Mucosal-associated invariant T(MAIT)cells are a population of evolutionarily conserved“innate”T cells that express the invariant T-cell receptor(TCR)α-chain Vα7.2-Jα33.MAIT cells are capable of rapidly producing ...Mucosal-associated invariant T(MAIT)cells are a population of evolutionarily conserved“innate”T cells that express the invariant T-cell receptor(TCR)α-chain Vα7.2-Jα33.MAIT cells are capable of rapidly producing several cytokines,including interferon gamma(IFNy),tumour necrosis factor alpha(TNFa)and interleukin 17(IL-17).1 MAIT cells,in particular IL-17-producing subsets,have been implicated in numerous chronic inflammatory diseases including rheumatoid arthritis,ankylosing spondylitis and psoriasis.2 We have previously described alterations in MAIT cell cytokine profiles in obesity,including reduced IFNy production and elevated IL-17 production.3 More recently,we have reported alterations in MAIT cell metabolism in patients with obesity that underpin the loss of IFNy production by MAIT cells.展开更多
基金supported by the National Children’s Research Centre.
文摘Mucosal-associated invariant T(MAIT)cells are a population of evolutionarily conserved“innate”T cells that express the invariant T-cell receptor(TCR)α-chain Vα7.2-Jα33.MAIT cells are capable of rapidly producing several cytokines,including interferon gamma(IFNy),tumour necrosis factor alpha(TNFa)and interleukin 17(IL-17).1 MAIT cells,in particular IL-17-producing subsets,have been implicated in numerous chronic inflammatory diseases including rheumatoid arthritis,ankylosing spondylitis and psoriasis.2 We have previously described alterations in MAIT cell cytokine profiles in obesity,including reduced IFNy production and elevated IL-17 production.3 More recently,we have reported alterations in MAIT cell metabolism in patients with obesity that underpin the loss of IFNy production by MAIT cells.
