblock and the flat-tile mock-up for the WEST divertor.This conceptual design is currently being applied to the engineering design of the CFETR and EAST flat-tile divertors.展开更多
In a fusion reactor,plasma-facing tungsten(W)materials inevitably suffer severe thermal shock,and the performance of W materials under repetitive high heat loads is one of the key concerns for long-term stable operati...In a fusion reactor,plasma-facing tungsten(W)materials inevitably suffer severe thermal shock,and the performance of W materials under repetitive high heat loads is one of the key concerns for long-term stable operation of the reactor.In this work,the microstructural evolution and thermal fatigue resistance of two representative W-0.5 wt.%ZrC(WZC)and W-1.0 wt.% Y_(2)O_(3)(WYO)composites were investigated under cyclic heat loads.Due to the intrinsic properties of ZrC and Y_(2)O_(3)particles such as coefficients of thermal expansion,particle size and distributions in W grains,the WZC composite exhibited a better thermal shock resistance than WYO.After thermal loads with the absorbed power density(APD)≥22 MW/m^(2),WYO showed obvious grain growth,Y_(2)O_(3)particles shedding and degradation of mechanical properties.While,in the case of WZC,these damage behaviors only occurred when APD≥25 MW/m^(2).Furthermore,an interesting crack mechanism in W composites was revealed due to interface debonding and progressive shedding of second-phase particles from the W matrix.The microstructures and tensile properties of the thermally loaded WZC and WYO specimens were also investigated and the correlations between the microstructure evolution and performance degradation are demonstrated.The results are useful for evaluating the thermal fatigue resistance of oxide/carbide dispersion strengthened W composites and their application in future fusion reactors.展开更多
Inositol polyphosphate-4-phosphatase type II(INPP4B)is a newly discovered PI(3,4,5)P3 phosphatase.Many studies have revealed that INPP4B is upregulated or downregulated in tumors of the digestive system,and the abnorm...Inositol polyphosphate-4-phosphatase type II(INPP4B)is a newly discovered PI(3,4,5)P3 phosphatase.Many studies have revealed that INPP4B is upregulated or downregulated in tumors of the digestive system,and the abnormal expression of INPP4B may be attributed to the occurrence,development,and prognosis of tumors of the digestive system.This paper reviews studies on the correlations between INPP4B and digestive system tumors and the roles of INPP4B in the development of different tumors to provide a theoretical basis for further research on its molecular mechanism and clinical application."INPP4B"and"tumor"were searched as key words in PubMed and in the CNKI series full text database retrieval system from January 2000 to August 2023.A total of 153 Englishlanguage studies and 30 Chinese-language studies were retrieved.The following enrollment criteria were applied:(1)Studies contained information on the biological structure and functions of INPP4B;(2)studies covered the influence of abnormal expression of INPP4B in digestive system tumors;and(3)studies covered the role of INPP4B in the diagnosis,treatment,and prognosis of digestive system tumors.After excluding the literature irrelevant to this study,61 papers were finally included in the analysis.INPP4B expression is low in gastric cancer,colon cancer,pancreatic cancer,and liver cancer but it has high expression in esophageal cancer,colon cancer,pancreatic cancer,and gallbladder cancer.INPP4B is involved in the occurrence and development of digestive system tumors through the regulation of gene expression and signal transduction.The abnormal expression of INPP4B plays an important role in the development of digestive system tumors.Studies on INPP4B provide new molecular insights for the diagnosis,treatment,and prognosis evaluation of digestive system tumors.展开更多
OBJECTIVE To investigated the regulatory effect of paeoniflorin-6′-O-benzene sulfonate(CP-25) on B cell activating factor(BAFF)/BAFF receptor-nuclear factor of kappa B(NF-κB) signaling in B cell of collagen induced-...OBJECTIVE To investigated the regulatory effect of paeoniflorin-6′-O-benzene sulfonate(CP-25) on B cell activating factor(BAFF)/BAFF receptor-nuclear factor of kappa B(NF-κB) signaling in B cell of collagen induced-arthritis(CIA) mice.METHODS Mice CIA was induced by injection of typeⅡcollagen(CⅡ).The arthritis index(AI) and swollen joint count(SJC) were assessed,and histopathology of spleen and joints were observed.The percentage of B cells subsets,BAFF receptor expressions were analyzed by flow cytometry.BAFF and immunoglobulin(Ig) levels were measured by protein antibody array.The expressions of TRAF2,MKK3,MKK6,p-P38,and p-NF-κB65 in NF-κB signaling mediated by BAFF were analyzed by western blot.RESULTS CP-25 decreased AI and SJC,restored abnormal weights,reduced thymus index and spleen index,inhibited T/B cells proliferation,alleviated the histopathology of spleen and joints in CIA mice.CP-25 also reduced high levels of serum BAFF and immunoglobulin,decreased CD19+B cells,CD19+CD27+B cells,and CD19-CD27+CD138+plasma cells,inhibited BAFFR and TACI expressions,decreased the expressions of TRAF2,MKK3,MKK6,p-P38,and p-NF-κB65.Compared with biological agents etanercept and rituximab,CP-25 restored high T cells proliferation and percentages of B subsets to normal level,and recovered the high levels of IgA,IgD,IgG1,IgG2 a and high expressions molecules in NF-κB signaling to normal levels.The action intensity of rituximab and etanercept was more strong than CP-25.The inhibitor effects of rituximab and etanercept on AI and SJC,thymus index,proliferation of T cells and B cells subsets were strong,and down-regulated the indexes to under normal levels.CONCLUSION CP-25 might be a promising anti-inflammatory immune and regulation drug,which alleviated CIA and regulated the functions of B cells through BAFF/BAFF receptor-NF-κB signaling.展开更多
