Suitable heat treatment processes were adopted to regulate the precipitation of the lamellar LPSO phase andβ′phase in Mg−Gd−Y−Zn−Zr−Nd alloy.The effects of lamellar LPSO phase andβ′phase on the mechanical properti...Suitable heat treatment processes were adopted to regulate the precipitation of the lamellar LPSO phase andβ′phase in Mg−Gd−Y−Zn−Zr−Nd alloy.The effects of lamellar LPSO phase andβ′phase on the mechanical properties and damping capacity of the alloy were studied systematically.Experimental results demonstrate that the lamellar LPSO phase is more conducive to dynamic recrystallization processes,leading to a high degree of recrystallization and a weak texture intensity,resulting in a higher plasticity and damping capacity.After aging treatment,theβ′precipitates exhibit pronounced aging strengthening and increase the number of mobile interfaces,thus enhancing the strength and damping capacity at the same time.Through regulating lamellar LPSO and agedβ′phase,the alloy achieves high strength and high damping capacity:ultimate tensile strength of 498 MPa,yield strength of 371 MPa and damping capacity of 0.02 at strain amplitude of 1×10^(−3).展开更多
目的探索黄芪-莪术配伍对乳腺癌的抑制作用及其机制。方法用浸泡法、水煎法提取黄芪、莪术的有效成分,并制备灌胃液。采用裸鼠皮下注射1.8×10^(6)个MDA-MB-231细胞的方法构建人乳腺癌细胞系裸鼠移植瘤模型。待裸鼠成瘤80 mm 3左右...目的探索黄芪-莪术配伍对乳腺癌的抑制作用及其机制。方法用浸泡法、水煎法提取黄芪、莪术的有效成分,并制备灌胃液。采用裸鼠皮下注射1.8×10^(6)个MDA-MB-231细胞的方法构建人乳腺癌细胞系裸鼠移植瘤模型。待裸鼠成瘤80 mm 3左右,开始分为6组:模型组(生理盐水)、黄芪组(黄芪0.4 g/ml)、莪术组(莪术0.4 g/ml)、黄芪莪术2∶1组、黄芪莪术1∶1组、黄芪莪术1∶2组。然后用灌胃针对小鼠进行灌胃给药处理,每日给药一次,连续给药4周。处死后游标卡尺测量肿瘤的大小,用HE染色法检测肿瘤细胞排列情况和病理学特征,用TUNEL检测细胞凋亡的情况,用RT-PCR检测PI3K、Akt1、Akt2、PTEN基因的表达情况,用Western blot检测各组p-Akt、PTEN蛋白的表达水平。结果黄芪莪术2∶1组的乳腺肿瘤明显小于模型组和药物单独作用组(P<0.05),并且肿瘤细胞排列更疏松、坏死更严重,肿瘤细胞凋亡数目最多。RT-PCR和Western blot结果显示黄芪莪术2∶1组PI3K、Akt1、Akt2基因表达水平显著低于模型组和药物单独作用组,PTEN蛋白表达水平显著高于模型组和药物单独作用组(P<0.05)。结论黄芪-莪术配伍对乳腺癌有明显的抑制作用,可能是通过抑制PI3K、Akt1、Akt2基因的表达并促进PTEN基因的表达实现的。展开更多
AIM:To evaluate the safety and efficacy of Densiron 68 heavy silicone oil (HSO) tamponade for complicated retinal detachment(RD)in Chinese eyes.METHODS:Twenty-one eyes of 21 patients with complicated RD were included ...AIM:To evaluate the safety and efficacy of Densiron 68 heavy silicone oil (HSO) tamponade for complicated retinal detachment(RD)in Chinese eyes.METHODS:Twenty-one eyes of 21 patients with complicated RD were included in this retrospective study.All patients underwent pars plana vitrectomy with an internal tamponade using Densiron 68 HSO.Anatomical and functional results and complications were evaluated,including retinal status,visual acuity(VA),intraocular pressure(IOP),intraocular inflammation,lens opacity,and HSO emulsification.RESULTS:Allthepatients were followed up for 3mo to1y(5.8±1.16mo).Retinal reattachment was achieved in 19of 21 patients(90.5%).VA improved in 18 of 21 patients(85.7%),from 1.93 logMAR(±0.48)to 1.52 logMAR(±0.45)(P=0.001).Postoperative complications included early dispersion of HSO in 7 eyes(38.8%),cataract in 10 of 18phakic eyes(55.5%),moderate postoperative inflammation reaction in 10 eyes(47.6%),and elevated IOP in 5 eyes(23.8%),all of which were controlled by medication or by surgery.CONCLUSION:Highanatomical and functional success rates can be achieved with primary vitrectomy for complicated RD by using Densiron 68 HSO;however,it should not be ignored that Densiron 68 HSO can cause some complications in the eye.展开更多
基金financially supported by the National Key Research and Development Program of China(No.2021YFB3701100)the National Natural Science Foundation of China(Nos.U20A20234,51874062)+1 种基金the Postdoctoral Science Foundation of China(Nos.2023M730390,2022M710563)the Natural Science Foundation Commission,China(Nos.CSTB2023NSCQ-BHX0164,CSTB2022NSCQ-BHX0029)。
文摘Suitable heat treatment processes were adopted to regulate the precipitation of the lamellar LPSO phase andβ′phase in Mg−Gd−Y−Zn−Zr−Nd alloy.The effects of lamellar LPSO phase andβ′phase on the mechanical properties and damping capacity of the alloy were studied systematically.Experimental results demonstrate that the lamellar LPSO phase is more conducive to dynamic recrystallization processes,leading to a high degree of recrystallization and a weak texture intensity,resulting in a higher plasticity and damping capacity.After aging treatment,theβ′precipitates exhibit pronounced aging strengthening and increase the number of mobile interfaces,thus enhancing the strength and damping capacity at the same time.Through regulating lamellar LPSO and agedβ′phase,the alloy achieves high strength and high damping capacity:ultimate tensile strength of 498 MPa,yield strength of 371 MPa and damping capacity of 0.02 at strain amplitude of 1×10^(−3).
文摘AIM:To evaluate the safety and efficacy of Densiron 68 heavy silicone oil (HSO) tamponade for complicated retinal detachment(RD)in Chinese eyes.METHODS:Twenty-one eyes of 21 patients with complicated RD were included in this retrospective study.All patients underwent pars plana vitrectomy with an internal tamponade using Densiron 68 HSO.Anatomical and functional results and complications were evaluated,including retinal status,visual acuity(VA),intraocular pressure(IOP),intraocular inflammation,lens opacity,and HSO emulsification.RESULTS:Allthepatients were followed up for 3mo to1y(5.8±1.16mo).Retinal reattachment was achieved in 19of 21 patients(90.5%).VA improved in 18 of 21 patients(85.7%),from 1.93 logMAR(±0.48)to 1.52 logMAR(±0.45)(P=0.001).Postoperative complications included early dispersion of HSO in 7 eyes(38.8%),cataract in 10 of 18phakic eyes(55.5%),moderate postoperative inflammation reaction in 10 eyes(47.6%),and elevated IOP in 5 eyes(23.8%),all of which were controlled by medication or by surgery.CONCLUSION:Highanatomical and functional success rates can be achieved with primary vitrectomy for complicated RD by using Densiron 68 HSO;however,it should not be ignored that Densiron 68 HSO can cause some complications in the eye.