As an important component of tokamaks,the divertor is mainly responsible for extracting heat and helium ash,and the targets of the divertor need to withstand high heat flux of 10 MW m-2 for steady-state operation.In t...As an important component of tokamaks,the divertor is mainly responsible for extracting heat and helium ash,and the targets of the divertor need to withstand high heat flux of 10 MW m-2 for steady-state operation.In this study,we proposed a new strategy,using microchannel cooling technology to remove high heat load on the targets of the divertor.The results demonstrated that the microchannel-based W/Cu flat-type mock-up successfully withstood the thermal fatigue test of 1000 cycles at 10 MW m^(-2)with cooling water of 26 l min^(-1),30°C(inlet),0.8 MPa(inlet),15 s power on and 15 s dwell time;the maximum temperature on the heat-loaded surface(W surface)of the mock-up was 493°C,which is much lower than the recrystallization temperature of W(1200°C).Moreover,no occurrence of macrocrack and‘hot spot’at the W surface,as well as no detachment of W/Cu tiles were observed during the thermal fatigue testing.These results indicate that microchannel cooling technology is an efflcient method for removing the heat load of the divertor at a low flow rate.The present study offers a promising solution to replace the monoblock design for the EAST divertor.展开更多
The precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg rats.However,the current stimulation techniques cannot realize the graded control of the speed.In this s...The precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg rats.However,the current stimulation techniques cannot realize the graded control of the speed.In this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(CnF)of the Mesencephalic Locomotor Region(MLR).Detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration period.We concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg rats.Whereas the amplitude of stimulation was found to affect the response time exhibited by the cyborg rats.Our study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.展开更多
This study investigates the forced vibration response of a two-row model of an Inlet Guide Vane(IGV)and rotor at resonance speed through numerical simulations.A resonant response prediction method based on equivalent ...This study investigates the forced vibration response of a two-row model of an Inlet Guide Vane(IGV)and rotor at resonance speed through numerical simulations.A resonant response prediction method based on equivalent damping balance has been validated,which ensures computational accuracy while reducing response calculation time to only 1%of the traditional transient response method.At resonance speed,unsteady pressure disturbances on the rotor blade surface mainly arise from two sources:IGV wakes and blade vibrations.The unsteady pressure caused by the IGV wakes provides excitation for the system,while the unsteady pressure caused by rotor blade vibrations provides damping.By studying the characteristics of unsteady pressure caused by IGV wakes and vibrations at resonance speed,a method for separating unsteady pressure caused by stator wakes and vibrations has been presented,accurately obtaining aerodynamic damping under multi-row resonance conditions.Compared to the aerodynamic damping obtained from multi-row scenarios without separating unsteady pressures caused by stator wakes and vibrations,and the traditional isolated blade row scheme,the aerodynamic damping considering the effects of multi-row and IGV wakes at resonance speed is smaller.Based on the separated unsteady pressures caused by IGV wakes and vibrations,and combined with the equivalent damping balance method for predicting forced response,a forced response analysis method considering both flow field disturbance excitation and damping effects has been established.展开更多
OBJECTIVE This study was to investigate the effects of CP-25 on the functions of activated human B cells through regulating BAFF and TNF-alpha signaling.METHODS B cells from peripheral blood mononuclear cells(PBMCs) o...OBJECTIVE This study was to investigate the effects of CP-25 on the functions of activated human B cells through regulating BAFF and TNF-alpha signaling.METHODS B cells from peripheral blood mononuclear cells(PBMCs) of normal human were isolated using magnetic cell separation(MACS) by a positive selection.B cells(107 cells·mL^(-1)) were stimulated by BAFF(100 ng·mL^(-1))or TNF-alpha(100 ng·mL^(-1)) for two hours,and then were treated with CP-25(10-5 mol·L^(-1)) or Rituximab(5 μg·mL^(-1)) or Etanercept(10 μg·mL^(-1)).B cell proliferation was detected by CCK-8.B cell subsets and BAFF receptors(BAFFR,BCMA and TACI) were analyzed by flow cytometry.The expression of TNFR1 and TNFR2 on B cells was analyzed by flow cytometry.The expression of MKK3,MKK6,P-p38,P-p65,TRAF2 and p100/52 was analyzed by Western blotting.RESULTS CP-25 inhibited B cells proliferation stimulated by BAFF or TNF-alpha.CP-25,Rituximab and Etanercept reduced the percentage and numbers of CD19^+B cells,CD19^+CD20^+B cells,CD19^+CD27^+B cells and CD19^+CD20^+CD27^+B cells induced by BAFF or TNF-alpha.CP-25 down-regulated the high expression of BAFFR,BCMA and TACI stimulated by BAFF or TNF-alpha.CP-25,Rituximab and Etanercept down-regulated significantly the expression of TNFR1 and TNFR2 on B cell stimulated by BAFF or TNF-alpha.CP-25,Rituximab and Etanercept down-regulated the expression of MKK3,P-p38,P-p65,TRAF2 and p52 in B cells stimulated by BAFF and the expression of TRAF2 and P-p65 in B cells stimulated by TNF-alpha.CONCLUSION CP-25 regulated moderately activated B cells function by by regulating the classical and alternative NF-κB signaling pathway mediated by BAFF and TNF-alpha-TRAF2-NF-κB signaling pathway.This study suggests that CP-25 may be a promising anti-inflammatory immune and soft regulation drug.展开更多
The aeroelastic stability associated with the acoustic wave propagation characteristics of transonic rotor blades was numerically investigated in this study.The influence of the vibration frequency on the aerodynamic ...The aeroelastic stability associated with the acoustic wave propagation characteristics of transonic rotor blades was numerically investigated in this study.The influence of the vibration frequency on the aerodynamic damping of the first bending mode was primarily considered at different speeds,including both work and stall points.We found that the state of acoustic wave propagation associated with aeroelastic instability is closely related to rotational speed.At low speeds near stall points,the risk of aeroelastic instability is confined to the upstream cut-off state.However,at high speeds near stall points,aeroelastic instability may occur in both the downstream cut-off state and the acoustic wave propagation state of the upstream cut-off frequency,further expanding the range of the acoustic wave propagation state in which aeroelastic instability can arise.The research findings show that for suction surfaces,aerodynamic work is affected not only by acoustic wave propagation characteristics,but also by shock waves,radial flow,and reflux in the flow field.However,for pressure surfaces,the acoustic wave propagation characteristics play a significant role.When aeroelastic instability occurs,negative damping predominantly arises from the pressure surface.To investigate why lower-order modes are more prone to aeroelastic instability,specific simulations were conducted for the first bending and twisting modes under different operating conditions in the downstream cut-on state.When the vibration frequency significantly exceeds the downstream cutoff frequency,the blade phase is minimally influenced by acoustic wave propagation characteristics,and the rotor is aeroelastically stable in these phases.Simultaneously,there is an approximately linear increase in the unsteady pressure amplitude with increasing vibration frequency,and the aerodynamic work is predominantly influenced by the unsteady pressure amplitude.展开更多
Experimental and numerical investigations were performed to reveal the effect of prestress on the fatigue properties of FGH4097 so as to quantitatively evaluate the overspeed benefit of the disc of aeroengine. A corre...Experimental and numerical investigations were performed to reveal the effect of prestress on the fatigue properties of FGH4097 so as to quantitatively evaluate the overspeed benefit of the disc of aeroengine. A corresponding experiment was performed to examine the effect of prestress on the fatigue life of FGH97. A complete model describing the fatigue properties of the prestressed notch specimen was proposed. After the modification of mean stress, stress gradient and prestressing treatment, the model is finally verified by fatigue test of presstressed notch specimens machined from FGH4097 with satisfactory accuracy and good engineering applicability. The new model highlights that for the variable fatigue loads, the introduction of appropriate prestress is expected to benefit to the notch specimens and certainly to the disc of aeroengine regards of their fatigue properties. Both the calculation method of fatigue life parameters and the prestress correction model are proved to have good prediction accuracy.展开更多
To evaluate the quality of Pollen Typhae as used in traditional Chinese medicine,a high-performance capillary electrophoresis(HPCE)method has been developed,validated and applied to chromatographic fingerprinting and ...To evaluate the quality of Pollen Typhae as used in traditional Chinese medicine,a high-performance capillary electrophoresis(HPCE)method has been developed,validated and applied to chromatographic fingerprinting and quantitation of its eight main bioactive flavonoids(naringenin,isorhamnetin 3-0-(2^(G)-α-L-rhamnosy)-rutinoside,rhamnetin 3-0-neohesperidoside,isorhamnetin,quercetin 3-0-(2^(G)-α-L-rhamnosyl)-rutinoside,quercetin 3-O-neohesperidoside,kaempferol and quer-cetin).Fingerprinting was based on the selection of nine characteristic chromatographic peaks.In quantitative analysis,the recovery of all eight compounds was in the range 98.5-102.2% with good linearity(r^(2)>0.9919)over a relatively wide concentration range.The assay was successfully applied to the analysis of the eight bioactive flavonoids in 14 different samples.The results indicate that the assay is reproducible and precise and can be used for convenient quality assessment of Pollen Typhae.展开更多
Ammonia recovery from wastewater is crucial,yet technology of low carbon emission and high ammonia perm-selectivity against complex stream compositions is urgently needed.Herein,a membrane-based hybrid process of the ...Ammonia recovery from wastewater is crucial,yet technology of low carbon emission and high ammonia perm-selectivity against complex stream compositions is urgently needed.Herein,a membrane-based hybrid process of the Donnan dialysiseelectrodialysis process(DDeED)was proposed for sustainable and efficient ammonia recovery.In principle,DD removes the majority of ammonia in wastewater by exploring the concentration gradient of NH4 t and driven cation(Nat)across the cation exchange membrane,given industrial sodium salt as a driving chemical.An additional ED stage driven by solar energy realizes a further removal of ammonia,recovery of driven cation,and replenishment of OHtoward ammonia stripping.Our results demonstrated that the hybrid DDeED process achieved ammonia removal efficiency>95%,driving cation(Nat)recovery efficiency>87.1%for synthetic streams,and reduced the OH-loss by up to 78%compared to a standalone DD case.Ammonia fluxes of 98.2 gN m^(-2)d^(-1)with the real anaerobic digestion effluent were observed using only solar energy input at 3.8 kWh kgN^(-1).With verified mass transfer modeling,reasonably controlled operation,and beneficial recovery performance,the hybrid process can be a promising candidate for future nutrient recovery from wastewater in a rural,remote area.展开更多
This paper is concerned with the structured simultaneous low-rank and sparse recovery,which can be formulated as the rank and zero-norm regularized least squares problem with a hard constraint diag(■)=0.For this clas...This paper is concerned with the structured simultaneous low-rank and sparse recovery,which can be formulated as the rank and zero-norm regularized least squares problem with a hard constraint diag(■)=0.For this class of NP-hard problems,we propose a convex relaxation algorithm by applying the accelerated proximal gradient method to a convex relaxation model,which is yielded by the smoothed nuclear norm and the weighted l1-norm regularized least squares problem.A theoretical guarantee is provided by establishing the error bounds of the iterates to the true solution under mild restricted strong convexity conditions.To the best of our knowledge,this work is the first one to characterize the error bound of the iterates of the algorithm to the true solution.Finally,numerical results are reported for some random test problems and synthetic data in subspace clustering to verify the efficiency of the proposed convex relaxation algorithm.展开更多
This study investigated the influence of casing profiles on the aeroelastic stability of a transonic compressor rotor.To elucidate the influence of casing profiles on aerodynamic damping(AD)and delve into more detaile...This study investigated the influence of casing profiles on the aeroelastic stability of a transonic compressor rotor.To elucidate the influence of casing profiles on aerodynamic damping(AD)and delve into more detailed insights,the influence coefficient method and phase-shift theory were incorporated into the conventional energy method to establish the multi-passage energy method.The unsteady pressure was calculated using the influence coef-ficient method and the outcomes at various nodal diameters(NDs)were reconstructed based on the phase-shift theory.Thus,the multi-passage energy method offers more comprehensive information than the conventional energy method,the aeroelastic eigenvalue method,and the coupled fluid-structure interaction method.Four casing profiles were simulated.In contrast to the straight casing configuration,the concave shrinking casing was found to be detrimental to aeroelastic stability.The convex shrinking casing can alleviate the blockage in the tip flow field and improve both the aerodynamic performance and aeroelastic stability.The multi-passage energy method further revealed that the AD is contributed by the blade itself and the adjacent blades.In comparison to the straight casing,the convex shrinking casing not only enhances the AD of the blade itself but also diminishes the AD fluctuation of the adjacent blades.Consequently,the minimum AD is increased.展开更多
In the original publication the Supplementary Material and Fig.2 are in correct.The correct versi on of Supplementary Material and Fig.2 are provided in this correction article.The text HBG2 appearing in the article s...In the original publication the Supplementary Material and Fig.2 are in correct.The correct versi on of Supplementary Material and Fig.2 are provided in this correction article.The text HBG2 appearing in the article should be read as HBG1.展开更多
Dear Editor, Clustered regularly interspaced short palindromic repeats （CRISPR） system is part of the adaptive immunity of bacteria and archaea that defends them against phage infection （Barrangou and Doudna, 2016...Dear Editor, Clustered regularly interspaced short palindromic repeats （CRISPR） system is part of the adaptive immunity of bacteria and archaea that defends them against phage infection （Barrangou and Doudna, 2016）. Variant CRISPR systems have been identified and harnessed for a wide range of applications in various organisms, exemplified by gene editing with the CRISPR/Cas9 system from Streptococcuspyogenes （Barrangou and Doudna, 2016）.展开更多
基金supported by National Natural Science Foundation of China(No.22171040)Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(No.RC230784)+1 种基金Guangdong Basic and Applied Basic Research Foundation(No.2023A1515140011)Fundamental Research Funds for the Central Universities,China(No.N2305017)。
文摘Metal halide perovskite nanocrystals(MHP NCs)are of great candidates in photocatalytic applications due to their extreme light utilization efficiency.However,the instability towards humid environment severely restrict their practical application.Herein,the CsPbBr_(3)/CsPb_(2)Br_(5)heteronanocrystals(HNCs)were successfully encapsulated into ZIF-8 through a thermal injection method via controlling the molar ratio of Cs^(+)/Pb2^(+).The surface of ZIF-8 was then modified with hydrophobic copolymer of poly(methyl methacrylate)(PMMA)to improve the water stability.Benefiting from the intimate interfacial interaction and staggered energy band structure,the type-II heterojunction of CsPb Br_(3)/CsPb_(2)Br_(5)guarantees efficient separation and migration of photogenerated electron/hole pairs.Meanwhile,the formation of Z-scheme heterojunction between ZIF-8 and CsPbBr_(3)/CsPb_(2)Br_(5)HNCs contributes to the adsorption and enrichment of pollutants,further accelerates the photocatalytic antibiotic degradation efficiency towards tetracycline hydrochloride(TCH)in aqueous solution.Nearly 87%of TCH(40 mg/L,50 mL)was degraded by 40 mg catalyst within 100 min.This work offers a feasible approach in assembling high-performance MHP NCsbased efficient photocatalyst with expanding application in aqueous solution.
基金supported by the National Natural Science Foundation of China(No.51475022)。
文摘In this study,the lock-in phenomenon of Tip Clearance Flow(TCF)instabilities and their relationship to blade vibration are investigated numerically on an axial transonic rotor with a large tip clearance.The capabilities of simulating instability flow and lock-in phenomenon are verified on a transonic rotor and a NACA0012 airfoil by comparing with the test data,respectively.The lock-in phenomenon is first numerically confirmed that may occur to TCF instabilities when its frequency is close to the blade vibration frequency.The lock-in region becomes wider with the vibration amplitude increasing,and it is also affected by modal shapes.For the rotor at the simulation conditions in this study,the bending mode results in a wider lock-in region than the torsional mode.In the lock-in region,the phase difference between the Tip Clearance Vortex(TCV)and the blade vibration changes with the flow condition and the frequency ratio of the blade vibration and the TCV instabilities.The frequency of the TCV instabilities reduces with the mass flow decreasing.Therefore,reducing mass flow and increasing frequency ratio have similar effects on the TCV phase,which causes a significant variation on the unsteady pressure amplitude in the blade tip area.Thus,the aerodynamic damping changes significantly with the TCV phase.The aerodynamic damping displays a nonlinear relationship with the vibration amplitude,and it changes from negative to positive with the vibration amplitude increasing at the same frequency ratio.The negative damping is mainly provided by the tip area of the blade.For unlocked conditions,the period of the TCF instabilities fluctuates over time,and it cannot be directly separated by their frequency features.Inter Blade Phase Angle(IBPA)also has an important influence on the feature of the TCV instabilities.The occurrence of frequency lock-in also requires“appropriate”IBPA.For the examined working conditions,the frequency lock-in occurs under 0 ND(Nodal Diameter),but not under 8 ND.However,no matter 0 ND or 8 ND,the phase of TCV always locks onto the IBPA at the examined conditions.
基金supported by the Hebei Medical Science Research Project(20242002)S&T Program of Hebei(21377722D)the National Natural Science Foundation of China(82001145)。
文摘Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host health.As important mediators between the gut microbiota and the host,SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics,activating G protein-coupled receptors,and inhibiting pathogenic microbial infections.This review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health,enhancing energy metabolism,mitigating diseases such as cancer,obesity,and diabetes,modulating the gut-brain axis and gut-l ung axis,and promoting bone health.
基金supported by the National MCF Energy R&D Program(No.2018YFE0312300)the National Key Research and Development Program of China(No.2017YFA0402500)the Science Foundation of the Institute of Plasma Physics,Chinese Academy of Sciences(No.Y45ETY2302)。
文摘The divertor target components for the Chinese fusion engineering test reactor(CFETR)and the future experimental advanced superconducting tokamak(EAST)need to remove a heat flux of up to20 MW m-2.In view of such a high heat flux removal requirement,this study proposes a conceptual design for a flat-tile divertor target based on explosive welding and brazing technology.Rectangular water-cooled channels with a special thermal transfer structure(TTS)are designed in the heat sink to improve the flat-tile divertor target’s heat transfer performance(HTP).The parametric design and optimization methods are applied to study the influence of the TTS variation parameters,including height(H),width(W*),thickness(T),and spacing(L),on the HTP.The research results show that the flat-tile divertor target’s HTP is sensitive to the TTS parameter changes,and the sensitivity is T>L>W*>H.The HTP first increases and then decreases with the increase of T,L,and W*and gradually increases with the increase of H.The optimal design parameters are as follows:H=5.5 mm,W*=25.8 mm,T=2.2 mm,and L=9.7 mm.The HTP of the optimized flat-tile divertor target at different flow speeds and tungsten tile thicknesses is studied using the numerical simulation method.A flat-tile divertor mock-up is developed according to the optimized parameters.In addition,high heat flux(HHF)tests are performed on an electron beam facility to further investigate the mock-up HTP.The numerical simulation calculation results show that the optimized flat-tile divertor target has great potential for handling the steady-state heat load of 20 MW m-2under the tungsten tile thickness<5 mm and the flow speed7 m s^(-1).The heat transfer efficiency of the flat-tile divertor target with rectangular cooling channels improves by13%and30%compared to that of the flat-tile divertor target with circular cooling channels and the ITER-like monoblock,respectively.The HHF tests indicate that the flat-tile divertor mock-up can successfully withstand 1000 cycles of20 MW m-2of heat load without visible deformation,damage,and HTP degradation.The surface temperature of the flat-tile divertor mock-up at the 1000th cycle is only930℃.The flat-tile divertor target’s HTP is greatly improved by the parametric design and optimization method,and is better than the ITER-like monoblock and the flat-tile mock-up for the WEST divertor.This conceptual design is currently being applied to the engineering design of the CFETR and EAST flat-tile divertors.
基金supported by the National Key Research and Development Program of China(Nos.2019YFE03110200,2017YFE0302400,and 2019YFE03120001)the National Natural Science Foundation of China(Nos.11735015,52171084,52173303,U1967211)+1 种基金Anhui Provincial Natural Science Foundation(No.1908085J17)the HFIPS Director’s Fund(Nos.YZJJZX202012,YZJJ202206-CX,BJPY2021A05).
文摘In a fusion reactor,plasma-facing tungsten(W)materials inevitably suffer severe thermal shock,and the performance of W materials under repetitive high heat loads is one of the key concerns for long-term stable operation of the reactor.In this work,the microstructural evolution and thermal fatigue resistance of two representative W-0.5 wt.%ZrC(WZC)and W-1.0 wt.% Y_(2)O_(3)(WYO)composites were investigated under cyclic heat loads.Due to the intrinsic properties of ZrC and Y_(2)O_(3)particles such as coefficients of thermal expansion,particle size and distributions in W grains,the WZC composite exhibited a better thermal shock resistance than WYO.After thermal loads with the absorbed power density(APD)≥22 MW/m^(2),WYO showed obvious grain growth,Y_(2)O_(3)particles shedding and degradation of mechanical properties.While,in the case of WZC,these damage behaviors only occurred when APD≥25 MW/m^(2).Furthermore,an interesting crack mechanism in W composites was revealed due to interface debonding and progressive shedding of second-phase particles from the W matrix.The microstructures and tensile properties of the thermally loaded WZC and WYO specimens were also investigated and the correlations between the microstructure evolution and performance degradation are demonstrated.The results are useful for evaluating the thermal fatigue resistance of oxide/carbide dispersion strengthened W composites and their application in future fusion reactors.
文摘Inositol polyphosphate-4-phosphatase type II(INPP4B)is a newly discovered PI(3,4,5)P3 phosphatase.Many studies have revealed that INPP4B is upregulated or downregulated in tumors of the digestive system,and the abnormal expression of INPP4B may be attributed to the occurrence,development,and prognosis of tumors of the digestive system.This paper reviews studies on the correlations between INPP4B and digestive system tumors and the roles of INPP4B in the development of different tumors to provide a theoretical basis for further research on its molecular mechanism and clinical application."INPP4B"and"tumor"were searched as key words in PubMed and in the CNKI series full text database retrieval system from January 2000 to August 2023.A total of 153 Englishlanguage studies and 30 Chinese-language studies were retrieved.The following enrollment criteria were applied:(1)Studies contained information on the biological structure and functions of INPP4B;(2)studies covered the influence of abnormal expression of INPP4B in digestive system tumors;and(3)studies covered the role of INPP4B in the diagnosis,treatment,and prognosis of digestive system tumors.After excluding the literature irrelevant to this study,61 papers were finally included in the analysis.INPP4B expression is low in gastric cancer,colon cancer,pancreatic cancer,and liver cancer but it has high expression in esophageal cancer,colon cancer,pancreatic cancer,and gallbladder cancer.INPP4B is involved in the occurrence and development of digestive system tumors through the regulation of gene expression and signal transduction.The abnormal expression of INPP4B plays an important role in the development of digestive system tumors.Studies on INPP4B provide new molecular insights for the diagnosis,treatment,and prognosis evaluation of digestive system tumors.
基金supported by National Natural Science Foundation of China(81330081,81473223and 81673444)Anhui Province Postdoctoral Science Foundation(2016B134)
文摘OBJECTIVE To investigated the regulatory effect of paeoniflorin-6′-O-benzene sulfonate(CP-25) on B cell activating factor(BAFF)/BAFF receptor-nuclear factor of kappa B(NF-κB) signaling in B cell of collagen induced-arthritis(CIA) mice.METHODS Mice CIA was induced by injection of typeⅡcollagen(CⅡ).The arthritis index(AI) and swollen joint count(SJC) were assessed,and histopathology of spleen and joints were observed.The percentage of B cells subsets,BAFF receptor expressions were analyzed by flow cytometry.BAFF and immunoglobulin(Ig) levels were measured by protein antibody array.The expressions of TRAF2,MKK3,MKK6,p-P38,and p-NF-κB65 in NF-κB signaling mediated by BAFF were analyzed by western blot.RESULTS CP-25 decreased AI and SJC,restored abnormal weights,reduced thymus index and spleen index,inhibited T/B cells proliferation,alleviated the histopathology of spleen and joints in CIA mice.CP-25 also reduced high levels of serum BAFF and immunoglobulin,decreased CD19+B cells,CD19+CD27+B cells,and CD19-CD27+CD138+plasma cells,inhibited BAFFR and TACI expressions,decreased the expressions of TRAF2,MKK3,MKK6,p-P38,and p-NF-κB65.Compared with biological agents etanercept and rituximab,CP-25 restored high T cells proliferation and percentages of B subsets to normal level,and recovered the high levels of IgA,IgD,IgG1,IgG2 a and high expressions molecules in NF-κB signaling to normal levels.The action intensity of rituximab and etanercept was more strong than CP-25.The inhibitor effects of rituximab and etanercept on AI and SJC,thymus index,proliferation of T cells and B cells subsets were strong,and down-regulated the indexes to under normal levels.CONCLUSION CP-25 might be a promising anti-inflammatory immune and regulation drug,which alleviated CIA and regulated the functions of B cells through BAFF/BAFF receptor-NF-κB signaling.
基金financial support from the National MCF Energy R&D Program(No.2018YFE0312300)National Natural Science Foundation of China(No.51706100)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20180477)Fundamental Research Funds for the Central Universities(No.30918011205)。
文摘As an important component of tokamaks,the divertor is mainly responsible for extracting heat and helium ash,and the targets of the divertor need to withstand high heat flux of 10 MW m-2 for steady-state operation.In this study,we proposed a new strategy,using microchannel cooling technology to remove high heat load on the targets of the divertor.The results demonstrated that the microchannel-based W/Cu flat-type mock-up successfully withstood the thermal fatigue test of 1000 cycles at 10 MW m^(-2)with cooling water of 26 l min^(-1),30°C(inlet),0.8 MPa(inlet),15 s power on and 15 s dwell time;the maximum temperature on the heat-loaded surface(W surface)of the mock-up was 493°C,which is much lower than the recrystallization temperature of W(1200°C).Moreover,no occurrence of macrocrack and‘hot spot’at the W surface,as well as no detachment of W/Cu tiles were observed during the thermal fatigue testing.These results indicate that microchannel cooling technology is an efflcient method for removing the heat load of the divertor at a low flow rate.The present study offers a promising solution to replace the monoblock design for the EAST divertor.
基金the National Key R&D Program of China(2020YFB1313501)Zhejiang Provincial Natural Science Foundation(LZ24F020003)+2 种基金National Natural Science Foundation of China(T2293723)the Key R&D program of Zhejiang Province(2021C03003)the Fundamental Research Funds for the Central Universities(No.226-2022-00051).
文摘The precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg rats.However,the current stimulation techniques cannot realize the graded control of the speed.In this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(CnF)of the Mesencephalic Locomotor Region(MLR).Detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration period.We concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg rats.Whereas the amplitude of stimulation was found to affect the response time exhibited by the cyborg rats.Our study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.
基金co-supported by the National Natural Science Foundation of China(No.52306034)the National Science and Technology Major Project,China(No.J2022-IV-00100024)+1 种基金the Fundamental Research Funds for the Central Universities,Chinathe National Science and Technology Major Project,China(No.J2017-IV-0002-0039)。
文摘This study investigates the forced vibration response of a two-row model of an Inlet Guide Vane(IGV)and rotor at resonance speed through numerical simulations.A resonant response prediction method based on equivalent damping balance has been validated,which ensures computational accuracy while reducing response calculation time to only 1%of the traditional transient response method.At resonance speed,unsteady pressure disturbances on the rotor blade surface mainly arise from two sources:IGV wakes and blade vibrations.The unsteady pressure caused by the IGV wakes provides excitation for the system,while the unsteady pressure caused by rotor blade vibrations provides damping.By studying the characteristics of unsteady pressure caused by IGV wakes and vibrations at resonance speed,a method for separating unsteady pressure caused by stator wakes and vibrations has been presented,accurately obtaining aerodynamic damping under multi-row resonance conditions.Compared to the aerodynamic damping obtained from multi-row scenarios without separating unsteady pressures caused by stator wakes and vibrations,and the traditional isolated blade row scheme,the aerodynamic damping considering the effects of multi-row and IGV wakes at resonance speed is smaller.Based on the separated unsteady pressures caused by IGV wakes and vibrations,and combined with the equivalent damping balance method for predicting forced response,a forced response analysis method considering both flow field disturbance excitation and damping effects has been established.
基金supported by National Natural Science Foundation of China(81330081,81473223and 81673444)Anhui Province Postdoctoral Science Foundation(2016B134)
文摘OBJECTIVE This study was to investigate the effects of CP-25 on the functions of activated human B cells through regulating BAFF and TNF-alpha signaling.METHODS B cells from peripheral blood mononuclear cells(PBMCs) of normal human were isolated using magnetic cell separation(MACS) by a positive selection.B cells(107 cells·mL^(-1)) were stimulated by BAFF(100 ng·mL^(-1))or TNF-alpha(100 ng·mL^(-1)) for two hours,and then were treated with CP-25(10-5 mol·L^(-1)) or Rituximab(5 μg·mL^(-1)) or Etanercept(10 μg·mL^(-1)).B cell proliferation was detected by CCK-8.B cell subsets and BAFF receptors(BAFFR,BCMA and TACI) were analyzed by flow cytometry.The expression of TNFR1 and TNFR2 on B cells was analyzed by flow cytometry.The expression of MKK3,MKK6,P-p38,P-p65,TRAF2 and p100/52 was analyzed by Western blotting.RESULTS CP-25 inhibited B cells proliferation stimulated by BAFF or TNF-alpha.CP-25,Rituximab and Etanercept reduced the percentage and numbers of CD19^+B cells,CD19^+CD20^+B cells,CD19^+CD27^+B cells and CD19^+CD20^+CD27^+B cells induced by BAFF or TNF-alpha.CP-25 down-regulated the high expression of BAFFR,BCMA and TACI stimulated by BAFF or TNF-alpha.CP-25,Rituximab and Etanercept down-regulated significantly the expression of TNFR1 and TNFR2 on B cell stimulated by BAFF or TNF-alpha.CP-25,Rituximab and Etanercept down-regulated the expression of MKK3,P-p38,P-p65,TRAF2 and p52 in B cells stimulated by BAFF and the expression of TRAF2 and P-p65 in B cells stimulated by TNF-alpha.CONCLUSION CP-25 regulated moderately activated B cells function by by regulating the classical and alternative NF-κB signaling pathway mediated by BAFF and TNF-alpha-TRAF2-NF-κB signaling pathway.This study suggests that CP-25 may be a promising anti-inflammatory immune and soft regulation drug.
基金co-supported by the National Natural Science Foundation of China(No.52306034)the National Science and Technology Major Project,China(No.J2022-IV-00100024)the Fundamental Research Funds for the Central Universities,China and the National Science and Technology Major Project,China(No.J2017-IV-0002-0039)。
文摘The aeroelastic stability associated with the acoustic wave propagation characteristics of transonic rotor blades was numerically investigated in this study.The influence of the vibration frequency on the aerodynamic damping of the first bending mode was primarily considered at different speeds,including both work and stall points.We found that the state of acoustic wave propagation associated with aeroelastic instability is closely related to rotational speed.At low speeds near stall points,the risk of aeroelastic instability is confined to the upstream cut-off state.However,at high speeds near stall points,aeroelastic instability may occur in both the downstream cut-off state and the acoustic wave propagation state of the upstream cut-off frequency,further expanding the range of the acoustic wave propagation state in which aeroelastic instability can arise.The research findings show that for suction surfaces,aerodynamic work is affected not only by acoustic wave propagation characteristics,but also by shock waves,radial flow,and reflux in the flow field.However,for pressure surfaces,the acoustic wave propagation characteristics play a significant role.When aeroelastic instability occurs,negative damping predominantly arises from the pressure surface.To investigate why lower-order modes are more prone to aeroelastic instability,specific simulations were conducted for the first bending and twisting modes under different operating conditions in the downstream cut-on state.When the vibration frequency significantly exceeds the downstream cutoff frequency,the blade phase is minimally influenced by acoustic wave propagation characteristics,and the rotor is aeroelastically stable in these phases.Simultaneously,there is an approximately linear increase in the unsteady pressure amplitude with increasing vibration frequency,and the aerodynamic work is predominantly influenced by the unsteady pressure amplitude.
基金supported by the National Science and Technology Major Project, China (No. J2019-IV-0012-0080)the National Natural Science Foundation of China (No. 12202030)the China Postdoctoral Science Foundation (No. 2022M720340)。
文摘Experimental and numerical investigations were performed to reveal the effect of prestress on the fatigue properties of FGH4097 so as to quantitatively evaluate the overspeed benefit of the disc of aeroengine. A corresponding experiment was performed to examine the effect of prestress on the fatigue life of FGH97. A complete model describing the fatigue properties of the prestressed notch specimen was proposed. After the modification of mean stress, stress gradient and prestressing treatment, the model is finally verified by fatigue test of presstressed notch specimens machined from FGH4097 with satisfactory accuracy and good engineering applicability. The new model highlights that for the variable fatigue loads, the introduction of appropriate prestress is expected to benefit to the notch specimens and certainly to the disc of aeroengine regards of their fatigue properties. Both the calculation method of fatigue life parameters and the prestress correction model are proved to have good prediction accuracy.
基金The authors are grateful for financial support for this project as an Opening Project of the Jiangsu Key Laboratory of Chinese Medicine Processing(ZYPZ007)by the Priority Academic Program Development of Jiangsu Higher Education Institutions(ysxk-2010).
文摘To evaluate the quality of Pollen Typhae as used in traditional Chinese medicine,a high-performance capillary electrophoresis(HPCE)method has been developed,validated and applied to chromatographic fingerprinting and quantitation of its eight main bioactive flavonoids(naringenin,isorhamnetin 3-0-(2^(G)-α-L-rhamnosy)-rutinoside,rhamnetin 3-0-neohesperidoside,isorhamnetin,quercetin 3-0-(2^(G)-α-L-rhamnosyl)-rutinoside,quercetin 3-O-neohesperidoside,kaempferol and quer-cetin).Fingerprinting was based on the selection of nine characteristic chromatographic peaks.In quantitative analysis,the recovery of all eight compounds was in the range 98.5-102.2% with good linearity(r^(2)>0.9919)over a relatively wide concentration range.The assay was successfully applied to the analysis of the eight bioactive flavonoids in 14 different samples.The results indicate that the assay is reproducible and precise and can be used for convenient quality assessment of Pollen Typhae.
基金support provided by the National Natural Science Foundation of China(51908083,52270058)the Venture&Innovation Support Program for Chongqing Overseas Returnees(CX2021121)+1 种基金the National Key Research and Development Program of China(2022YFC3203402)the Graduate Research and Innovation Foundation of Chongqing,China(CYS22066)。
文摘Ammonia recovery from wastewater is crucial,yet technology of low carbon emission and high ammonia perm-selectivity against complex stream compositions is urgently needed.Herein,a membrane-based hybrid process of the Donnan dialysiseelectrodialysis process(DDeED)was proposed for sustainable and efficient ammonia recovery.In principle,DD removes the majority of ammonia in wastewater by exploring the concentration gradient of NH4 t and driven cation(Nat)across the cation exchange membrane,given industrial sodium salt as a driving chemical.An additional ED stage driven by solar energy realizes a further removal of ammonia,recovery of driven cation,and replenishment of OHtoward ammonia stripping.Our results demonstrated that the hybrid DDeED process achieved ammonia removal efficiency>95%,driving cation(Nat)recovery efficiency>87.1%for synthetic streams,and reduced the OH-loss by up to 78%compared to a standalone DD case.Ammonia fluxes of 98.2 gN m^(-2)d^(-1)with the real anaerobic digestion effluent were observed using only solar energy input at 3.8 kWh kgN^(-1).With verified mass transfer modeling,reasonably controlled operation,and beneficial recovery performance,the hybrid process can be a promising candidate for future nutrient recovery from wastewater in a rural,remote area.
基金This work is supported by the National Natural Science Foundation of China(Nos.61402182 and 61273295).
文摘This paper is concerned with the structured simultaneous low-rank and sparse recovery,which can be formulated as the rank and zero-norm regularized least squares problem with a hard constraint diag(■)=0.For this class of NP-hard problems,we propose a convex relaxation algorithm by applying the accelerated proximal gradient method to a convex relaxation model,which is yielded by the smoothed nuclear norm and the weighted l1-norm regularized least squares problem.A theoretical guarantee is provided by establishing the error bounds of the iterates to the true solution under mild restricted strong convexity conditions.To the best of our knowledge,this work is the first one to characterize the error bound of the iterates of the algorithm to the true solution.Finally,numerical results are reported for some random test problems and synthetic data in subspace clustering to verify the efficiency of the proposed convex relaxation algorithm.
基金supported by the National Nature Science Foundation of China(Grant No.52306034).
文摘This study investigated the influence of casing profiles on the aeroelastic stability of a transonic compressor rotor.To elucidate the influence of casing profiles on aerodynamic damping(AD)and delve into more detailed insights,the influence coefficient method and phase-shift theory were incorporated into the conventional energy method to establish the multi-passage energy method.The unsteady pressure was calculated using the influence coef-ficient method and the outcomes at various nodal diameters(NDs)were reconstructed based on the phase-shift theory.Thus,the multi-passage energy method offers more comprehensive information than the conventional energy method,the aeroelastic eigenvalue method,and the coupled fluid-structure interaction method.Four casing profiles were simulated.In contrast to the straight casing configuration,the concave shrinking casing was found to be detrimental to aeroelastic stability.The convex shrinking casing can alleviate the blockage in the tip flow field and improve both the aerodynamic performance and aeroelastic stability.The multi-passage energy method further revealed that the AD is contributed by the blade itself and the adjacent blades.In comparison to the straight casing,the convex shrinking casing not only enhances the AD of the blade itself but also diminishes the AD fluctuation of the adjacent blades.Consequently,the minimum AD is increased.
文摘In the original publication the Supplementary Material and Fig.2 are in correct.The correct versi on of Supplementary Material and Fig.2 are provided in this correction article.The text HBG2 appearing in the article should be read as HBG1.
基金We thank Rong and Lin lab members for constructive criticism and discussions. The research was funded by the National Natural Sci- ence Foundation of China （Grant Nos, 81670093 and 81372494）, the Natural Science Foundation of Guangdong Province （2014B020212018 and 2017A030310331）, the Program of Guangzhou Science Technology and Innovation Commission （201508020120）, and the Thousand Young Talents Program of China.
文摘Dear Editor, Clustered regularly interspaced short palindromic repeats （CRISPR） system is part of the adaptive immunity of bacteria and archaea that defends them against phage infection （Barrangou and Doudna, 2016）. Variant CRISPR systems have been identified and harnessed for a wide range of applications in various organisms, exemplified by gene editing with the CRISPR/Cas9 system from Streptococcuspyogenes （Barrangou and Doudna, 2016）.
